JPS57126461A - Novel guanidino compound and its preparation - Google Patents
Novel guanidino compound and its preparationInfo
- Publication number
- JPS57126461A JPS57126461A JP1083081A JP1083081A JPS57126461A JP S57126461 A JPS57126461 A JP S57126461A JP 1083081 A JP1083081 A JP 1083081A JP 1083081 A JP1083081 A JP 1083081A JP S57126461 A JPS57126461 A JP S57126461A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- preparation
- formula
- acid
- guanidino compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A compound of the formula (R is straight-chained, branched cyclic alkyl or aralkyl) and its acid adduct.
EXAMPLE: Ethyl trans-4-guanidinomethylcyclohexanecarboxylate hydrochloride.
USE: A drug showing an action of inhibition of proteases. Especially, it shows high activity against tripsin, chymotripsin and kallikrein.
PREPARATION: 4-Guanidinocyclohexanecarboxylic acid or its reactive derivative such as its acid chloride or ethyl chloroformate and a compound of R-OH are stirred in a solvent such as dimethylformamide at room temperatureWunder reflux for 1hrW20 days, preferably in the presence of a tertiary amine to form the compound of the formula.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1083081A JPS57126461A (en) | 1981-01-29 | 1981-01-29 | Novel guanidino compound and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1083081A JPS57126461A (en) | 1981-01-29 | 1981-01-29 | Novel guanidino compound and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57126461A true JPS57126461A (en) | 1982-08-06 |
JPH0139420B2 JPH0139420B2 (en) | 1989-08-21 |
Family
ID=11761270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1083081A Granted JPS57126461A (en) | 1981-01-29 | 1981-01-29 | Novel guanidino compound and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57126461A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0585130A2 (en) * | 1992-08-27 | 1994-03-02 | Shiseido Company Limited | External preparation for skin containing a depigmentation agent |
US6284791B1 (en) | 1994-08-30 | 2001-09-04 | Teikoku Chemical Industries Co., Ltd. | Guanidinomethyl cyclohexane carboxylic acid ester derivatives |
US6444703B1 (en) | 1995-12-22 | 2002-09-03 | Teikoku Chemical Industries Co., Ltd. | Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections |
CN109232326A (en) * | 2018-08-09 | 2019-01-18 | 铜仁学院 | A kind of extraction Mount Fanjing green tea amino acid technique |
-
1981
- 1981-01-29 JP JP1083081A patent/JPS57126461A/en active Granted
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0585130A2 (en) * | 1992-08-27 | 1994-03-02 | Shiseido Company Limited | External preparation for skin containing a depigmentation agent |
EP0585130A3 (en) * | 1992-08-27 | 1994-06-08 | Shiseido Co Ltd | External preparation for skin containing a depigmentation agent |
US5690914A (en) * | 1992-08-27 | 1997-11-25 | Shiseido Co., Ltd | External preparation for skin |
US6284791B1 (en) | 1994-08-30 | 2001-09-04 | Teikoku Chemical Industries Co., Ltd. | Guanidinomethyl cyclohexane carboxylic acid ester derivatives |
US6831190B1 (en) | 1994-08-30 | 2004-12-14 | Teikoku Chemical Industries Co., Ltd. | Guanidinomethyl cyclohexane carboxylic acid ester derivatives |
US6444703B1 (en) | 1995-12-22 | 2002-09-03 | Teikoku Chemical Industries Co., Ltd. | Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections |
CN109232326A (en) * | 2018-08-09 | 2019-01-18 | 铜仁学院 | A kind of extraction Mount Fanjing green tea amino acid technique |
Also Published As
Publication number | Publication date |
---|---|
JPH0139420B2 (en) | 1989-08-21 |
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