JPS57139073A - Novel dibenzo(b, e)oxepin derivative - Google Patents

Novel dibenzo(b, e)oxepin derivative

Info

Publication number
JPS57139073A
JPS57139073A JP56023139A JP2313981A JPS57139073A JP S57139073 A JPS57139073 A JP S57139073A JP 56023139 A JP56023139 A JP 56023139A JP 2313981 A JP2313981 A JP 2313981A JP S57139073 A JPS57139073 A JP S57139073A
Authority
JP
Japan
Prior art keywords
formula
compound shown
compound
formulai
cyclohexyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56023139A
Other languages
Japanese (ja)
Other versions
JPH0125749B2 (en
Inventor
Hiroshi Takizawa
Osamu Morita
Yoshimasa Ikuji
Tamotsu Hashimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP56023139A priority Critical patent/JPS57139073A/en
Publication of JPS57139073A publication Critical patent/JPS57139073A/en
Publication of JPH0125749B2 publication Critical patent/JPH0125749B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound shown by the formulaI[R1 is 1W5C alkyl; R2 is group shown by the formula II or III; or R1 is cyclohexyl; R2 is -NH-(CH2)n-Y (Y is 1W5C alkylamino or hetero ring; n is 0, 1, 2, or 3)]and its acid addition salt.
EXAMPLE: 2-Cyclohexyl-11-{2-( diethylamino )ethyl}aimo-6,11-dihydrodibenzo[b, e]oxepin.
USE: An anticonvulsant, an antihistamine, or an improver for cerebral circulation.
PROCESS: A compound shown by the formula IV is reduced into a compound shown by the formula V, which is reacted with a halogenating agent, to give a compound shown by the formula VI. This compound is reacted with an amine (H-formula II, H-formula III, Y-(CH2)n-NH2), to give a compound shown by the formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP56023139A 1981-02-20 1981-02-20 Novel dibenzo(b, e)oxepin derivative Granted JPS57139073A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56023139A JPS57139073A (en) 1981-02-20 1981-02-20 Novel dibenzo(b, e)oxepin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56023139A JPS57139073A (en) 1981-02-20 1981-02-20 Novel dibenzo(b, e)oxepin derivative

Publications (2)

Publication Number Publication Date
JPS57139073A true JPS57139073A (en) 1982-08-27
JPH0125749B2 JPH0125749B2 (en) 1989-05-19

Family

ID=12102215

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56023139A Granted JPS57139073A (en) 1981-02-20 1981-02-20 Novel dibenzo(b, e)oxepin derivative

Country Status (1)

Country Link
JP (1) JPS57139073A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4999363A (en) * 1988-06-09 1991-03-12 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds
US5010104A (en) * 1987-10-14 1991-04-23 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5010104A (en) * 1987-10-14 1991-04-23 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds
US5010087A (en) * 1987-10-14 1991-04-23 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds and TXA2 antagonistic compositions thereof
US4999363A (en) * 1988-06-09 1991-03-12 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds
US5302596A (en) * 1988-06-09 1994-04-12 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds as TXA2 antagonists

Also Published As

Publication number Publication date
JPH0125749B2 (en) 1989-05-19

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