FI890302A0 - Parannus androsta-1,4-dieeni-3,17-dionin 6-metyleenijohdannaisten synteesissä - Google Patents

Parannus androsta-1,4-dieeni-3,17-dionin 6-metyleenijohdannaisten synteesissä

Info

Publication number
FI890302A0
FI890302A0 FI890302A FI890302A FI890302A0 FI 890302 A0 FI890302 A0 FI 890302A0 FI 890302 A FI890302 A FI 890302A FI 890302 A FI890302 A FI 890302A FI 890302 A0 FI890302 A0 FI 890302A0
Authority
FI
Finland
Prior art keywords
androsta
dione
diene
synthesis
improvement
Prior art date
Application number
FI890302A
Other languages
English (en)
Swedish (sv)
Other versions
FI91070B (fi
FI890302A (fi
FI91070C (fi
Inventor
Antonio Longo
Paolo Lombardi
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of FI890302A0 publication Critical patent/FI890302A0/fi
Publication of FI890302A publication Critical patent/FI890302A/fi
Publication of FI91070B publication Critical patent/FI91070B/fi
Application granted granted Critical
Publication of FI91070C publication Critical patent/FI91070C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI890302A 1988-01-26 1989-01-20 Parannus androsta-1,4-dieeni-3,17-dionin 6-metyleenijohdannaisten synteesissä FI91070C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888801697A GB8801697D0 (en) 1988-01-26 1988-01-26 Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione
GB8801697 1988-01-26

Publications (4)

Publication Number Publication Date
FI890302A0 true FI890302A0 (fi) 1989-01-20
FI890302A FI890302A (fi) 1989-07-27
FI91070B FI91070B (fi) 1994-01-31
FI91070C FI91070C (fi) 1994-05-10

Family

ID=10630548

Family Applications (1)

Application Number Title Priority Date Filing Date
FI890302A FI91070C (fi) 1988-01-26 1989-01-20 Parannus androsta-1,4-dieeni-3,17-dionin 6-metyleenijohdannaisten synteesissä

Country Status (13)

Country Link
US (1) US4990635A (fi)
EP (1) EP0326340B1 (fi)
JP (1) JP2721002B2 (fi)
KR (1) KR0132570B1 (fi)
AT (1) ATE98253T1 (fi)
CA (1) CA1319680C (fi)
DE (1) DE68911157T2 (fi)
ES (1) ES2061966T3 (fi)
FI (1) FI91070C (fi)
GB (1) GB8801697D0 (fi)
HU (1) HU204064B (fi)
IL (1) IL88396A (fi)
SU (1) SU1757470A3 (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121484A1 (de) * 1991-06-26 1993-01-07 Schering Ag Verfahren zur herstellung von 6-methylensteroiden
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
WO2005070951A1 (en) * 2004-01-16 2005-08-04 Cedarburg Pharmaceuticals, Inc. Exemestane and its intermediates and methods of making the same
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
DE102007026636A1 (de) 2007-06-06 2008-12-11 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17α-Acetoxy-6-methylenpregn-4-en-3,20-dion, Medroxyprogesteronacetat und Megestrolacetat
JP2010531305A (ja) * 2007-06-25 2010-09-24 サイノファーム タイワン リミテッド エキセメスタンの結晶多形体
AU2008269148B2 (en) * 2007-06-25 2013-02-21 Scinopharm Taiwan, Ltd. Crystalline polymorph of 7-ethyl-10-hydroxycamptothecin
CN101429224B (zh) * 2007-11-07 2012-05-02 江苏希迪制药有限公司 1,4-双烯-6-亚甲基甾体化合物的合成方法及中间体
CA2809639C (en) 2010-09-14 2015-06-30 Endece, Llc 6-substituted demethyl-estradiol derivatives as selective er-beta agonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3112305A (en) * 1960-11-07 1963-11-26 British Drug Houses Ltd 6-methylene-3-oxo-delta4-steroids and process for their preparation
DE3004508C2 (de) * 1980-02-05 1981-12-10 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von 6-Methylensteroiden
US4416821A (en) * 1982-02-17 1983-11-22 The Upjohn Company Process for preparing 16-methylene steroids
US4512986A (en) * 1983-07-26 1985-04-23 Research Triangle Institute Progrestationally active steroids
DE3338212C2 (de) * 1983-10-18 1995-05-18 Schering Ag 1-Methyl-androsta-1,4,6-trien-3,17-dione, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Also Published As

Publication number Publication date
DE68911157D1 (de) 1994-01-20
FI91070B (fi) 1994-01-31
JPH01224395A (ja) 1989-09-07
AU607565B2 (en) 1991-03-07
US4990635A (en) 1991-02-05
JP2721002B2 (ja) 1998-03-04
GB8801697D0 (en) 1988-02-24
DE68911157T2 (de) 1994-04-07
ES2061966T3 (es) 1994-12-16
EP0326340B1 (en) 1993-12-08
SU1757470A3 (ru) 1992-08-23
HUT49368A (en) 1989-09-28
FI890302A (fi) 1989-07-27
KR0132570B1 (ko) 1998-04-14
ATE98253T1 (de) 1993-12-15
CA1319680C (en) 1993-06-29
IL88396A0 (en) 1989-06-30
EP0326340A3 (en) 1990-03-14
IL88396A (en) 1992-12-01
HU204064B (en) 1991-11-28
KR890011904A (ko) 1989-08-23
AU2759888A (en) 1989-07-27
EP0326340A2 (en) 1989-08-02
FI91070C (fi) 1994-05-10

Similar Documents

Publication Publication Date Title
AU602608B2 (en) Process for the preparation of methylene derivatives of androsta-1, 4-diene-3,17-dione
FI91070B (fi) Parannus androsta-1,4-dieeni-3,17-dionin 6-metyleenijohdannaisten synteesissä
ATE44748T1 (de) 4-substituierte 6-alkylidene-androsten-3,17-dion- derivate und verfahren zu ihrer herstellung.
AU589269B2 (en) New 6- or 7-methylenandrosta-1,4-diene-3,17-dione derivatives and process for their preparation
AU2197988A (en) 17-substituted androsta-1,4-dien-3-one derivatives
HUT42783A (en) Process for preparing steroid aromatase-inhibitors

Legal Events

Date Code Title Description
FG Patent granted

Owner name: PHARMACIA & UPJOHN S.P.A.

BB Publication of examined application
PC Transfer of assignment of patent

Owner name: PHARMACIA & UPJOHN S.P.A.

SPCG Supplementary protection certificate granted

Spc suppl protection certif: L167

Extension date: 20131215

FG Patent granted

Owner name: PHARMACIA ITALIA S.P.A.

MA Patent expired