JPS57126461A - Novel guanidino compound and its preparation - Google Patents

Novel guanidino compound and its preparation

Info

Publication number
JPS57126461A
JPS57126461A JP1083081A JP1083081A JPS57126461A JP S57126461 A JPS57126461 A JP S57126461A JP 1083081 A JP1083081 A JP 1083081A JP 1083081 A JP1083081 A JP 1083081A JP S57126461 A JPS57126461 A JP S57126461A
Authority
JP
Japan
Prior art keywords
compound
preparation
formula
acid
guanidino compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1083081A
Other languages
Japanese (ja)
Other versions
JPH0139420B2 (en
Inventor
Mutsumi Muramatsu
Toshio Sato
Hiroyasu Sekine
Atsushi Tendou
Yoshio Kikawa
Kaname Kindo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP1083081A priority Critical patent/JPS57126461A/en
Publication of JPS57126461A publication Critical patent/JPS57126461A/en
Publication of JPH0139420B2 publication Critical patent/JPH0139420B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A compound of the formula (R is straight-chained, branched cyclic alkyl or aralkyl) and its acid adduct.
EXAMPLE: Ethyl trans-4-guanidinomethylcyclohexanecarboxylate hydrochloride.
USE: A drug showing an action of inhibition of proteases. Especially, it shows high activity against tripsin, chymotripsin and kallikrein.
PREPARATION: 4-Guanidinocyclohexanecarboxylic acid or its reactive derivative such as its acid chloride or ethyl chloroformate and a compound of R-OH are stirred in a solvent such as dimethylformamide at room temperatureWunder reflux for 1hrW20 days, preferably in the presence of a tertiary amine to form the compound of the formula.
COPYRIGHT: (C)1982,JPO&Japio
JP1083081A 1981-01-29 1981-01-29 Novel guanidino compound and its preparation Granted JPS57126461A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1083081A JPS57126461A (en) 1981-01-29 1981-01-29 Novel guanidino compound and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1083081A JPS57126461A (en) 1981-01-29 1981-01-29 Novel guanidino compound and its preparation

Publications (2)

Publication Number Publication Date
JPS57126461A true JPS57126461A (en) 1982-08-06
JPH0139420B2 JPH0139420B2 (en) 1989-08-21

Family

ID=11761270

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1083081A Granted JPS57126461A (en) 1981-01-29 1981-01-29 Novel guanidino compound and its preparation

Country Status (1)

Country Link
JP (1) JPS57126461A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0585130A2 (en) * 1992-08-27 1994-03-02 Shiseido Company Limited External preparation for skin containing a depigmentation agent
US6284791B1 (en) 1994-08-30 2001-09-04 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic acid ester derivatives
US6444703B1 (en) 1995-12-22 2002-09-03 Teikoku Chemical Industries Co., Ltd. Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections
CN109232326A (en) * 2018-08-09 2019-01-18 铜仁学院 A kind of extraction Mount Fanjing green tea amino acid technique

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0585130A2 (en) * 1992-08-27 1994-03-02 Shiseido Company Limited External preparation for skin containing a depigmentation agent
EP0585130A3 (en) * 1992-08-27 1994-06-08 Shiseido Co Ltd External preparation for skin containing a depigmentation agent
US5690914A (en) * 1992-08-27 1997-11-25 Shiseido Co., Ltd External preparation for skin
US6284791B1 (en) 1994-08-30 2001-09-04 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic acid ester derivatives
US6831190B1 (en) 1994-08-30 2004-12-14 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic acid ester derivatives
US6444703B1 (en) 1995-12-22 2002-09-03 Teikoku Chemical Industries Co., Ltd. Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections
CN109232326A (en) * 2018-08-09 2019-01-18 铜仁学院 A kind of extraction Mount Fanjing green tea amino acid technique

Also Published As

Publication number Publication date
JPH0139420B2 (en) 1989-08-21

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