DK108491A - NUCLEOSIDES AND NUCLEOSIDALALOGS AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE RELATIONSHIPS - Google Patents

NUCLEOSIDES AND NUCLEOSIDALALOGS AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE RELATIONSHIPS Download PDF

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Publication number
DK108491A
DK108491A DK108491A DK108491A DK108491A DK 108491 A DK108491 A DK 108491A DK 108491 A DK108491 A DK 108491A DK 108491 A DK108491 A DK 108491A DK 108491 A DK108491 A DK 108491A
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Prior art keywords
formula
carbon
nucleosidalalogs
nucleosides
relationships
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DK108491A
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Danish (da)
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DK108491D0 (en
Inventor
Roelf Datema
Zsuzanna Maria Ilona Kovacs
Karl Nils Gunnar Johansson
Bjorn Gunnar Lindborg
Goeran Bertil Stening
Bo Frederik Oeberg
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Medivir Ab
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Application filed by Medivir Ab filed Critical Medivir Ab
Publication of DK108491D0 publication Critical patent/DK108491D0/en
Publication of DK108491A publication Critical patent/DK108491A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A compound of formula (I), wherein the radicals A, X, R<1>, R<2>, and R<3> are defined as follows: A: formula (a) or formula (b); X: (a) O; (b) S; (c) CH2; R<1>: H; alkyl containing 1-3 carbon atoms; -CH=CH2; -CH=CH-CH3; -CH2-CH=CH2; formula (II); -C=CH; R<2>: H; or R<2> constitutes together with R<3> a carbon-carbon bond; R<3>: H; F; Cl; Br; I; N3; CN; C=CH; OH; OCH3; CH2OH; and when R<3> is F; Cl; Br; I; N3; CN; C=CH; OH; OCH3 or CH2OH it may have either the cis-configuration or trans-configuration relative to the hydroxymethyl function at position 4', or R<3> constitutes together with R<2> a carbon-carbon bond, and therapeutically acceptable salts thereof, for use in therapy, in particular for the treatment of HIV virus infections.
DK108491A 1987-04-16 1991-06-07 NUCLEOSIDES AND NUCLEOSIDALALOGS AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE RELATIONSHIPS DK108491A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8701605A SE8701605D0 (en) 1987-04-16 1987-04-16 NOVEL MEDICINAL COMPOUNDS
CA000580141A CA1336088C (en) 1987-04-16 1988-10-14 1-(3'-substitued-2', 3'-dideoxy-d-ribofuranosyl) thymine and uracil

Publications (2)

Publication Number Publication Date
DK108491D0 DK108491D0 (en) 1991-06-07
DK108491A true DK108491A (en) 1991-06-07

Family

ID=25672174

Family Applications (3)

Application Number Title Priority Date Filing Date
DK696988A DK168443B1 (en) 1987-04-16 1988-12-15 Pyrimid-2-on-1-yl compounds, pharmaceutical preparations which comprise these compounds, and a process for preparing the compounds
DK108491A DK108491A (en) 1987-04-16 1991-06-07 NUCLEOSIDES AND NUCLEOSIDALALOGS AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE RELATIONSHIPS
DK104994A DK104994A (en) 1987-04-16 1994-09-13 Use of Beta-Anomeric Compounds for the Preparation of Pharmaceuticals for the Treatment or Prevention of HIV or Hepatitis B Virus

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK696988A DK168443B1 (en) 1987-04-16 1988-12-15 Pyrimid-2-on-1-yl compounds, pharmaceutical preparations which comprise these compounds, and a process for preparing the compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK104994A DK104994A (en) 1987-04-16 1994-09-13 Use of Beta-Anomeric Compounds for the Preparation of Pharmaceuticals for the Treatment or Prevention of HIV or Hepatitis B Virus

Country Status (9)

Country Link
JP (1) JPH01503069A (en)
AT (1) ATE115958T1 (en)
AU (1) AU614082B2 (en)
CA (1) CA1336088C (en)
DE (1) DE3852531T2 (en)
DK (3) DK168443B1 (en)
HU (1) HU211547A9 (en)
SE (1) SE8701605D0 (en)
WO (1) WO1988008001A1 (en)

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US4950758A (en) * 1988-01-20 1990-08-21 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
US5175292A (en) * 1988-01-20 1992-12-29 Regents Of The University Of Minnesota Intermediates for the preparation of dideoxycarbocyclic nucleosides
US5631370A (en) * 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
JPH03504492A (en) * 1988-02-24 1991-10-03 エンスティテュ　デ　ルシェルシェ　シミク　エ　ビョーロジク　アプリケ　（イ　エール　セ　エ　ベ　ア） New derivatives of 2'-deoxyuridine substituted in the 5-, 3'-, or 5'-position by an α-aminoacyl group and methods for their production and drugs in which they exist.
US7119202B1 (en) 1989-02-08 2006-10-10 Glaxo Wellcome Inc. Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
US5198539A (en) * 1988-08-19 1993-03-30 Burroughs Wellcome Co. 5'-esters of 2',3'-dideoxy-3'-fluoro-5-ethynyluridine
FI95384C (en) * 1989-04-06 1996-01-25 Squibb Bristol Myers Co Process for the preparation of 3'-deoxy-3'-substituted methyl nucleosides and intermediates used in the process
FR2648045B1 (en) * 1989-06-13 1991-09-27 Centre Nat Rech Scient ALPHA ANOMERIC OLIGONUCLEOTIDE COMPOUNDS INHIBITING REPLICATION OF RETROVIRUSES
IE902574A1 (en) * 1989-07-17 1991-02-27 Univ Birmingham Antiviral pyrimidine nucleosides
ATE311399T1 (en) * 1989-09-15 2005-12-15 Southern Res Inst 2'-DEOXY-4'-THIORIBONUCLEOSIDE AS ANTIVIRAL AND ANTICANCER AGENTS
US5591722A (en) * 1989-09-15 1997-01-07 Southern Research Institute 2'-deoxy-4'-thioribonucleosides and their antiviral activity
US5827727A (en) * 1990-02-01 1998-10-27 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
GB9008696D0 (en) * 1990-04-18 1990-06-13 Wellcome Found Anti-viral compounds
US5521163A (en) * 1990-07-13 1996-05-28 University Of Birmingham Antiviral pyrimidine nucleosides and methods for using same
SE9003151D0 (en) * 1990-10-02 1990-10-02 Medivir Ab NUCLEOSIDE DERIVATIVES
AU8864191A (en) * 1990-11-13 1992-06-11 Biochem Pharma Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
US5587480A (en) * 1990-11-13 1996-12-24 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
US6228860B1 (en) 1990-11-13 2001-05-08 Biochem Pharma Inc. Substituted 1,3-oxathiolanes with antiviral properties
US6369066B1 (en) 1990-11-13 2002-04-09 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes with antiviral properties
DE637965T1 (en) * 1991-11-26 1995-12-14 Gilead Sciences Inc INCREASED FORMATION OF TRIPLE AND DOUBLE HELICOS FROM OLIGOMERS WITH MODIFIED PYRIMIDINES.
US6235887B1 (en) 1991-11-26 2001-05-22 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
TW393513B (en) * 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US20020120130A1 (en) 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
EP0763048A1 (en) * 1994-05-31 1997-03-19 Medivir Aktiebolag Post exposure prevention of hiv
US5612319A (en) * 1994-05-31 1997-03-18 Medivir Ab Postexposure prevention of HIV infection or seroconversion
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
CA2219132C (en) 1995-06-07 2007-03-06 Emory University Nucleosides with anti-hepatitis b virus activity
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
CN100349913C (en) 1998-02-25 2007-11-21 埃莫里大学 2' -fluoro nucleosides
PT1411954E (en) 2000-10-18 2011-03-16 Pharmasset Inc Modified nucleosides for treatment of viral infections and abnormal cellular proliferation
KR20090078347A (en) 2006-10-10 2009-07-17 메디비르 아베 Hcv nucleoside inhibitor
WO2014109384A1 (en) * 2013-01-10 2014-07-17 塩野義製薬株式会社 Method for producing cross-linked nucleic acid derivative

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DD75084A (en) *
US3116282A (en) * 1960-04-27 1963-12-31 Upjohn Co Pyrimidine nucleosides and process
FR2040177A1 (en) * 1969-01-31 1971-01-22 Robugen Gmbh 2-deoxyribosyl-uracil derivs
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
DE2918260A1 (en) * 1979-05-07 1980-11-27 Robugen Gmbh 5-alkyl-5'-deoxy-uridine deriVs. use - for normalising cancerous cell functions and accelerating wound healing
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides
US4247544A (en) * 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides
DE2930904A1 (en) * 1979-07-30 1981-02-19 Kailash Kumar Dr Gauri Antitumour use of 5-alkyl-pyrimidine nucleoside derivs. - as potentiators of 5-fluoro-uracil
DE3002197A1 (en) * 1980-01-22 1981-07-23 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen 5-Alkyl- and 5-alkenyl-uracil and -cytidine nucleoside derivs. - prepd. e.g. by reaction of 5'-chloro-5'-deoxy cpds. with ammonia
DE3045375A1 (en) * 1980-12-02 1982-07-01 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen 5-Substd. pyrimidine nucleoside derivs. - useful as antiviral agents
DE3229169A1 (en) * 1982-08-05 1984-02-09 Robugen GmbH Pharmazeutische Fabrik, 7300 Esslingen Use of 5-alkylpyrimidine nucleosides and their derivatives as cytostatics
DK166805B1 (en) * 1985-03-16 1993-07-19 Wellcome Found THE THREO ISOMER OF 3'-AZIDO-3'-DEOXYTHYMIDINE FOR USING THE TREATMENT OR PROPHYLAXY OF HUMAN RETROVIRUS INFECTIONS, USING THE COMPOUND FOR THE PREPARATION OF A PHARMACEUTICAL PREPARATION OF A MEDICINAL PRODUCT AND NAVE MEDICINE
DE196185T1 (en) * 1985-03-16 1987-04-30 The Wellcome Foundation Ltd., London ANTIVIRAL NUCLEOSIDES.
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
NZ216172A (en) * 1985-05-15 1989-08-29 Wellcome Found Nucleosides and pharmaceutical compositions
ATE190064T1 (en) * 1985-09-17 2000-03-15 Wellcome Found COMBINATION THERAPEUTIC NUCLEOSIDES WITH OTHER THERAPEUTICALLY EFFECTIVE COMPONENTS.

Also Published As

Publication number Publication date
DE3852531D1 (en) 1995-02-02
DK696988D0 (en) 1988-12-15
DE3852531T2 (en) 1995-08-10
DK108491D0 (en) 1991-06-07
DK168443B1 (en) 1994-03-28
WO1988008001A1 (en) 1988-10-20
AU614082B2 (en) 1991-08-22
ATE115958T1 (en) 1995-01-15
HU211547A9 (en) 1995-12-28
SE8701605D0 (en) 1987-04-16
CA1336088C (en) 1995-06-27
DK696988A (en) 1989-01-31
JPH01503069A (en) 1989-10-19
DK104994A (en) 1994-09-13
AU1689988A (en) 1988-11-04

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