JP5068172B2 - 鼻に噴霧を噴射する方法 - Google Patents
鼻に噴霧を噴射する方法 Download PDFInfo
- Publication number
- JP5068172B2 JP5068172B2 JP2007543080A JP2007543080A JP5068172B2 JP 5068172 B2 JP5068172 B2 JP 5068172B2 JP 2007543080 A JP2007543080 A JP 2007543080A JP 2007543080 A JP2007543080 A JP 2007543080A JP 5068172 B2 JP5068172 B2 JP 5068172B2
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- JP
- Japan
- Prior art keywords
- spray
- formulation
- olopatadine
- nasal
- pump
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
- A61L9/04—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
- A61M11/007—Syringe-type or piston-type sprayers or atomisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
- A61M15/0025—Mouthpieces therefor with caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mechanical Engineering (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
本発明の一つの特徴は、鼻用噴霧器を噴射する方法にある。オロパタジン(olopatadine)を含む配合物(formulation)を有する噴霧器が提供される。配合物の噴霧は主体の鼻に対して噴射される。この噴霧は、20−45mmの長軸、14−20mmの短軸、および1−18の長円率を有する噴霧パターンを含む噴霧特性を有する。
D50=30−60μm、更に好適には39−53μm、最適には47μm、
D90=50−150μm、更に好適には83−128μm、最適には106μm、
スパン=3より多くない、更に好適には1.6−2.1、最適には1.8、
容量%<10μm=4%より小さい、更に好適には0.8−2.4%、最適には1.6%
Claims (10)
- オロパタジン(olopatadine)含有配合物を収容するボトルを有する鼻用噴霧器であって、
前記ボトルと封止可能に係合するポンプ、および
前記ポンプの一部を受けるアクチュエータを含み、
前記噴霧器は、前記ポンプに対する前記アクチュエータの移動によって前記配合物の噴霧を発射し、かつ前記噴霧は、
20−45mmの最長軸、14−20mmの最短軸、および1−18の長円率を有する噴霧パターン、ならびに
15−30μmのD10、30−60μmのD50、50−150μmのD90、3よりも大きくないスパン(SPAN)を有し、かつ容量%<10μmが4%未満である小滴寸法分布を含む噴霧特性を有し、
前記配合物は0.38−0.62%オロパタジンを含有し、粘度が1−2cpsであり、射出重量90−110mgの噴霧特性を有する、前記配合物の噴霧を噴射する鼻用噴霧器。 - 前記最長軸が23.5mmである噴霧特性を有する、請求項1の鼻用噴霧器。
- 前記最短軸は17.5mmである噴霧特性を有する、請求項1の鼻用噴霧器。
- 前記長円率は1−14である噴霧特性を有する、請求項1の鼻用噴霧器。
- 前記配合物は0.6%オロパタジンを含む、請求項1の鼻用噴霧器。
- D10が18−25μm、前記D50が39−53μm、前記D90が83−128μm、前記スパンが1.6−2.1、および前記容量%<10μmが0.8−2.4%である小滴寸法分布を含む、請求項1の鼻用噴霧器。
- 鼻のアレルギーまたは鼻炎症状の治療に利用される鼻用噴霧器の製造においてオロパタジンを使用する方法であって、
オロパタジン配合物を収容するボトルを鼻用噴霧器に連結し、
前記鼻用噴霧器は、前記ボトルと封止可能に係合するポンプ、および前記ポンプの一部を受けるアクチュエータを含み、
前記噴霧器は、前記アクチュエータを前記ポンプに対して移動させることによって前記配合物の噴霧を発射し、かつ前記噴霧は、
20−45mmの最長軸、14−20mmの最短軸、および1−18の長円率を有する噴霧パターン、ならびに
15−30μmのD10、30−60μmのD50、50−150μmのD90、3よりも大きくないスパン(SPAN)を有し、かつ容量%<10μmが4%未満である小滴寸法分布を含む噴霧特性を有する前記配合物の噴霧を噴射するように前記鼻用噴霧器を構成することを含む、使用法。 - 0.38−0.62%オロパタジンを含む配合物としてオロパタジンを提供する、請求項7の使用法。
- 前記配合物が0.6%オロパタジンを含む、請求項8の使用法。
- D10が18−25μm、前記D50が39−53μm、前記D90が83−128μm、前記スパンが1.6−2.1、および前記容量%<10μmが0.8−2.4%である小滴寸法分布を含む、請求項7の使用法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63088604P | 2004-11-24 | 2004-11-24 | |
US60/630,886 | 2004-11-24 | ||
PCT/US2005/039268 WO2006057769A2 (en) | 2004-11-24 | 2005-10-31 | Method of delivering nasal spray |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2008521488A JP2008521488A (ja) | 2008-06-26 |
JP2008521488A5 JP2008521488A5 (ja) | 2008-11-13 |
JP5068172B2 true JP5068172B2 (ja) | 2012-11-07 |
Family
ID=36498400
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007543080A Active JP5068172B2 (ja) | 2004-11-24 | 2005-10-31 | 鼻に噴霧を噴射する方法 |
Country Status (19)
Country | Link |
---|---|
US (3) | US20060110328A1 (ja) |
EP (1) | EP1814538B1 (ja) |
JP (1) | JP5068172B2 (ja) |
KR (1) | KR101158603B1 (ja) |
CN (2) | CN103860540A (ja) |
AT (1) | ATE443516T1 (ja) |
AU (1) | AU2005309951B2 (ja) |
BR (1) | BRPI0518283A2 (ja) |
CA (1) | CA2586553C (ja) |
CY (1) | CY1110528T1 (ja) |
DE (1) | DE602005016833D1 (ja) |
DK (1) | DK1814538T3 (ja) |
ES (1) | ES2331619T3 (ja) |
MX (1) | MX2007005845A (ja) |
PL (1) | PL1814538T3 (ja) |
PT (1) | PT1814538E (ja) |
SI (1) | SI1814538T1 (ja) |
WO (1) | WO2006057769A2 (ja) |
ZA (1) | ZA200704139B (ja) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6788460B2 (en) | 1998-04-15 | 2004-09-07 | Duke University | Projection screen apparatus |
US6816306B2 (en) | 1998-04-15 | 2004-11-09 | Bright View Technologies Inc. | Micro-lens array based light transmitting screen with high resolution and low imaging artifacts |
US6829087B2 (en) | 1998-04-15 | 2004-12-07 | Bright View Technologies, Inc. | Micro-lens array based light transmitting screen with tunable gain |
US7977376B2 (en) * | 2001-06-27 | 2011-07-12 | Novartis Ag | Olopatadine formulations for topical nasal administration |
EP2114367B1 (en) | 2007-02-07 | 2015-11-04 | Novartis AG | Olopatadine formulations for topical nasal administration |
EP2453872B1 (en) * | 2009-07-17 | 2013-08-21 | Alcon Research, Ltd. | Olopatadine nasal spray regimen for children |
WO2011027322A1 (en) | 2009-09-03 | 2011-03-10 | Ranbaxy Laboratories Limited | Extended release dosage form containing olopatadine for oral administration |
GB2485604A (en) * | 2010-11-22 | 2012-05-23 | Martin Chard | Device for marking a surface |
HUE056448T2 (hu) | 2013-09-13 | 2022-02-28 | Glenmark Specialty Sa | Stabil, rögzített adagolású gyógyszerkészítmény, amely mometazont és olopatadint tartalmaz orrba történõ beadásra |
US9370483B2 (en) | 2013-09-13 | 2016-06-21 | Glenmark Specialty S.A. | Stable fixed dose pharmaceutical composition comprising mometasone and olopatadine |
US9937189B2 (en) * | 2013-09-13 | 2018-04-10 | Glenmark Specialty S.A. | Stable fixed dose pharmaceutical composition comprising mometasone and olopatadine |
US10016443B2 (en) | 2013-10-04 | 2018-07-10 | Glenmark Specialty S.A. | Treatment of allergic rhinitis using a combination of mometasone and olopatadine |
US10653661B2 (en) | 2013-10-04 | 2020-05-19 | Glenmark Specialty S.A. | Treatment of allergic rhinitis using a combination of mometasone and olopatadine |
US10548907B2 (en) | 2013-10-04 | 2020-02-04 | Glenmark Specialty S.A. | Treatment of allergic rhinitis using a combination of mometasone and olopatadine |
US10758550B2 (en) | 2013-10-04 | 2020-09-01 | Glenmark Specialty S.A. | Treatment of allergic rhinitis using a combination of mometasone and olopatadine |
UA120587C2 (uk) | 2013-10-04 | 2020-01-10 | Гленмарк Спешіалті С.А. | Спосіб лікування алергічного риніту з використанням комбінації мометазону та олопатадину |
CN104063850B (zh) * | 2014-06-24 | 2017-02-01 | 广东互维科技有限公司 | 红眼修复方法 |
US11679210B2 (en) | 2014-10-03 | 2023-06-20 | Glenmark Specialty S.A. | Dispensing device and pharmaceutical composition for the treatment of rhinitis |
CN107569454B (zh) * | 2017-09-29 | 2018-05-04 | 深圳大佛药业股份有限公司 | 一种盐酸奥洛他定鼻喷雾剂及其制备方法 |
US11890409B1 (en) * | 2019-11-19 | 2024-02-06 | Saeed Rezakhany | Methods of curing early stages of, and preventing, upper respiratory infections and applicators therefor |
USD969992S1 (en) * | 2020-12-23 | 2022-11-15 | Aptar France Sas | Device for nasal spray |
WO2023167909A2 (en) * | 2022-03-02 | 2023-09-07 | Vijay Duggal | A hydrogen peroxide-based therapeutic spray for protection and treatment of mucosa |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
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BE555319A (ja) * | 1956-03-21 | 1900-01-01 | ||
GB8520662D0 (en) * | 1985-08-17 | 1985-09-25 | Wellcome Found | Tricyclic aromatic compounds |
US4923892A (en) * | 1985-08-17 | 1990-05-08 | Burroughs Wellcome Co. | Tricyclic aromatic compounds |
JPS6310784A (ja) * | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | 抗アレルギー剤 |
EP0303507B1 (en) * | 1987-08-13 | 1993-07-28 | Glaxo Group Limited | Indole derivatives |
JPH0323237U (ja) * | 1989-07-19 | 1991-03-11 | ||
US5641805A (en) * | 1995-06-06 | 1997-06-24 | Alcon Laboratories, Inc. | Topical ophthalmic formulations for treating allergic eye diseases |
US5976573A (en) * | 1996-07-03 | 1999-11-02 | Rorer Pharmaceutical Products Inc. | Aqueous-based pharmaceutical composition |
FR2803612B1 (fr) * | 2000-01-12 | 2002-12-06 | Michel Jean Louis Mar Doustaly | Point d'eau sanitaire adaptable a une cuvette de wc |
GB0014892D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Novel pharmaceutical formulation |
IT1317998B1 (it) * | 2000-06-26 | 2003-07-21 | Medical Internat Licensing N V | Valvola erogatrice per spray nasale. |
TWI231759B (en) * | 2001-06-27 | 2005-05-01 | Alcon Inc | Olopatadine formulations for topical administration |
WO2003024484A1 (fr) * | 2001-09-14 | 2003-03-27 | Ono Pharmaceutical Co., Ltd. | Medicaments pour traiter le prurit |
MXPA05005044A (es) * | 2002-11-12 | 2005-07-01 | Alcon Inc | El uso de un agente antialergico y un esteroide para tratar rinitis alergica. |
WO2004084859A2 (en) * | 2003-03-21 | 2004-10-07 | Nastech Pharmaceutical Company Inc. | Nasal calcitonin formulations containing chlorobutanol |
-
2005
- 2005-10-31 AT AT05820776T patent/ATE443516T1/de active
- 2005-10-31 CN CN201410053676.7A patent/CN103860540A/zh active Pending
- 2005-10-31 AU AU2005309951A patent/AU2005309951B2/en active Active
- 2005-10-31 CN CNA2005800402263A patent/CN101065122A/zh active Pending
- 2005-10-31 JP JP2007543080A patent/JP5068172B2/ja active Active
- 2005-10-31 WO PCT/US2005/039268 patent/WO2006057769A2/en active Application Filing
- 2005-10-31 DE DE602005016833T patent/DE602005016833D1/de active Active
- 2005-10-31 SI SI200530855T patent/SI1814538T1/sl unknown
- 2005-10-31 ZA ZA200704139A patent/ZA200704139B/xx unknown
- 2005-10-31 ES ES05820776T patent/ES2331619T3/es active Active
- 2005-10-31 DK DK05820776T patent/DK1814538T3/da active
- 2005-10-31 EP EP05820776A patent/EP1814538B1/en active Active
- 2005-10-31 PL PL05820776T patent/PL1814538T3/pl unknown
- 2005-10-31 CA CA2586553A patent/CA2586553C/en active Active
- 2005-10-31 KR KR1020077014446A patent/KR101158603B1/ko active IP Right Grant
- 2005-10-31 MX MX2007005845A patent/MX2007005845A/es active IP Right Grant
- 2005-10-31 US US11/263,240 patent/US20060110328A1/en not_active Abandoned
- 2005-10-31 BR BRPI0518283-2A patent/BRPI0518283A2/pt not_active Application Discontinuation
- 2005-10-31 PT PT05820776T patent/PT1814538E/pt unknown
-
2009
- 2009-11-03 CY CY20091101136T patent/CY1110528T1/el unknown
-
2013
- 2013-11-14 US US14/079,730 patent/US20140227326A1/en not_active Abandoned
-
2017
- 2017-03-03 US US15/448,834 patent/US20170172974A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2586553C (en) | 2015-02-10 |
EP1814538A4 (en) | 2007-11-07 |
US20060110328A1 (en) | 2006-05-25 |
CY1110528T1 (el) | 2015-04-29 |
WO2006057769A2 (en) | 2006-06-01 |
EP1814538B1 (en) | 2009-09-23 |
SI1814538T1 (sl) | 2010-01-29 |
US20170172974A1 (en) | 2017-06-22 |
KR101158603B1 (ko) | 2012-07-09 |
CA2586553A1 (en) | 2006-06-01 |
BRPI0518283A2 (pt) | 2008-11-11 |
US20140227326A1 (en) | 2014-08-14 |
PT1814538E (pt) | 2009-11-10 |
EP1814538A2 (en) | 2007-08-08 |
DE602005016833D1 (de) | 2009-11-05 |
MX2007005845A (es) | 2007-07-04 |
WO2006057769A3 (en) | 2006-08-31 |
AU2005309951B2 (en) | 2011-07-07 |
DK1814538T3 (da) | 2009-11-02 |
CN101065122A (zh) | 2007-10-31 |
ES2331619T3 (es) | 2010-01-11 |
JP2008521488A (ja) | 2008-06-26 |
PL1814538T3 (pl) | 2010-02-26 |
AU2005309951A1 (en) | 2006-06-01 |
ATE443516T1 (de) | 2009-10-15 |
CN103860540A (zh) | 2014-06-18 |
KR20070086638A (ko) | 2007-08-27 |
ZA200704139B (en) | 2008-10-29 |
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