DE69217873T2 - Verfahren zur Herstellung von 2-Chlor-2'-Desoxyadenosin - Google Patents

Verfahren zur Herstellung von 2-Chlor-2'-Desoxyadenosin

Info

Publication number
DE69217873T2
DE69217873T2 DE69217873T DE69217873T DE69217873T2 DE 69217873 T2 DE69217873 T2 DE 69217873T2 DE 69217873 T DE69217873 T DE 69217873T DE 69217873 T DE69217873 T DE 69217873T DE 69217873 T2 DE69217873 T2 DE 69217873T2
Authority
DE
Germany
Prior art keywords
deoxyadenosine
chloro
cda
preparation
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69217873T
Other languages
English (en)
Other versions
DE69217873D1 (de
Inventor
Robert H K Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Application granted granted Critical
Publication of DE69217873D1 publication Critical patent/DE69217873D1/de
Publication of DE69217873T2 publication Critical patent/DE69217873T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69217873T 1991-12-18 1992-12-17 Verfahren zur Herstellung von 2-Chlor-2'-Desoxyadenosin Expired - Lifetime DE69217873T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81099291A 1991-12-18 1991-12-18
US07/869,689 US5208327A (en) 1991-12-18 1992-04-16 Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine

Publications (2)

Publication Number Publication Date
DE69217873D1 DE69217873D1 (de) 1997-04-10
DE69217873T2 true DE69217873T2 (de) 1997-06-12

Family

ID=27123419

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69217873T Expired - Lifetime DE69217873T2 (de) 1991-12-18 1992-12-17 Verfahren zur Herstellung von 2-Chlor-2'-Desoxyadenosin

Country Status (11)

Country Link
US (1) US5208327A (de)
EP (1) EP0547910B1 (de)
JP (1) JPH05255378A (de)
AT (1) ATE149509T1 (de)
AU (1) AU653457B2 (de)
CA (1) CA2085503C (de)
DE (1) DE69217873T2 (de)
DK (1) DK0547910T3 (de)
ES (1) ES2101053T3 (de)
GR (1) GR3023317T3 (de)
ZA (1) ZA929792B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641757A (en) * 1994-12-21 1997-06-24 Ortho Pharmaceutical Corporation Stable 2-chloro-2'-deoxyadenosine formulations
EP0801571B1 (de) * 1994-12-22 2002-09-04 Ortho Pharmaceutical Corporation Lösliche arzneizusammensetzungen enthaltend 2-chloro-2'-deoxyadenosine
US6252061B1 (en) * 1998-03-23 2001-06-26 Reliable Biopharmaceutical, Inc. Process for the production of 2-halo-6-aminopurine derivatives
US6274725B1 (en) 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
WO2000064918A1 (en) * 1999-04-28 2000-11-02 Sterrenbeld Biotechnologie North America, Inc. METHOD FOR THE PRODUCTION OF 2-CHLORO-2'-DEOXYADENOSINE (CLADRIBINE) AND ITS 3,5-DI-O-p-TOLUOYL DERIVATIVE
AU2003275267A1 (en) * 2002-09-25 2004-04-19 Brigham Young University, Technology Transfer Office Method for the preparation of 2-halo-2'-deoxyadenosine compounds from 2'-deoxyguanosine
US20050173323A1 (en) * 2003-10-28 2005-08-11 Meuleners William J. Designs for filtration systems within appliances
PL1835922T3 (pl) * 2004-12-22 2009-10-30 Merck Serono Sa Terapia skojarzona stwardnienia rozsianego
LT3332789T (lt) 2004-12-22 2022-07-25 Merck Serono Sa Kladribino režimas, skirtas išsėtinės sklerozės gydymui
JP2009537605A (ja) 2006-05-24 2009-10-29 メルク セローノ ソシエテ アノニム 多発性硬化症を治療するためのクラドリビン・レジメン
PL1932918T3 (pl) * 2006-12-15 2010-03-31 Explora Laboratories Sa Sposób otrzymywania kladrybiny
EP2343074A1 (de) 2009-12-23 2011-07-13 Merck Serono S.A. Verwendung von Purinanaloga zur Behandlung von Atemwegserkrankungen
WO2011113476A2 (en) 2010-03-16 2011-09-22 Cilag Ag Method for producing 2'-deoxyadenosine compounds
GB201401465D0 (en) 2014-01-29 2014-03-12 Roach Arthur H Use of cladribine for treating autoimmune inflammatory disease
CN106397516B (zh) * 2016-08-30 2019-09-27 北京沣瑞医药科技有限公司 坎格雷洛中间体及其制备方法和应用
JP7125144B2 (ja) 2016-09-09 2022-08-24 キャリセラ バイオサイエンシーズ， インコーポレイテッド エクトヌクレオチダーゼ阻害剤およびその使用方法
GB2564717A (en) 2017-07-21 2019-01-23 Chord Therapeutics S A R L Use of cladribine for treating autoimmune neuromuscular disease
AU2018372007A1 (en) 2017-11-24 2020-07-09 Merck Patent Gmbh Cladribine regimen for use intreating progressive forms of multiple sclerosis
EP4210710A1 (de) 2020-09-10 2023-07-19 Merck Patent GmbH Neuartiges behandlungsschema zur behandlung von autoimmunerkrankungen
GB2601786A (en) 2020-12-10 2022-06-15 Chord Therapeutics S A R L Use of cladribine for treating immune brain disease
WO2022184867A1 (en) 2021-03-03 2022-09-09 Merck Patent Gmbh Improved treatment methods using dmds for the treatment of autoimmune diseases, and biomarker for predicting and/or optimising said treatment methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1269659A (en) * 1984-08-06 1990-05-29 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
US4760137A (en) * 1984-08-06 1988-07-26 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
HUT63170A (en) * 1990-01-11 1993-07-28 Isis Pharmaceuticals Inc Process and composition for detecting and modifying rna activity and gene expression

Also Published As

Publication number Publication date
DK0547910T3 (da) 1997-03-24
CA2085503C (en) 1997-08-19
EP0547910B1 (de) 1997-03-05
AU3012292A (en) 1993-07-01
CA2085503A1 (en) 1993-06-19
US5208327A (en) 1993-05-04
AU653457B2 (en) 1994-09-29
ES2101053T3 (es) 1997-07-01
DE69217873D1 (de) 1997-04-10
EP0547910A1 (de) 1993-06-23
JPH05255378A (ja) 1993-10-05
ZA929792B (en) 1994-06-17
ATE149509T1 (de) 1997-03-15
GR3023317T3 (en) 1997-08-29

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