DE68911157T2 - Synthese von 6-Methylenandrosta-1,4-dien-3,17-dion-Derivate. - Google Patents

Synthese von 6-Methylenandrosta-1,4-dien-3,17-dion-Derivate.

Info

Publication number
DE68911157T2
DE68911157T2 DE89300673T DE68911157T DE68911157T2 DE 68911157 T2 DE68911157 T2 DE 68911157T2 DE 89300673 T DE89300673 T DE 89300673T DE 68911157 T DE68911157 T DE 68911157T DE 68911157 T2 DE68911157 T2 DE 68911157T2
Authority
DE
Germany
Prior art keywords
diene
synthesis
hydrogen
dione derivatives
methylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE89300673T
Other languages
English (en)
Other versions
DE68911157D1 (de
Inventor
Antonio Longo
Paolo Lombardi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Publication of DE68911157D1 publication Critical patent/DE68911157D1/de
Application granted granted Critical
Publication of DE68911157T2 publication Critical patent/DE68911157T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
DE89300673T 1988-01-26 1989-01-25 Synthese von 6-Methylenandrosta-1,4-dien-3,17-dion-Derivate. Expired - Lifetime DE68911157T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888801697A GB8801697D0 (en) 1988-01-26 1988-01-26 Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione

Publications (2)

Publication Number Publication Date
DE68911157D1 DE68911157D1 (de) 1994-01-20
DE68911157T2 true DE68911157T2 (de) 1994-04-07

Family

ID=10630548

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89300673T Expired - Lifetime DE68911157T2 (de) 1988-01-26 1989-01-25 Synthese von 6-Methylenandrosta-1,4-dien-3,17-dion-Derivate.

Country Status (13)

Country Link
US (1) US4990635A (de)
EP (1) EP0326340B1 (de)
JP (1) JP2721002B2 (de)
KR (1) KR0132570B1 (de)
AT (1) ATE98253T1 (de)
CA (1) CA1319680C (de)
DE (1) DE68911157T2 (de)
ES (1) ES2061966T3 (de)
FI (1) FI91070C (de)
GB (1) GB8801697D0 (de)
HU (1) HU204064B (de)
IL (1) IL88396A (de)
SU (1) SU1757470A3 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121484A1 (de) * 1991-06-26 1993-01-07 Schering Ag Verfahren zur herstellung von 6-methylensteroiden
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
US8183401B2 (en) 2004-01-16 2012-05-22 Cedarburg Pharmaceuticals, Inc. Exemestane and its intermediates and methods of making the same
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
DE102007026636A1 (de) * 2007-06-06 2008-12-11 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17α-Acetoxy-6-methylenpregn-4-en-3,20-dion, Medroxyprogesteronacetat und Megestrolacetat
NZ581667A (en) * 2007-06-25 2012-03-30 Scinopharm Taiwan Ltd Crystalline polymorph of 7-ethyl-10-hydroxycamptothecin
KR20100051791A (ko) * 2007-06-25 2010-05-18 시노팜 타이완 리미티드 엑세메스테인의 결정형 다형체
CN101429224B (zh) * 2007-11-07 2012-05-02 江苏希迪制药有限公司 1,4-双烯-6-亚甲基甾体化合物的合成方法及中间体
EP2616477B1 (de) 2010-09-14 2016-11-09 Endece, LLC 6-substituierte demethyl-estradiol-derivate als er-beta-agonisten

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3112305A (en) * 1960-11-07 1963-11-26 British Drug Houses Ltd 6-methylene-3-oxo-delta4-steroids and process for their preparation
DE3004508C2 (de) * 1980-02-05 1981-12-10 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von 6-Methylensteroiden
US4416821A (en) * 1982-02-17 1983-11-22 The Upjohn Company Process for preparing 16-methylene steroids
US4512986A (en) * 1983-07-26 1985-04-23 Research Triangle Institute Progrestationally active steroids
DE3338212C2 (de) * 1983-10-18 1995-05-18 Schering Ag 1-Methyl-androsta-1,4,6-trien-3,17-dione, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Also Published As

Publication number Publication date
EP0326340A2 (de) 1989-08-02
SU1757470A3 (ru) 1992-08-23
EP0326340A3 (en) 1990-03-14
GB8801697D0 (en) 1988-02-24
KR0132570B1 (ko) 1998-04-14
FI890302A0 (fi) 1989-01-20
DE68911157D1 (de) 1994-01-20
JP2721002B2 (ja) 1998-03-04
FI890302A (fi) 1989-07-27
FI91070B (fi) 1994-01-31
IL88396A (en) 1992-12-01
ATE98253T1 (de) 1993-12-15
ES2061966T3 (es) 1994-12-16
EP0326340B1 (de) 1993-12-08
JPH01224395A (ja) 1989-09-07
HUT49368A (en) 1989-09-28
AU2759888A (en) 1989-07-27
IL88396A0 (en) 1989-06-30
FI91070C (fi) 1994-05-10
CA1319680C (en) 1993-06-29
AU607565B2 (en) 1991-03-07
HU204064B (en) 1991-11-28
KR890011904A (ko) 1989-08-23
US4990635A (en) 1991-02-05

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ATE44748T1 (de) 4-substituierte 6-alkylidene-androsten-3,17-dion- derivate und verfahren zu ihrer herstellung.
AU589269B2 (en) New 6- or 7-methylenandrosta-1,4-diene-3,17-dione derivatives and process for their preparation
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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA & UPJOHN S.P.A., MAILAND/MILANO, IT

8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA ITALIA S.P.A., MAILAND/MILANO, IT