DE3409801A1 - Thiazolidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel - Google Patents

Thiazolidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Info

Publication number
DE3409801A1
DE3409801A1 DE3409801A DE3409801A DE3409801A1 DE 3409801 A1 DE3409801 A1 DE 3409801A1 DE 3409801 A DE3409801 A DE 3409801A DE 3409801 A DE3409801 A DE 3409801A DE 3409801 A1 DE3409801 A1 DE 3409801A1
Authority
DE
Germany
Prior art keywords
ppm
substituted
compounds
general formula
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE3409801A
Other languages
German (de)
English (en)
Inventor
György Dr. Domány
Elemér Ezer
Kálmán Dr. Harsányi
Béla Dr. Hegedüs
Judith Matuz
Katalin Pallagi
István Szabadkai
László Dr. Szporny
Péter Budapest Tétényi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of DE3409801A1 publication Critical patent/DE3409801A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE3409801A 1983-03-16 1984-03-16 Thiazolidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel Withdrawn DE3409801A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU83888A HU188852B (en) 1983-03-16 1983-03-16 Process for producing thiazolidine derivatives active against gastric ulcer and intestinal ulcer

Publications (1)

Publication Number Publication Date
DE3409801A1 true DE3409801A1 (de) 1984-09-20

Family

ID=10951891

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3409801A Withdrawn DE3409801A1 (de) 1983-03-16 1984-03-16 Thiazolidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Country Status (32)

Country Link
US (1) US4616025A (OSRAM)
JP (1) JPS59196877A (OSRAM)
KR (1) KR840008001A (OSRAM)
AT (1) AT383596B (OSRAM)
AU (1) AU559753B2 (OSRAM)
BE (1) BE899132A (OSRAM)
CA (1) CA1273933A (OSRAM)
CH (1) CH660592A5 (OSRAM)
CS (1) CS241074B2 (OSRAM)
DD (1) DD216929A5 (OSRAM)
DE (1) DE3409801A1 (OSRAM)
DK (1) DK143284A (OSRAM)
ES (2) ES8601170A1 (OSRAM)
FI (1) FI79843C (OSRAM)
FR (1) FR2542740B1 (OSRAM)
GB (1) GB2140412B (OSRAM)
GR (1) GR81883B (OSRAM)
HU (1) HU188852B (OSRAM)
IE (1) IE57101B1 (OSRAM)
IL (1) IL71249A (OSRAM)
IN (1) IN157738B (OSRAM)
IT (1) IT1196048B (OSRAM)
LU (1) LU85248A1 (OSRAM)
NL (1) NL8400817A (OSRAM)
NO (1) NO162858C (OSRAM)
NZ (1) NZ207516A (OSRAM)
PL (2) PL142909B1 (OSRAM)
PT (1) PT78260B (OSRAM)
SE (1) SE455945B (OSRAM)
SU (2) SU1240355A3 (OSRAM)
YU (1) YU47384A (OSRAM)
ZA (1) ZA841938B (OSRAM)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0192060A1 (de) * 1985-02-04 1986-08-27 Nihon Bayer Agrochem K.K. Heterocyclische Verbindungen
US4849432A (en) * 1986-03-07 1989-07-18 Nihon Tokushu Noyaku Seizo K.K. Heterocyclic compounds
US5001138A (en) * 1985-02-04 1991-03-19 Nihon Tokushu Noyaku Seizo, K.K. Novel heterocyclic compounds
DE4427539A1 (de) * 1994-08-04 1996-02-08 Sueddeutsche Kalkstickstoff Verfahren zur Herstellung von 2-Cyaniminothiazolidin
USRE39130E1 (en) * 1986-03-07 2006-06-13 Bayer Cropscience K.K. Heterocyclic compounds

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6051184A (ja) * 1983-08-30 1985-03-22 Fujimoto Seiyaku Kk Ν−シアノイミノチアゾリジン誘導体およびその製造法
US5204360A (en) * 1985-02-04 1993-04-20 Nihon Bayer Agrochem K.K. Heterocyclic compounds
JPH0730070B2 (ja) * 1985-10-03 1995-04-05 日本バイエルアグロケム株式会社 新規複素環式化合物
JPH066585B2 (ja) * 1985-02-04 1994-01-26 日本バイエルアグロケム株式会社 ニトロメチレン誘導体、その製法及び殺虫剤
JPH0649699B2 (ja) * 1985-02-04 1994-06-29 日本バイエルアグロケム株式会社 ニトロメチレン誘導体、その製法及び殺虫剤
JP2607369B2 (ja) * 1987-02-20 1997-05-07 興和株式会社 新規な複素環化合物
ES2136686T3 (es) * 1989-06-21 1999-12-01 Univ Pennsylvania Tratamiento y control de desarrollo ocular con agonistas colinergicos.
US5122522A (en) * 1989-06-21 1992-06-16 The Trustees Of The University Of Pennsylvania Treatment and control of ocular development
HU207047B (en) * 1989-11-07 1993-03-01 Richter Gedeon Vegyeszet Process for producing new pyridine derivatives and pharmaceutical copositions comprising same
CA2063865A1 (en) * 1992-03-24 1993-09-25 Karoly Lempert 2-(substituted imino)-thiazolidines and process for the preparation thereof
JP2721805B2 (ja) * 1994-07-22 1998-03-04 日本バイエルアグロケム株式会社 新規ヘテロ環式化合物
DE4427569A1 (de) * 1994-08-04 1996-02-08 Bayer Ag Verfahren zur Herstellung von Cyanimino-1,3-thiazolidin
DE19904310A1 (de) * 1999-01-28 2000-08-03 Bayer Ag Verfahren zur Herstellung heterocyclischer Verbindungen
CN1198803C (zh) * 1999-03-05 2005-04-27 第一三得利制药株式会社 具有激活烟碱性乙酰胆碱α4β2受体作用的杂环化合物
CA2402467C (en) * 2000-01-19 2010-03-23 Bayer Aktiengesellschaft Method for producing heterocyclic compounds
BR0210013A (pt) * 2001-05-25 2004-08-10 Valley Forge Pharmaceuticals Gel oftálmico de pirenzepina
JP2006509765A (ja) * 2002-11-22 2006-03-23 スミスクライン・ビーチャム・コーポレイション 新規化合物
EP1611120A4 (en) * 2003-04-07 2008-04-23 Cortical Pty Ltd NEW METHODS FOR THE TREATMENT OF INFLAMMATORY DISEASES
RU2535674C2 (ru) * 2008-07-01 2014-12-20 Мейдзи Сейка Фарма Ко.,Лтд. Новые иминопроизводные, способы их получения и инсектициды, содержащие такие иминопроизводные
JP2014525422A (ja) * 2011-09-02 2014-09-29 バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー ［３−［（６−クロロ−３−ピリジニル）メチル］−２−チアゾリジニリデン］シアナミドを製造する方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3264316A (en) * 1963-09-18 1966-08-02 Res Lab Dr C Janssen N V Certain 2-acylimino-3-substitutedthiazoline-4 compounds
DE2205745A1 (de) * 1972-02-08 1973-08-23 Thomae Gmbh Dr K Neue durch den n-cyaniminorest substituierten heterocyclen und verfahren zu ihrer herstellung
US4006156A (en) * 1975-06-27 1977-02-01 Shell Oil Company 3-Alkyl-2-(nitromethylene) thiazolidine
DK173777A (da) * 1976-05-03 1977-11-04 Merck & Co Inc Fremgangsmade til fremstilling af derivater af 2-iminothiazolidiner og thiazoliner
JPS57171986A (en) * 1981-04-14 1982-10-22 Taiho Yakuhin Kogyo Kk Heterocylic ring compound containing sulfur
JPS5823682A (ja) * 1981-08-03 1983-02-12 Santen Pharmaceut Co Ltd 複素五員環化合物
DE3133918A1 (de) * 1981-08-27 1983-03-17 Bayer Ag, 5090 Leverkusen 2-arylhydrazino-2-thiazoline, acylderivate derselben, 2-arylazo-2-thiazoline, herstellungsverfahren und ihre verwendung zur bekaempfung von ekto- und endoparasiten
JPS58222886A (ja) * 1982-06-19 1983-12-24 Ricoh Co Ltd 感熱記録シ−ト
JPS5933267A (ja) * 1982-08-19 1984-02-23 Fujimoto Seiyaku Kk グアニジン誘導体およびその製造法

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022967A (en) * 1985-02-04 2000-02-08 Nihon Bayer Agrochem K.K. Heterocyclic compounds
US4742060A (en) * 1985-02-04 1988-05-03 Nihon Tokushu Noyaku Seizo K. K. Heterocyclic compounds
US4845106A (en) * 1985-02-04 1989-07-04 Nihon Tokushu Noyaku Seizo K.K. Heterocyclic thiazole compounds
EP0192060A1 (de) * 1985-02-04 1986-08-27 Nihon Bayer Agrochem K.K. Heterocyclische Verbindungen
US5001138A (en) * 1985-02-04 1991-03-19 Nihon Tokushu Noyaku Seizo, K.K. Novel heterocyclic compounds
US6297374B1 (en) 1985-02-04 2001-10-02 Nihon Bayer Agrochem K.K. Nitroimino-nitromethylene—azole or-azine heterocyclic compounds, insecticidal compositions containing them, and insecticidal methods of using them
US5750704A (en) * 1985-02-04 1998-05-12 Nihon Bayer Agrochem K.K. 1-heterocyclylmethyl-2-halonitromethyl-imidazolines and-tetrahydropyrimidines
US4849432A (en) * 1986-03-07 1989-07-18 Nihon Tokushu Noyaku Seizo K.K. Heterocyclic compounds
USRE39130E1 (en) * 1986-03-07 2006-06-13 Bayer Cropscience K.K. Heterocyclic compounds
USRE39129E1 (en) * 1986-03-07 2006-06-13 Bayer Cropscience K.K. Heterocyclic compounds
USRE39131E1 (en) 1986-03-07 2006-06-13 Bayer Cropscience K.K. Heterocyclic compounds
USRE39127E1 (en) 1986-03-07 2006-06-13 Bayer Cropscience K.K. Heterocyclic compounds
USRE39140E1 (en) 1986-03-07 2006-06-20 Bayer Cropscience K.K. Heterocyclic compounds
DE4427539A1 (de) * 1994-08-04 1996-02-08 Sueddeutsche Kalkstickstoff Verfahren zur Herstellung von 2-Cyaniminothiazolidin

Also Published As

Publication number Publication date
GB2140412A (en) 1984-11-28
ES530738A0 (es) 1985-11-01
CS241074B2 (en) 1986-03-13
SE455945B (sv) 1988-08-22
ES544286A0 (es) 1986-01-16
AU559753B2 (en) 1987-03-19
CA1273933A (en) 1990-09-11
FI79843C (fi) 1990-03-12
ATA88284A (de) 1986-12-15
SE8401463D0 (sv) 1984-03-15
PT78260B (en) 1986-04-30
FR2542740B1 (fr) 1987-02-20
FI841066A0 (fi) 1984-03-16
IE840655L (en) 1984-09-16
PL142749B1 (en) 1987-11-30
IT8420057A0 (it) 1984-03-15
YU47384A (OSRAM) 1986-10-31
FR2542740A1 (fr) 1984-09-21
PL142909B1 (en) 1987-12-31
PT78260A (en) 1984-04-01
IT1196048B (it) 1988-11-10
DD216929A5 (de) 1985-01-02
JPS59196877A (ja) 1984-11-08
DK143284D0 (da) 1984-02-29
IL71249A (en) 1987-02-27
SU1240355A3 (ru) 1986-06-23
GR81883B (OSRAM) 1984-12-12
NO162858C (no) 1990-02-28
NO162858B (no) 1989-11-20
KR840008001A (ko) 1984-12-12
LU85248A1 (fr) 1985-10-14
PL246683A1 (en) 1985-07-16
BE899132A (fr) 1984-09-12
AU2583384A (en) 1984-09-20
AT383596B (de) 1987-07-27
NL8400817A (nl) 1984-10-16
PL252129A1 (en) 1985-11-19
SE8401463L (sv) 1984-09-17
IN157738B (OSRAM) 1986-05-31
GB2140412B (en) 1987-02-11
HU188852B (en) 1986-05-28
GB8406790D0 (en) 1984-04-18
ES8601170A1 (es) 1985-11-01
ES8604179A1 (es) 1986-01-16
IE57101B1 (en) 1992-04-22
US4616025A (en) 1986-10-07
CS188584A2 (en) 1985-06-13
NZ207516A (en) 1986-06-11
DK143284A (da) 1984-09-17
FI79843B (fi) 1989-11-30
IL71249A0 (en) 1984-06-29
ZA841938B (en) 1985-05-29
NO841002L (no) 1984-09-17
CH660592A5 (de) 1987-05-15
SU1240356A3 (ru) 1986-06-23
FI841066L (fi) 1984-09-17

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Legal Events

Date Code Title Description
8141 Disposal/no request for examination