ATE371490T1 - Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung - Google Patents

Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung

Info

Publication number
ATE371490T1
ATE371490T1 AT00945042T AT00945042T ATE371490T1 AT E371490 T1 ATE371490 T1 AT E371490T1 AT 00945042 T AT00945042 T AT 00945042T AT 00945042 T AT00945042 T AT 00945042T AT E371490 T1 ATE371490 T1 AT E371490T1
Authority
AT
Austria
Prior art keywords
conditioning zone
formulation
dry powder
producing dry
spray drying
Prior art date
Application number
AT00945042T
Other languages
German (de)
English (en)
Inventor
David Bennett
Thomas Brewer
Robert Platz
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Application granted granted Critical
Publication of ATE371490T1 publication Critical patent/ATE371490T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/16—Evaporating by spraying
    • B01D1/18—Evaporating by spraying to obtain dry solids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Drying Of Solid Materials (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT00945042T 1999-06-30 2000-06-30 Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung ATE371490T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14167099P 1999-06-30 1999-06-30
US14171999P 1999-06-30 1999-06-30

Publications (1)

Publication Number Publication Date
ATE371490T1 true ATE371490T1 (de) 2007-09-15

Family

ID=26839351

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00945042T ATE371490T1 (de) 1999-06-30 2000-06-30 Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung

Country Status (11)

Country Link
EP (1) EP1196236B1 (https=)
JP (2) JP4327394B2 (https=)
KR (1) KR100667720B1 (https=)
AT (1) ATE371490T1 (https=)
AU (1) AU780327B2 (https=)
CA (1) CA2376937C (https=)
DE (1) DE60036214T2 (https=)
HK (1) HK1044130B (https=)
MX (1) MXPA01013168A (https=)
TW (1) TW453876B (https=)
WO (1) WO2001000312A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6956021B1 (en) 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
FI20002217A7 (fi) * 1999-12-30 2001-07-01 Orion Yhtymae Oyj Inhalaatiopartikkelit
US6848197B2 (en) * 2001-04-18 2005-02-01 Advanced Inhalation Research, Inc. Control of process humidity to produce large, porous particles
WO2003037303A1 (en) 2001-11-01 2003-05-08 Nektar Therapeutics Spray drying methods and compositions thereof
CA2465675C (en) 2001-11-20 2008-06-10 Advanced Inhalation Research, Inc. Improved particulate compositions for pulmonary delivery
CA2523475C (en) 2003-05-28 2013-02-05 Nektar Therapeutics Pharmaceutical formulation comprising a water-insoluble active agent
TWI348408B (en) 2004-04-28 2011-09-11 Olympus Corp Laser processing device
MXPA06015220A (es) 2004-06-21 2007-12-13 Nektar Therapeutics Composiciones comprendiendo anfotericina b, metodos y sistemas.
US8513204B2 (en) 2004-06-21 2013-08-20 Novartis Ag Compositions comprising amphotericin B, mehods and systems
DE102006030166A1 (de) * 2006-06-29 2008-01-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tempern
PL220269B1 (pl) * 2008-04-21 2015-09-30 Przedsiębiorstwo Produkcji Farmaceutycznej Hasco Lek Spółka Akcyjna Kompozytowy nośnik leków proszkowych, sposób wytwarzania nośnika leków oraz urządzenie do wytwarzania cząstek nośnika kompozytowego
MX337126B (es) 2009-05-29 2016-02-12 Pearl Therapeutics Inc Administracion respiratoria de agentes activos.
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
ES2622462T3 (es) 2009-12-03 2017-07-06 Purac Biochem Bv Polvo de cinamato de metal alcalino y procedimiento de preparación del mismo
US9707275B2 (en) 2012-12-19 2017-07-18 Wockhardt Limited Stable aqueous composition comprising human insulin or an analogue or derivative thereof
KR102391332B1 (ko) * 2013-03-15 2022-04-26 펄 테라퓨틱스 인코포레이티드 미립자 결정질 재료를 컨디셔닝하는 방법 및 시스템
PT107567B (pt) * 2014-03-31 2019-02-13 Hovione Farm S A Secador por atomização com atomizador múltiplo, método para o aumento de escala de pós para inalação secos por dispositivo de atomização múltiplo e uso de vários atomizadores num secador por atomização
CA2996072C (en) 2015-09-09 2020-06-30 Vectura Limited Jet milling method

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1567348B2 (de) * 1964-10-13 1976-10-14 Nihon Shiryo Kogyo Co., Ltd., Tokushima (Japan) Verfahren zur herstellung eines dextroseproduktes aus staerkehydrolysat
WO1995013684A1 (en) * 1993-11-11 1995-05-18 Hisato Sugawara Time-division three-dimensional projecting method of projecting three-dimensional image and additionally displaying signal
JPH09505516A (ja) * 1993-11-17 1997-06-03 ニロ・ホールディング・アー／エス 凝集塊粉体を製造するための噴霧乾燥方法及び装置
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US6077543A (en) * 1996-12-31 2000-06-20 Inhale Therapeutic Systems Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
JP2001513697A (ja) * 1997-02-24 2001-09-04 スーペリア マイクロパウダーズ リミテッド ライアビリティ カンパニー エアロゾル法及び装置、粒子製品、並びに該粒子製品から製造される電子装置

Also Published As

Publication number Publication date
HK1044130B (en) 2008-03-14
EP1196236B1 (en) 2007-08-29
WO2001000312A9 (en) 2002-07-25
EP1196236A1 (en) 2002-04-17
MXPA01013168A (es) 2002-07-30
KR100667720B1 (ko) 2007-01-15
JP2003503122A (ja) 2003-01-28
AU5903800A (en) 2001-01-31
TW453876B (en) 2001-09-11
JP2009106790A (ja) 2009-05-21
JP4327394B2 (ja) 2009-09-09
CA2376937A1 (en) 2001-01-04
DE60036214T2 (de) 2008-05-21
AU780327B2 (en) 2005-03-17
CA2376937C (en) 2009-01-06
DE60036214D1 (de) 2007-10-11
KR20020015066A (ko) 2002-02-27
HK1044130A1 (en) 2002-10-11
WO2001000312A1 (en) 2001-01-04

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