ATE371490T1 - Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung - Google Patents

Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung

Info

Publication number
ATE371490T1
ATE371490T1 AT00945042T AT00945042T ATE371490T1 AT E371490 T1 ATE371490 T1 AT E371490T1 AT 00945042 T AT00945042 T AT 00945042T AT 00945042 T AT00945042 T AT 00945042T AT E371490 T1 ATE371490 T1 AT E371490T1
Authority
AT
Austria
Prior art keywords
conditioning zone
formulation
dry powder
producing dry
spray drying
Prior art date
Application number
AT00945042T
Other languages
English (en)
Inventor
David Bennett
Thomas Brewer
Robert Platz
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Application granted granted Critical
Publication of ATE371490T1 publication Critical patent/ATE371490T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/16—Evaporating by spraying
    • B01D1/18—Evaporating by spraying to obtain dry solids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Drying Of Solid Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
AT00945042T 1999-06-30 2000-06-30 Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung ATE371490T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14167099P 1999-06-30 1999-06-30
US14171999P 1999-06-30 1999-06-30

Publications (1)

Publication Number Publication Date
ATE371490T1 true ATE371490T1 (de) 2007-09-15

Family

ID=26839351

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00945042T ATE371490T1 (de) 1999-06-30 2000-06-30 Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung

Country Status (11)

Country Link
EP (1) EP1196236B1 (de)
JP (2) JP4327394B2 (de)
KR (1) KR100667720B1 (de)
AT (1) ATE371490T1 (de)
AU (1) AU780327B2 (de)
CA (1) CA2376937C (de)
DE (1) DE60036214T2 (de)
HK (1) HK1044130B (de)
MX (1) MXPA01013168A (de)
TW (1) TW453876B (de)
WO (1) WO2001000312A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
FI20002217A (fi) * 1999-12-30 2001-07-01 Orion Yhtymae Oyj Inhalaatiopartikkelit
US6848197B2 (en) 2001-04-18 2005-02-01 Advanced Inhalation Research, Inc. Control of process humidity to produce large, porous particles
TW200300696A (en) 2001-11-01 2003-06-16 Inhale Therapeutic Syst Spray drying methods and related compositions
EP1635786A2 (de) 2003-05-28 2006-03-22 Nektar Therapeutics Sprühtrocknung einer alkoholischen wässrigen lösung zur herstellung eines wasserunlöslichen wirkstoff-mikroteilchens mit einem teilweisen oder kompletten aminosäure- und/oder phospholipid-überzug
BRPI0512326A (pt) 2004-06-21 2008-02-26 Nektar Therapeutics composições compreendendo anfotericina b, métodos e sistemas
US8513204B2 (en) 2004-06-21 2013-08-20 Novartis Ag Compositions comprising amphotericin B, mehods and systems
DE102006030166A1 (de) * 2006-06-29 2008-01-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tempern
PL220269B1 (pl) * 2008-04-21 2015-09-30 Przedsiębiorstwo Produkcji Farmaceutycznej Hasco Lek Spółka Akcyjna Kompozytowy nośnik leków proszkowych, sposób wytwarzania nośnika leków oraz urządzenie do wytwarzania cząstek nośnika kompozytowego
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
EP3106149B1 (de) 2009-05-29 2019-11-20 Pearl Therapeutics, Inc. Zusammensetzung für die pulmonale freisetzung von muskarinischen antagonisten mit langzeitwirkung und adrenergischen beta-2-rezeptoragonisten mit langzeitwirkung sowie zugehörige verfahren und systeme
ES2622462T3 (es) 2009-12-03 2017-07-06 Purac Biochem Bv Polvo de cinamato de metal alcalino y procedimiento de preparación del mismo
BR112015011179A8 (pt) 2012-12-19 2019-10-01 Wockhardt Ltd composições farmacêuticas aquosas estáveis compreendendo insulina humana ou um análogo ou derivado das mesmas, seu uso e processos para sua preparação
CN105188679B (zh) * 2013-03-15 2018-10-16 珍珠治疗公司 用于微粒晶体材料的状态调节的方法和系统
PT107567B (pt) * 2014-03-31 2019-02-13 Hovione Farm S A Secador por atomização com atomizador múltiplo, método para o aumento de escala de pós para inalação secos por dispositivo de atomização múltiplo e uso de vários atomizadores num secador por atomização
JP6655169B2 (ja) 2015-09-09 2020-02-26 ベクトゥラ・リミテッド ジェット粉砕法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1567348B2 (de) * 1964-10-13 1976-10-14 Nihon Shiryo Kogyo Co., Ltd., Tokushima (Japan) Verfahren zur herstellung eines dextroseproduktes aus staerkehydrolysat
WO1995013684A1 (fr) * 1993-11-11 1995-05-18 Hisato Sugawara Procede de projection tridimensionnelle en temps partage permettant de projeter une image en trois dimensions et signal d'affichage supplementaire
JPH09505516A (ja) * 1993-11-17 1997-06-03 ニロ・ホールディング・アー／エス 凝集塊粉体を製造するための噴霧乾燥方法及び装置
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
JP2001507702A (ja) * 1996-12-31 2001-06-12 インヘイル・セラピューティックス・システムズ・インコーポレテッド 親水性賦形剤を有する疎水性薬剤の水性懸濁液を噴霧乾燥させる方法およびその方法によって作製された組成物
AU6438398A (en) * 1997-02-24 1998-09-09 Superior Micropowders Llc Aerosol method and apparatus, particulate products, and electronic devices made therefrom

Also Published As

Publication number Publication date
JP2009106790A (ja) 2009-05-21
EP1196236B1 (de) 2007-08-29
TW453876B (en) 2001-09-11
HK1044130B (zh) 2008-03-14
DE60036214T2 (de) 2008-05-21
KR20020015066A (ko) 2002-02-27
CA2376937C (en) 2009-01-06
WO2001000312A1 (en) 2001-01-04
KR100667720B1 (ko) 2007-01-15
DE60036214D1 (de) 2007-10-11
WO2001000312A9 (en) 2002-07-25
JP2003503122A (ja) 2003-01-28
EP1196236A1 (de) 2002-04-17
AU780327B2 (en) 2005-03-17
JP4327394B2 (ja) 2009-09-09
HK1044130A1 (en) 2002-10-11
MXPA01013168A (es) 2002-07-30
AU5903800A (en) 2001-01-31
CA2376937A1 (en) 2001-01-04

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