JPS56150083A - Novel dibenzo b,e oxepin derivative - Google Patents

Novel dibenzo b,e oxepin derivative

Info

Publication number
JPS56150083A
JPS56150083A JP5226280A JP5226280A JPS56150083A JP S56150083 A JPS56150083 A JP S56150083A JP 5226280 A JP5226280 A JP 5226280A JP 5226280 A JP5226280 A JP 5226280A JP S56150083 A JPS56150083 A JP S56150083A
Authority
JP
Japan
Prior art keywords
formula
compound
halogen
oxepin
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5226280A
Other languages
Japanese (ja)
Inventor
Hiroshi Takizawa
Osamu Morita
Yoshimasa Ikuji
Tamotsu Hashimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP5226280A priority Critical patent/JPS56150083A/en
Priority to US06/256,037 priority patent/US4396550A/en
Priority to EP81103036A priority patent/EP0038564B1/en
Priority to DE8181103036T priority patent/DE3165946D1/en
Publication of JPS56150083A publication Critical patent/JPS56150083A/en
Priority to US06/486,425 priority patent/US4465835A/en
Pending legal-status Critical Current

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  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A dibenzo[b,e]oxepin derivative of formula I [R1 is 1W5C alkyl, halogen, phenyl, etc.; R2 is group of formula V (X is H, OH, NH2, etc.; n is 0 or an integer 1W3), etc.; however, X is not H when R1 is alkyl, alkoxyl or halogen] and an acid addition salt thereof.
EXAMPLE: 2-Ethyl-11-[ 2-( diethylamino )ethyl ]amino-6,11-dihydrodibenzo[ b,e ] oxepin.
USE: An antispasmodic agent and antihistaminic agent having an anticholinergic and antihistaminic actions.
PROCESS: A compound of formula II is reduced with NaBH4, etc. to give a compound of formula III, which is then reacted with a halogenating agent to afford a compound of formula IV (Z is halogen). The resultant compound of formula IV is further reacted with an amine of formula VI, etc. to afford the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP5226280A 1980-04-22 1980-04-22 Novel dibenzo b,e oxepin derivative Pending JPS56150083A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP5226280A JPS56150083A (en) 1980-04-22 1980-04-22 Novel dibenzo b,e oxepin derivative
US06/256,037 US4396550A (en) 1980-04-22 1981-04-21 Dibenz [b,e] oxepin derivatives
EP81103036A EP0038564B1 (en) 1980-04-22 1981-04-22 Dibenz (b,e) oxepin derivatives and pharmaceutical compositions comprising them
DE8181103036T DE3165946D1 (en) 1980-04-22 1981-04-22 Dibenz (b,e) oxepin derivatives and pharmaceutical compositions comprising them
US06/486,425 US4465835A (en) 1980-04-22 1983-04-19 Dibenz [b,e] oxepin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5226280A JPS56150083A (en) 1980-04-22 1980-04-22 Novel dibenzo b,e oxepin derivative

Publications (1)

Publication Number Publication Date
JPS56150083A true JPS56150083A (en) 1981-11-20

Family

ID=12909844

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5226280A Pending JPS56150083A (en) 1980-04-22 1980-04-22 Novel dibenzo b,e oxepin derivative

Country Status (1)

Country Link
JP (1) JPS56150083A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6310784A (en) * 1986-03-03 1988-01-18 Kyowa Hakko Kogyo Co Ltd Dibenz(b,e)oxepin derivative, antiallergic agent and anti-inflammatory agent

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1061946A (en) * 1965-01-06 1967-03-15 Hoffmann La Roche Novel dibenzocycloheptene derivatives and a process for the manufacture thereof
US3509176A (en) * 1966-04-30 1970-04-28 Boehringer & Soehne Gmbh Basic derivatives of dibenzo-oxepine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1061946A (en) * 1965-01-06 1967-03-15 Hoffmann La Roche Novel dibenzocycloheptene derivatives and a process for the manufacture thereof
US3509176A (en) * 1966-04-30 1970-04-28 Boehringer & Soehne Gmbh Basic derivatives of dibenzo-oxepine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6310784A (en) * 1986-03-03 1988-01-18 Kyowa Hakko Kogyo Co Ltd Dibenz(b,e)oxepin derivative, antiallergic agent and anti-inflammatory agent
JPH0586925B2 (en) * 1986-03-03 1993-12-14 Kyowa Hakko Kogyo Kk

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