DE3872995T2 - Verfahren zur herstellung von androsta-1,4-dien-3,17-dion-methylen-derivaten. - Google Patents

Verfahren zur herstellung von androsta-1,4-dien-3,17-dion-methylen-derivaten.

Info

Publication number
DE3872995T2
DE3872995T2 DE8888308103T DE3872995T DE3872995T2 DE 3872995 T2 DE3872995 T2 DE 3872995T2 DE 8888308103 T DE8888308103 T DE 8888308103T DE 3872995 T DE3872995 T DE 3872995T DE 3872995 T2 DE3872995 T2 DE 3872995T2
Authority
DE
Germany
Prior art keywords
formula
methyleneandrosta
compound
diene
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8888308103T
Other languages
German (de)
English (en)
Other versions
DE3872995D1 (de
Inventor
Paolo Lombardi
Antonio Longo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carlo Erba SpA filed Critical Carlo Erba SpA
Publication of DE3872995D1 publication Critical patent/DE3872995D1/de
Application granted granted Critical
Publication of DE3872995T2 publication Critical patent/DE3872995T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
DE8888308103T 1987-09-11 1988-09-01 Verfahren zur herstellung von androsta-1,4-dien-3,17-dion-methylen-derivaten. Expired - Lifetime DE3872995T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878721383A GB8721383D0 (en) 1987-09-11 1987-09-11 Preparation of methylene derivatives

Publications (2)

Publication Number Publication Date
DE3872995D1 DE3872995D1 (de) 1992-08-27
DE3872995T2 true DE3872995T2 (de) 1992-12-10

Family

ID=10623618

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888308103T Expired - Lifetime DE3872995T2 (de) 1987-09-11 1988-09-01 Verfahren zur herstellung von androsta-1,4-dien-3,17-dion-methylen-derivaten.

Country Status (16)

Country Link
US (1) US4876045A (enExample)
EP (1) EP0307134B1 (enExample)
JP (1) JP2791046B2 (enExample)
KR (1) KR970005315B1 (enExample)
AT (1) ATE78488T1 (enExample)
AU (1) AU602608B2 (enExample)
CA (1) CA1316914C (enExample)
DE (1) DE3872995T2 (enExample)
ES (1) ES2051858T3 (enExample)
FI (1) FI884087A7 (enExample)
GB (1) GB8721383D0 (enExample)
GR (1) GR3005296T3 (enExample)
HU (1) HU199156B (enExample)
IL (1) IL87657A (enExample)
SU (1) SU1681731A3 (enExample)
UA (1) UA6044A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
AU5873300A (en) * 1999-07-07 2001-01-30 Pharmacia & Upjohn Company Process to prepare exemestane
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
ATE548375T1 (de) * 2004-01-16 2012-03-15 Cedarburg Pharmaceuticals Inc Exemestan und zwischenprodukte davon und verfahren zu dessen herstellung
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US20070225354A1 (en) * 2006-03-21 2007-09-27 Eric Marchewitz Use of dihydrolipoamide for enhancing physical performance
US7569719B1 (en) * 2006-10-25 2009-08-04 Loctite (R&D) Limited Method of preparing electron deficient olefins
US20080275259A1 (en) 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
US20090018356A1 (en) * 2007-06-25 2009-01-15 Scinopharm Taiwan Ltd. Crystalline polymorph of exemestane
US8138343B2 (en) * 2007-06-25 2012-03-20 Scinopharm Taiwan Ltd. Crystalline polymorph of 7-ethyl-10-hydroxycamptothecin
US8686105B2 (en) 2007-10-24 2014-04-01 Henkel IP & Holding GmbH Adhesive systems using imines and salts thereof, precursors to electron deficient olefins and coreactants therefor
CA2703603A1 (en) 2007-10-24 2009-04-30 Loctite (R&D) Limited Electron deficient olefins
US8053589B1 (en) * 2007-10-24 2011-11-08 Henkel Ireland Limited Imines and methods of preparing electron deficient olefins using such novel imines
CN101896454B (zh) * 2007-10-24 2013-07-10 洛克泰特(R&D)有限公司 活化的亚甲基试剂和由其制备的可固化组合物
US7973119B1 (en) 2007-10-24 2011-07-05 Loctite (R&D) Limited Adhesive systems using imines and salts thereof and precursurs to electron deficient olefins
US10196471B1 (en) 2008-10-24 2019-02-05 Henkel IP & Holding GmbH Curable composition having an electron deficient olefin
US8399698B1 (en) 2008-10-24 2013-03-19 Henkel Ireland Limited Substituted activated methylene reagents and methods of using such reagents to form electron deficient olefins
WO2010127297A1 (en) 2009-05-01 2010-11-04 Parviz Gharagozloo Treating male infertility secondary to sperm oxidative stress
ES2605960T3 (es) 2010-09-14 2017-03-17 Endece, Llc Derivados de desmetil-estradiol 6-sustituido como agonistas del RE-beta
CN105085599A (zh) * 2014-05-16 2015-11-25 绍兴文理学院 一种依西美坦中间体17,17-乙二氧基-6-亚甲基雄甾-1,4-二烯-3-酮及其制备方法和应用
CN105294807A (zh) * 2014-06-26 2016-02-03 浙江医药股份有限公司新昌制药厂 一种依西美坦中间体肟化合物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3004508C2 (de) * 1980-02-05 1981-12-10 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von 6-Methylensteroiden
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Also Published As

Publication number Publication date
SU1681731A3 (ru) 1991-09-30
GR3005296T3 (enExample) 1993-05-24
FI884087L (fi) 1989-03-12
FI884087A7 (fi) 1989-03-12
DE3872995D1 (de) 1992-08-27
KR970005315B1 (ko) 1997-04-15
CA1316914C (en) 1993-04-27
UA6044A1 (uk) 1994-12-29
EP0307134A1 (en) 1989-03-15
US4876045A (en) 1989-10-24
HU199156B (en) 1990-01-29
JPH01104095A (ja) 1989-04-21
AU2198088A (en) 1989-03-16
EP0307134B1 (en) 1992-07-22
ATE78488T1 (de) 1992-08-15
IL87657A0 (en) 1989-02-28
IL87657A (en) 1993-02-21
GB8721383D0 (en) 1987-10-21
JP2791046B2 (ja) 1998-08-27
HUT48273A (en) 1989-05-29
FI884087A0 (fi) 1988-09-06
KR890005141A (ko) 1989-05-13
AU602608B2 (en) 1990-10-18
ES2051858T3 (es) 1994-07-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA & UPJOHN S.P.A., MAILAND/MILANO, IT

8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA ITALIA S.P.A., MAILAND/MILANO, IT