JPS57126461A - Novel guanidino compound and its preparation - Google Patents

Novel guanidino compound and its preparation

Info

Publication number
JPS57126461A
JPS57126461A JP1083081A JP1083081A JPS57126461A JP S57126461 A JPS57126461 A JP S57126461A JP 1083081 A JP1083081 A JP 1083081A JP 1083081 A JP1083081 A JP 1083081A JP S57126461 A JPS57126461 A JP S57126461A
Authority
JP
Grant status
Application
Patent type
Prior art keywords
compound
preparation
acid
formula
guanidino compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1083081A
Other versions
JPH0139420B2 (en )
Inventor
Yoshio Kikawa
Kaname Kindo
Mutsumi Muramatsu
Toshio Sato
Hiroyasu Sekine
Atsushi Tendou
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Abstract

NEW MATERIAL:A compound of the formula (R is straight-chained, branched cyclic alkyl or aralkyl) and its acid adduct.
EXAMPLE: Ethyl trans-4-guanidinomethylcyclohexanecarboxylate hydrochloride.
USE: A drug showing an action of inhibition of proteases. Especially, it shows high activity against tripsin, chymotripsin and kallikrein.
PREPARATION: 4-Guanidinocyclohexanecarboxylic acid or its reactive derivative such as its acid chloride or ethyl chloroformate and a compound of R-OH are stirred in a solvent such as dimethylformamide at room temperatureWunder reflux for 1hrW20 days, preferably in the presence of a tertiary amine to form the compound of the formula.
COPYRIGHT: (C)1982,JPO&Japio
JP1083081A 1981-01-29 1981-01-29 Expired JPH0139420B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1083081A JPH0139420B2 (en) 1981-01-29 1981-01-29

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1083081A JPH0139420B2 (en) 1981-01-29 1981-01-29

Publications (2)

Publication Number Publication Date
JPS57126461A true true JPS57126461A (en) 1982-08-06
JPH0139420B2 JPH0139420B2 (en) 1989-08-21

Family

ID=11761270

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1083081A Expired JPH0139420B2 (en) 1981-01-29 1981-01-29

Country Status (1)

Country Link
JP (1) JPH0139420B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0585130A2 (en) * 1992-08-27 1994-03-02 Shiseido Company Limited External preparation for skin containing a depigmentation agent
US6284791B1 (en) 1994-08-30 2001-09-04 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic acid ester derivatives
US6444703B1 (en) 1995-12-22 2002-09-03 Teikoku Chemical Industries Co., Ltd. Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0585130A2 (en) * 1992-08-27 1994-03-02 Shiseido Company Limited External preparation for skin containing a depigmentation agent
EP0585130A3 (en) * 1992-08-27 1994-06-08 Shiseido Co Ltd External preparation for skin containing a depigmentation agent
US5690914A (en) * 1992-08-27 1997-11-25 Shiseido Co., Ltd External preparation for skin
US6284791B1 (en) 1994-08-30 2001-09-04 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic acid ester derivatives
US6831190B1 (en) 1994-08-30 2004-12-14 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic acid ester derivatives
US6444703B1 (en) 1995-12-22 2002-09-03 Teikoku Chemical Industries Co., Ltd. Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections

Also Published As

Publication number Publication date Type
JPH0139420B2 (en) 1989-08-21 grant

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