KR0132570B1 - 안드로스타-1.4-디엔-3.17-디온의6-메틸렌 유도체 합성방법 - Google Patents

안드로스타-1.4-디엔-3.17-디온의6-메틸렌 유도체 합성방법

Info

Publication number
KR0132570B1
KR0132570B1 KR1019890000718A KR890000718A KR0132570B1 KR 0132570 B1 KR0132570 B1 KR 0132570B1 KR 1019890000718 A KR1019890000718 A KR 1019890000718A KR 890000718 A KR890000718 A KR 890000718A KR 0132570 B1 KR0132570 B1 KR 0132570B1
Authority
KR
South Korea
Prior art keywords
compound
formula
dione
ene
methyl
Prior art date
Application number
KR1019890000718A
Other languages
English (en)
Korean (ko)
Other versions
KR890011904A (ko
Inventor
론고 안토니오
롬 바르 디 파울로
Original Assignee
모리 페라리오 비토리노
파이탈리아 카를로 에르바 에스.알.엘.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 모리 페라리오 비토리노, 파이탈리아 카를로 에르바 에스.알.엘. filed Critical 모리 페라리오 비토리노
Publication of KR890011904A publication Critical patent/KR890011904A/ko
Application granted granted Critical
Publication of KR0132570B1 publication Critical patent/KR0132570B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019890000718A 1988-01-26 1989-01-24 안드로스타-1.4-디엔-3.17-디온의6-메틸렌 유도체 합성방법 KR0132570B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888801697A GB8801697D0 (en) 1988-01-26 1988-01-26 Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione
GB8801697 1988-01-26

Publications (2)

Publication Number Publication Date
KR890011904A KR890011904A (ko) 1989-08-23
KR0132570B1 true KR0132570B1 (ko) 1998-04-14

Family

ID=10630548

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890000718A KR0132570B1 (ko) 1988-01-26 1989-01-24 안드로스타-1.4-디엔-3.17-디온의6-메틸렌 유도체 합성방법

Country Status (13)

Country Link
US (1) US4990635A (de)
EP (1) EP0326340B1 (de)
JP (1) JP2721002B2 (de)
KR (1) KR0132570B1 (de)
AT (1) ATE98253T1 (de)
CA (1) CA1319680C (de)
DE (1) DE68911157T2 (de)
ES (1) ES2061966T3 (de)
FI (1) FI91070C (de)
GB (1) GB8801697D0 (de)
HU (1) HU204064B (de)
IL (1) IL88396A (de)
SU (1) SU1757470A3 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121484A1 (de) * 1991-06-26 1993-01-07 Schering Ag Verfahren zur herstellung von 6-methylensteroiden
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
ATE548375T1 (de) 2004-01-16 2012-03-15 Cedarburg Pharmaceuticals Inc Exemestan und zwischenprodukte davon und verfahren zu dessen herstellung
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
US10174070B2 (en) * 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US20080275259A1 (en) 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
DE102007026636A1 (de) 2007-06-06 2008-12-11 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17α-Acetoxy-6-methylenpregn-4-en-3,20-dion, Medroxyprogesteronacetat und Megestrolacetat
SI2170329T1 (sl) * 2007-06-25 2015-03-31 Scinopharm Taiwan Ltd. Postopek za izdelavo kristaliničnega polimorfa 7-etil-10-hidroksikamptotecina
KR20100051791A (ko) * 2007-06-25 2010-05-18 시노팜 타이완 리미티드 엑세메스테인의 결정형 다형체
CN101429224B (zh) * 2007-11-07 2012-05-02 江苏希迪制药有限公司 1,4-双烯-6-亚甲基甾体化合物的合成方法及中间体
US20120071455A1 (en) 2010-09-14 2012-03-22 Yarger James G 6-substituted demethyl-estradiol derivatives as selective er-beta agonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3112305A (en) * 1960-11-07 1963-11-26 British Drug Houses Ltd 6-methylene-3-oxo-delta4-steroids and process for their preparation
DE3004508C2 (de) * 1980-02-05 1981-12-10 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von 6-Methylensteroiden
US4416821A (en) * 1982-02-17 1983-11-22 The Upjohn Company Process for preparing 16-methylene steroids
US4512986A (en) * 1983-07-26 1985-04-23 Research Triangle Institute Progrestationally active steroids
DE3338212C2 (de) * 1983-10-18 1995-05-18 Schering Ag 1-Methyl-androsta-1,4,6-trien-3,17-dione, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Also Published As

Publication number Publication date
DE68911157D1 (de) 1994-01-20
HU204064B (en) 1991-11-28
DE68911157T2 (de) 1994-04-07
ATE98253T1 (de) 1993-12-15
IL88396A (en) 1992-12-01
JP2721002B2 (ja) 1998-03-04
FI91070C (fi) 1994-05-10
ES2061966T3 (es) 1994-12-16
CA1319680C (en) 1993-06-29
GB8801697D0 (en) 1988-02-24
FI890302A0 (fi) 1989-01-20
FI91070B (fi) 1994-01-31
KR890011904A (ko) 1989-08-23
HUT49368A (en) 1989-09-28
FI890302A (fi) 1989-07-27
JPH01224395A (ja) 1989-09-07
AU607565B2 (en) 1991-03-07
EP0326340A3 (en) 1990-03-14
AU2759888A (en) 1989-07-27
SU1757470A3 (ru) 1992-08-23
US4990635A (en) 1991-02-05
EP0326340B1 (de) 1993-12-08
EP0326340A2 (de) 1989-08-02
IL88396A0 (en) 1989-06-30

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