JPS56150083A - Novel dibenzo b,e oxepin derivative - Google Patents
Novel dibenzo b,e oxepin derivativeInfo
- Publication number
- JPS56150083A JPS56150083A JP5226280A JP5226280A JPS56150083A JP S56150083 A JPS56150083 A JP S56150083A JP 5226280 A JP5226280 A JP 5226280A JP 5226280 A JP5226280 A JP 5226280A JP S56150083 A JPS56150083 A JP S56150083A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- halogen
- oxepin
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A dibenzo[b,e]oxepin derivative of formula I [R1 is 1W5C alkyl, halogen, phenyl, etc.; R2 is group of formula V (X is H, OH, NH2, etc.; n is 0 or an integer 1W3), etc.; however, X is not H when R1 is alkyl, alkoxyl or halogen] and an acid addition salt thereof.
EXAMPLE: 2-Ethyl-11-[ 2-( diethylamino )ethyl ]amino-6,11-dihydrodibenzo[ b,e ] oxepin.
USE: An antispasmodic agent and antihistaminic agent having an anticholinergic and antihistaminic actions.
PROCESS: A compound of formula II is reduced with NaBH4, etc. to give a compound of formula III, which is then reacted with a halogenating agent to afford a compound of formula IV (Z is halogen). The resultant compound of formula IV is further reacted with an amine of formula VI, etc. to afford the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5226280A JPS56150083A (en) | 1980-04-22 | 1980-04-22 | Novel dibenzo b,e oxepin derivative |
US06/256,037 US4396550A (en) | 1980-04-22 | 1981-04-21 | Dibenz [b,e] oxepin derivatives |
EP81103036A EP0038564B1 (en) | 1980-04-22 | 1981-04-22 | Dibenz (b,e) oxepin derivatives and pharmaceutical compositions comprising them |
DE8181103036T DE3165946D1 (en) | 1980-04-22 | 1981-04-22 | Dibenz (b,e) oxepin derivatives and pharmaceutical compositions comprising them |
US06/486,425 US4465835A (en) | 1980-04-22 | 1983-04-19 | Dibenz [b,e] oxepin derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5226280A JPS56150083A (en) | 1980-04-22 | 1980-04-22 | Novel dibenzo b,e oxepin derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56150083A true JPS56150083A (en) | 1981-11-20 |
Family
ID=12909844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5226280A Pending JPS56150083A (en) | 1980-04-22 | 1980-04-22 | Novel dibenzo b,e oxepin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56150083A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6310784A (en) * | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | Dibenz(b,e)oxepin derivative, antiallergic agent and anti-inflammatory agent |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1061946A (en) * | 1965-01-06 | 1967-03-15 | Hoffmann La Roche | Novel dibenzocycloheptene derivatives and a process for the manufacture thereof |
US3509176A (en) * | 1966-04-30 | 1970-04-28 | Boehringer & Soehne Gmbh | Basic derivatives of dibenzo-oxepine |
-
1980
- 1980-04-22 JP JP5226280A patent/JPS56150083A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1061946A (en) * | 1965-01-06 | 1967-03-15 | Hoffmann La Roche | Novel dibenzocycloheptene derivatives and a process for the manufacture thereof |
US3509176A (en) * | 1966-04-30 | 1970-04-28 | Boehringer & Soehne Gmbh | Basic derivatives of dibenzo-oxepine |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6310784A (en) * | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | Dibenz(b,e)oxepin derivative, antiallergic agent and anti-inflammatory agent |
JPH0586925B2 (en) * | 1986-03-03 | 1993-12-14 | Kyowa Hakko Kogyo Kk |
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