AU1689988A - Nucleosides and nucleoside analogues, pharmaceutical composition and processes for the preparation of the compounds - Google Patents
Nucleosides and nucleoside analogues, pharmaceutical composition and processes for the preparation of the compoundsInfo
- Publication number
- AU1689988A AU1689988A AU16899/88A AU1689988A AU1689988A AU 1689988 A AU1689988 A AU 1689988A AU 16899/88 A AU16899/88 A AU 16899/88A AU 1689988 A AU1689988 A AU 1689988A AU 1689988 A AU1689988 A AU 1689988A
- Authority
- AU
- Australia
- Prior art keywords
- formula
- nucleosides
- compounds
- processes
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Abstract
A compound of formula (I), wherein the radicals A, X, R<1>, R<2>, and R<3> are defined as follows: A: formula (a) or formula (b); X: (a) O; (b) S; (c) CH2; R<1>: H; alkyl containing 1-3 carbon atoms; -CH=CH2; -CH=CH-CH3; -CH2-CH=CH2; formula (II); -C=CH; R<2>: H; or R<2> constitutes together with R<3> a carbon-carbon bond; R<3>: H; F; Cl; Br; I; N3; CN; C=CH; OH; OCH3; CH2OH; and when R<3> is F; Cl; Br; I; N3; CN; C=CH; OH; OCH3 or CH2OH it may have either the cis-configuration or trans-configuration relative to the hydroxymethyl function at position 4', or R<3> constitutes together with R<2> a carbon-carbon bond, and therapeutically acceptable salts thereof, for use in therapy, in particular for the treatment of HIV virus infections.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8701605A SE8701605D0 (en) | 1987-04-16 | 1987-04-16 | NOVEL MEDICINAL COMPOUNDS |
SE8701605 | 1987-04-16 | ||
CA000580141A CA1336088C (en) | 1987-04-16 | 1988-10-14 | 1-(3'-substitued-2', 3'-dideoxy-d-ribofuranosyl) thymine and uracil |
Publications (2)
Publication Number | Publication Date |
---|---|
AU1689988A true AU1689988A (en) | 1988-11-04 |
AU614082B2 AU614082B2 (en) | 1991-08-22 |
Family
ID=25672174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU16899/88A Ceased AU614082B2 (en) | 1987-04-16 | 1988-04-06 | Nucleosides and nucleoside analogues, pharmaceutical composition and processes for the preparation of the compounds |
Country Status (9)
Country | Link |
---|---|
JP (1) | JPH01503069A (en) |
AT (1) | ATE115958T1 (en) |
AU (1) | AU614082B2 (en) |
CA (1) | CA1336088C (en) |
DE (1) | DE3852531T2 (en) |
DK (3) | DK168443B1 (en) |
HU (1) | HU211547A9 (en) |
SE (1) | SE8701605D0 (en) |
WO (1) | WO1988008001A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU601529B2 (en) * | 1986-12-15 | 1990-09-13 | Wellcome Foundation Limited, The | Antiviral pyrimidine nucleosides |
AU631119B2 (en) * | 1988-02-24 | 1992-11-19 | Institut De Recherches Chimiques Et Biologiques Appliquees (I.R.C.E.B.A.) | New derivatives of deoxy-2'-uridine substituted in the 5,3' or 5' position by acylated alpha-amino groups, process for obtaining them and drugs containing them |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5175292A (en) * | 1988-01-20 | 1992-12-29 | Regents Of The University Of Minnesota | Intermediates for the preparation of dideoxycarbocyclic nucleosides |
US4950758A (en) * | 1988-01-20 | 1990-08-21 | Regents Of The University Of Minnesota | Optically-active isomers of dideoxycarbocyclic nucleosides |
US5631370A (en) * | 1988-01-20 | 1997-05-20 | Regents Of The University Of Minnesota | Optically-active isomers of dideoxycarbocyclic nucleosides |
US7119202B1 (en) | 1989-02-08 | 2006-10-10 | Glaxo Wellcome Inc. | Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties |
US5198539A (en) * | 1988-08-19 | 1993-03-30 | Burroughs Wellcome Co. | 5'-esters of 2',3'-dideoxy-3'-fluoro-5-ethynyluridine |
US5157114A (en) * | 1988-08-19 | 1992-10-20 | Burroughs Wellcome Co. | 2',3'-dideoxy-3'-fluoro-5-ethyngluridine |
FI95384C (en) * | 1989-04-06 | 1996-01-25 | Squibb Bristol Myers Co | Process for the preparation of 3'-deoxy-3'-substituted methyl nucleosides and intermediates used in the process |
FR2648045B1 (en) * | 1989-06-13 | 1991-09-27 | Centre Nat Rech Scient | ALPHA ANOMERIC OLIGONUCLEOTIDE COMPOUNDS INHIBITING REPLICATION OF RETROVIRUSES |
NZ234534A (en) * | 1989-07-17 | 1994-12-22 | Univ Birmingham | Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor |
WO1991004033A1 (en) * | 1989-09-15 | 1991-04-04 | Southern Research Institute | 2'-deoxy-4'-thioribonucleosides as antiviral and anticancer agents |
US5591722A (en) * | 1989-09-15 | 1997-01-07 | Southern Research Institute | 2'-deoxy-4'-thioribonucleosides and their antiviral activity |
US6069252A (en) | 1990-02-01 | 2000-05-30 | Emory University | Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers |
GB9008696D0 (en) * | 1990-04-18 | 1990-06-13 | Wellcome Found | Anti-viral compounds |
US5521163A (en) * | 1990-07-13 | 1996-05-28 | University Of Birmingham | Antiviral pyrimidine nucleosides and methods for using same |
SE9003151D0 (en) * | 1990-10-02 | 1990-10-02 | Medivir Ab | NUCLEOSIDE DERIVATIVES |
US6228860B1 (en) | 1990-11-13 | 2001-05-08 | Biochem Pharma Inc. | Substituted 1,3-oxathiolanes with antiviral properties |
US6369066B1 (en) | 1990-11-13 | 2002-04-09 | Biochem Pharma, Inc. | Substituted 1,3-oxathiolanes with antiviral properties |
US5587480A (en) * | 1990-11-13 | 1996-12-24 | Biochem Pharma, Inc. | Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties |
AU8864191A (en) * | 1990-11-13 | 1992-06-11 | Biochem Pharma Inc. | Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties |
TW393513B (en) * | 1991-11-26 | 2000-06-11 | Isis Pharmaceuticals Inc | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
EP1256589A3 (en) * | 1991-11-26 | 2003-09-17 | Isis Pharmaceuticals, Inc. | Oligomers containing modified pyrimidines |
US6235887B1 (en) | 1991-11-26 | 2001-05-22 | Isis Pharmaceuticals, Inc. | Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines |
US20020120130A1 (en) | 1993-09-10 | 2002-08-29 | Gilles Gosselin | 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents |
US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
AU697612B2 (en) * | 1994-05-31 | 1998-10-15 | Medivir Ab | Post exposure prevention of HIV |
US5612319A (en) * | 1994-05-31 | 1997-03-18 | Medivir Ab | Postexposure prevention of HIV infection or seroconversion |
US6391859B1 (en) | 1995-01-27 | 2002-05-21 | Emory University | [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides |
US5703058A (en) | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
US5808040A (en) * | 1995-01-30 | 1998-09-15 | Yale University | L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides |
ATE346651T1 (en) | 1995-06-07 | 2006-12-15 | Univ Emory | NUCLEOSIDES WITH ANTI-HEPATITIS B VIRUS EFFECTIVENESS |
US5869493A (en) | 1996-02-16 | 1999-02-09 | Medivir Ab | Acyclic nucleoside derivatives |
US5753789A (en) * | 1996-07-26 | 1998-05-19 | Yale University | Oligonucleotides containing L-nucleosides |
EA008609B1 (en) | 1998-02-25 | 2007-06-29 | Эмори Юниверсити | 2'-fluoronucleosides |
CN101862345B (en) | 2000-10-18 | 2014-06-04 | 吉利德制药有限责任公司 | Modified nucleosides for treatment of viral infections and abnormal cellular proliferation |
CN101573370B (en) | 2006-10-10 | 2013-09-11 | 美迪维尔公司 | HCV nucleoside inhibitor |
JP6270742B2 (en) * | 2013-01-10 | 2018-01-31 | 塩野義製薬株式会社 | Method for producing cross-linked nucleic acid derivative |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD75084A (en) * | ||||
US3116282A (en) * | 1960-04-27 | 1963-12-31 | Upjohn Co | Pyrimidine nucleosides and process |
FR2040177A1 (en) * | 1969-01-31 | 1971-01-22 | Robugen Gmbh | 2-deoxyribosyl-uracil derivs |
US3817982A (en) * | 1971-12-29 | 1974-06-18 | Syntex Inc | 2{40 ,3{40 -unsaturated nucleosides and method of making |
DE2918260A1 (en) * | 1979-05-07 | 1980-11-27 | Robugen Gmbh | 5-alkyl-5'-deoxy-uridine deriVs. use - for normalising cancerous cell functions and accelerating wound healing |
US4267171A (en) * | 1979-07-02 | 1981-05-12 | The Regents Of The University Of California | C-5 Substituted cytosine nucleosides |
US4247544A (en) * | 1979-07-02 | 1981-01-27 | The Regents Of The University Of California | C-5 Substituted uracil nucleosides |
DE2930904A1 (en) * | 1979-07-30 | 1981-02-19 | Kailash Kumar Dr Gauri | Antitumour use of 5-alkyl-pyrimidine nucleoside derivs. - as potentiators of 5-fluoro-uracil |
DE3002197A1 (en) * | 1980-01-22 | 1981-07-23 | Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen | 5-Alkyl- and 5-alkenyl-uracil and -cytidine nucleoside derivs. - prepd. e.g. by reaction of 5'-chloro-5'-deoxy cpds. with ammonia |
DE3045375A1 (en) * | 1980-12-02 | 1982-07-01 | Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen | 5-Substd. pyrimidine nucleoside derivs. - useful as antiviral agents |
DE3229169A1 (en) * | 1982-08-05 | 1984-02-09 | Robugen GmbH Pharmazeutische Fabrik, 7300 Esslingen | Use of 5-alkylpyrimidine nucleosides and their derivatives as cytostatics |
AP11A (en) * | 1985-03-16 | 1987-12-22 | The Wellcome Foundation Ltd | Antiviral nucleosides. |
DK166805B1 (en) * | 1985-03-16 | 1993-07-19 | Wellcome Found | THE THREO ISOMER OF 3'-AZIDO-3'-DEOXYTHYMIDINE FOR USING THE TREATMENT OR PROPHYLAXY OF HUMAN RETROVIRUS INFECTIONS, USING THE COMPOUND FOR THE PREPARATION OF A PHARMACEUTICAL PREPARATION OF A MEDICINAL PRODUCT AND NAVE MEDICINE |
US4724232A (en) * | 1985-03-16 | 1988-02-09 | Burroughs Wellcome Co. | Treatment of human viral infections |
HU196607B (en) * | 1985-05-15 | 1988-12-28 | Wellcome Found | Process for producing dideoxy-nucleosides and pharmaceutics comprising such compounds |
DK167377B1 (en) * | 1985-09-17 | 1993-10-25 | Wellcome Found | 3'-AZIDOPYRIMIDINE NUCLEOSIDES OR PHARMACEUTICAL ACCEPTABLE SALTS OR ESTERS THEREOF USED FOR TREATMENT OR PROPHYLAXY FOR A HUMAN RETROVIRUS INFECTION |
-
1987
- 1987-04-16 SE SE8701605A patent/SE8701605D0/en unknown
-
1988
- 1988-04-06 DE DE3852531T patent/DE3852531T2/en not_active Expired - Fee Related
- 1988-04-06 AU AU16899/88A patent/AU614082B2/en not_active Ceased
- 1988-04-06 AT AT88903972T patent/ATE115958T1/en not_active IP Right Cessation
- 1988-04-06 JP JP63503532A patent/JPH01503069A/en active Pending
- 1988-04-06 WO PCT/SE1988/000169 patent/WO1988008001A1/en active IP Right Grant
- 1988-10-14 CA CA000580141A patent/CA1336088C/en not_active Expired - Fee Related
- 1988-12-15 DK DK696988A patent/DK168443B1/en not_active IP Right Cessation
-
1991
- 1991-06-07 DK DK108491A patent/DK108491A/en not_active Application Discontinuation
-
1994
- 1994-09-13 DK DK104994A patent/DK104994A/en not_active Application Discontinuation
-
1995
- 1995-05-12 HU HU95P/P00134P patent/HU211547A9/en unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU601529B2 (en) * | 1986-12-15 | 1990-09-13 | Wellcome Foundation Limited, The | Antiviral pyrimidine nucleosides |
AU631119B2 (en) * | 1988-02-24 | 1992-11-19 | Institut De Recherches Chimiques Et Biologiques Appliquees (I.R.C.E.B.A.) | New derivatives of deoxy-2'-uridine substituted in the 5,3' or 5' position by acylated alpha-amino groups, process for obtaining them and drugs containing them |
Also Published As
Publication number | Publication date |
---|---|
DK108491D0 (en) | 1991-06-07 |
ATE115958T1 (en) | 1995-01-15 |
AU614082B2 (en) | 1991-08-22 |
DK168443B1 (en) | 1994-03-28 |
HU211547A9 (en) | 1995-12-28 |
DK104994A (en) | 1994-09-13 |
CA1336088C (en) | 1995-06-27 |
JPH01503069A (en) | 1989-10-19 |
DE3852531T2 (en) | 1995-08-10 |
WO1988008001A1 (en) | 1988-10-20 |
DK696988A (en) | 1989-01-31 |
DE3852531D1 (en) | 1995-02-02 |
SE8701605D0 (en) | 1987-04-16 |
DK696988D0 (en) | 1988-12-15 |
DK108491A (en) | 1991-06-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU1689988A (en) | Nucleosides and nucleoside analogues, pharmaceutical composition and processes for the preparation of the compounds | |
IL100502A0 (en) | Pharmaceutical compositions containing 1,3-oxathiolane nucleoside analogues | |
KR900701817A (en) | Nucleoside derivatives and preparation methods thereof | |
ES2157929T3 (en) | BETA-D-DIOXOLANO-NUCLEOSIDOS ENANTIOMERAMENTLY PURE. | |
IL90166A0 (en) | Purine derivatives and use thereof in therapy | |
ATE152352T1 (en) | PHARMACEUTICAL COMPOSITIONS FOR INHIBITING THE MAILLARD REACTION | |
OA09454A (en) | New peptide derivatives, their preparation process and pharmaceutical compositions which contain them. | |
DE69031340T2 (en) | ANTIVIRAL COMPOSITIONS CONTAINING 3'-AZIDO-2 ', 3'-DIDEOXY-5-METHYLCYTIDINE | |
ES8501416A1 (en) | Nucleoside 5'-alkyl- or alkenylphosphate. | |
ES2038600T3 (en) | COMPOSITIONS FOR THERAPEUTIC USE UNDERSTANDING ORGAN-SILICON COMPOUNDS. | |
GB2122197B (en) | Antiviral guanine derivatives | |
ES8308335A1 (en) | Antiviral deoxyuridine compounds. | |
KR950703976A (en) | Compositions Containing Acyclovir-Like Compounds and 2'-Vinyl substituted Nucleoside Analogs for the Treatment of Viral Infections | |
KR970070015A (en) | Phospholipid Derivatives of Acyclic Nucleosides and Their Preparation Method | |
IT1245631B (en) | Use of macrolide compounds as anti-inflammatory agents for the treatment of diseases caused by histamine release | |
ES2013350A6 (en) | A procedure for preparing nucleosides and analogues of nucleosides |