MX9203155A - Derivado [b,e] oxepina como agente antialergico. - Google Patents

Derivado [b,e] oxepina como agente antialergico.

Info

Publication number
MX9203155A
MX9203155A MX9203155A MX9203155A MX9203155A MX 9203155 A MX9203155 A MX 9203155A MX 9203155 A MX9203155 A MX 9203155A MX 9203155 A MX9203155 A MX 9203155A MX 9203155 A MX9203155 A MX 9203155A
Authority
MX
Mexico
Prior art keywords
oxepine
derivative
allergic agent
allergic
agent
Prior art date
Application number
MX9203155A
Other languages
English (en)
Inventor
Etsuo Oshima
Toshiaki Kumazawa
Shizuo Otaki
Hiroyuki Obase
Kenji Ohmori
Hidee Ishii
Haruhiko Manabe
Tadafumi Tamura
Katsuichi Shuto
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=12725992&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9203155(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Publication of MX9203155A publication Critical patent/MX9203155A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MX9203155A 1986-03-03 1992-06-23 Derivado [b,e] oxepina como agente antialergico. MX9203155A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4567686 1986-03-03

Publications (1)

Publication Number Publication Date
MX9203155A true MX9203155A (es) 1992-07-01

Family

ID=12725992

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9203155A MX9203155A (es) 1986-03-03 1992-06-23 Derivado [b,e] oxepina como agente antialergico.

Country Status (7)

Country Link
US (1) US5116863A (es)
EP (1) EP0235796B2 (es)
JP (1) JPS6310784A (es)
DE (1) DE3778734D1 (es)
ES (1) ES2038608T5 (es)
HK (1) HK68996A (es)
MX (1) MX9203155A (es)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
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US5574173A (en) * 1993-12-06 1996-11-12 Schering Corporation Tricyclic derivatives, compositions and methods of use
US5686442A (en) * 1993-12-28 1997-11-11 Meiji Seika Kabushiki Kaisha Tricyclic benzazepine and benzothiazepine derivatives
US5641805A (en) * 1995-06-06 1997-06-24 Alcon Laboratories, Inc. Topical ophthalmic formulations for treating allergic eye diseases
AU700386B2 (en) * 1995-10-16 1999-01-07 Kyowa Hakko Kogyo Co. Ltd. Triciclic compounds
JP2000516210A (ja) 1996-07-12 2000-12-05 ロイコサイト，インコーポレーテッド ケモカインレセプターアンタゴニストとその使用方法
US6323206B1 (en) 1996-07-12 2001-11-27 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
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US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en) * 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
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HUP0101320A3 (en) 1998-01-21 2002-11-28 Kyowa Hakko Kogyo Kk Benzo- and pyridobenzoxepine and -benzazepine derivatives and use thereof
DE69900207T2 (de) * 1998-07-14 2001-11-22 Alcon Laboratories, Inc. Verwendung von 11-(3-dimethylaminopropyliden)-6,11-dihydrodibenz[b,e]oxepin-2-essigsäure und deren pharmazeutisch annehmbaren salzen zur herstellung eines medikaments zur behandlung nicht-allergisch-bedingten augenentzündungen und zur prevention der okularen neovaskularisation
US7271176B2 (en) * 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US6174914B1 (en) 1999-06-15 2001-01-16 Alcon Laboratories, Inc. Method of inhibiting cytokine release from human ocular cells
US20040097486A1 (en) * 1999-11-18 2004-05-20 Yanni John M. Use of an H1 antagonist and a safe steroid to treat eye conditions
CA2395866C (en) * 2000-01-25 2009-10-13 Alcon, Inc. Ophthalmic anti-allergy compositions suitable for use with contact lenses
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US20040248926A1 (en) * 2001-11-13 2004-12-09 Hayashi Ken-Ichi Preventive or remedy for pruritus
US7541365B2 (en) * 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
MXPA04005417A (es) * 2001-12-05 2004-10-11 Alcon Inc Uso de antagonista de h1 y un esteroide seguro para el tratamiento de la rinitis.
TWI291467B (en) * 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
JPWO2005011674A1 (ja) * 2003-08-05 2006-09-14 協和醗酵工業株式会社 気管支喘息の予防及び／または治療剤
US20050209312A1 (en) * 2004-03-19 2005-09-22 Bausch & Lomb Incorporated Carboxylic acid derivatives of doxepin formulations preserved with low-irritation preservative
CA2563684A1 (en) * 2004-04-21 2005-11-03 Kyowa Hakko Kogyo Co., Ltd. Preventive and/or therapeutic agent for chronic sinusitis
JP2008504300A (ja) * 2004-06-28 2008-02-14 アルコン，インコーポレイテッド アレルギー性疾患を処置するための局所処方物
JPWO2006009093A1 (ja) * 2004-07-16 2008-05-01 協和醗酵工業株式会社 睡眠障害の予防および／または治療剤
ES2253996B1 (es) * 2004-07-28 2007-08-16 Urquima, S.A. Procedimiento para la preparacion del acido 11-((z)-3-(dimetilamino)propiliden)-6,11-dihidrodibenz(b,e)oxepinacetico.
PL1814538T3 (pl) * 2004-11-24 2010-02-26 Alcon Inc Sposób dostarczania donosowego sprayu
US20060280821A1 (en) * 2005-04-04 2006-12-14 Foo Lai Y Method of treating inflammation disorders using extracts of passion fruit
EP1901708B1 (en) * 2005-07-08 2013-09-11 Senju Pharmaceutical Co., Ltd. Percutaneously absorptive ophthalmic preparation comprising olopatadine
US20100137619A1 (en) * 2005-12-22 2010-06-03 Medichem, S.A. Crystalline polymorphic forms of olopatadine hydrochloride and processes for their preparation
WO2007105234A2 (en) * 2006-03-14 2007-09-20 Usv Limited A PROCESS FOR THE PREPARATION OF ISOMERS OF 11-[3-(DIMETHYLAMINO)PROPYLIDENE]-6, 11-DIHYDRODIBENZ [b, e] OXEPIN-2-ACETIC ACID HYDROCHLORIDE AND POLYMORPHS THEREOF
US7950020B2 (en) * 2006-03-16 2011-05-24 Ntt Docomo, Inc. Secure operating system switching
US7687646B2 (en) * 2006-03-28 2010-03-30 Azad Pharmaceutical Ingredients, Ag Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof
WO2008041734A1 (fr) * 2006-10-02 2008-04-10 Sumitomo Chemical Company, Limited Ester d'alkyle tertiaire d'acide oxodibenzoxépinacétique
JP5139016B2 (ja) * 2006-10-02 2013-02-06 住友化学株式会社 オキソジベンゾオキセピン酢酸第３級アルキルエステルの製造方法
US20080139531A1 (en) * 2006-12-04 2008-06-12 Alcon Manufacturing Ltd. Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair
ES2781090T3 (es) 2007-02-07 2020-08-28 Novartis Ag Formulaciones de olopatadina para administración nasal tópica
CN101605773B (zh) * 2007-02-16 2014-07-23 住友化学株式会社 二苯并氧杂*化合物的制造方法
JP5139104B2 (ja) * 2007-02-16 2013-02-06 住友化学株式会社 ジベンゾオキセピン化合物の製造方法
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
JP2010523695A (ja) * 2007-04-11 2010-07-15 アルコン リサーチ， リミテッド アレルギー性鼻炎およびアレルギー性結膜炎を処置するためのＴＮＦαのインヒビターおよび抗ヒスタミン薬の使用
WO2009031682A1 (ja) 2007-09-06 2009-03-12 Kyowa Hakko Kirin Co., Ltd. ジベンゾ[b,e]オキセピン誘導体含有点眼剤
US20090069413A1 (en) * 2007-09-09 2009-03-12 Protia, Llc Deuterium-enriched olopatadine
JP5248078B2 (ja) * 2007-10-05 2013-07-31 住友化学株式会社 ジベンゾオキセピン化合物の製造方法
ES2433715T3 (es) * 2008-07-16 2013-12-12 Crystal Pharma, S.A.U. Procedimiento de obtención de olopatadina e intermedios
TWI457341B (zh) 2008-08-01 2014-10-21 Nippon Zoki Pharmaceutical Co 胺基亞丙基衍生物
WO2010025236A1 (en) * 2008-08-27 2010-03-04 Alexander Goldin Composition and method for treating colds
JP5503877B2 (ja) 2009-01-30 2014-05-28 住友化学株式会社 ジベンゾオキセピン化合物の製造方法
CN102292326B (zh) 2009-02-05 2015-04-22 Zach系统股份公司 奥洛他定和/或其药学上可接受的盐的制备方法
IT1397503B1 (it) 2009-04-21 2013-01-16 F S I Fabbrica Italiana Sint Processo per la preparazione di olopatadina
US20110011392A1 (en) * 2009-07-17 2011-01-20 Wall G Michael Olopatadine nasal spray regimen for children
WO2011027322A1 (en) 2009-09-03 2011-03-10 Ranbaxy Laboratories Limited Extended release dosage form containing olopatadine for oral administration
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AU2010300421B2 (en) * 2009-10-01 2014-01-23 Alcon Research, Ltd. Olopatadine compositions and uses thereof
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WO2011141929A2 (en) 2010-05-11 2011-11-17 Cadila Healthcare Limited Aqueous pharmaceutical compositions of fluticasone and olopatadine
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TWI544922B (zh) 2011-05-19 2016-08-11 愛爾康研究有限公司 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物
TW201336527A (zh) 2012-02-10 2013-09-16 Alcon Res Ltd 具增強的穩定性之水性藥學組成物
CN103664861B (zh) * 2013-12-18 2018-01-30 北京华禧联合科技发展有限公司 一种用高活性有机锌试剂制备盐酸奥洛他定的新方法
JP7424115B2 (ja) 2019-06-26 2024-01-30 住友化学株式会社 エステル化合物の製造方法
CN111548369B (zh) * 2020-05-29 2023-02-28 内蒙古京东药业有限公司 一种简便制备高纯度奥洛他定盐酸盐中间体的方法
CN112457287B (zh) * 2020-12-09 2024-02-06 重庆西南制药二厂有限责任公司 一种e-奥洛他定的制备方法
CN114380783B (zh) * 2022-01-18 2023-02-10 梯尔希（南京）药物研发有限公司 一种奥洛他定氘标记代谢物的制备方法

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JPS56150083A (en) * 1980-04-22 1981-11-20 Kyowa Hakko Kogyo Co Ltd Novel dibenzo b,e oxepin derivative
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JPS59227879A (ja) * 1983-06-10 1984-12-21 Kyowa Hakko Kogyo Co Ltd ジベンゾ［ｂ，ｅ］オキセピン誘導体
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Also Published As

Publication number Publication date
EP0235796A3 (en) 1988-09-21
EP0235796A2 (en) 1987-09-09
JPH0586925B2 (es) 1993-12-14
ES2038608T5 (es) 1997-07-16
EP0235796B2 (en) 1997-03-12
ES2038608T3 (es) 1993-08-01
JPS6310784A (ja) 1988-01-18
HK68996A (en) 1996-04-26
US5116863A (en) 1992-05-26
DE3778734D1 (de) 1992-06-11
EP0235796B1 (en) 1992-05-06

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