ATE402191T1 - Rekombinante il-18 antikörper und deren verwendung - Google Patents

Rekombinante il-18 antikörper und deren verwendung

Info

Publication number
ATE402191T1
ATE402191T1 AT00918152T AT00918152T ATE402191T1 AT E402191 T1 ATE402191 T1 AT E402191T1 AT 00918152 T AT00918152 T AT 00918152T AT 00918152 T AT00918152 T AT 00918152T AT E402191 T1 ATE402191 T1 AT E402191T1
Authority
AT
Austria
Prior art keywords
recombinant
antibodies
Prior art date
Application number
AT00918152T
Other languages
English (en)
Inventor
Yen Ho
Stephen D Holmes
Alexander Taylor
Sherin ABDEL-MEGUID
Original Assignee
Smithkline Beecham Corp
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Smithkline Beecham Plc filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE402191T1 publication Critical patent/ATE402191T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT00918152T 1999-03-19 2000-03-17 Rekombinante il-18 antikörper und deren verwendung ATE402191T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12529999P 1999-03-19 1999-03-19

Publications (1)

Publication Number Publication Date
ATE402191T1 true ATE402191T1 (de) 2008-08-15

Family

ID=22419067

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00918152T ATE402191T1 (de) 1999-03-19 2000-03-17 Rekombinante il-18 antikörper und deren verwendung

Country Status (28)

Country Link
US (2) US6706487B1 (de)
EP (2) EP1163271B1 (de)
JP (1) JP2002542769A (de)
KR (1) KR100697120B1 (de)
CN (1) CN1246335C (de)
AR (1) AR022952A1 (de)
AT (1) ATE402191T1 (de)
AU (1) AU764622B2 (de)
BR (1) BR0008688A (de)
CA (1) CA2368965C (de)
CO (1) CO5470287A1 (de)
CY (1) CY1108387T1 (de)
CZ (1) CZ303704B6 (de)
DE (1) DE60039589D1 (de)
DK (1) DK1163271T3 (de)
ES (1) ES2308974T3 (de)
HK (1) HK1043798B (de)
HU (1) HU228931B1 (de)
IL (1) IL144995A0 (de)
MY (1) MY124219A (de)
NO (1) NO330391B1 (de)
NZ (1) NZ513699A (de)
PL (1) PL202396B1 (de)
PT (1) PT1163271E (de)
SI (1) SI1163271T1 (de)
TR (3) TR200102733T2 (de)
WO (1) WO2000056771A1 (de)
ZA (1) ZA200107639B (de)

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IL121860A0 (en) 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
CA2276216A1 (en) * 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
AR022952A1 (es) * 1999-03-19 2002-09-04 Smithkline Beecham Corp ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL
US7229619B1 (en) 2000-11-28 2007-06-12 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
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PL356836A1 (en) * 2000-02-10 2004-07-12 Abbott Laboratories Antibodies that bind human interleukin-18 and methods of making and using
NZ535299A (en) * 2000-02-21 2006-06-30 Applied Research Systems Use of IL-18 inhibitors
AU2002224417A1 (en) * 2000-10-18 2002-04-29 Immunex Corporation Methods for treating il-18 mediated disorders
US6855493B2 (en) 2000-11-28 2005-02-15 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
US7179900B2 (en) 2000-11-28 2007-02-20 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
EP1494710A4 (de) * 2002-03-26 2007-03-21 Centocor Inc Diabetes-relevante von immunoglobulin stammende proteine, zusammensetzungen, verfahren und verwendungszwecke
US7132100B2 (en) 2002-06-14 2006-11-07 Medimmune, Inc. Stabilized liquid anti-RSV antibody formulations
AU2002343870A1 (en) * 2002-11-07 2004-06-07 Kumamoto Technology And Industry Foundation Transgenic mammal carrying ganp and utilization thereof
CA2523912A1 (en) 2003-04-30 2004-11-11 Japan Science And Technology Agency Human antihuman interleukin-18 antibody, fragment thereof and method of using the same
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
AU2011224023C1 (en) * 2003-11-12 2013-08-29 Abbvie Inc. IL-18 binding proteins
US20050100965A1 (en) * 2003-11-12 2005-05-12 Tariq Ghayur IL-18 binding proteins
US7141382B1 (en) 2004-10-12 2006-11-28 Parikh Chirag R Methods for detection of IL-18 as an early marker for diagnosis of acute renal failure and predictor of mortality
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AU2007267213B2 (en) * 2006-05-25 2012-03-29 Glaxo Group Limited Modified humanised anti-interleukin-18 antibodies
GB0610438D0 (en) * 2006-05-25 2006-07-05 Glaxo Group Ltd Immunoglobulins
EP1997830A1 (de) 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV-spezifische Bindemoleküle und Mittel zu ihrer Herstellung
US8048420B2 (en) 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
EP2586795B1 (de) 2007-10-05 2018-05-16 Genentech, Inc. Verwendung eines Anti-Amyloid-Beta-Antikörpers bei Augenkrankheiten
EP2210901A4 (de) * 2007-10-19 2012-04-25 Immunas Pharma Inc Zur spezifischen bindung an ein oligomer fähiger antikörper, und dessen verwendung
US20100291071A1 (en) * 2008-08-01 2010-11-18 Immunas Pharma, Inc. Antibody Specific Binding to A-Beta Oligomer and the Use
EP2246427B1 (de) * 2008-02-08 2016-11-30 Immunas Pharma, Inc. Antikörper mit fähigkeit zur spezifischen bindung an amyloid-beta oligomere und deren verwendung
EP2281004A4 (de) * 2008-04-14 2012-02-15 Proscan Rx Pharma Inc Prostataspezifische membranantigenantikörper und antigenbindende fragmente
US9085614B2 (en) 2008-08-01 2015-07-21 Immunas Pharma, Inc. Antibodies that specifically bind to Aβ oligomers and uses thereof
EP2326315A1 (de) * 2008-08-18 2011-06-01 Glaxo Group Limited Behandlung einer autoimmunkrankheit mit il-18-antagonisten
WO2010040736A2 (en) * 2008-10-07 2010-04-15 Ablynx Nv Amino acid sequences directed against il18 and/or the il-18 receptor and polypeptides comprising the same for the treatment of diseases and/or disorders associated with il-18 mediated signaling
US8168165B2 (en) * 2008-12-23 2012-05-01 Abbott Laboratories Alkylated interleukin-18 compositions
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EP2377583A1 (de) * 2009-06-30 2011-10-19 Gosen Co., Ltd. Schlägersaite, herstellungsverfahren dafür und damit bespannter schläger
DK2462162T3 (en) 2009-08-06 2017-01-16 Immunas Pharma Inc Antibodies that specifically bind to A-beta oligomers and their use
DK2462161T3 (en) 2009-08-06 2017-06-06 Immunas Pharma Inc Antibodies specifically binding to A-beta oligomers and their use
US8623358B2 (en) 2009-08-29 2014-01-07 Abbvie Inc. Therapeutic DLL4 binding proteins
US8568726B2 (en) 2009-10-06 2013-10-29 Medimmune Limited RSV specific binding molecule
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EP2542582A4 (de) * 2010-03-02 2013-12-04 Abbvie Inc Therapeutische dll4-bindende proteine
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US9376489B2 (en) 2012-09-07 2016-06-28 Novartis Ag IL-18 binding molecules
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EP4371573A4 (de) 2021-07-13 2025-08-20 National Univ Corporation Tokai National Higher Education And Research System Medizinische zusammensetzung zur behandlung von entzündlicher darmerkrankung
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AR022952A1 (es) * 1999-03-19 2002-09-04 Smithkline Beecham Corp ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL

Also Published As

Publication number Publication date
AU3901600A (en) 2000-10-09
NZ513699A (en) 2004-02-27
EP1163271A4 (de) 2003-04-09
CO5470287A1 (es) 2004-12-30
CZ20013362A3 (cs) 2002-03-13
IL144995A0 (en) 2002-06-30
TR200202253T2 (tr) 2002-12-23
DK1163271T3 (da) 2008-11-10
NO20014524L (no) 2001-11-14
KR100697120B1 (ko) 2007-03-20
CN1246335C (zh) 2006-03-22
KR20020008130A (ko) 2002-01-29
EP1163271A1 (de) 2001-12-19
US6706487B1 (en) 2004-03-16
DE60039589D1 (de) 2008-09-04
CN1352650A (zh) 2002-06-05
NO20014524D0 (no) 2001-09-18
CY1108387T1 (el) 2014-02-12
TR200102733T2 (tr) 2002-04-22
CA2368965A1 (en) 2000-09-28
HK1043798A1 (en) 2002-09-27
PL350460A1 (en) 2002-12-16
JP2002542769A (ja) 2002-12-17
EP1961768A1 (de) 2008-08-27
CA2368965C (en) 2010-05-18
NO330391B1 (no) 2011-04-04
HUP0200502A3 (en) 2003-12-29
MY124219A (en) 2006-06-30
SI1163271T1 (sl) 2008-10-31
HUP0200502A2 (en) 2002-06-29
AU764622B2 (en) 2003-08-28
TR200202254T2 (tr) 2002-12-23
CZ303704B6 (cs) 2013-03-27
WO2000056771A1 (en) 2000-09-28
BR0008688A (pt) 2002-01-08
PT1163271E (pt) 2008-09-16
PL202396B1 (pl) 2009-06-30
ZA200107639B (en) 2002-09-17
HK1043798B (en) 2009-04-09
US20040141964A1 (en) 2004-07-22
ES2308974T3 (es) 2008-12-16
EP1163271B1 (de) 2008-07-23
HU228931B1 (en) 2013-06-28
AR022952A1 (es) 2002-09-04

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