DE60032082D1 - Vorrichtung zur transdermalen Verabreichung von einer Substanz - Google Patents

Vorrichtung zur transdermalen Verabreichung von einer Substanz

Info

Publication number
DE60032082D1
DE60032082D1 DE60032082T DE60032082T DE60032082D1 DE 60032082 D1 DE60032082 D1 DE 60032082D1 DE 60032082 T DE60032082 T DE 60032082T DE 60032082 T DE60032082 T DE 60032082T DE 60032082 D1 DE60032082 D1 DE 60032082D1
Authority
DE
Germany
Prior art keywords
housing
pharmaceutical agent
microneedles
substance
microns
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60032082T
Other languages
English (en)
Other versions
DE60032082T2 (de
Inventor
Zeil B Rosenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of DE60032082D1 publication Critical patent/DE60032082D1/de
Application granted granted Critical
Publication of DE60032082T2 publication Critical patent/DE60032082T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Surgical Instruments (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60032082T 1999-09-22 2000-08-07 Vorrichtung zur transdermalen Verabreichung von einer Substanz Expired - Lifetime DE60032082T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/401,452 US6623457B1 (en) 1999-09-22 1999-09-22 Method and apparatus for the transdermal administration of a substance
US401452 1999-09-22

Publications (2)

Publication Number Publication Date
DE60032082D1 true DE60032082D1 (de) 2007-01-11
DE60032082T2 DE60032082T2 (de) 2007-06-21

Family

ID=23587826

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60032082T Expired - Lifetime DE60032082T2 (de) 1999-09-22 2000-08-07 Vorrichtung zur transdermalen Verabreichung von einer Substanz

Country Status (9)

Country Link
US (4) US6623457B1 (de)
EP (1) EP1086718B1 (de)
JP (1) JP2001149485A (de)
AT (1) ATE346644T1 (de)
AU (1) AU778234B2 (de)
CA (1) CA2315469C (de)
DE (1) DE60032082T2 (de)
ES (1) ES2273639T3 (de)
SG (1) SG92728A1 (de)

Families Citing this family (301)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6641591B1 (en) 1999-08-26 2003-11-04 John H. Shadduck Instruments and techniques for controlled removal of epidermal layers
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US6494865B1 (en) 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
AU2736501A (en) * 1999-12-30 2001-07-16 Redeon, Inc. Stacked microneedle systems
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US7473244B2 (en) * 2000-06-02 2009-01-06 The University Of Utah Research Foundation Active needle devices with integrated functionality
US20040175360A1 (en) * 2000-06-29 2004-09-09 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
WO2002028471A1 (de) 2000-10-05 2002-04-11 Thomas Marsoner Medizinische injektionseinrichtung
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
AU2002237703A1 (en) * 2000-11-09 2002-06-18 Biovalve Technologies, Inc. Microneedle adapter
WO2002064193A2 (en) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
US7850663B2 (en) 2001-01-12 2010-12-14 Becton, Dickinson And Company Medicament microdevice delivery system, cartridge and method of use
PT1361890E (pt) * 2001-02-23 2011-06-07 Glaxosmithkline Biolog Sa Formulações vacinais de influenza para distribuição intradérmica
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
CA2444391A1 (en) * 2001-04-13 2002-10-24 Becton Dickinson And Company Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US7963935B2 (en) * 2001-04-20 2011-06-21 Alza Corporation Microprojection array having a beneficial agent containing coating
AU2007203302B2 (en) * 2001-04-20 2010-07-01 Alza Corporation Microprojection array immunization patch and method
WO2002087494A2 (en) * 2001-04-27 2002-11-07 Glaxosmithkline Biologicals, Sa Novel vaccine
US20060018877A1 (en) * 2001-06-29 2006-01-26 Mikszta John A Intradermal delivery of vacccines and therapeutic agents
WO2003002069A2 (en) * 2001-06-29 2003-01-09 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US6830562B2 (en) 2001-09-27 2004-12-14 Unomedical A/S Injector device for placing a subcutaneous infusion set
WO2003053258A1 (en) * 2001-12-20 2003-07-03 Alza Corporation Skin-piercing microprojections having piercing depth control
US6908453B2 (en) 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7115108B2 (en) * 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US7047070B2 (en) * 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
BR0311443A (pt) 2002-05-06 2005-03-22 Becton Dickinson Co Método e dispositivo para controlar farmacocinética de droga
US20060264886A9 (en) * 2002-05-06 2006-11-23 Pettis Ronald J Method for altering insulin pharmacokinetics
JP2005533625A (ja) 2002-07-19 2005-11-10 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルデバイスおよびマイクロニードル送達装置
CA2497086A1 (en) * 2002-08-30 2004-03-11 Becton, Dickinson And Company Method of controlling pharmacokinetics of immunomodulatory compounds
US20040051019A1 (en) 2002-09-02 2004-03-18 Mogensen Lasse Wesseltoft Apparatus for and a method of adjusting the length of an infusion tube
US20040106904A1 (en) * 2002-10-07 2004-06-03 Gonnelli Robert R. Microneedle array patch
DK200201823A (da) 2002-11-26 2004-05-27 Maersk Medical As Forbindelsesstykke for en slangeforbindelse
BRPI0409984A (pt) * 2003-05-06 2006-05-09 Becton Dickinson Co processo para alterar a farmacocinética da insulina
WO2004108205A1 (en) * 2003-06-02 2004-12-16 Becton Dickinson And Company Medicament microdevice delivery system with a cartridge
JP2005021678A (ja) * 2003-06-10 2005-01-27 Medorekkusu:Kk 経皮投薬用パッドベースの製造方法及び経皮投薬用パッドベース、並びに注射針
US20060127465A1 (en) * 2003-06-10 2006-06-15 Shinya Maenosono Pad base for transdermal administration and needle
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
EP1638523B8 (de) * 2003-06-30 2013-12-25 ALZA Corporation Formulierungen für beschichtete mikrovorsprünge mit nichtflüchtigen gegenionen
US7888546B2 (en) 2003-07-03 2011-02-15 Corium International, Inc. Wound dressing, ingredient delivery device and IV hold-down, and method relating to same
US7766902B2 (en) 2003-08-13 2010-08-03 Wisconsin Alumni Research Foundation Microfluidic device for drug delivery
US8353861B2 (en) * 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
WO2005041871A2 (en) * 2003-10-24 2005-05-12 Alza Corporation Apparatus and method for enhancing transdermal drug delivery
AU2004311977A1 (en) * 2003-12-29 2005-07-21 3M Innovative Properties Company Medical devices and kits including same
US7611481B2 (en) * 2004-03-24 2009-11-03 Corium International, Inc. Transdermal delivery device
MXPA06010923A (es) 2004-03-26 2006-12-15 Unomedical As Perfusor.
US20050251095A1 (en) * 2004-05-07 2005-11-10 Giap Brandon C Improved medication injection device
AU2005244734A1 (en) 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
US20080039805A1 (en) * 2004-06-10 2008-02-14 Frederickson Franklyn L Patch Application Device and Kit
US8062250B2 (en) 2004-08-10 2011-11-22 Unomedical A/S Cannula device
DE602005025138D1 (de) 2004-08-16 2011-01-13 Fuctional Microstructures Ltd Verfahren zur herstellung einer mikronadel oder eines mikroimplantats
AR050608A1 (es) * 2004-08-19 2006-11-08 Alza Corp Aparato y metodo para administracion transdermica de factores de crecimiento endotelial vascular
US7316665B2 (en) * 2004-08-25 2008-01-08 Becton, Dickinson And Company Method and device for the delivery of a substance including a covering
CA2588080C (en) * 2004-11-18 2013-01-08 3M Innovative Properties Company Masking method for coating a microneedle array
CA2587505C (en) 2004-11-18 2013-01-08 3M Innovative Properties Company Low-profile microneedle array applicator
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
ATE504328T1 (de) 2004-11-18 2011-04-15 3M Innovative Properties Co Mikronadelanordungsapplikator und halter
KR101246015B1 (ko) 2004-11-18 2013-03-20 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로니들 어레이를 접촉 코팅하는 방법
WO2006057619A1 (en) * 2004-11-26 2006-06-01 Agency For Science, Technology And Research Method and apparatus for forming microstructures
WO2006061027A2 (en) 2004-12-10 2006-06-15 Unomedical A/S Cannula inserter
WO2006064270A1 (en) * 2004-12-17 2006-06-22 Functional Microstructures Limited Microneedle device for transdermal transport of fluid
AR055310A1 (es) * 2005-02-16 2007-08-15 Alza Corp Arreglos de microproyecciones con mejor biocompatibilidad
US7985199B2 (en) 2005-03-17 2011-07-26 Unomedical A/S Gateway system
EP1871459B1 (de) 2005-04-07 2019-06-19 3M Innovative Properties Company SYSTEM ZUR ERFASSUNG DER WERKZEUGRüCKMELDUNG
EP1871457B1 (de) 2005-04-11 2012-05-02 Infotonics Technology Center, Inc. Blutüberwachungssysteme und verfahren dafür
WO2006115502A1 (en) * 2005-04-25 2006-11-02 Giap, Brandon, C. Improved medication injection device
US8048017B2 (en) * 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8043250B2 (en) * 2005-05-18 2011-10-25 Nanomed Devices, Inc. High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US20080195035A1 (en) * 2005-06-24 2008-08-14 Frederickson Franklyn L Collapsible Patch and Method of Application
US20100256568A1 (en) * 2005-06-27 2010-10-07 Frederickson Franklyn L Microneedle cartridge assembly and method of applying
EP2474338B1 (de) * 2005-06-27 2013-07-24 3M Innovative Properties Company Vorrichtung zum Aufbringen einer Mikronadelanordnung
US20080214952A1 (en) 2005-07-11 2008-09-04 Jose Mir Replaceable Cartridge for Allergy Testing System
US20070088248A1 (en) * 2005-09-02 2007-04-19 Iomai Corporation Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9358033B2 (en) * 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
DK1762259T3 (da) 2005-09-12 2011-01-03 Unomedical As Indføringsindretning til infusionssæt med en første og en anden fjederenhed
GB0520757D0 (en) * 2005-10-12 2005-11-23 Vuppalapati Gunasekar Delivery device
WO2007047539A2 (en) * 2005-10-14 2007-04-26 Medtronic, Inc. Localized delivery to the lymphatic system
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
US9248317B2 (en) 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
EP1957132A4 (de) * 2005-12-08 2010-04-21 Nanopass Technologies Ltd Mikronadel-adapter für vorrichtungen zur dosierten arzneiabgabe
USD655807S1 (en) 2005-12-09 2012-03-13 Unomedical A/S Medical device
EP2301601B1 (de) 2005-12-23 2013-01-30 Unomedical A/S Injektionsvorrichtung
US8048089B2 (en) 2005-12-30 2011-11-01 Edge Systems Corporation Apparatus and methods for treating the skin
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9211379B2 (en) 2006-02-28 2015-12-15 Unomedical A/S Inserter for infusion part and infusion part provided with needle protector
US9566088B2 (en) 2006-03-29 2017-02-14 Edge Systems Llc Devices, systems and methods for treating the skin
US10172644B2 (en) 2006-03-29 2019-01-08 Edge Systems Llc Devices, systems and methods for treating the skin
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
US20070265570A1 (en) * 2006-04-27 2007-11-15 Gerut Zachary E Device and method for treating skin prior to performing surgery
US20070276318A1 (en) * 2006-05-26 2007-11-29 Mit, Llp Iontosonic-microneedle applicator apparatus and methods
US20070276330A1 (en) * 2006-05-28 2007-11-29 Beck Patricia A Microneedles and methods of fabricating thereof
US20070276425A1 (en) * 2006-05-29 2007-11-29 Stanley Kim Painless Blood Sampling Lancet with Bundled Multiple Thin Needles
US20070282246A1 (en) * 2006-06-05 2007-12-06 Mit, Llp Iontosonic-microneedle biosensor apparatus and methods
WO2007140783A2 (en) 2006-06-07 2007-12-13 Unomedical A/S Inserter for transcutaneous sensor
CN101489604B (zh) 2006-06-09 2012-05-23 优诺医疗有限公司 安装垫
US8012566B2 (en) * 2006-07-12 2011-09-06 Hewlett-Packard Development Company, L.P. Microneedles formed by electroplating and selectively releasing temperature sensitive layers
US8250729B2 (en) * 2006-07-12 2012-08-28 University Of Utah Research Foundation 3D fabrication of needle tip geometry and knife blade
US20080015516A1 (en) * 2006-07-12 2008-01-17 Nanopass Technologies Ltd. Microneedle Devices With Controlled Uncapping
KR100886633B1 (ko) * 2006-07-14 2009-03-04 호남석유화학 주식회사 전면부에 피부를 통해 체내로 전달하고자 하는 물질의 수용공간을 갖는 피부 침투용 미세 돌기 장치
JP2008029710A (ja) * 2006-07-31 2008-02-14 Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai マイクロニードル型パッチ及びその製造方法
MX2009001119A (es) 2006-08-02 2009-06-02 Unomedical As Canula y dispositivo de administracion.
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
AU2007303223C1 (en) 2006-10-02 2013-01-10 Emkinetics, Inc. Method and apparatus for magnetic induction therapy
EP1917990A1 (de) 2006-10-31 2008-05-07 Unomedical A/S Infusionsset
US20080114340A1 (en) * 2006-11-01 2008-05-15 Biotex, Inc. System and method for reducing photon scatter in dermal tissue
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
EP2111251B1 (de) * 2007-01-19 2018-09-12 Joseph Neev Vorrichtungen zur erzeugung von mikrounterbrechungen unter der oberfläche für biomedizinische anwendungen
US10588694B1 (en) 2007-01-19 2020-03-17 Joseph Neev Devices and methods for generation of subsurface micro-disruptions for biomedical applications
US8821446B2 (en) 2007-01-22 2014-09-02 Corium International, Inc. Applicators for microneedles
EP2664323B1 (de) 2007-04-16 2020-07-29 Corium, Inc. Lösemittelgegossene Mikronadelfelder mit Wirkstoffen
JP2010529166A (ja) * 2007-06-14 2010-08-26 クルセル スウィツァーランド アーゲー 皮内インフルエンザワクチン
CA2691369A1 (en) 2007-06-20 2008-12-24 Unomedical A/S A catheter and a method and an apparatus for making such catheter
WO2009004026A1 (en) 2007-07-03 2009-01-08 Unomedical A/S Inserter having bistable equilibrium states
CA2692740A1 (en) * 2007-07-09 2009-01-15 Apogee Technology, Inc. Immunostimulating polyphosphazene compounds for intradermal immunization
US8486003B2 (en) 2007-07-10 2013-07-16 Unomedical A/S Inserter having two springs
EP2175913A1 (de) 2007-07-18 2010-04-21 Unomedical A/S Einsetzvorrichtung mit schwenkwirkung
AU2008279294A1 (en) * 2007-07-21 2009-01-29 Stanley Kim Lancet system
US8328720B2 (en) 2007-08-10 2012-12-11 Infotonics Technology Center, Inc. MEMS interstitial prothrombin time test
JP5223278B2 (ja) * 2007-09-27 2013-06-26 凸版印刷株式会社 マイクロニードル製造方法
ES2612061T3 (es) * 2007-09-28 2017-05-11 The Queen's University Of Belfast Dispositivo y método de suministro
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
EP2240099B1 (de) 2008-01-04 2018-02-21 Edge Systems LLC Vorrichtung zur hautbehandlung
US9056193B2 (en) 2008-01-29 2015-06-16 Edge Systems Llc Apparatus and method for treating the skin
DK2252349T3 (da) 2008-02-13 2011-10-10 Unomedical As Forsegling mellem en kanyledel og en væskebane
CA2715667A1 (en) 2008-02-20 2009-08-27 Unomedical A/S Insertion device with horizontally moving part
US9408971B2 (en) * 2008-03-31 2016-08-09 Covidien Lp Self-capping syringe assembly with one-way valve
WO2009130926A1 (ja) * 2008-04-22 2009-10-29 南部化成株式会社 経皮投薬方法、ニードル形成体及び経皮投薬装置
US10543123B2 (en) 2008-04-28 2020-01-28 Joseph Neev Devices and methods for generation of subsurface micro-disruptions for opthalmic surgery and opthalmic applications
JP5476062B2 (ja) * 2008-07-25 2014-04-23 南部化成株式会社 経皮投薬デバイス
US8986250B2 (en) 2008-08-01 2015-03-24 Wisconsin Alumni Research Foundation Drug delivery platform utilizing hydrogel pumping mechanism
US8795259B2 (en) 2008-08-01 2014-08-05 Wisconsin Alumni Research Foundation Drug delivery platform incorporating hydrogel pumping mechanism with guided fluid flow
US9056047B2 (en) 2008-10-31 2015-06-16 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US8731842B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US9060931B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US9050070B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8798932B2 (en) 2008-10-31 2014-08-05 The Invention Science Fund I, Llc Frozen compositions and methods for piercing a substrate
US8721583B2 (en) 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8725420B2 (en) 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8545857B2 (en) 2008-10-31 2013-10-01 The Invention Science Fund I, Llc Compositions and methods for administering compartmentalized frozen particles
US8731840B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US9072688B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8603495B2 (en) 2008-10-31 2013-12-10 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US8409376B2 (en) 2008-10-31 2013-04-02 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9060926B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8551505B2 (en) 2008-10-31 2013-10-08 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US9060934B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8788211B2 (en) 2008-10-31 2014-07-22 The Invention Science Fund I, Llc Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition
US8762067B2 (en) 2008-10-31 2014-06-24 The Invention Science Fund I, Llc Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data
US9072799B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8545855B2 (en) 2008-10-31 2013-10-01 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8731841B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US20100111857A1 (en) 2008-10-31 2010-05-06 Boyden Edward S Compositions and methods for surface abrasion with frozen particles
US8256233B2 (en) 2008-10-31 2012-09-04 The Invention Science Fund I, Llc Systems, devices, and methods for making or administering frozen particles
US8793075B2 (en) 2008-10-31 2014-07-29 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US9050317B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8603494B2 (en) 2008-10-31 2013-12-10 The Invention Science Fund I, Llc Compositions and methods for administering compartmentalized frozen particles
US8814837B2 (en) 2008-11-17 2014-08-26 Yoichi Inaba Simple device for treating tinea unguium
EP3300765A1 (de) * 2008-11-18 2018-04-04 3M Innovative Properties Co. Hohlmikronadelfeld
RU2011130565A (ru) 2008-12-22 2013-01-27 Уномедикал А/С Медицинское устройство, содержащее клеящую прокладку
FI20095433A0 (fi) * 2009-04-20 2009-04-20 Valtion Teknillinen Mikroneula
EP2451367B1 (de) 2009-07-08 2020-01-22 Edge Systems Corporation Vorrichtungen zur hautbehandlung mithilfe zeitgesteuert freigesetzter substanzen
CA2766475A1 (en) 2009-07-30 2011-02-03 Unomedical A/S Inserter device with horizontal moving part
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
WO2011015659A1 (en) 2009-08-07 2011-02-10 Unomedical A/S Delivery device with sensor and one or more cannulas
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US8088108B2 (en) * 2009-08-22 2012-01-03 Joseph Wayne Kraft Rapid local anesthesia injection cone
US8409147B2 (en) * 2009-08-22 2013-04-02 Joseph Wayne Kraft Rapid local anesthesia linear injection device
CA2773915A1 (en) * 2009-09-17 2011-04-14 Zipline Medical, Inc. Rapid closing surgical closure device
US10159825B2 (en) * 2009-09-17 2018-12-25 Zipline Medical, Inc. Rapid closing surgical closure device
EP2493551A4 (de) 2009-10-26 2013-04-17 Emkinetics Inc Verfahren und vorrichtung zur elektromagnetischen stimulation von nerven, muskeln und körpergewebe
DE102009046581A1 (de) * 2009-11-10 2011-05-12 Robert Bosch Gmbh Herstellungsverfahren für eine poröse Mikronadelanordnung und entsprechende poröse Mikronadelanordnung und entsprechender Substratverbund
CN102770156B (zh) 2009-12-16 2016-01-20 克洛恩泰克制药股份公司 密码子优化的乙型肝炎病毒核心抗原(hbcag)
CA2689400C (en) * 2009-12-30 2023-01-10 Kenneth W. Adams Therapeutic agent delivery apparatus and process
US20110172638A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including multi-functional cover
US8328757B2 (en) * 2010-01-08 2012-12-11 Wisconsin Alumni Research Foundation Bladder arrangement for microneedle-based drug delivery device
US9327105B2 (en) 2010-03-26 2016-05-03 Itrace Biomedical Inc. Active transdermal drug delivery system and the method thereof
CA2792138A1 (en) 2010-03-30 2011-10-06 Unomedical A/S Medical device
US8439945B2 (en) 2010-05-03 2013-05-14 Zipline Medical, Inc. Methods for biopsying tissue
ES2719595T3 (es) 2010-05-04 2019-07-11 Corium Int Inc Método y dispositivo para la administración transdérmica de la hormona paratiroidea usando una matriz de microproyección
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
JP6030551B2 (ja) 2010-06-14 2016-11-24 ジップライン メディカル, インコーポレイテッド 瘢痕形成を阻止する方法および装置
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2433663A1 (de) 2010-09-27 2012-03-28 Unomedical A/S Einführsystem
CN104531812A (zh) 2010-10-01 2015-04-22 现代治疗公司 设计核酸及其使用方法
EP2436412A1 (de) 2010-10-04 2012-04-04 Unomedical A/S Sprinklerkanüle
JP6068143B2 (ja) * 2010-10-27 2017-01-25 Asti株式会社 マイクロニードルアレイ装着用治具とマイクロニードルアレイ装置
WO2012061556A1 (en) 2010-11-03 2012-05-10 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
US20120135526A1 (en) * 2010-11-23 2012-05-31 Kenneth Greenberg Low-pressure biolistic barrels
US10244981B2 (en) 2011-03-30 2019-04-02 SensiVida Medical Technologies, Inc. Skin test image analysis apparatuses and methods thereof
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
CN103717249B (zh) 2011-06-15 2017-03-22 克洛恩泰克制药股份公司 注射针和装置
US9334306B2 (en) 2011-07-09 2016-05-10 The Regents Of The University Of California Leukemia stem cell targeting ligands and methods of use
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US9700245B2 (en) 2011-09-23 2017-07-11 Itrace Biomedical Inc. Transdermal analyte extraction and detection system and the method thereof
RU2707251C2 (ru) 2011-10-03 2019-11-25 Модерна Терапьютикс, Инк. Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
EP2763723B1 (de) 2011-10-05 2016-04-13 Unomedical A/S Inserter zum gleichzeitigen einsetzen mehrerer transkutaner teile
EP2578190A1 (de) * 2011-10-07 2013-04-10 Sanofi-Aventis Deutschland GmbH Intraokulare Injektionsvorrichtung
EP2583715A1 (de) 2011-10-19 2013-04-24 Unomedical A/S Infusionsschlauchsystem und Herstellungsverfahren
US9440051B2 (en) 2011-10-27 2016-09-13 Unomedical A/S Inserter for a multiplicity of subcutaneous parts
US10123801B2 (en) 2011-11-01 2018-11-13 Zipline Medical, Inc. Means to prevent wound dressings from adhering to closure device
US10123800B2 (en) 2011-11-01 2018-11-13 Zipline Medical, Inc. Surgical incision and closure apparatus with integrated force distribution
US8323313B1 (en) 2011-11-01 2012-12-04 Zipline Medical, Inc. Surgical incision and closure apparatus with integrated force distribution
US9050086B2 (en) 2011-11-01 2015-06-09 Zipline Medical, Inc. Surgical incision and closure apparatus
US9561034B2 (en) 2011-11-01 2017-02-07 Zipline Medical, Inc. Surgical incision and closure apparatus
KR20140102759A (ko) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
WO2013138118A1 (en) 2012-03-14 2013-09-19 The Regents Of The University Of California Treatment of inflammatory disorders in non-human mammals
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
EP2833892A4 (de) 2012-04-02 2016-07-20 Moderna Therapeutics Inc Modifizierte polynukleotide zur herstellung von in der onkologie nützlichen proteinen und peptiden
CN104185475A (zh) * 2012-04-03 2014-12-03 谢拉杰克特股份有限公司 面颊给药的可溶微针阵列疫苗
WO2013171907A1 (ja) * 2012-05-18 2013-11-21 大勝 明 注射針、および、キット製剤
KR200466758Y1 (ko) 2012-06-01 2013-05-07 인싸이토(주) 경피내 주사기 모듈
JP6418544B2 (ja) * 2012-06-27 2018-11-07 コスメディ製薬株式会社 マイクロニードルパッチの保護離型シート
JP5903016B2 (ja) * 2012-06-27 2016-04-13 コスメディ製薬株式会社 マイクロニードルパッチの保護離型シート
WO2014064534A2 (en) 2012-10-05 2014-05-01 Chrontech Pharma Ab Injection needle, device, immunogenic compositions and method of use
JP6144355B2 (ja) 2012-11-26 2017-06-07 モデルナティエックス インコーポレイテッドModernaTX,Inc. 化学修飾mRNA
EP2934660B1 (de) 2012-12-21 2019-07-17 Corium, Inc. Mikroarray zur freisetzung therapeutischer wirkstoffe und verfahren zur herstellung davon
US10179239B2 (en) 2013-01-15 2019-01-15 Itrace Biomedical Inc. Personalized pain management treatments
US9710607B2 (en) 2013-01-15 2017-07-18 Itrace Biomedical Inc. Portable electronic therapy device and the method thereof
US9717893B2 (en) 2013-02-13 2017-08-01 Hisamitsu Pharmaceutical Co., Ltd. Microneedle array
WO2014132239A1 (en) 2013-02-28 2014-09-04 Kimberly-Clark Worldwide, Inc. Drug delivery device
CN109621083B (zh) 2013-02-28 2022-03-22 索伦托治疗有限公司 药物递送装置
CA2903748C (en) 2013-03-12 2021-11-02 Corium International, Inc. Microprojection applicators
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
EP3903704B1 (de) 2013-03-15 2022-11-02 HydraFacial LLC Vorrichtungen und systeme zur hautbehandlung
US10238812B2 (en) 2013-03-15 2019-03-26 Edge Systems Llc Skin treatment systems and methods using needles
AU2014237279B2 (en) 2013-03-15 2018-11-22 Corium Pharma Solutions, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
JP2016512754A (ja) 2013-03-15 2016-05-09 コリウム インターナショナル, インコーポレイテッド 治療剤の送達のためのマイクロアレイ、使用方法および製造方法
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
CN105246458B (zh) 2013-03-15 2020-09-15 考里安公司 用于治疗剂递送的微阵列及其使用方法
CA2923010C (en) 2013-09-03 2022-08-30 Georgia Tech Research Corporation Thermally stable vaccine formulations and microneedles
US10323076B2 (en) 2013-10-03 2019-06-18 Modernatx, Inc. Polynucleotides encoding low density lipoprotein receptor
EP3089677B1 (de) 2014-01-05 2020-04-01 Zipline Medical, Inc. Instrumentierte wundverschlussvorrichtung
US20160279401A1 (en) 2015-03-27 2016-09-29 Allergan, Inc. Dissolvable microneedles for skin treatment
WO2015159525A1 (ja) * 2014-04-14 2015-10-22 凸版印刷株式会社 注入器具
CN106232172B (zh) 2014-04-30 2020-05-22 索伦托治疗有限公司 透皮药物递送设备的插座部分和方法
MX2016013187A (es) 2014-04-30 2017-01-16 Kimberly Clark Co Porcion del controlador de un dispositivo y metodos para administrar medicamentos transdermicos.
CA2944997C (en) 2014-04-30 2023-04-04 Kimberly-Clark Worldwide, Inc. Transdermal drug delivery apparatus and methods
KR101724655B1 (ko) * 2014-06-02 2017-04-13 주식회사 아모라이프사이언스 마이크로 니들 패치 및 그의 제조 방법
US9987427B1 (en) * 2014-06-24 2018-06-05 National Technology & Engineering Solutions Of Sandia, Llc Diagnostic/drug delivery “sense-respond” devices, systems, and uses thereof
US9968765B2 (en) 2014-07-21 2018-05-15 The Cleveland Clinic Foundation Convection enhanced delivery device and system
US9907941B2 (en) 2014-07-21 2018-03-06 The Cleveland Clinic Foundation Convection enhanced delivery device and system
KR101636775B1 (ko) * 2014-08-19 2016-07-08 아주대학교산학협력단 부위마취 장치 및 방법
WO2016036866A1 (en) 2014-09-04 2016-03-10 Corium International, Inc. Microstructure array, methods of making, and methods of use
JP5931155B2 (ja) * 2014-09-30 2016-06-08 日本写真印刷株式会社 マイクロニードルシートの梱包体及びその製造方法
JP6906885B2 (ja) 2014-11-14 2021-07-21 ロレアル しわを減少させるためのマイクロニードルシート
EP3795204B1 (de) 2014-12-23 2023-10-25 HydraFacial LLC Vorrichtung zur behandlung der haut mittels eines rollballens
US10179229B2 (en) 2014-12-23 2019-01-15 Edge Systems Llc Devices and methods for treating the skin using a porous member
CN104922791B (zh) * 2015-05-26 2018-10-26 上海交通大学 无创针灸贴片及其制备方法
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US11241357B2 (en) 2015-07-08 2022-02-08 Edge Systems Llc Devices, systems and methods for promoting hair growth
JP2019513070A (ja) 2016-03-01 2019-05-23 キトテック メディカル, インコーポレイテッド 創傷閉鎖のための微細構造に基づくシステム、装置および方法
WO2018081795A1 (en) 2016-10-31 2018-05-03 Zipline Medical, Inc. Systems and methods for monitoring physical therapy of the knee and other joints
US11241563B2 (en) * 2016-12-22 2022-02-08 Johnson & Johnson Consumer Inc. Microneedle arrays and methods for making and using
WO2018119090A1 (en) * 2016-12-22 2018-06-28 Ohio State Innovation Foundation Interpentrating microstructures for nanochannel-based cargo delivery
CA3053641A1 (en) 2017-02-17 2018-08-23 Allergan, Inc. Microneedle array with active ingredient
CN109394236B (zh) * 2017-08-17 2022-04-01 李泉 一种采血装置及其控制设备
WO2019033362A1 (zh) * 2017-08-17 2019-02-21 深圳华迈兴微医疗科技有限公司 一种采血装置及其控制设备
WO2019059265A1 (ja) * 2017-09-20 2019-03-28 シンクランド株式会社 マイクロニードルの製造方法及びマイクロニードル
TWI666036B (zh) * 2017-10-27 2019-07-21 研能科技股份有限公司 穿戴式人體胰島素注入供液裝置
TWI657842B (zh) * 2017-10-27 2019-05-01 研能科技股份有限公司 人體胰島素注入之供液裝置
EP3813809A1 (de) 2018-06-29 2021-05-05 Johnson & Johnson Consumer Inc. Vorrichtungen für dreidimensionale mikrofluidik zur abgabe von wirkstoffen
GB2574074B (en) 2018-07-27 2020-05-20 Mclaren Applied Tech Ltd Time synchronisation
GB2588236B (en) 2019-10-18 2024-03-20 Mclaren Applied Ltd Gyroscope bias estimation
KR20220097412A (ko) * 2019-10-24 2022-07-07 자닌 홉킨스 어플리케이터 장치 및 사용 방법
WO2021168345A1 (en) 2020-02-19 2021-08-26 Kitotech Medical, Inc. Microstructure systems and methods for pain treatment
EP4117768A4 (de) * 2020-04-09 2024-04-24 Carnegie Mellon University Hybride mikronadelanordnungen
CN112869871B (zh) * 2021-01-11 2022-10-14 杭州维纳安可医疗科技有限责任公司 消融装置及其控制方法、装置、系统、存储介质
CN117813128A (zh) * 2021-01-22 2024-04-02 索伦托药业有限公司 用于微升级淋巴递送冠状病毒疫苗的装置
US11452474B1 (en) 2021-04-14 2022-09-27 Satio, Inc. Dual lever dermal patch system
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
US11510602B1 (en) 2021-11-08 2022-11-29 Satio, Inc. Dermal patch for collecting a physiological sample
KR102577073B1 (ko) * 2021-04-27 2023-09-11 주식회사 이엘홀딩스 마이크로 니들을 이용한 문신 패치
USD1016615S1 (en) 2021-09-10 2024-03-05 Hydrafacial Llc Container for a skin treatment device
WO2023159181A1 (en) 2022-02-18 2023-08-24 Kitotech Medical, Inc. Force modulating deep skin staples and instruments
WO2023193010A1 (en) 2022-04-01 2023-10-05 The Regents Of The University Of California Methods of improving cancer immunotherapy
EP4391999A1 (de) 2022-04-29 2024-07-03 Colgate-Palmolive Company Körperpflegezusammensetzungen

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1699012A (en) * 1927-11-22 1929-01-15 Joseph S Naylor Stock and poultry marker
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
FR1584474A (de) 1968-02-20 1969-12-26
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) 1972-02-14 1973-08-13 Ici Ltd Pansements
DE2513467C3 (de) * 1975-03-26 1979-10-31 Siemens Ag, 1000 Berlin Und 8000 Muenchen Gerät zur Infusion von Flüssigkeiten in den menschlichen oder tierischen Körper
IT1202218B (it) * 1985-05-21 1989-02-02 Mario Aluigi Piastre di derivazione multi-aghi per uso mesoterapico e relative custodie salva punte
EP0429842B1 (de) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
DE69524867T2 (de) * 1994-02-28 2002-09-05 Novo Nordisk As Nadeleinheit
WO1996037256A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
AR008242A1 (es) * 1996-06-18 1999-12-29 Alza Corp Dispositivo para atravesar el estrato corneo de una superficie corporal
US6183434B1 (en) 1996-07-03 2001-02-06 Spectrx, Inc. Multiple mechanical microporation of skin or mucosa
CA2241615A1 (en) 1997-06-26 1998-12-26 An-Go-Gen Inc. Catheters
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
CA2352974A1 (en) * 1998-12-18 2000-06-22 John H. Livingston Insertion sets with micro-piercing members for use with medical devices and methods of using the same
US6611707B1 (en) * 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
EP1187653B1 (de) * 1999-06-04 2010-03-31 Georgia Tech Research Corporation Vorrichtungen zur vergrösserten penetration von mikronadeln in biologischen hautschichten
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance

Also Published As

Publication number Publication date
EP1086718B1 (de) 2006-11-29
US20060047243A1 (en) 2006-03-02
US20080287864A1 (en) 2008-11-20
EP1086718A1 (de) 2001-03-28
CA2315469A1 (en) 2001-03-22
ATE346644T1 (de) 2006-12-15
AU778234B2 (en) 2004-11-25
SG92728A1 (en) 2002-11-19
US6623457B1 (en) 2003-09-23
CA2315469C (en) 2009-04-21
DE60032082T2 (de) 2007-06-21
AU5352800A (en) 2001-03-29
JP2001149485A (ja) 2001-06-05
US6960193B2 (en) 2005-11-01
ES2273639T3 (es) 2007-05-16
US20030199812A1 (en) 2003-10-23

Similar Documents

Publication Publication Date Title
ATE346644T1 (de) Vorrichtung zur transdermalen verabreichung von einer substanz
WO2000032259A3 (en) Apparatus for painless intramuscular or subcutaneous injections
ATE525055T1 (de) Vorrichtung zur abgabe von flüssigarzneimitteln zur verwendung mit spritzen mit erweiterten distalen spitzen
ATE72630T1 (de) Vorrichtung zur dosierten verabreichung eines fluessigen arzneimittels.
BR0208064A (pt) dispositivo médico, e, processo para injetar medicamento
ATE406928T1 (de) Subkutane infusionsvorrichtung
US6379328B1 (en) Disposable syringe
DE60130582D1 (de) Vorgefüllte intradermalverabreichungsvorrichtung
CA2471493A1 (en) A method and device for reducing therapeutic dosage
DE60325949D1 (de) Nadellose spritze zur subkutanen injektion von tropfen von flüssigen wirkstoffen
BR9908839A (pt) Dispositivo médico
ATE366595T1 (de) System zur verabreichung eines injizierbaren produkts
DE60019451D1 (de) Medizinsiche vorrichtung mit einer zurückziehbaren nadel
SE0303387L (sv) Kateteranordning samt infusionssystem med inre och yttre kateter
RU96106336A (ru) Способ введения лекарственных средств в полость сустава
CA2394699C (en) Device for injection of antiparasitic agents in domestic animals
JPH0313322Y2 (de)
CN2482424Y (zh) 埋入式腹腔给药装置
KR200362525Y1 (ko) 메조테라피 주사 보조장치
WO2004043514A3 (en) Pre-filled retractable needle injection device
Shah et al. Over Review On Needle Less Injection and Medicated Tattoo Upcoming Trends in Drug Delivery System
JPS61257654A (ja) 薬液移注具
TH82739A (th) การคุมกำเนิดที่ใช้ได้ด้วยตัวเอง
JPH026536B2 (de)
TH82739B (th) การคุมกำเนิดที่ใช้ได้ด้วยตัวเอง

Legal Events

Date Code Title Description
8364 No opposition during term of opposition