HK68996A - Dibenz (b,e) oxepin derivative and antiallergic and antiinflammatory agent - Google Patents

Dibenz (b,e) oxepin derivative and antiallergic and antiinflammatory agent

Info

Publication number
HK68996A
HK68996A HK68996A HK68996A HK68996A HK 68996 A HK68996 A HK 68996A HK 68996 A HK68996 A HK 68996A HK 68996 A HK68996 A HK 68996A HK 68996 A HK68996 A HK 68996A
Authority
HK
Hong Kong
Prior art keywords
dibenz
antiallergic
antiinflammatory agent
oxepin derivative
oxepin
Prior art date
Application number
HK68996A
Other languages
English (en)
Inventor
Etsuo Oshima
Toshiaki Kumazawa
Shizuo Otaki
Hiroyuki Obase
Kenji Ohmori
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=12725992&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK68996(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Publication of HK68996A publication Critical patent/HK68996A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
HK68996A 1986-03-03 1996-04-18 Dibenz (b,e) oxepin derivative and antiallergic and antiinflammatory agent HK68996A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4567686 1986-03-03

Publications (1)

Publication Number Publication Date
HK68996A true HK68996A (en) 1996-04-26

Family

ID=12725992

Family Applications (1)

Application Number Title Priority Date Filing Date
HK68996A HK68996A (en) 1986-03-03 1996-04-18 Dibenz (b,e) oxepin derivative and antiallergic and antiinflammatory agent

Country Status (7)

Country Link
US (1) US5116863A (xx)
EP (1) EP0235796B2 (xx)
JP (1) JPS6310784A (xx)
DE (1) DE3778734D1 (xx)
ES (1) ES2038608T5 (xx)
HK (1) HK68996A (xx)
MX (1) MX9203155A (xx)

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GB8914061D0 (en) * 1989-06-19 1989-08-09 Wellcome Found Agents for potentiating the effects of antitumour agents and combating multiple drug resistance
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US7271176B2 (en) * 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US6174914B1 (en) 1999-06-15 2001-01-16 Alcon Laboratories, Inc. Method of inhibiting cytokine release from human ocular cells
US20040097486A1 (en) * 1999-11-18 2004-05-20 Yanni John M. Use of an H1 antagonist and a safe steroid to treat eye conditions
CA2395866C (en) 2000-01-25 2009-10-13 Alcon, Inc. Ophthalmic anti-allergy compositions suitable for use with contact lenses
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US7977376B2 (en) * 2001-06-27 2011-07-12 Novartis Ag Olopatadine formulations for topical nasal administration
CA2466790A1 (en) * 2001-11-13 2003-05-22 Kyowa Hakko Kogyo Co., Ltd. Preventive or therapeutic agent for pruritus
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
CN1599625A (zh) * 2001-12-05 2005-03-23 爱尔康公司 H1拮抗剂和安全类固醇治疗鼻炎的用途
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JPWO2005011674A1 (ja) * 2003-08-05 2006-09-14 協和醗酵工業株式会社 気管支喘息の予防及び／または治療剤
US20050209312A1 (en) * 2004-03-19 2005-09-22 Bausch & Lomb Incorporated Carboxylic acid derivatives of doxepin formulations preserved with low-irritation preservative
EP1757285A4 (en) * 2004-04-21 2007-11-07 Kyowa Hakko Kogyo Kk PREVENTIVE AND / OR THERAPEUTIC AGENT FOR CHRONIC SINUSITIS
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JP5068172B2 (ja) * 2004-11-24 2012-11-07 アルコン，インコーポレイティド 鼻に噴霧を噴射する方法
US20060280821A1 (en) * 2005-04-04 2006-12-14 Foo Lai Y Method of treating inflammation disorders using extracts of passion fruit
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WO2007105234A2 (en) * 2006-03-14 2007-09-20 Usv Limited A PROCESS FOR THE PREPARATION OF ISOMERS OF 11-[3-(DIMETHYLAMINO)PROPYLIDENE]-6, 11-DIHYDRODIBENZ [b, e] OXEPIN-2-ACETIC ACID HYDROCHLORIDE AND POLYMORPHS THEREOF
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US7687646B2 (en) * 2006-03-28 2010-03-30 Azad Pharmaceutical Ingredients, Ag Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof
JP5139016B2 (ja) * 2006-10-02 2013-02-06 住友化学株式会社 オキソジベンゾオキセピン酢酸第３級アルキルエステルの製造方法
CN101516865B (zh) * 2006-10-02 2013-01-23 住友化学株式会社 氧代二苯并氧杂*乙酸的叔烷基酯
US20080139531A1 (en) * 2006-12-04 2008-06-12 Alcon Manufacturing Ltd. Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair
BRPI0721255B8 (pt) 2007-02-07 2021-05-25 Alcon Pharmaceuticals Ltd composições de olopatadina para administração nasal tópica
ES2344242B1 (es) * 2007-02-16 2011-06-06 Sumitomo Chemical Company, Limited Metodo para la produccion de un compuesto de dibenzoxepina.
JP5139104B2 (ja) * 2007-02-16 2013-02-06 住友化学株式会社 ジベンゾオキセピン化合物の製造方法
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
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CA2698651A1 (en) * 2007-09-06 2009-03-12 Kyowa Hakko Kirin Co., Ltd. Eye drop containing dibenz [b,e] oxepin derivative
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JP5248078B2 (ja) * 2007-10-05 2013-07-31 住友化学株式会社 ジベンゾオキセピン化合物の製造方法
EP2145882B1 (en) 2008-07-16 2013-08-21 Crystal Pharma, S.A.U. Process for obtaining olopatadine and intermediates
CN102112462B (zh) 2008-08-01 2015-02-18 日本脏器制药株式会社 氨基亚丙基衍生物
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JP5503877B2 (ja) 2009-01-30 2014-05-28 住友化学株式会社 ジベンゾオキセピン化合物の製造方法
SI2393797T1 (sl) * 2009-02-05 2016-07-29 Zach System S.P.A. Proces za pripravo olopatadina in/ali njegove farmacevtsko sprejemljive soli
IT1397503B1 (it) 2009-04-21 2013-01-16 F S I Fabbrica Italiana Sint Processo per la preparazione di olopatadina
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WO2011027322A1 (en) 2009-09-03 2011-03-10 Ranbaxy Laboratories Limited Extended release dosage form containing olopatadine for oral administration
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WO2011128911A2 (en) * 2010-04-12 2011-10-20 Msn Laboratories Limited Improved process for ll-[(z)-3-(dimethylamino)propyiidenel-6-ll- dihydrodibenz[b,el oxepin-2-aceticacid
WO2011141929A2 (en) 2010-05-11 2011-11-17 Cadila Healthcare Limited Aqueous pharmaceutical compositions of fluticasone and olopatadine
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TWI544922B (zh) 2011-05-19 2016-08-11 愛爾康研究有限公司 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物
TW201336527A (zh) 2012-02-10 2013-09-16 Alcon Res Ltd 具增強的穩定性之水性藥學組成物
CN103664861B (zh) * 2013-12-18 2018-01-30 北京华禧联合科技发展有限公司 一种用高活性有机锌试剂制备盐酸奥洛他定的新方法
JP7424115B2 (ja) 2019-06-26 2024-01-30 住友化学株式会社 エステル化合物の製造方法
CN111548369B (zh) * 2020-05-29 2023-02-28 内蒙古京东药业有限公司 一种简便制备高纯度奥洛他定盐酸盐中间体的方法
CN112457287B (zh) * 2020-12-09 2024-02-06 重庆西南制药二厂有限责任公司 一种e-奥洛他定的制备方法
CN114380783B (zh) * 2022-01-18 2023-02-10 梯尔希（南京）药物研发有限公司 一种奥洛他定氘标记代谢物的制备方法

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Also Published As

Publication number Publication date
JPS6310784A (ja) 1988-01-18
US5116863A (en) 1992-05-26
EP0235796A2 (en) 1987-09-09
EP0235796A3 (en) 1988-09-21
ES2038608T5 (es) 1997-07-16
JPH0586925B2 (xx) 1993-12-14
MX9203155A (es) 1992-07-01
DE3778734D1 (de) 1992-06-11
ES2038608T3 (es) 1993-08-01
EP0235796B2 (en) 1997-03-12
EP0235796B1 (en) 1992-05-06

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Effective date: 20070302