ES2013350A6 - A procedure for preparing nucleosides and analogues of nucleosides - Google Patents

A procedure for preparing nucleosides and analogues of nucleosides

Info

Publication number
ES2013350A6
ES2013350A6 ES8803122A ES8803122A ES2013350A6 ES 2013350 A6 ES2013350 A6 ES 2013350A6 ES 8803122 A ES8803122 A ES 8803122A ES 8803122 A ES8803122 A ES 8803122A ES 2013350 A6 ES2013350 A6 ES 2013350A6
Authority
ES
Spain
Prior art keywords
nucleosides
carbon
image
procedure
analogues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8803122A
Other languages
Spanish (es)
Inventor
Roelf Datema
Zsuzsanna M I Kovacs
Karl Nils Gunna Johansson
Bjorn Gunnar Lindborg
Goran Bertil Stening
Bo Fredrik Oberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Priority to ES8803122A priority Critical patent/ES2013350A6/en
Publication of ES2013350A6 publication Critical patent/ES2013350A6/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for preparing nucleosides and analogues of nucleosides of the formula < IMAGE > where A is < IMAGE > X is O, S or CH2 R1 is H, alkyl of 1-3 carbons, -CH=CH2, -CH=CH-CH3, -CH2-CH=CH2, < IMAGE > or -C[triple bond]CH R2 is H or constitutes a carbon-carbon bond together with R3 and R3 is H, halogen, N3, CN, C=CH, OH, OCH3 or CH2OH, with R3 being able to have a cis or trans configuration, relative to the hydroxymethyl function, or with R3 constituting a carbon-carbon bond together with R2. This procedure involves condensing a glycoside included in formula I in the N-1 position of a pyrimidine derivative corresponding to an aforesaid radical A, separating the [alpha]-anomer of the compound I formed and eliminating any protecting group present. There are other methods of preparation which are described in the specification. The compounds obtained are useful for preventing and treating hepatitis B, AIDS and other infections in mammals.
ES8803122A 1988-10-14 1988-10-14 A procedure for preparing nucleosides and analogues of nucleosides Expired - Lifetime ES2013350A6 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES8803122A ES2013350A6 (en) 1988-10-14 1988-10-14 A procedure for preparing nucleosides and analogues of nucleosides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8803122A ES2013350A6 (en) 1988-10-14 1988-10-14 A procedure for preparing nucleosides and analogues of nucleosides

Publications (1)

Publication Number Publication Date
ES2013350A6 true ES2013350A6 (en) 1990-05-01

Family

ID=8258486

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8803122A Expired - Lifetime ES2013350A6 (en) 1988-10-14 1988-10-14 A procedure for preparing nucleosides and analogues of nucleosides

Country Status (1)

Country Link
ES (1) ES2013350A6 (en)

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2008-10-14

FD1A Patent lapsed

Effective date: 20010201