SU1681731A3 - Способ получени метиленовых производных андроста-1,4-диен-3,17-диона - Google Patents

Способ получени метиленовых производных андроста-1,4-диен-3,17-диона Download PDF

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Publication number
SU1681731A3
SU1681731A3 SU884356486A SU4356486A SU1681731A3 SU 1681731 A3 SU1681731 A3 SU 1681731A3 SU 884356486 A SU884356486 A SU 884356486A SU 4356486 A SU4356486 A SU 4356486A SU 1681731 A3 SU1681731 A3 SU 1681731A3
Authority
SU
USSR - Soviet Union
Prior art keywords
diene
dione
preparation
androsta
methylene derivatives
Prior art date
Application number
SU884356486A
Other languages
English (en)
Russian (ru)
Inventor
Лонго Антонио
Ломбарди Паоло
Original Assignee
Фармиталиа Карло Эрба С.Р.Л.(Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармиталиа Карло Эрба С.Р.Л.(Фирма) filed Critical Фармиталиа Карло Эрба С.Р.Л.(Фирма)
Application granted granted Critical
Publication of SU1681731A3 publication Critical patent/SU1681731A3/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
SU884356486A 1987-09-11 1988-09-09 Способ получени метиленовых производных андроста-1,4-диен-3,17-диона SU1681731A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878721383A GB8721383D0 (en) 1987-09-11 1987-09-11 Preparation of methylene derivatives

Publications (1)

Publication Number Publication Date
SU1681731A3 true SU1681731A3 (ru) 1991-09-30

Family

ID=10623618

Family Applications (1)

Application Number Title Priority Date Filing Date
SU884356486A SU1681731A3 (ru) 1987-09-11 1988-09-09 Способ получени метиленовых производных андроста-1,4-диен-3,17-диона

Country Status (16)

Country Link
US (1) US4876045A (enExample)
EP (1) EP0307134B1 (enExample)
JP (1) JP2791046B2 (enExample)
KR (1) KR970005315B1 (enExample)
AT (1) ATE78488T1 (enExample)
AU (1) AU602608B2 (enExample)
CA (1) CA1316914C (enExample)
DE (1) DE3872995T2 (enExample)
ES (1) ES2051858T3 (enExample)
FI (1) FI884087A7 (enExample)
GB (1) GB8721383D0 (enExample)
GR (1) GR3005296T3 (enExample)
HU (1) HU199156B (enExample)
IL (1) IL87657A (enExample)
SU (1) SU1681731A3 (enExample)
UA (1) UA6044A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
AU5873300A (en) * 1999-07-07 2001-01-30 Pharmacia & Upjohn Company Process to prepare exemestane
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
ATE548375T1 (de) * 2004-01-16 2012-03-15 Cedarburg Pharmaceuticals Inc Exemestan und zwischenprodukte davon und verfahren zu dessen herstellung
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US20070225354A1 (en) * 2006-03-21 2007-09-27 Eric Marchewitz Use of dihydrolipoamide for enhancing physical performance
US7569719B1 (en) * 2006-10-25 2009-08-04 Loctite (R&D) Limited Method of preparing electron deficient olefins
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
AU2008269148B2 (en) * 2007-06-25 2013-02-21 Scinopharm Taiwan, Ltd. Crystalline polymorph of 7-ethyl-10-hydroxycamptothecin
EP2170328A2 (en) * 2007-06-25 2010-04-07 ScinoPharm Taiwan, Ltd. Crystalline polymorph of exemestane
US7973119B1 (en) 2007-10-24 2011-07-05 Loctite (R&D) Limited Adhesive systems using imines and salts thereof and precursurs to electron deficient olefins
US8053589B1 (en) * 2007-10-24 2011-11-08 Henkel Ireland Limited Imines and methods of preparing electron deficient olefins using such novel imines
KR101561712B1 (ko) * 2007-10-24 2015-10-19 헨켈 아이피 앤드 홀딩 게엠베하 활성화된 메틸렌 시약 및 그로부터 제조되는 경화가능한 조성물
US8686105B2 (en) 2007-10-24 2014-04-01 Henkel IP & Holding GmbH Adhesive systems using imines and salts thereof, precursors to electron deficient olefins and coreactants therefor
EP2217559B1 (en) * 2007-10-24 2017-06-28 Henkel IP & Holding GmbH Electron deficient olefins
US8399698B1 (en) 2008-10-24 2013-03-19 Henkel Ireland Limited Substituted activated methylene reagents and methods of using such reagents to form electron deficient olefins
US10196471B1 (en) 2008-10-24 2019-02-05 Henkel IP & Holding GmbH Curable composition having an electron deficient olefin
ES2587977T3 (es) 2009-05-01 2016-10-28 Celloxess Llc Tratamiento de la infertilidad masculina secundaria al estrés oxidativo de esperma
MX343059B (es) 2010-09-14 2016-10-24 Endece Llc Derivados de desmetil-estradiol sustituido en 6 como agonistas de er-beta selectivos.
CN105085599A (zh) * 2014-05-16 2015-11-25 绍兴文理学院 一种依西美坦中间体17,17-乙二氧基-6-亚甲基雄甾-1,4-二烯-3-酮及其制备方法和应用
CN105294807A (zh) * 2014-06-26 2016-02-03 浙江医药股份有限公司新昌制药厂 一种依西美坦中间体肟化合物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3004508C2 (de) * 1980-02-05 1981-12-10 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von 6-Methylensteroiden
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
D. Burn, et al. Tetrahedron. 20,597 (1964). К. Annen et. al. Synthesis, 1982, 34. *

Also Published As

Publication number Publication date
HU199156B (en) 1990-01-29
FI884087L (fi) 1989-03-12
HUT48273A (en) 1989-05-29
ATE78488T1 (de) 1992-08-15
CA1316914C (en) 1993-04-27
JPH01104095A (ja) 1989-04-21
KR970005315B1 (ko) 1997-04-15
GR3005296T3 (enExample) 1993-05-24
JP2791046B2 (ja) 1998-08-27
FI884087A0 (fi) 1988-09-06
US4876045A (en) 1989-10-24
UA6044A1 (uk) 1994-12-29
AU602608B2 (en) 1990-10-18
ES2051858T3 (es) 1994-07-01
GB8721383D0 (en) 1987-10-21
FI884087A7 (fi) 1989-03-12
EP0307134B1 (en) 1992-07-22
AU2198088A (en) 1989-03-16
DE3872995D1 (de) 1992-08-27
KR890005141A (ko) 1989-05-13
IL87657A (en) 1993-02-21
EP0307134A1 (en) 1989-03-15
IL87657A0 (en) 1989-02-28
DE3872995T2 (de) 1992-12-10

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