JP4327394B2 - 乾燥粉末を調製するための噴霧乾燥法 - Google Patents

乾燥粉末を調製するための噴霧乾燥法 Download PDF

Info

Publication number
JP4327394B2
JP4327394B2 JP2001506011A JP2001506011A JP4327394B2 JP 4327394 B2 JP4327394 B2 JP 4327394B2 JP 2001506011 A JP2001506011 A JP 2001506011A JP 2001506011 A JP2001506011 A JP 2001506011A JP 4327394 B2 JP4327394 B2 JP 4327394B2
Authority
JP
Japan
Prior art keywords
composition
conditioning zone
dry powder
zone
spray
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2001506011A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003503122A (ja
JP2003503122A5 (https=
Inventor
ビー． ベネット，デイビッド
ケー． ブリューワー，トーマス
エム． プラッツ，ロバート
Original Assignee
ネクター セラピューティクス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ネクター セラピューティクス filed Critical ネクター セラピューティクス
Publication of JP2003503122A publication Critical patent/JP2003503122A/ja
Publication of JP2003503122A5 publication Critical patent/JP2003503122A5/ja
Application granted granted Critical
Publication of JP4327394B2 publication Critical patent/JP4327394B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/16—Evaporating by spraying
    • B01D1/18—Evaporating by spraying to obtain dry solids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Drying Of Solid Materials (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2001506011A 1999-06-30 2000-06-30 乾燥粉末を調製するための噴霧乾燥法 Expired - Fee Related JP4327394B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14167099P 1999-06-30 1999-06-30
US14171999P 1999-06-30 1999-06-30
US60/141,670 1999-06-30
US60/141,719 1999-06-30
PCT/US2000/018087 WO2001000312A1 (en) 1999-06-30 2000-06-30 Spray drying process for preparing dry powders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009035590A Division JP2009106790A (ja) 1999-06-30 2009-02-18 乾燥粉末を調整するための噴霧乾燥法

Publications (3)

Publication Number Publication Date
JP2003503122A JP2003503122A (ja) 2003-01-28
JP2003503122A5 JP2003503122A5 (https=) 2009-04-09
JP4327394B2 true JP4327394B2 (ja) 2009-09-09

Family

ID=26839351

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2001506011A Expired - Fee Related JP4327394B2 (ja) 1999-06-30 2000-06-30 乾燥粉末を調製するための噴霧乾燥法
JP2009035590A Withdrawn JP2009106790A (ja) 1999-06-30 2009-02-18 乾燥粉末を調整するための噴霧乾燥法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009035590A Withdrawn JP2009106790A (ja) 1999-06-30 2009-02-18 乾燥粉末を調整するための噴霧乾燥法

Country Status (11)

Country Link
EP (1) EP1196236B1 (https=)
JP (2) JP4327394B2 (https=)
KR (1) KR100667720B1 (https=)
AT (1) ATE371490T1 (https=)
AU (1) AU780327B2 (https=)
CA (1) CA2376937C (https=)
DE (1) DE60036214T2 (https=)
HK (1) HK1044130B (https=)
MX (1) MXPA01013168A (https=)
TW (1) TW453876B (https=)
WO (1) WO2001000312A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8022332B2 (en) 2004-04-28 2011-09-20 Olympus Corporation Laser processing device

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6956021B1 (en) 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
FI20002217A7 (fi) * 1999-12-30 2001-07-01 Orion Yhtymae Oyj Inhalaatiopartikkelit
US6848197B2 (en) * 2001-04-18 2005-02-01 Advanced Inhalation Research, Inc. Control of process humidity to produce large, porous particles
WO2003037303A1 (en) 2001-11-01 2003-05-08 Nektar Therapeutics Spray drying methods and compositions thereof
CA2465675C (en) 2001-11-20 2008-06-10 Advanced Inhalation Research, Inc. Improved particulate compositions for pulmonary delivery
CA2523475C (en) 2003-05-28 2013-02-05 Nektar Therapeutics Pharmaceutical formulation comprising a water-insoluble active agent
MXPA06015220A (es) 2004-06-21 2007-12-13 Nektar Therapeutics Composiciones comprendiendo anfotericina b, metodos y sistemas.
US8513204B2 (en) 2004-06-21 2013-08-20 Novartis Ag Compositions comprising amphotericin B, mehods and systems
DE102006030166A1 (de) * 2006-06-29 2008-01-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tempern
PL220269B1 (pl) * 2008-04-21 2015-09-30 Przedsiębiorstwo Produkcji Farmaceutycznej Hasco Lek Spółka Akcyjna Kompozytowy nośnik leków proszkowych, sposób wytwarzania nośnika leków oraz urządzenie do wytwarzania cząstek nośnika kompozytowego
MX337126B (es) 2009-05-29 2016-02-12 Pearl Therapeutics Inc Administracion respiratoria de agentes activos.
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
ES2622462T3 (es) 2009-12-03 2017-07-06 Purac Biochem Bv Polvo de cinamato de metal alcalino y procedimiento de preparación del mismo
US9707275B2 (en) 2012-12-19 2017-07-18 Wockhardt Limited Stable aqueous composition comprising human insulin or an analogue or derivative thereof
KR102391332B1 (ko) * 2013-03-15 2022-04-26 펄 테라퓨틱스 인코포레이티드 미립자 결정질 재료를 컨디셔닝하는 방법 및 시스템
PT107567B (pt) * 2014-03-31 2019-02-13 Hovione Farm S A Secador por atomização com atomizador múltiplo, método para o aumento de escala de pós para inalação secos por dispositivo de atomização múltiplo e uso de vários atomizadores num secador por atomização
CA2996072C (en) 2015-09-09 2020-06-30 Vectura Limited Jet milling method

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1567348B2 (de) * 1964-10-13 1976-10-14 Nihon Shiryo Kogyo Co., Ltd., Tokushima (Japan) Verfahren zur herstellung eines dextroseproduktes aus staerkehydrolysat
WO1995013684A1 (en) * 1993-11-11 1995-05-18 Hisato Sugawara Time-division three-dimensional projecting method of projecting three-dimensional image and additionally displaying signal
JPH09505516A (ja) * 1993-11-17 1997-06-03 ニロ・ホールディング・アー／エス 凝集塊粉体を製造するための噴霧乾燥方法及び装置
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US6077543A (en) * 1996-12-31 2000-06-20 Inhale Therapeutic Systems Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
JP2001513697A (ja) * 1997-02-24 2001-09-04 スーペリア マイクロパウダーズ リミテッド ライアビリティ カンパニー エアロゾル法及び装置、粒子製品、並びに該粒子製品から製造される電子装置

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8022332B2 (en) 2004-04-28 2011-09-20 Olympus Corporation Laser processing device

Also Published As

Publication number Publication date
HK1044130B (en) 2008-03-14
EP1196236B1 (en) 2007-08-29
WO2001000312A9 (en) 2002-07-25
EP1196236A1 (en) 2002-04-17
MXPA01013168A (es) 2002-07-30
KR100667720B1 (ko) 2007-01-15
JP2003503122A (ja) 2003-01-28
AU5903800A (en) 2001-01-31
TW453876B (en) 2001-09-11
JP2009106790A (ja) 2009-05-21
CA2376937A1 (en) 2001-01-04
DE60036214T2 (de) 2008-05-21
AU780327B2 (en) 2005-03-17
CA2376937C (en) 2009-01-06
ATE371490T1 (de) 2007-09-15
DE60036214D1 (de) 2007-10-11
KR20020015066A (ko) 2002-02-27
HK1044130A1 (en) 2002-10-11
WO2001000312A1 (en) 2001-01-04

Similar Documents

Publication Publication Date Title
JP2009106790A (ja) 乾燥粉末を調整するための噴霧乾燥法
US8337895B2 (en) Spray drying process control of drying kinetics
DK1280520T3 (en) Phospholipid-based powders for drug release
JP4378057B2 (ja) 流動抵抗調節されたエアロゾル化活性薬剤送達
US20040105820A1 (en) Phospholipid-based powders for inhalation
PL190732B1 (pl) Sposób wytwarzania dyspergowalnych suchych proszków makrocząsteczek biologicznych
US20140212504A1 (en) Phospholipid-based powders for drug delivery
KR20050042052A (ko) 분무 건조 방법 및 그 조성물
JP2006518748A (ja) 改良されたワクチン接種のための大気圧噴霧凍結乾燥によって作製される組換えブドウ球菌エンテロトキシンｂ（＜ｓｂ＞ｒ＜／ｓｂ＞ｓｅｂ）の粉末処方物
MXPA01003614A (en) Flow resistance modulated aerosolized active agent delivery

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070518

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070518

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20071218

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080318

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080326

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080613

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20081021

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20090218

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20090224

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20090512

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20090611

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120619

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees