JPS5740482A - Novel piperidine derivative - Google Patents
Novel piperidine derivativeInfo
- Publication number
- JPS5740482A JPS5740482A JP11475980A JP11475980A JPS5740482A JP S5740482 A JPS5740482 A JP S5740482A JP 11475980 A JP11475980 A JP 11475980A JP 11475980 A JP11475980 A JP 11475980A JP S5740482 A JPS5740482 A JP S5740482A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- halogen
- carbonyl
- nitro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A compound of formula I (m is O or an integer 1W5; A is OH, halogen, lower alkyl, nitro, amino, carbamoyl, etc.; X is O, S, carbonyl, hydroxymethylene or methylene; R is 1W4C alkylene, etc.; R1 is H or lower alkyl; n is O or an integer 1W4; R2 is OH, alkoxyl, halogen, CF3, nitro, amino, etc.) and a pharmacologically acceptable acid addition salt thereof.
EXAMPLE: 1-[ 2-( 3, 4-Dimethoxyphenyl )-2-oxoethyl ]-4-( octahydro-2H-benzimidazole-2-on-1-yl)piperidine.
USE: A hypotensive agent.
PROCESS: A compound of formula II (a novel substance) is reacted with a compound of formula III (X' is O, S, carbonyl or methylene; Z is halogen or eliminative group) at 0W150° for 1W48hr to give the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11475980A JPS5740482A (en) | 1980-08-22 | 1980-08-22 | Novel piperidine derivative |
EP19800304147 EP0029707B1 (en) | 1979-11-21 | 1980-11-19 | Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them |
DE8080304147T DE3066434D1 (en) | 1979-11-21 | 1980-11-19 | Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them |
US06/264,810 US4410528A (en) | 1980-05-16 | 1981-05-18 | Hypotensive piperidine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11475980A JPS5740482A (en) | 1980-08-22 | 1980-08-22 | Novel piperidine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5740482A true JPS5740482A (en) | 1982-03-06 |
Family
ID=14645968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11475980A Pending JPS5740482A (en) | 1979-11-21 | 1980-08-22 | Novel piperidine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5740482A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5656642A (en) * | 1993-04-07 | 1997-08-12 | Otsuka Pharmaceutical Co., Ltd. | Peripheral vasodilating agent containing piperidine derivative as active ingredient |
US8445516B2 (en) | 2004-01-29 | 2013-05-21 | Otsuka Pharmaceutical Co., Ltd. | Pharmaceutical composition for promoting angiogenesis |
-
1980
- 1980-08-22 JP JP11475980A patent/JPS5740482A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5656642A (en) * | 1993-04-07 | 1997-08-12 | Otsuka Pharmaceutical Co., Ltd. | Peripheral vasodilating agent containing piperidine derivative as active ingredient |
US5760058A (en) * | 1993-04-07 | 1998-06-02 | Otsuka Pharmaceutical Co., Ltd. | Peripheral vasodilating agent containing piperidine derivative as active ingredient |
US8445516B2 (en) | 2004-01-29 | 2013-05-21 | Otsuka Pharmaceutical Co., Ltd. | Pharmaceutical composition for promoting angiogenesis |
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