CA2376937C - Spray drying process for preparing dry powders - Google Patents
Spray drying process for preparing dry powders Download PDFInfo
- Publication number
- CA2376937C CA2376937C CA002376937A CA2376937A CA2376937C CA 2376937 C CA2376937 C CA 2376937C CA 002376937 A CA002376937 A CA 002376937A CA 2376937 A CA2376937 A CA 2376937A CA 2376937 C CA2376937 C CA 2376937C
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- Prior art keywords
- formulation
- conditioning zone
- conditioning
- dry
- zone
- Prior art date
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- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/16—Evaporating by spraying
- B01D1/18—Evaporating by spraying to obtain dry solids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
- Drying Of Solid Materials (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14167099P | 1999-06-30 | 1999-06-30 | |
| US14171999P | 1999-06-30 | 1999-06-30 | |
| US60/141,670 | 1999-06-30 | ||
| US60/141,719 | 1999-06-30 | ||
| PCT/US2000/018087 WO2001000312A1 (en) | 1999-06-30 | 2000-06-30 | Spray drying process for preparing dry powders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2376937A1 CA2376937A1 (en) | 2001-01-04 |
| CA2376937C true CA2376937C (en) | 2009-01-06 |
Family
ID=26839351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002376937A Expired - Fee Related CA2376937C (en) | 1999-06-30 | 2000-06-30 | Spray drying process for preparing dry powders |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1196236B1 (https=) |
| JP (2) | JP4327394B2 (https=) |
| KR (1) | KR100667720B1 (https=) |
| AT (1) | ATE371490T1 (https=) |
| AU (1) | AU780327B2 (https=) |
| CA (1) | CA2376937C (https=) |
| DE (1) | DE60036214T2 (https=) |
| HK (1) | HK1044130B (https=) |
| MX (1) | MXPA01013168A (https=) |
| TW (1) | TW453876B (https=) |
| WO (1) | WO2001000312A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6956021B1 (en) | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
| US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
| US6749835B1 (en) | 1999-08-25 | 2004-06-15 | Advanced Inhalation Research, Inc. | Formulation for spray-drying large porous particles |
| FI20002217A7 (fi) * | 1999-12-30 | 2001-07-01 | Orion Yhtymae Oyj | Inhalaatiopartikkelit |
| US6848197B2 (en) * | 2001-04-18 | 2005-02-01 | Advanced Inhalation Research, Inc. | Control of process humidity to produce large, porous particles |
| WO2003037303A1 (en) | 2001-11-01 | 2003-05-08 | Nektar Therapeutics | Spray drying methods and compositions thereof |
| CA2465675C (en) | 2001-11-20 | 2008-06-10 | Advanced Inhalation Research, Inc. | Improved particulate compositions for pulmonary delivery |
| CA2523475C (en) | 2003-05-28 | 2013-02-05 | Nektar Therapeutics | Pharmaceutical formulation comprising a water-insoluble active agent |
| TWI348408B (en) | 2004-04-28 | 2011-09-11 | Olympus Corp | Laser processing device |
| MXPA06015220A (es) | 2004-06-21 | 2007-12-13 | Nektar Therapeutics | Composiciones comprendiendo anfotericina b, metodos y sistemas. |
| US8513204B2 (en) | 2004-06-21 | 2013-08-20 | Novartis Ag | Compositions comprising amphotericin B, mehods and systems |
| DE102006030166A1 (de) * | 2006-06-29 | 2008-01-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tempern |
| PL220269B1 (pl) * | 2008-04-21 | 2015-09-30 | Przedsiębiorstwo Produkcji Farmaceutycznej Hasco Lek Spółka Akcyjna | Kompozytowy nośnik leków proszkowych, sposób wytwarzania nośnika leków oraz urządzenie do wytwarzania cząstek nośnika kompozytowego |
| MX337126B (es) | 2009-05-29 | 2016-02-12 | Pearl Therapeutics Inc | Administracion respiratoria de agentes activos. |
| US8815258B2 (en) | 2009-05-29 | 2014-08-26 | Pearl Therapeutics, Inc. | Compositions, methods and systems for respiratory delivery of two or more active agents |
| ES2622462T3 (es) | 2009-12-03 | 2017-07-06 | Purac Biochem Bv | Polvo de cinamato de metal alcalino y procedimiento de preparación del mismo |
| US9707275B2 (en) | 2012-12-19 | 2017-07-18 | Wockhardt Limited | Stable aqueous composition comprising human insulin or an analogue or derivative thereof |
| KR102391332B1 (ko) * | 2013-03-15 | 2022-04-26 | 펄 테라퓨틱스 인코포레이티드 | 미립자 결정질 재료를 컨디셔닝하는 방법 및 시스템 |
| PT107567B (pt) * | 2014-03-31 | 2019-02-13 | Hovione Farm S A | Secador por atomização com atomizador múltiplo, método para o aumento de escala de pós para inalação secos por dispositivo de atomização múltiplo e uso de vários atomizadores num secador por atomização |
| CA2996072C (en) | 2015-09-09 | 2020-06-30 | Vectura Limited | Jet milling method |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1567348B2 (de) * | 1964-10-13 | 1976-10-14 | Nihon Shiryo Kogyo Co., Ltd., Tokushima (Japan) | Verfahren zur herstellung eines dextroseproduktes aus staerkehydrolysat |
| WO1995013684A1 (en) * | 1993-11-11 | 1995-05-18 | Hisato Sugawara | Time-division three-dimensional projecting method of projecting three-dimensional image and additionally displaying signal |
| JPH09505516A (ja) * | 1993-11-17 | 1997-06-03 | ニロ・ホールディング・アー／エス | 凝集塊粉体を製造するための噴霧乾燥方法及び装置 |
| US6051256A (en) * | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| US6077543A (en) * | 1996-12-31 | 2000-06-20 | Inhale Therapeutic Systems | Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients |
| JP2001513697A (ja) * | 1997-02-24 | 2001-09-04 | スーペリア マイクロパウダーズ リミテッド ライアビリティ カンパニー | エアロゾル法及び装置、粒子製品、並びに該粒子製品から製造される電子装置 |
-
2000
- 2000-06-30 EP EP00945042A patent/EP1196236B1/en not_active Expired - Lifetime
- 2000-06-30 MX MXPA01013168A patent/MXPA01013168A/es active IP Right Grant
- 2000-06-30 TW TW089113048A patent/TW453876B/zh not_active IP Right Cessation
- 2000-06-30 AU AU59038/00A patent/AU780327B2/en not_active Ceased
- 2000-06-30 HK HK02105782.9A patent/HK1044130B/en not_active IP Right Cessation
- 2000-06-30 DE DE60036214T patent/DE60036214T2/de not_active Expired - Lifetime
- 2000-06-30 CA CA002376937A patent/CA2376937C/en not_active Expired - Fee Related
- 2000-06-30 WO PCT/US2000/018087 patent/WO2001000312A1/en not_active Ceased
- 2000-06-30 KR KR1020017016831A patent/KR100667720B1/ko not_active Expired - Fee Related
- 2000-06-30 AT AT00945042T patent/ATE371490T1/de not_active IP Right Cessation
- 2000-06-30 JP JP2001506011A patent/JP4327394B2/ja not_active Expired - Fee Related
-
2009
- 2009-02-18 JP JP2009035590A patent/JP2009106790A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| HK1044130B (en) | 2008-03-14 |
| EP1196236B1 (en) | 2007-08-29 |
| WO2001000312A9 (en) | 2002-07-25 |
| EP1196236A1 (en) | 2002-04-17 |
| MXPA01013168A (es) | 2002-07-30 |
| KR100667720B1 (ko) | 2007-01-15 |
| JP2003503122A (ja) | 2003-01-28 |
| AU5903800A (en) | 2001-01-31 |
| TW453876B (en) | 2001-09-11 |
| JP2009106790A (ja) | 2009-05-21 |
| JP4327394B2 (ja) | 2009-09-09 |
| CA2376937A1 (en) | 2001-01-04 |
| DE60036214T2 (de) | 2008-05-21 |
| AU780327B2 (en) | 2005-03-17 |
| ATE371490T1 (de) | 2007-09-15 |
| DE60036214D1 (de) | 2007-10-11 |
| KR20020015066A (ko) | 2002-02-27 |
| HK1044130A1 (en) | 2002-10-11 |
| WO2001000312A1 (en) | 2001-01-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |