DE312867T1 - Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten. - Google Patents

Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten.

Info

Publication number
DE312867T1
DE312867T1 DE198888116747T DE88116747T DE312867T1 DE 312867 T1 DE312867 T1 DE 312867T1 DE 198888116747 T DE198888116747 T DE 198888116747T DE 88116747 T DE88116747 T DE 88116747T DE 312867 T1 DE312867 T1 DE 312867T1
Authority
DE
Germany
Prior art keywords
methyl
group
general formula
compounds
gallen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE198888116747T
Other languages
German (de)
English (en)
Inventor
Giuliano I-20129 Milano Frigerio
Roberto Istituto Di Chimica Farmac. I-06100 Perugia Pellicciari
Aldo I-40100 Bologna Roda
Original Assignee
Gipharmex S.P.A., Mailand/Milano
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gipharmex S.P.A., Mailand/Milano filed Critical Gipharmex S.P.A., Mailand/Milano
Publication of DE312867T1 publication Critical patent/DE312867T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE198888116747T 1987-10-20 1988-10-10 Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten. Pending DE312867T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22343/87A IT1223313B (it) 1987-10-20 1987-10-20 Derivati di acidi biliari loro preparazione e composizioni farmaceutiche che li contengono

Publications (1)

Publication Number Publication Date
DE312867T1 true DE312867T1 (de) 1989-10-05

Family

ID=11194953

Family Applications (2)

Application Number Title Priority Date Filing Date
DE198888116747T Pending DE312867T1 (de) 1987-10-20 1988-10-10 Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten.
DE8888116747T Expired - Fee Related DE3870801D1 (de) 1987-10-20 1988-10-10 Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8888116747T Expired - Fee Related DE3870801D1 (de) 1987-10-20 1988-10-10 Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten.

Country Status (8)

Country Link
US (1) US4921848A (enExample)
EP (1) EP0312867B1 (enExample)
JP (1) JP2813610B2 (enExample)
AT (1) ATE75750T1 (enExample)
DE (2) DE312867T1 (enExample)
ES (1) ES2009723T3 (enExample)
GR (2) GR890300125T1 (enExample)
IT (1) IT1223313B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1229569B (it) * 1989-04-17 1991-09-04 Giuliani Spa Derivati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono.
US5650967A (en) * 1995-07-06 1997-07-22 Micron Technology, Inc. Method and apparatus for writing and erasing flash memory
WO2000016701A1 (en) * 1998-09-18 2000-03-30 United States Surgical Corporation Endovascular fastener applicator
US7138390B2 (en) 2001-03-12 2006-11-21 Intercept Pharmaceuticals Steroids as agonists for FXR
ITMI20021532A1 (it) * 2002-07-12 2004-01-12 Roberto Pellicciari Composti chimici
EP1562915A1 (en) 2002-11-22 2005-08-17 SmithKline Beecham Corporation Farnesoid x receptor agonists
EP1568706A1 (en) * 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
US10987362B2 (en) 2004-03-12 2021-04-27 Intercept Pharmaceuticals, Inc. Treatment of fibrosis using FXR ligands
SI1734970T1 (sl) 2004-03-12 2015-04-30 Intercept Pharmaceuticals, Inc. Zdravljenje fibroze z uporabo FXR ligandov
ITMI20050912A1 (it) * 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
EP2112995B1 (en) 2007-01-19 2013-07-31 Intercept Pharmaceuticals, Inc. 23-substituted bile acids as tgr5 modulators and methods of use thereof
CN105037476B (zh) 2008-07-30 2018-06-12 英特塞普特医药品公司 Tgr5调节剂及其使用方法
EP2376519B1 (en) 2008-11-19 2013-11-13 Intercept Pharmaceuticals, Inc. Tgr5 modulators and method of use thereof
US9982008B2 (en) 2012-06-19 2018-05-29 Intercept Pharmaceuticals, Inc. Preparation and uses of obeticholic acid
SG11201408501UA (en) 2012-06-19 2015-01-29 Intercept Pharmaceuticals Inc Preparation, uses and solid forms of obeticholic acid
EP3006557A1 (en) 2014-10-07 2016-04-13 Heinrich-Heine-Universität Düsseldorf Bile acids for inducing hepatic differentiation
MA45761A (fr) 2015-10-07 2021-04-21 Intercept Pharmaceuticals Inc Modulateurs du récepteur farnésoïde x
CN106589039B (zh) * 2015-10-15 2019-12-17 苏州朗科生物技术股份有限公司 一种奥贝胆酸的制备方法及相关化合物
CN107033208A (zh) * 2017-04-07 2017-08-11 华东师范大学 一种7‑酮基石胆酸的合成方法
CN107021994B (zh) * 2017-04-07 2020-12-22 华东师范大学 一种奥贝胆酸的中间体3α-羟基-7-酮-5β-胆甾烷-24-酸的合成方法
CN106995478A (zh) * 2017-04-07 2017-08-01 华东师范大学 一种熊去氧胆酸的中间体7‑酮基石胆酸的合成方法
CN106939030A (zh) * 2017-04-07 2017-07-11 华东师范大学 一种奥贝胆酸的中间体7‑酮基石胆酸的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2615902A (en) * 1950-10-24 1952-10-28 Merck & Co Inc Chemical compounds and processes for preparing the same
US2966499A (en) * 1958-04-09 1960-12-27 Merck & Co Inc Oxidation of cholic acid with chlorine
US2938031A (en) * 1958-12-11 1960-05-24 Searle & Co 17-carboxyalkylated 3-oxygenated 6-methylandrosten-17-ol lactones and intermediates
US3591687A (en) * 1968-03-13 1971-07-06 George A Bray Bile acids and derivatives thereof as anorectic agents
US4172076A (en) * 1977-04-04 1979-10-23 Diamond Shamrock Corporation Process for preparing steroidal acids and their intermediate derivatives
US4460509A (en) 1981-08-19 1984-07-17 Beth Israel Medical Center Chemical synthesis
US4545938A (en) 1983-11-02 1985-10-08 Beth Israel Medical Center Chemical synthesis
US4648995A (en) 1983-11-02 1987-03-10 Beth Israel Medical Center Chemical synthesis

Also Published As

Publication number Publication date
ATE75750T1 (de) 1992-05-15
EP0312867A1 (en) 1989-04-26
JP2813610B2 (ja) 1998-10-22
ES2009723A4 (es) 1989-10-16
IT8722343A0 (it) 1987-10-20
GR3004980T3 (enExample) 1993-04-28
ES2009723T3 (es) 1993-02-16
US4921848A (en) 1990-05-01
JPH01135795A (ja) 1989-05-29
GR890300125T1 (en) 1990-01-31
EP0312867B1 (en) 1992-05-06
DE3870801D1 (de) 1992-06-11
IT1223313B (it) 1990-09-19

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