DE3852531T2 - Nukleoside und nukleosid-analoge, pharmazeutische zusammensetzung und verfahren für die herstellung der bestandteile. - Google Patents
Nukleoside und nukleosid-analoge, pharmazeutische zusammensetzung und verfahren für die herstellung der bestandteile.Info
- Publication number
- DE3852531T2 DE3852531T2 DE3852531T DE3852531T DE3852531T2 DE 3852531 T2 DE3852531 T2 DE 3852531T2 DE 3852531 T DE3852531 T DE 3852531T DE 3852531 T DE3852531 T DE 3852531T DE 3852531 T2 DE3852531 T2 DE 3852531T2
- Authority
- DE
- Germany
- Prior art keywords
- formula
- compound
- anomer
- therapeutically acceptable
- acceptable salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- 239000004615 ingredient Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 43
- 150000003839 salts Chemical class 0.000 claims abstract description 13
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- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 5
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims abstract description 4
- 150000003254 radicals Chemical class 0.000 claims abstract 2
- 125000006239 protecting group Chemical group 0.000 claims description 12
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- 125000000217 alkyl group Chemical group 0.000 abstract 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8701605A SE8701605D0 (sv) | 1987-04-16 | 1987-04-16 | Novel medicinal compounds |
| PCT/SE1988/000169 WO1988008001A1 (en) | 1987-04-16 | 1988-04-06 | Nucleosides and nucleoside analogues, pharmaceutical composition and processes for the preparation of the compounds |
| CA000580141A CA1336088C (en) | 1987-04-16 | 1988-10-14 | 1-(3'-substitued-2', 3'-dideoxy-d-ribofuranosyl) thymine and uracil |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3852531D1 DE3852531D1 (de) | 1995-02-02 |
| DE3852531T2 true DE3852531T2 (de) | 1995-08-10 |
Family
ID=25672174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3852531T Expired - Fee Related DE3852531T2 (de) | 1987-04-16 | 1988-04-06 | Nukleoside und nukleosid-analoge, pharmazeutische zusammensetzung und verfahren für die herstellung der bestandteile. |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPH01503069A (da) |
| AT (1) | ATE115958T1 (da) |
| AU (1) | AU614082B2 (da) |
| CA (1) | CA1336088C (da) |
| DE (1) | DE3852531T2 (da) |
| DK (3) | DK168443B1 (da) |
| HU (1) | HU211547A9 (da) |
| SE (1) | SE8701605D0 (da) |
| WO (1) | WO1988008001A1 (da) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8629892D0 (en) * | 1986-12-15 | 1987-01-28 | Wellcome Found | Antiviral compounds |
| US4950758A (en) * | 1988-01-20 | 1990-08-21 | Regents Of The University Of Minnesota | Optically-active isomers of dideoxycarbocyclic nucleosides |
| US5631370A (en) | 1988-01-20 | 1997-05-20 | Regents Of The University Of Minnesota | Optically-active isomers of dideoxycarbocyclic nucleosides |
| US5175292A (en) * | 1988-01-20 | 1992-12-29 | Regents Of The University Of Minnesota | Intermediates for the preparation of dideoxycarbocyclic nucleosides |
| AU631119B2 (en) * | 1988-02-24 | 1992-11-19 | Institut De Recherches Chimiques Et Biologiques Appliquees (I.R.C.E.B.A.) | New derivatives of deoxy-2'-uridine substituted in the 5,3' or 5' position by acylated alpha-amino groups, process for obtaining them and drugs containing them |
| US7119202B1 (en) | 1989-02-08 | 2006-10-10 | Glaxo Wellcome Inc. | Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties |
| US5198539A (en) * | 1988-08-19 | 1993-03-30 | Burroughs Wellcome Co. | 5'-esters of 2',3'-dideoxy-3'-fluoro-5-ethynyluridine |
| US5157114A (en) * | 1988-08-19 | 1992-10-20 | Burroughs Wellcome Co. | 2',3'-dideoxy-3'-fluoro-5-ethyngluridine |
| FI95384C (fi) * | 1989-04-06 | 1996-01-25 | Squibb Bristol Myers Co | Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita |
| FR2648045B1 (fr) * | 1989-06-13 | 1991-09-27 | Centre Nat Rech Scient | Composes oligonucleotidiques anomeres alpha inhibant la replication des retrovirus |
| NZ234534A (en) * | 1989-07-17 | 1994-12-22 | Univ Birmingham | Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor |
| US5591722A (en) * | 1989-09-15 | 1997-01-07 | Southern Research Institute | 2'-deoxy-4'-thioribonucleosides and their antiviral activity |
| EP0491793B1 (en) * | 1989-09-15 | 2005-11-30 | Southern Research Institute | 2'-deoxy-4'-thioribonucleosides as antiviral and anticancer agents |
| US5728575A (en) | 1990-02-01 | 1998-03-17 | Emory University | Method of resolution of 1,3-oxathiolane nucleoside enantiomers |
| GB9008696D0 (en) * | 1990-04-18 | 1990-06-13 | Wellcome Found | Anti-viral compounds |
| US5521163A (en) * | 1990-07-13 | 1996-05-28 | University Of Birmingham | Antiviral pyrimidine nucleosides and methods for using same |
| SE9003151D0 (sv) * | 1990-10-02 | 1990-10-02 | Medivir Ab | Nucleoside derivatives |
| US6369066B1 (en) | 1990-11-13 | 2002-04-09 | Biochem Pharma, Inc. | Substituted 1,3-oxathiolanes with antiviral properties |
| CA2095613C (en) * | 1990-11-13 | 2001-01-02 | Bernard Belleau | Substituted 1, 3-oxathiolanes and substituted 1, 3-dithiolanes with antiviral properties |
| US5587480A (en) * | 1990-11-13 | 1996-12-24 | Biochem Pharma, Inc. | Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties |
| US6228860B1 (en) | 1990-11-13 | 2001-05-08 | Biochem Pharma Inc. | Substituted 1,3-oxathiolanes with antiviral properties |
| US6235887B1 (en) | 1991-11-26 | 2001-05-22 | Isis Pharmaceuticals, Inc. | Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines |
| JP3739785B2 (ja) * | 1991-11-26 | 2006-01-25 | アイシス ファーマシューティカルズ，インコーポレイティド | 修飾されたピリミジンを含有するオリゴマーを使用する増強された三重らせんおよび二重らせんの成形 |
| TW393513B (en) * | 1991-11-26 | 2000-06-11 | Isis Pharmaceuticals Inc | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| US20020120130A1 (en) | 1993-09-10 | 2002-08-29 | Gilles Gosselin | 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents |
| US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
| WO1995032983A1 (en) * | 1994-05-31 | 1995-12-07 | Medivir Ab | Post exposure prevention of hiv |
| US5612319A (en) * | 1994-05-31 | 1997-03-18 | Medivir Ab | Postexposure prevention of HIV infection or seroconversion |
| US6391859B1 (en) | 1995-01-27 | 2002-05-21 | Emory University | [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides |
| US5703058A (en) | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
| US5808040A (en) * | 1995-01-30 | 1998-09-15 | Yale University | L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides |
| WO1996040164A1 (en) | 1995-06-07 | 1996-12-19 | Emory University | Nucleosides with anti-hepatitis b virus activity |
| US5869493A (en) | 1996-02-16 | 1999-02-09 | Medivir Ab | Acyclic nucleoside derivatives |
| US5753789A (en) * | 1996-07-26 | 1998-05-19 | Yale University | Oligonucleotides containing L-nucleosides |
| EP2390257A1 (en) | 1998-02-25 | 2011-11-30 | Emory University | 2'-fluoronucleosides |
| PT1411954E (pt) | 2000-10-18 | 2011-03-16 | Pharmasset Inc | Nucleosídeos modificados para o tratamento de infecções virais e proliferação celular anormal |
| PT2084175E (pt) | 2006-10-10 | 2011-04-01 | Medivir Ab | Inibidor nucleosídico de vhc |
| WO2014109384A1 (ja) * | 2013-01-10 | 2014-07-17 | 塩野義製薬株式会社 | 架橋型核酸誘導体の製造方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD75084A (da) * | ||||
| US3116282A (en) * | 1960-04-27 | 1963-12-31 | Upjohn Co | Pyrimidine nucleosides and process |
| FR2040177A1 (en) * | 1969-01-31 | 1971-01-22 | Robugen Gmbh | 2-deoxyribosyl-uracil derivs |
| US3817982A (en) * | 1971-12-29 | 1974-06-18 | Syntex Inc | 2{40 ,3{40 -unsaturated nucleosides and method of making |
| DE2918260A1 (de) * | 1979-05-07 | 1980-11-27 | Robugen Gmbh | Anwendung von 5-alkyl-2'-desoxyuridinen |
| US4267171A (en) * | 1979-07-02 | 1981-05-12 | The Regents Of The University Of California | C-5 Substituted cytosine nucleosides |
| US4247544A (en) * | 1979-07-02 | 1981-01-27 | The Regents Of The University Of California | C-5 Substituted uracil nucleosides |
| DE2930904A1 (de) * | 1979-07-30 | 1981-02-19 | Kailash Kumar Dr Gauri | Verwendung von 5-alkyl-pyrimidinnucleosiden bei der bekaempfung von krebs |
| DE3002197A1 (de) * | 1980-01-22 | 1981-07-23 | Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen | 5-alkylsubstituierte pyrimidin-nukleoside, verfahren zu deren herstellung und daraus hergestellte virostatische und cytostatische mittel |
| DE3045375A1 (de) * | 1980-12-02 | 1982-07-01 | Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen | Neue substituierte pyrimidin-nukleoside mit antiviraler wirkung, verfahren zu deren herstellung und daraus zubereitete arzneiformen |
| DE3229169A1 (de) * | 1982-08-05 | 1984-02-09 | Robugen GmbH Pharmazeutische Fabrik, 7300 Esslingen | Verwendung von 5-alkylpyrimidinnukleosiden und deren derivate als zytostatika |
| US4724232A (en) * | 1985-03-16 | 1988-02-09 | Burroughs Wellcome Co. | Treatment of human viral infections |
| DE3608606A1 (de) * | 1985-03-16 | 1986-09-18 | The Wellcome Foundation Ltd., London | 3'-azido-3'-deoxythymidin oder eine, ein pharmazeutisch vertraegliches derivat davon enthaltende pharmazeutische formulierung, verfahren zu ihrer herstellung und ihre verwendung |
| DE3650492T2 (de) * | 1985-03-16 | 1996-10-31 | The Wellcome Foundation Ltd., London | Therapeutische Nukleoside |
| NZ216172A (en) * | 1985-05-15 | 1989-08-29 | Wellcome Found | Nucleosides and pharmaceutical compositions |
| DE3650741T2 (de) * | 1985-09-17 | 2000-10-12 | The Wellcome Foundation Ltd., Greenford | Kombination therapeutische Nukleoside mit weiteren therapeutisch wirksamen Komponenten. |
-
1987
- 1987-04-16 SE SE8701605A patent/SE8701605D0/xx unknown
-
1988
- 1988-04-06 AU AU16899/88A patent/AU614082B2/en not_active Ceased
- 1988-04-06 AT AT88903972T patent/ATE115958T1/de not_active IP Right Cessation
- 1988-04-06 WO PCT/SE1988/000169 patent/WO1988008001A1/en active IP Right Grant
- 1988-04-06 DE DE3852531T patent/DE3852531T2/de not_active Expired - Fee Related
- 1988-04-06 JP JP63503532A patent/JPH01503069A/ja active Pending
- 1988-10-14 CA CA000580141A patent/CA1336088C/en not_active Expired - Fee Related
- 1988-12-15 DK DK696988A patent/DK168443B1/da not_active IP Right Cessation
-
1991
- 1991-06-07 DK DK108491A patent/DK108491A/da not_active Application Discontinuation
-
1994
- 1994-09-13 DK DK104994A patent/DK104994A/da not_active Application Discontinuation
-
1995
- 1995-05-12 HU HU95P/P00134P patent/HU211547A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK108491D0 (da) | 1991-06-07 |
| HU211547A9 (en) | 1995-12-28 |
| JPH01503069A (ja) | 1989-10-19 |
| DK168443B1 (da) | 1994-03-28 |
| DK696988D0 (da) | 1988-12-15 |
| WO1988008001A1 (en) | 1988-10-20 |
| ATE115958T1 (de) | 1995-01-15 |
| DE3852531D1 (de) | 1995-02-02 |
| DK108491A (da) | 1991-06-07 |
| CA1336088C (en) | 1995-06-27 |
| AU1689988A (en) | 1988-11-04 |
| DK696988A (da) | 1989-01-31 |
| AU614082B2 (en) | 1991-08-22 |
| SE8701605D0 (sv) | 1987-04-16 |
| DK104994A (da) | 1994-09-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |