DE60036214T2 - Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung - Google Patents
Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung Download PDFInfo
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- DE60036214T2 DE60036214T2 DE60036214T DE60036214T DE60036214T2 DE 60036214 T2 DE60036214 T2 DE 60036214T2 DE 60036214 T DE60036214 T DE 60036214T DE 60036214 T DE60036214 T DE 60036214T DE 60036214 T2 DE60036214 T2 DE 60036214T2
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- NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 description 1
- 229960004231 thymalfasin Drugs 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 229960000707 tobramycin Drugs 0.000 description 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- 229940073585 tromethamine hydrochloride Drugs 0.000 description 1
- CYHOMWAPJJPNMW-JIGDXULJSA-N tropine Chemical compound C1[C@@H](O)C[C@H]2CC[C@@H]1N2C CYHOMWAPJJPNMW-JIGDXULJSA-N 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/16—Evaporating by spraying
- B01D1/18—Evaporating by spraying to obtain dry solids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Medicinal Preparation (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
- Drying Of Solid Materials (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14167099P | 1999-06-30 | 1999-06-30 | |
| US14171999P | 1999-06-30 | 1999-06-30 | |
| US141670P | 1999-06-30 | ||
| US141719P | 1999-06-30 | ||
| PCT/US2000/018087 WO2001000312A1 (en) | 1999-06-30 | 2000-06-30 | Spray drying process for preparing dry powders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60036214D1 DE60036214D1 (de) | 2007-10-11 |
| DE60036214T2 true DE60036214T2 (de) | 2008-05-21 |
Family
ID=26839351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60036214T Expired - Lifetime DE60036214T2 (de) | 1999-06-30 | 2000-06-30 | Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1196236B1 (https=) |
| JP (2) | JP4327394B2 (https=) |
| KR (1) | KR100667720B1 (https=) |
| AT (1) | ATE371490T1 (https=) |
| AU (1) | AU780327B2 (https=) |
| CA (1) | CA2376937C (https=) |
| DE (1) | DE60036214T2 (https=) |
| HK (1) | HK1044130B (https=) |
| MX (1) | MXPA01013168A (https=) |
| TW (1) | TW453876B (https=) |
| WO (1) | WO2001000312A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6956021B1 (en) | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
| US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
| US6749835B1 (en) | 1999-08-25 | 2004-06-15 | Advanced Inhalation Research, Inc. | Formulation for spray-drying large porous particles |
| FI20002217A7 (fi) * | 1999-12-30 | 2001-07-01 | Orion Yhtymae Oyj | Inhalaatiopartikkelit |
| US6848197B2 (en) | 2001-04-18 | 2005-02-01 | Advanced Inhalation Research, Inc. | Control of process humidity to produce large, porous particles |
| KR100951750B1 (ko) | 2001-11-01 | 2010-04-09 | 노바르티스 아게 | 분무 건조 방법 및 그 조성물 |
| AU2002352836B2 (en) | 2001-11-20 | 2005-09-29 | Alkermes, Inc. | Improved particulate compositions for pulmonary delivery |
| KR20060015316A (ko) * | 2003-05-28 | 2006-02-16 | 넥타르 테라퓨틱스 | 아미노산 및/또는 인지질로 부분 또는 완전 코팅된수불용성 활성제 미립자의 제조를 위한 알코올성 수용액의분무 건조법 |
| TWI348408B (en) | 2004-04-28 | 2011-09-11 | Olympus Corp | Laser processing device |
| JP2008503586A (ja) | 2004-06-21 | 2008-02-07 | ネクター セラピューティクス | アンフォテリシンｂを含む組成物、方法、およびシステム |
| US8513204B2 (en) | 2004-06-21 | 2013-08-20 | Novartis Ag | Compositions comprising amphotericin B, mehods and systems |
| DE102006030166A1 (de) * | 2006-06-29 | 2008-01-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tempern |
| PL220269B1 (pl) * | 2008-04-21 | 2015-09-30 | Przedsiębiorstwo Produkcji Farmaceutycznej Hasco Lek Spółka Akcyjna | Kompozytowy nośnik leków proszkowych, sposób wytwarzania nośnika leków oraz urządzenie do wytwarzania cząstek nośnika kompozytowego |
| US8815258B2 (en) | 2009-05-29 | 2014-08-26 | Pearl Therapeutics, Inc. | Compositions, methods and systems for respiratory delivery of two or more active agents |
| PL3111927T3 (pl) | 2009-05-29 | 2020-06-29 | Pearl Therapeutics, Inc. | Kompozycje do wziewnego podawania środków aktywnych oraz związane z nimi sposoby i systemy |
| ES2622462T3 (es) | 2009-12-03 | 2017-07-06 | Purac Biochem Bv | Polvo de cinamato de metal alcalino y procedimiento de preparación del mismo |
| WO2014096985A2 (en) | 2012-12-19 | 2014-06-26 | Wockhardt Limited | A stable aqueous composition comprising human insulin or an analogue or derivative thereof |
| SG11201507286QA (en) | 2013-03-15 | 2015-10-29 | Pearl Therapeutics Inc | Methods and systems for conditioning of particulate crystalline materials |
| PT107567B (pt) * | 2014-03-31 | 2019-02-13 | Hovione Farm S A | Secador por atomização com atomizador múltiplo, método para o aumento de escala de pós para inalação secos por dispositivo de atomização múltiplo e uso de vários atomizadores num secador por atomização |
| EP3689339B1 (en) | 2015-09-09 | 2022-01-26 | Vectura Limited | Jet milling method |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1567348B2 (de) * | 1964-10-13 | 1976-10-14 | Nihon Shiryo Kogyo Co., Ltd., Tokushima (Japan) | Verfahren zur herstellung eines dextroseproduktes aus staerkehydrolysat |
| AU6010994A (en) * | 1993-11-11 | 1995-05-29 | Hisato Sugawara | Time-division three-dimensional projecting method of projecting three-dimensional image and additionally displaying signal |
| DE69325595T2 (de) * | 1993-11-17 | 2000-03-16 | Niro Holding A/S | Verfahren und sprühtrocknungsgerät zum erzeugen von agglomeriertem pulver |
| US6051256A (en) * | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| AU5719798A (en) * | 1996-12-31 | 1998-07-31 | Inhale Therapeutic Systems, Inc. | Processes for spray drying aqueous suspensions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes |
| US7625420B1 (en) * | 1997-02-24 | 2009-12-01 | Cabot Corporation | Copper powders methods for producing powders and devices fabricated from same |
-
2000
- 2000-06-30 EP EP00945042A patent/EP1196236B1/en not_active Expired - Lifetime
- 2000-06-30 KR KR1020017016831A patent/KR100667720B1/ko not_active Expired - Fee Related
- 2000-06-30 MX MXPA01013168A patent/MXPA01013168A/es active IP Right Grant
- 2000-06-30 CA CA002376937A patent/CA2376937C/en not_active Expired - Fee Related
- 2000-06-30 AT AT00945042T patent/ATE371490T1/de not_active IP Right Cessation
- 2000-06-30 HK HK02105782.9A patent/HK1044130B/en not_active IP Right Cessation
- 2000-06-30 AU AU59038/00A patent/AU780327B2/en not_active Ceased
- 2000-06-30 WO PCT/US2000/018087 patent/WO2001000312A1/en not_active Ceased
- 2000-06-30 JP JP2001506011A patent/JP4327394B2/ja not_active Expired - Fee Related
- 2000-06-30 DE DE60036214T patent/DE60036214T2/de not_active Expired - Lifetime
- 2000-06-30 TW TW089113048A patent/TW453876B/zh not_active IP Right Cessation
-
2009
- 2009-02-18 JP JP2009035590A patent/JP2009106790A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1196236A1 (en) | 2002-04-17 |
| KR100667720B1 (ko) | 2007-01-15 |
| CA2376937C (en) | 2009-01-06 |
| WO2001000312A9 (en) | 2002-07-25 |
| DE60036214D1 (de) | 2007-10-11 |
| WO2001000312A1 (en) | 2001-01-04 |
| ATE371490T1 (de) | 2007-09-15 |
| AU5903800A (en) | 2001-01-31 |
| JP4327394B2 (ja) | 2009-09-09 |
| JP2003503122A (ja) | 2003-01-28 |
| EP1196236B1 (en) | 2007-08-29 |
| CA2376937A1 (en) | 2001-01-04 |
| TW453876B (en) | 2001-09-11 |
| AU780327B2 (en) | 2005-03-17 |
| KR20020015066A (ko) | 2002-02-27 |
| JP2009106790A (ja) | 2009-05-21 |
| HK1044130A1 (en) | 2002-10-11 |
| HK1044130B (en) | 2008-03-14 |
| MXPA01013168A (es) | 2002-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |