JPS57126461A - Novel guanidino compound and its preparation - Google Patents

Novel guanidino compound and its preparation

Info

Publication number
JPS57126461A
JPS57126461A JP1083081A JP1083081A JPS57126461A JP S57126461 A JPS57126461 A JP S57126461A JP 1083081 A JP1083081 A JP 1083081A JP 1083081 A JP1083081 A JP 1083081A JP S57126461 A JPS57126461 A JP S57126461A
Authority
JP
Grant status
Application
Patent type
Prior art keywords
compound
preparation
acid
formula
guanidino compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1083081A
Other versions
JPH0139420B2 (en )
Inventor
Yoshio Kikawa
Kaname Kindo
Mutsumi Muramatsu
Toshio Sato
Hiroyasu Sekine
Atsushi Tendou
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Abstract

NEW MATERIAL:A compound of the formula (R is straight-chained, branched cyclic alkyl or aralkyl) and its acid adduct.
EXAMPLE: Ethyl trans-4-guanidinomethylcyclohexanecarboxylate hydrochloride.
USE: A drug showing an action of inhibition of proteases. Especially, it shows high activity against tripsin, chymotripsin and kallikrein.
PREPARATION: 4-Guanidinocyclohexanecarboxylic acid or its reactive derivative such as its acid chloride or ethyl chloroformate and a compound of R-OH are stirred in a solvent such as dimethylformamide at room temperatureWunder reflux for 1hrW20 days, preferably in the presence of a tertiary amine to form the compound of the formula.
COPYRIGHT: (C)1982,JPO&Japio
JP1083081A 1981-01-29 1981-01-29 Expired JPH0139420B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1083081A JPH0139420B2 (en) 1981-01-29 1981-01-29

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1083081A JPH0139420B2 (en) 1981-01-29 1981-01-29

Publications (2)

Publication Number Publication Date
JPS57126461A true true JPS57126461A (en) 1982-08-06
JPH0139420B2 JPH0139420B2 (en) 1989-08-21

Family

ID=11761270

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1083081A Expired JPH0139420B2 (en) 1981-01-29 1981-01-29

Country Status (1)

Country Link
JP (1) JPH0139420B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0585130A2 (en) * 1992-08-27 1994-03-02 Shiseido Company Limited External preparation for skin containing a depigmentation agent
US6284791B1 (en) 1994-08-30 2001-09-04 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic acid ester derivatives
US6444703B1 (en) 1995-12-22 2002-09-03 Teikoku Chemical Industries Co., Ltd. Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0585130A2 (en) * 1992-08-27 1994-03-02 Shiseido Company Limited External preparation for skin containing a depigmentation agent
EP0585130A3 (en) * 1992-08-27 1994-06-08 Shiseido Co Ltd External preparation for skin containing a depigmentation agent
US5690914A (en) * 1992-08-27 1997-11-25 Shiseido Co., Ltd External preparation for skin
US6284791B1 (en) 1994-08-30 2001-09-04 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic acid ester derivatives
US6831190B1 (en) 1994-08-30 2004-12-14 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic acid ester derivatives
US6444703B1 (en) 1995-12-22 2002-09-03 Teikoku Chemical Industries Co., Ltd. Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections

Also Published As

Publication number Publication date Type
JPH0139420B2 (en) 1989-08-21 grant
JP1554163C (en) grant

Similar Documents

Publication Publication Date Title
JPH02152966A (en) 4-hydroxycarbostyril derivative
JPS6058981A (en) 5-pyridyl-1,3-thiazole derivative, production thereof and medicinal composition containing the same
JPS63264467A (en) Benzamide derivative
JPS63198664A (en) Quinolonecarboxylic acid derivative
JPS5973575A (en) Propynylaminoisoxazole derivative
JPS63179850A (en) Amino alcohols
JPH0474167A (en) New quinolinecarboxylic acid derivative, ester and salt thereof
JPS5936666A (en) Aminopyrimidine derivative
JPH01268605A (en) Potency-enhancing agent for agricultural and horticultural antimicrobia and agricultural and horticultural antimicrobia composition
JPS57163369A (en) Novel geldanamycin derivative, its preparation, and drug comprising it as active ingredient
JPH04154741A (en) Amine derivative, its production and insecticide
JPS5626853A (en) N-benzyl-haloacetamide derivative, its preparation, and herbicide comprising the same as active constituent
JPS6360978A (en) Aminothiazole compound
JPS5735515A (en) Immunoregulating agent
JPS52282A (en) Process for preparation of carbostyril derivatives
JPS63188665A (en) 5-hydroxyindole-3-carboxylic acid ester compound
JPS6287574A (en) Novel n-substituted 3,4-dihydropyrimidin-2-one derivative, production thereof and remedy for circulatory disease containing same
JPH0248585A (en) Phospholipid derivative and production thereof
JPH04244065A (en) 3-amidopirazole derivative, its production and medical composition containing the same
JPS5936667A (en) Aminopyrimidine derivative
JPH0348680A (en) Antimicrobial agent
JPS62277362A (en) Novel quinolone derivative, ester and salt thereof
JPS5716855A (en) 4-guanidinomethylcyclohexanecarboxylic acid ester and its preparation
JPS63183564A (en) Pyrazoleoxime derivative, its preparation and use thereof
JPH04112877A (en) New cyanopyrazine derivative and production thereof