DE60036214D1 - Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung - Google Patents

Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung

Info

Publication number
DE60036214D1
DE60036214D1 DE60036214T DE60036214T DE60036214D1 DE 60036214 D1 DE60036214 D1 DE 60036214D1 DE 60036214 T DE60036214 T DE 60036214T DE 60036214 T DE60036214 T DE 60036214T DE 60036214 D1 DE60036214 D1 DE 60036214D1
Authority
DE
Germany
Prior art keywords
conditioning zone
formulation
dry powder
producing dry
spray drying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60036214T
Other languages
English (en)
Other versions
DE60036214T2 (de
Inventor
David B Bennett
Thomas K Brewer
Robert M Platz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nektar Therapeutics
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of DE60036214D1 publication Critical patent/DE60036214D1/de
Application granted granted Critical
Publication of DE60036214T2 publication Critical patent/DE60036214T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/16—Evaporating by spraying
    • B01D1/18—Evaporating by spraying to obtain dry solids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Drying Of Solid Materials (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60036214T 1999-06-30 2000-06-30 Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung Expired - Lifetime DE60036214T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14167099P 1999-06-30 1999-06-30
US14171999P 1999-06-30 1999-06-30
US141719P 1999-06-30
US141670P 1999-06-30
PCT/US2000/018087 WO2001000312A1 (en) 1999-06-30 2000-06-30 Spray drying process for preparing dry powders

Publications (2)

Publication Number Publication Date
DE60036214D1 true DE60036214D1 (de) 2007-10-11
DE60036214T2 DE60036214T2 (de) 2008-05-21

Family

ID=26839351

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60036214T Expired - Lifetime DE60036214T2 (de) 1999-06-30 2000-06-30 Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung

Country Status (11)

Country Link
EP (1) EP1196236B1 (de)
JP (2) JP4327394B2 (de)
KR (1) KR100667720B1 (de)
AT (1) ATE371490T1 (de)
AU (1) AU780327B2 (de)
CA (1) CA2376937C (de)
DE (1) DE60036214T2 (de)
HK (1) HK1044130B (de)
MX (1) MXPA01013168A (de)
TW (1) TW453876B (de)
WO (1) WO2001000312A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
FI20002217A (fi) * 1999-12-30 2001-07-01 Orion Yhtymae Oyj Inhalaatiopartikkelit
US6848197B2 (en) * 2001-04-18 2005-02-01 Advanced Inhalation Research, Inc. Control of process humidity to produce large, porous particles
ATE401058T1 (de) 2001-11-01 2008-08-15 Nektar Therapeutics Sprühtrocknungsverfahren
AU2004251623B2 (en) * 2003-05-28 2010-03-18 Novartis Ag Spray drying of an alcoholic aqueous solution for the manufacture of a water-in-soluble active agentmicroparticle with a partial or complete amino acid and/or phospholipid coat
US8513204B2 (en) 2004-06-21 2013-08-20 Novartis Ag Compositions comprising amphotericin B, mehods and systems
MXPA06015220A (es) 2004-06-21 2007-12-13 Nektar Therapeutics Composiciones comprendiendo anfotericina b, metodos y sistemas.
DE102006030166A1 (de) * 2006-06-29 2008-01-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tempern
PL220269B1 (pl) * 2008-04-21 2015-09-30 Przedsiębiorstwo Produkcji Farmaceutycznej Hasco Lek Spółka Akcyjna Kompozytowy nośnik leków proszkowych, sposób wytwarzania nośnika leków oraz urządzenie do wytwarzania cząstek nośnika kompozytowego
DK2435024T3 (en) 2009-05-29 2016-10-24 Pearl Therapeutics Inc Compositions for the respiratory delivery of active agents and related methods and systems
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
EP2330094B1 (de) * 2009-12-03 2017-02-08 PURAC Biochem BV Alkalimetallcinnamatpulver und Herstellungsverfahren dafür
US9707275B2 (en) 2012-12-19 2017-07-18 Wockhardt Limited Stable aqueous composition comprising human insulin or an analogue or derivative thereof
US20140275517A1 (en) 2013-03-15 2014-09-18 Pearl Therapeutics, Inc. Methods and systems for conditioning of particulate crystalline materials
PT107567B (pt) * 2014-03-31 2019-02-13 Hovione Farm S A Secador por atomização com atomizador múltiplo, método para o aumento de escala de pós para inalação secos por dispositivo de atomização múltiplo e uso de vários atomizadores num secador por atomização
US11229915B2 (en) 2015-09-09 2022-01-25 Vectura Limited Jet milling method

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1567348B2 (de) * 1964-10-13 1976-10-14 Nihon Shiryo Kogyo Co., Ltd., Tokushima (Japan) Verfahren zur herstellung eines dextroseproduktes aus staerkehydrolysat
AU6010994A (en) * 1993-11-11 1995-05-29 Hisato Sugawara Time-division three-dimensional projecting method of projecting three-dimensional image and additionally displaying signal
WO1995013864A1 (en) * 1993-11-17 1995-05-26 Niro Holding A/S A process and a spray drying apparatus for producing an agglomerated powder
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
WO1998029096A1 (en) * 1996-12-31 1998-07-09 Inhale Therapeutic Systems Aerosolized hydrophobic drug
US6165247A (en) * 1997-02-24 2000-12-26 Superior Micropowders, Llc Methods for producing platinum powders

Also Published As

Publication number Publication date
HK1044130A1 (en) 2002-10-11
ATE371490T1 (de) 2007-09-15
HK1044130B (zh) 2008-03-14
KR20020015066A (ko) 2002-02-27
WO2001000312A1 (en) 2001-01-04
CA2376937C (en) 2009-01-06
CA2376937A1 (en) 2001-01-04
EP1196236B1 (de) 2007-08-29
AU5903800A (en) 2001-01-31
MXPA01013168A (es) 2002-07-30
JP2009106790A (ja) 2009-05-21
AU780327B2 (en) 2005-03-17
WO2001000312A9 (en) 2002-07-25
EP1196236A1 (de) 2002-04-17
JP2003503122A (ja) 2003-01-28
JP4327394B2 (ja) 2009-09-09
DE60036214T2 (de) 2008-05-21
KR100667720B1 (ko) 2007-01-15
TW453876B (en) 2001-09-11

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