DE3739690A1 - Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen - Google Patents

Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen

Info

Publication number
DE3739690A1
DE3739690A1 DE19873739690 DE3739690A DE3739690A1 DE 3739690 A1 DE3739690 A1 DE 3739690A1 DE 19873739690 DE19873739690 DE 19873739690 DE 3739690 A DE3739690 A DE 3739690A DE 3739690 A1 DE3739690 A1 DE 3739690A1
Authority
DE
Germany
Prior art keywords
formula
active ingredient
ramipril
preparation
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19873739690
Other languages
German (de)
English (en)
Inventor
Werner Dr Fuelberth
Richard Dr Leeb
Manfred Dr Radau
Willi Dr Stammberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DE19873739690 priority Critical patent/DE3739690A1/de
Priority to EP88119014A priority patent/EP0317878B1/de
Priority to AT88119014T priority patent/ATE74513T1/de
Priority to ES198888119014T priority patent/ES2033400T3/es
Priority to DE8888119014T priority patent/DE3869919D1/de
Priority to JP63293761A priority patent/JPH0768140B2/ja
Priority to HU885992A priority patent/HU202100B/hu
Priority to NZ227032A priority patent/NZ227032A/en
Priority to PH37849A priority patent/PH27416A/en
Priority to FI885398A priority patent/FI93693C/fi
Priority to ZA888734A priority patent/ZA888734B/xx
Priority to US07/274,598 priority patent/US5151433A/en
Priority to PT89061A priority patent/PT89061B/pt
Priority to CN88108057A priority patent/CN1028962C/zh
Priority to AU25818/88A priority patent/AU615495B2/en
Priority to NO885213A priority patent/NO176550C/no
Priority to IL88460A priority patent/IL88460A0/xx
Priority to IE350588A priority patent/IE61173B1/en
Priority to CA000583952A priority patent/CA1338344C/en
Priority to KR1019880015400A priority patent/KR970004908B1/ko
Priority to DK653688A priority patent/DK168423B1/da
Publication of DE3739690A1 publication Critical patent/DE3739690A1/de
Priority to GR920401112T priority patent/GR3004925T3/el
Priority to US08/194,634 priority patent/US5442008A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G59/00—Polycondensates containing more than one epoxy group per molecule; Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups
    • C08G59/18—Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups ; e.g. general methods of curing
    • C08G59/40—Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups ; e.g. general methods of curing characterised by the curing agents used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Polymers & Plastics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE19873739690 1987-11-24 1987-11-24 Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen Withdrawn DE3739690A1 (de)

Priority Applications (23)

Application Number Priority Date Filing Date Title
DE19873739690 DE3739690A1 (de) 1987-11-24 1987-11-24 Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen
EP88119014A EP0317878B1 (de) 1987-11-24 1988-11-15 Stabilisierte Arzneistoffe, Verfahren zu ihrer Herstellung sowie stabile Arzneizubereitungen
AT88119014T ATE74513T1 (de) 1987-11-24 1988-11-15 Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen.
ES198888119014T ES2033400T3 (es) 1987-11-24 1988-11-15 Procedimiento para producir preparados farmaceuticos estables.
DE8888119014T DE3869919D1 (de) 1987-11-24 1988-11-15 Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen.
US07/274,598 US5151433A (en) 1987-11-24 1988-11-22 Stabilized medicinal substances, a process for the preparation thereof, and stable medicinal formulations
HU885992A HU202100B (en) 1987-11-24 1988-11-22 Process for producing stabile pharmaceutical compositions containing heterocyclic peptide derivatives as active components
NZ227032A NZ227032A (en) 1987-11-24 1988-11-22 Stabilised ace inhibitors, a process for their preparation and stable pharmaceutical compositions therefrom
PH37849A PH27416A (en) 1987-11-24 1988-11-22 Stabilized medicine formulations
FI885398A FI93693C (fi) 1987-11-24 1988-11-22 Menetelmä stabiilin, puristetussa muodossa olevan farmaseuttisen koostumuksen valmistamiseksi
ZA888734A ZA888734B (en) 1987-11-24 1988-11-22 Stabilized medicinal substances,a process for the preparation thereof,and stable medicinal formulations
JP63293761A JPH0768140B2 (ja) 1987-11-24 1988-11-22 安定化された医薬物質、その製法および安定な医薬製剤
AU25818/88A AU615495B2 (en) 1987-11-24 1988-11-23 Stabilized medicinal substances, a process for the preparation thereof, and stable medicinal formulations
CN88108057A CN1028962C (zh) 1987-11-24 1988-11-23 稳定性药物的生产方法
PT89061A PT89061B (pt) 1987-11-24 1988-11-23 Processo para a estabilizacao de acido 2-{n-{(s)-1-etoxicarbonil-3-fenilpropil}-l-alanil}-(1s,3s,5s)-2-azabiciclo-{3.3,0}-octano-3-carboxilico (ramipril) e de composicoes farmaceuticas estabilizadas que o contem
NO885213A NO176550C (no) 1987-11-24 1988-11-23 Fremgangsmåte for fremstilling av stabile, pressede, farmasöytiske formuleringer inneholdende en forbindelse
IL88460A IL88460A0 (en) 1987-11-24 1988-11-23 Stabilized medicinal substances,a process for the preparation thereof,and stable medicinal formulations
IE350588A IE61173B1 (en) 1987-11-24 1988-11-23 Stabilized medicinal substances, a process for the preparation thereof, and stable medicinal formulations
CA000583952A CA1338344C (en) 1987-11-24 1988-11-23 Stabilized medicinal substances, a process for the preparation thereof, and stable medicinal formulations
KR1019880015400A KR970004908B1 (ko) 1987-11-24 1988-11-23 기계적 응력에 대한 안정성이 증진된 약제학적 조성물 및 이의 제조방법
DK653688A DK168423B1 (da) 1987-11-24 1988-11-23 Stabilt, presset farmaceutisk præparat og fremgangsmåde til fremstilling deraf.
GR920401112T GR3004925T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1987-11-24 1992-06-17
US08/194,634 US5442008A (en) 1987-11-24 1994-02-10 Stabilized polymer film coated compounds and stabilized formulations in compressed from using same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873739690 DE3739690A1 (de) 1987-11-24 1987-11-24 Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen

Publications (1)

Publication Number Publication Date
DE3739690A1 true DE3739690A1 (de) 1989-06-08

Family

ID=6341084

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19873739690 Withdrawn DE3739690A1 (de) 1987-11-24 1987-11-24 Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen
DE8888119014T Expired - Lifetime DE3869919D1 (de) 1987-11-24 1988-11-15 Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8888119014T Expired - Lifetime DE3869919D1 (de) 1987-11-24 1988-11-15 Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen.

Country Status (21)

Country Link
US (2) US5151433A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0317878B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH0768140B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR970004908B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1028962C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE74513T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU615495B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1338344C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE3739690A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK168423B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2033400T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI93693C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3004925T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU202100B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE61173B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL88460A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO176550C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ227032A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH27416A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT89061B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA888734B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
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SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
RU2276997C2 (ru) 1999-08-30 2006-05-27 Санофи-Авентис Дойчланд Гмбх Применение ингибиторов ренин-ангиотензиновой системы для профилактики сердечно-сосудистых явлений
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FR2824477B1 (fr) * 2001-05-09 2005-09-09 Ethypharm Lab Prod Ethiques Granules enrobes a base d'inhibiteur de l'enzyme de conversion de l'anfiotensine, leur procede de preparation et comprimes orodispersibles contenant les granules enrobes
CA2357982A1 (en) * 2001-09-28 2003-03-28 Bernard Charles Sherman Solid compositions comprising ramipril
US20050202081A1 (en) * 2002-01-15 2005-09-15 Deepak Bahl Stable pharmaceutical compositions comprising ace inhibitor(s)
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GB2394660A (en) * 2003-12-17 2004-05-05 Niche Generics Ltd Stabilisation of pharmaceutical compositions comprising ACE inhibitor by absence of acidic excipients having large specific surface area, eg silicon dioxide
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US20080096979A1 (en) * 2004-11-08 2008-04-24 Rubicon Research Pvt. Ltd. Aqueous Pharmaceutical Coating
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KR100679166B1 (ko) 2005-10-04 2007-02-06 신풍제약주식회사 안정성이 증진된 약제학적 조성물 및 그의 제조방법
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US20070098782A1 (en) * 2005-10-28 2007-05-03 Selamine Limited Ramipril Formulation
BRPI0708842A2 (pt) * 2006-03-28 2011-06-14 Gelesis Inc uso de materiais polimÉricos com outras substÂncias para aumento do desempenho
US20070232680A1 (en) * 2006-04-04 2007-10-04 Vijayabhaskar Bolugoddu Preparation of ramipril and stable pharmaceutical compositions
BRPI0710172A2 (pt) * 2006-04-19 2011-08-23 Teva Pharma composição farmacêutica estável de ácido carboxìlico derivado de 2-aza-biciclo[3,3,0]-octana-3
US20070281000A1 (en) * 2006-06-02 2007-12-06 Michael Fox Stable formulation comprising moisture sensitive drug/s and manufacturing procedure thereof
PT1864677E (pt) * 2006-06-02 2008-03-13 Teva Pharma Formulação estável compreendendo um fármaco sensível à humidade e processo para a sua produção
BRPI0621739A2 (pt) * 2006-06-02 2011-12-20 Teva Pharma formulação estável que consiste em drogas sensìveis à umectação e seu procedimento de fabricação
US20100035955A1 (en) * 2006-06-30 2010-02-11 Panagiotis Keramidas Stabilised Composition Comprising ACE Inhibitors
JP2010501604A (ja) * 2006-08-28 2010-01-21 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング グルコースレベルを低下させる方法
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
PL382311A1 (pl) * 2007-04-27 2008-11-10 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Kompozycja farmaceutyczna o polepszonej stabilności zawierająca inhibitor acetylocholinoesterazy lub farmaceutycznie dopuszczalną jego sól oraz sposób jej wytwarzania
DK2273985T3 (en) 2008-03-28 2016-04-25 Ferrer Int Capsule for the prevention of cardiovascular diseases
WO2010030735A2 (en) * 2008-09-11 2010-03-18 Aethos Pharmaceuticals, Inc. Stabilized coating for pharmaceutical formulations
TR200906322A2 (tr) 2009-08-17 2011-07-21 Bi̇lgi̇ç Mahmut Çözünürlük ve stabilite özellikleri geliştirilmiş granüller.
ES2364011B1 (es) 2009-11-20 2013-01-24 Gp Pharm, S.A. Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados para el tratamiento de enfermedades cardiovasculares.
HUE046229T2 (hu) 2012-02-17 2020-02-28 Egyt Gyogyszervegyeszeti Gyar Javított stabilitású gyógyászati készítmény
PL227900B1 (pl) 2012-11-15 2018-01-31 Adamed Spolka Z Ograniczona Odpowiedzialnoscia Kompozycja farmaceutyczna zawierająca inhibitor ACE i bloker kanałów wapniowych, sposób jej wytwarzania i jednostka dawkowania zawierająca tę kompozycję
HUP1300496A2 (hu) 2013-08-16 2015-03-02 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Stabil kombinációs gyógyszerkészítmény
TWI668285B (zh) * 2015-12-31 2019-08-11 長興材料工業股份有限公司 可熱聚合之組合物、由此形成之組成液及其用途
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HUT48455A (en) 1989-06-28
PT89061B (pt) 1993-03-31
PT89061A (pt) 1988-12-01
DE3869919D1 (de) 1992-05-14
FI885398A0 (fi) 1988-11-22
KR970004908B1 (ko) 1997-04-08
AU2581888A (en) 1989-05-25
DK653688A (da) 1989-05-25
PH27416A (en) 1993-06-21
FI93693C (fi) 1995-05-26
IE61173B1 (en) 1994-10-05
EP0317878A1 (de) 1989-05-31
NO176550B (no) 1995-01-16
ZA888734B (en) 1989-07-26
DK653688D0 (da) 1988-11-23
NO885213D0 (no) 1988-11-23
JPH0768140B2 (ja) 1995-07-26
ATE74513T1 (de) 1992-04-15
AU615495B2 (en) 1991-10-03
CN1042917A (zh) 1990-06-13
US5151433A (en) 1992-09-29
HU202100B (en) 1991-02-28
NO176550C (no) 1995-04-26
NO885213L (no) 1989-05-25
DK168423B1 (da) 1994-03-28
FI93693B (fi) 1995-02-15
ES2033400T3 (es) 1993-03-16
IL88460A0 (en) 1989-06-30
CA1338344C (en) 1996-05-21
GR3004925T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-04-28
JPH01165596A (ja) 1989-06-29
FI885398A7 (fi) 1989-05-25
NZ227032A (en) 1991-05-28
IE883505L (en) 1989-05-24
CN1028962C (zh) 1995-06-21
EP0317878B1 (de) 1992-04-08
KR890007739A (ko) 1989-07-05
US5442008A (en) 1995-08-15

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