DE3778734D1 - Dibenzo(b,e)oxepin-derivate sowie antiallergische und entzuendunghemmende mittel. - Google Patents

Dibenzo(b,e)oxepin-derivate sowie antiallergische und entzuendunghemmende mittel.

Info

Publication number
DE3778734D1
DE3778734D1 DE8787102983T DE3778734T DE3778734D1 DE 3778734 D1 DE3778734 D1 DE 3778734D1 DE 8787102983 T DE8787102983 T DE 8787102983T DE 3778734 T DE3778734 T DE 3778734T DE 3778734 D1 DE3778734 D1 DE 3778734D1
Authority
DE
Germany
Prior art keywords
dibenzo
allergic
inflammatory agents
oxepine derivatives
oxepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787102983T
Other languages
English (en)
Inventor
Ltd Oshima
Ltd Kumazawa
Ltd Otaki
Ltd Obase
Ltd Ohmori
Ltd Ishii
Ltd Manabe
Ltd Tamura
Ltd Shuto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=12725992&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3778734(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of DE3778734D1 publication Critical patent/DE3778734D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
DE8787102983T 1986-03-03 1987-03-03 Dibenzo(b,e)oxepin-derivate sowie antiallergische und entzuendunghemmende mittel. Expired - Lifetime DE3778734D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4567686 1986-03-03

Publications (1)

Publication Number Publication Date
DE3778734D1 true DE3778734D1 (de) 1992-06-11

Family

ID=12725992

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787102983T Expired - Lifetime DE3778734D1 (de) 1986-03-03 1987-03-03 Dibenzo(b,e)oxepin-derivate sowie antiallergische und entzuendunghemmende mittel.

Country Status (7)

Country Link
US (1) US5116863A (de)
EP (1) EP0235796B2 (de)
JP (1) JPS6310784A (de)
DE (1) DE3778734D1 (de)
ES (1) ES2038608T5 (de)
HK (1) HK68996A (de)
MX (1) MX9203155A (de)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882351A (en) * 1987-10-14 1989-11-21 Roussel Uclaf Tricyclic compounds
AU612437B2 (en) * 1987-12-14 1991-07-11 Kyowa Hakko Kogyo Co. Ltd. Tricyclic compounds
US4999363A (en) * 1988-06-09 1991-03-12 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds
US5242931A (en) * 1988-06-09 1993-09-07 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds as TXA2 antagonists
GB8914061D0 (en) * 1989-06-19 1989-08-09 Wellcome Found Agents for potentiating the effects of antitumour agents and combating multiple drug resistance
US5840749A (en) * 1989-08-25 1998-11-24 Hoechst Marion Roussel, Inc. N-hydroxy-dibenz b,e!oxepinalkylamines, N-hydroxy-dibenz b,e!oxepinalkanoic acid amides and related heterocyclic analogues
TW209861B (de) * 1989-08-25 1993-07-21 Hoechst Roussel Pharma
US5574173A (en) * 1993-12-06 1996-11-12 Schering Corporation Tricyclic derivatives, compositions and methods of use
US5686442A (en) * 1993-12-28 1997-11-11 Meiji Seika Kabushiki Kaisha Tricyclic benzazepine and benzothiazepine derivatives
US5641805A (en) * 1995-06-06 1997-06-24 Alcon Laboratories, Inc. Topical ophthalmic formulations for treating allergic eye diseases
EP0798288B1 (de) * 1995-10-16 2001-05-16 Kyowa Hakko Kogyo Co., Ltd. Tricyclische verbindungen
EP0920306A2 (de) 1996-07-12 1999-06-09 Leukosite, Inc. Chemokinrezeptor antagoniste und verfahren zu deren herstellung
US6323206B1 (en) 1996-07-12 2001-11-27 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
WO1998046587A1 (fr) 1997-04-15 1998-10-22 Kyowa Hakko Kogyo Co., Ltd. Composes tricycliques
US6613905B1 (en) * 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
ID26618A (id) 1998-01-21 2001-01-25 Millennium Pharm Inc Antagonis-antagonis reseptor kemokin dan metode penggunaannya
JP2002501052A (ja) 1998-01-21 2002-01-15 ミレニアム・ファーマシューティカルズ・インコーポレイテッド ケモカイン受容体アンタゴニストおよびその使用方法
US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
JP2002520355A (ja) * 1998-07-14 2002-07-09 アルコン ラボラトリーズ， インコーポレイテッド 非アレルギー性眼炎症障害を処置および眼新生血管形成を予防する医薬製造のための、１１−（３−ジメチルアミノプロピリデン）−６，１１−ジヒドロジベンズ［ｂ，ｅ］オキセピン−２−酢酸の使用
US7271176B2 (en) * 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US6174914B1 (en) 1999-06-15 2001-01-16 Alcon Laboratories, Inc. Method of inhibiting cytokine release from human ocular cells
US20040097486A1 (en) * 1999-11-18 2004-05-20 Yanni John M. Use of an H1 antagonist and a safe steroid to treat eye conditions
WO2001054687A1 (en) * 2000-01-25 2001-08-02 Alcon Universal Ltd. Ophthalmic anti-allergy compositions suitable for use with contact lenses
US6372802B2 (en) 2000-05-19 2002-04-16 Alcon Universal Ltd. Aniline disulfide derivatives for treating allergic diseases
CA2407767A1 (en) 2000-05-19 2001-11-29 Alcon, Inc. Compositions containing a benzamide disulfide derivative for treating allergic diseases
ATE330938T1 (de) 2000-05-19 2006-07-15 Alcon Inc Disulfid-derivate verwendbar zur behandlung von allergischen erkrankungen
US7977376B2 (en) * 2001-06-27 2011-07-12 Novartis Ag Olopatadine formulations for topical nasal administration
TWI231759B (en) 2001-06-27 2005-05-01 Alcon Inc Olopatadine formulations for topical administration
WO2003041704A1 (fr) * 2001-11-13 2003-05-22 Kyowa Hakko Kogyo Co., Ltd. Agent preventif ou remede destine au prurit
US7541365B2 (en) * 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
AU2002366567B2 (en) * 2001-12-05 2006-11-16 Alcon, Inc. Use of an H1 antagonist and a safe steroid to treat rhinitis
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
JPWO2005011674A1 (ja) * 2003-08-05 2006-09-14 協和醗酵工業株式会社 気管支喘息の予防及び／または治療剤
US20050209312A1 (en) * 2004-03-19 2005-09-22 Bausch & Lomb Incorporated Carboxylic acid derivatives of doxepin formulations preserved with low-irritation preservative
JPWO2005102313A1 (ja) * 2004-04-21 2007-08-16 協和醗酵工業株式会社 慢性副鼻腔炎の予防および／または治療剤
KR20070024618A (ko) * 2004-06-28 2007-03-02 알콘, 인코퍼레이티드 알레르기성 질환 치료용 국소 제제
KR20070032785A (ko) * 2004-07-16 2007-03-22 교와 핫꼬 고교 가부시끼가이샤 수면 장해의 예방 및/또는 치료제
ES2253996B1 (es) * 2004-07-28 2007-08-16 Urquima, S.A. Procedimiento para la preparacion del acido 11-((z)-3-(dimetilamino)propiliden)-6,11-dihidrodibenz(b,e)oxepinacetico.
CN101065122A (zh) * 2004-11-24 2007-10-31 爱尔康公司 输送鼻孔喷雾剂的方法
US20060280821A1 (en) * 2005-04-04 2006-12-14 Foo Lai Y Method of treating inflammation disorders using extracts of passion fruit
EP1901708B1 (de) * 2005-07-08 2013-09-11 Senju Pharmaceutical Co., Ltd. Perkutan saugfähiges ophthalmisches präparat mit olopatadin
WO2007119120A2 (en) 2005-12-22 2007-10-25 Medichem, S.A. Crystalline polymorphic forms of olopatadine hydrochloride and processes for their preparation
WO2007105234A2 (en) * 2006-03-14 2007-09-20 Usv Limited A PROCESS FOR THE PREPARATION OF ISOMERS OF 11-[3-(DIMETHYLAMINO)PROPYLIDENE]-6, 11-DIHYDRODIBENZ [b, e] OXEPIN-2-ACETIC ACID HYDROCHLORIDE AND POLYMORPHS THEREOF
US7950020B2 (en) * 2006-03-16 2011-05-24 Ntt Docomo, Inc. Secure operating system switching
US7687646B2 (en) * 2006-03-28 2010-03-30 Azad Pharmaceutical Ingredients, Ag Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof
JP5139016B2 (ja) * 2006-10-02 2013-02-06 住友化学株式会社 オキソジベンゾオキセピン酢酸第３級アルキルエステルの製造方法
ES2409840T3 (es) * 2006-10-02 2013-06-28 Sumitomo Chemical Co., Ltd Proceso para la preparación de olopatadina
US20080139531A1 (en) * 2006-12-04 2008-06-12 Alcon Manufacturing Ltd. Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair
ES2557939T3 (es) 2007-02-07 2016-01-29 Novartis Ag Formulaciones de olopatadina para administración nasal tópica
JP5139104B2 (ja) * 2007-02-16 2013-02-06 住友化学株式会社 ジベンゾオキセピン化合物の製造方法
CH698773B1 (de) * 2007-02-16 2011-06-30 Sumitomo Chemical Co Verfahren zur Herstellung einer Dibenzoxepin-Verbindung.
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
KR20100014565A (ko) * 2007-04-11 2010-02-10 알콘 리서치, 리미티드 알레르기성 비염 및 알레르기성 결막염을 치료하기 위한 ｔｎｆａ의 억제제 및 항히스타민의 용도
US20100227917A1 (en) * 2007-09-06 2010-09-09 Masashi Nakakura EYE DROP CONTAINING DIBENZ[b,e]OXEPIN DERIVATIVE
US20090069413A1 (en) * 2007-09-09 2009-03-12 Protia, Llc Deuterium-enriched olopatadine
JP5248078B2 (ja) * 2007-10-05 2013-07-31 住友化学株式会社 ジベンゾオキセピン化合物の製造方法
EP2666770A1 (de) * 2008-07-16 2013-11-27 Crystal Pharma S.A.U Verfahren zur Herstellung von Olopatadin und Zwischenprodukten
AU2009277496B2 (en) 2008-08-01 2013-09-26 Nippon Zoki Pharmaceutical Co., Ltd. Aminopropylidene derivative
WO2010025236A1 (en) * 2008-08-27 2010-03-04 Alexander Goldin Composition and method for treating colds
JP5503877B2 (ja) 2009-01-30 2014-05-28 住友化学株式会社 ジベンゾオキセピン化合物の製造方法
PL2393797T3 (pl) 2009-02-05 2016-12-30 Sposób wytwarzania olopatadyny i/lub jej farmaceutycznie dopuszczalnej soli
IT1397503B1 (it) 2009-04-21 2013-01-16 F S I Fabbrica Italiana Sint Processo per la preparazione di olopatadina
BR112012001169A2 (pt) * 2009-07-17 2016-03-01 Alcon Res Ltd sistema de pulverização nasal de olopatadina para crianças
WO2011027322A1 (en) 2009-09-03 2011-03-10 Ranbaxy Laboratories Limited Extended release dosage form containing olopatadine for oral administration
WO2011033532A1 (en) 2009-09-17 2011-03-24 Indoco Remedies Limited Process for preparation of olopatadine hydrochloride
WO2011041640A1 (en) 2009-10-01 2011-04-07 Alcon Research, Ltd. Olopatadine compositions and uses thereof
WO2011128911A2 (en) * 2010-04-12 2011-10-20 Msn Laboratories Limited Improved process for ll-[(z)-3-(dimethylamino)propyiidenel-6-ll- dihydrodibenz[b,el oxepin-2-aceticacid
WO2011141929A2 (en) 2010-05-11 2011-11-17 Cadila Healthcare Limited Aqueous pharmaceutical compositions of fluticasone and olopatadine
TW201206936A (en) 2010-07-19 2012-02-16 Alcon Res Ltd Methods and compositions for the treatment of allergy
TWI544922B (zh) 2011-05-19 2016-08-11 愛爾康研究有限公司 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物
TW201336527A (zh) 2012-02-10 2013-09-16 Alcon Res Ltd 具增強的穩定性之水性藥學組成物
CN103664861B (zh) * 2013-12-18 2018-01-30 北京华禧联合科技发展有限公司 一种用高活性有机锌试剂制备盐酸奥洛他定的新方法
JP7424115B2 (ja) 2019-06-26 2024-01-30 住友化学株式会社 エステル化合物の製造方法
CN111548369B (zh) * 2020-05-29 2023-02-28 内蒙古京东药业有限公司 一种简便制备高纯度奥洛他定盐酸盐中间体的方法
CN112457287B (zh) * 2020-12-09 2024-02-06 重庆西南制药二厂有限责任公司 一种e-奥洛他定的制备方法
CN114380783B (zh) * 2022-01-18 2023-02-10 梯尔希（南京）药物研发有限公司 一种奥洛他定氘标记代谢物的制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE641498A (de) * 1962-03-13
US3420851A (en) * 1962-12-19 1969-01-07 Pfizer & Co C Novel dibenzoxepines
FR88751E (de) * 1963-07-09 1967-06-07
SE368825B (de) * 1963-10-14 1974-07-22 Pfizer
DE1543346A1 (de) * 1966-04-30 1969-09-25 Boehringer Mannheim Gmbh Verfahren zur Herstellung basischer Derivate des Dibenzoxepins und Dibenzothiepins
US4585788A (en) * 1973-09-06 1986-04-29 American Hoechst Corporation 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives
US4282365A (en) * 1978-11-24 1981-08-04 Merck & Co., Inc. Dibenz[b,e]oxepin compounds
US4396550A (en) * 1980-04-22 1983-08-02 Kyowa Hakko Kogyo Co., Ltd. Dibenz [b,e] oxepin derivatives
JPS56150083A (en) * 1980-04-22 1981-11-20 Kyowa Hakko Kogyo Co Ltd Novel dibenzo b,e oxepin derivative
EP0069810B1 (de) * 1981-07-09 1986-12-03 Merck & Co. Inc. Dibenzoxepine, ihre Herstellung, diese Verbindungen enthaltende Zusammensetzungen und ihre Verwendung bei der Behandlung von allergischen Zuständen
JPS5821679A (ja) * 1981-07-31 1983-02-08 メルク　エンド　カムパニー　インコーポレーテツド ジベンツ〔ｂ，ｅ〕オキセピン化合物
JPS58126883A (ja) * 1982-01-25 1983-07-28 Kyowa Hakko Kogyo Co Ltd ジベンゾ〔ｂ，ｅ〕オキセピン誘導体を含有してなる抗喘息剤
JPS59227879A (ja) * 1983-06-10 1984-12-21 Kyowa Hakko Kogyo Co Ltd ジベンゾ［ｂ，ｅ］オキセピン誘導体
JPS6028972A (ja) * 1983-06-29 1985-02-14 Kyowa Hakko Kogyo Co Ltd ジベンゾ［ｂ，ｅ］オキセピン誘導体
EP0188802A3 (de) * 1984-12-26 1986-08-20 Kyowa Hakko Kogyo Co., Ltd. Dibenz(b,e)oxepin-Derivat und antiallergisches Mittel
US4923892A (en) * 1985-08-17 1990-05-08 Burroughs Wellcome Co. Tricyclic aromatic compounds
GB8520662D0 (en) * 1985-08-17 1985-09-25 Wellcome Found Tricyclic aromatic compounds

Also Published As

Publication number Publication date
JPH0586925B2 (de) 1993-12-14
JPS6310784A (ja) 1988-01-18
HK68996A (en) 1996-04-26
EP0235796A3 (en) 1988-09-21
MX9203155A (es) 1992-07-01
US5116863A (en) 1992-05-26
ES2038608T5 (es) 1997-07-16
ES2038608T3 (es) 1993-08-01
EP0235796B1 (de) 1992-05-06
EP0235796B2 (de) 1997-03-12
EP0235796A2 (de) 1987-09-09

Similar Documents

Publication Publication Date Title
DE3778734D1 (de) Dibenzo(b,e)oxepin-derivate sowie antiallergische und entzuendunghemmende mittel.
DE3674906D1 (de) Selbstklemmende medizinische prothese und ihre herstellung.
DE3775430D1 (de) Mehrfachverglasung, sowie herstellungsverfahren und vorrichtung hierfuer.
DE3788709D1 (de) Piperidin-Derivate, ihre Herstellung und Anwendung.
DE3484473D1 (de) Chroman-verbindungen und deren herstellung.
DE3671010D1 (de) Antiallergische mittel.
DE3763573D1 (de) Dihydropyridine als antiallergische und antiinflammatorische mittel.
DE3773722D1 (de) Inosose-derivate und ihre herstellung.
DE3776620D1 (de) 3-propenylcephemderivate, ihre herstellung, zwischenverbindungen, pharmazeutische praeparate und anwendung.
DE3770020D1 (de) Sulfoxidderivate und ihre herstellung.
DE3788195D1 (de) DIBENZ[b,e]OXEPINDERIVATE, SOWIE ARZNEIMITTEL, DIE DIESE ALS AKTIVE MITTEL ENTHALTEN.
DE69009122D1 (de) Aufwärts und abwärts Zerhacker.
DE3782636D1 (de) Isoindolin-1-on-derivat und antiarrhythmisches mittel.
DE3779842D1 (de) Antiallergisches mittel.
DE3783401D1 (de) Medizinische roehre und herstellungsverfahren.
DE3678021D1 (de) Elasthanfaeden, ihre herstellung und dazu erforderliche zwischenprodukte.
DE68919512D1 (de) Chinoxalin-Derivate und antiulzerierendes Mittel.
DE3674873D1 (de) N,n-dimethylethylaminoxidderivat, herstellungsverfahren und pharmazeutische mittel.
NL189233C (nl) Patienthefinrichting.
DE3689036D1 (de) Lankacidinderivate und ihre Herstellung.
FI875325A (fi) Bestraolningsanordning foer synbart ljus vid medicinal anvaendning.
DE3583536D1 (de) Substituierte und bruecken enthaltende pyridine, als heilmittel verwendbar.
IT1213417B (it) Laminatoio obliquo.
ATE54316T1 (de) Dihydropyridine als antiallergische und antiinflammatorische mittel.
ATE74753T1 (de) Entzuendungshemmende mittel.

Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings