JPS5740482A - Novel piperidine derivative - Google Patents

Novel piperidine derivative

Info

Publication number
JPS5740482A
JPS5740482A JP11475980A JP11475980A JPS5740482A JP S5740482 A JPS5740482 A JP S5740482A JP 11475980 A JP11475980 A JP 11475980A JP 11475980 A JP11475980 A JP 11475980A JP S5740482 A JPS5740482 A JP S5740482A
Authority
JP
Japan
Prior art keywords
compound
formula
halogen
carbonyl
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11475980A
Other languages
Japanese (ja)
Inventor
Masayuki Teranishi
Hiroyuki Obase
Yoshihiro Nakamizo
Kazuhiro Kubo
Yutaka Kasuya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP11475980A priority Critical patent/JPS5740482A/en
Priority to EP19800304147 priority patent/EP0029707B1/en
Priority to DE8080304147T priority patent/DE3066434D1/en
Priority to US06/264,810 priority patent/US4410528A/en
Publication of JPS5740482A publication Critical patent/JPS5740482A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound of formula I (m is O or an integer 1W5; A is OH, halogen, lower alkyl, nitro, amino, carbamoyl, etc.; X is O, S, carbonyl, hydroxymethylene or methylene; R is 1W4C alkylene, etc.; R1 is H or lower alkyl; n is O or an integer 1W4; R2 is OH, alkoxyl, halogen, CF3, nitro, amino, etc.) and a pharmacologically acceptable acid addition salt thereof.
EXAMPLE: 1-[ 2-( 3, 4-Dimethoxyphenyl )-2-oxoethyl ]-4-( octahydro-2H-benzimidazole-2-on-1-yl)piperidine.
USE: A hypotensive agent.
PROCESS: A compound of formula II (a novel substance) is reacted with a compound of formula III (X' is O, S, carbonyl or methylene; Z is halogen or eliminative group) at 0W150° for 1W48hr to give the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP11475980A 1979-11-21 1980-08-22 Novel piperidine derivative Pending JPS5740482A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP11475980A JPS5740482A (en) 1980-08-22 1980-08-22 Novel piperidine derivative
EP19800304147 EP0029707B1 (en) 1979-11-21 1980-11-19 Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them
DE8080304147T DE3066434D1 (en) 1979-11-21 1980-11-19 Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them
US06/264,810 US4410528A (en) 1980-05-16 1981-05-18 Hypotensive piperidine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11475980A JPS5740482A (en) 1980-08-22 1980-08-22 Novel piperidine derivative

Publications (1)

Publication Number Publication Date
JPS5740482A true JPS5740482A (en) 1982-03-06

Family

ID=14645968

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11475980A Pending JPS5740482A (en) 1979-11-21 1980-08-22 Novel piperidine derivative

Country Status (1)

Country Link
JP (1) JPS5740482A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5656642A (en) * 1993-04-07 1997-08-12 Otsuka Pharmaceutical Co., Ltd. Peripheral vasodilating agent containing piperidine derivative as active ingredient
US8445516B2 (en) 2004-01-29 2013-05-21 Otsuka Pharmaceutical Co., Ltd. Pharmaceutical composition for promoting angiogenesis

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5656642A (en) * 1993-04-07 1997-08-12 Otsuka Pharmaceutical Co., Ltd. Peripheral vasodilating agent containing piperidine derivative as active ingredient
US5760058A (en) * 1993-04-07 1998-06-02 Otsuka Pharmaceutical Co., Ltd. Peripheral vasodilating agent containing piperidine derivative as active ingredient
US8445516B2 (en) 2004-01-29 2013-05-21 Otsuka Pharmaceutical Co., Ltd. Pharmaceutical composition for promoting angiogenesis

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