DE551844T1 - Thiolderivate von Gallensäure. - Google Patents
Thiolderivate von Gallensäure.Info
- Publication number
- DE551844T1 DE551844T1 DE93100266T DE93100266T DE551844T1 DE 551844 T1 DE551844 T1 DE 551844T1 DE 93100266 T DE93100266 T DE 93100266T DE 93100266 T DE93100266 T DE 93100266T DE 551844 T1 DE551844 T1 DE 551844T1
- Authority
- DE
- Germany
- Prior art keywords
- hydrogen
- acid
- bile acid
- mercapto
- thiol derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 Thiol derivatives of bile acid Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 5
- 208000010643 digestive system disease Diseases 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (5)
- worinR die Bedeutung von OH oder SH in a- oder ß-Stellung hat; R1 und R" Wasserstoff sind oder eines Wasserstoff und das andere OH oder SH ist;R1" und R!V Wasserstoff sind oder eines Wasserstoff und das andere OH oder SH ist;Rv Wasserstoff oder Methyl ist;mit der Maßgabe, daß mindestens eines von R, R1, R", Rm und RIV eine SH-Gruppe ist,die glyko- oder tauro-konjugierten Derivate davon und die pharmazeutisch brauchbaren Salze davon.
- 2. Verbindungen nach Anspruch 1, worin nur eine der Gruppen R, R1, R", Rm und RIV die Bedeutung von SH hat.
- 3. Verbindung nach Anspruch 1, ausgewählt aus 3a,7a-Dihydroxy-12ßmercapto-5ß-cholan-24-säure;3ß-Mercapto-5ß-lithocholan-24-säure;3a-Mercapto-la-hydroxy-5ß-chenodesoxycholan-24-säure; und 3ß-Mercapto-7a-hydroxy-5ß-chenodesoxycholan-24-säure.
- 4. Pharmazeutische Zusammensetzungen, enthaltend als aktiven Bestandteil eine Verbindung nach den Ansprüchen 1-3.
- 5. Verwendung der Verbindungen nach den Ansprüchen 1-3 zur Herstellung eines Arzneimittels zur Behandlung von hepatobiliären Erkrankungen.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI920082A IT1258788B (it) | 1992-01-17 | 1992-01-17 | Derivati solforati di acidi biliari |
Publications (1)
Publication Number | Publication Date |
---|---|
DE551844T1 true DE551844T1 (de) | 1993-11-25 |
Family
ID=11361585
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE93100266T Pending DE551844T1 (de) | 1992-01-17 | 1993-01-11 | Thiolderivate von Gallensäure. |
DE69319356T Expired - Fee Related DE69319356T2 (de) | 1992-01-17 | 1993-01-11 | Thiolderivate von Gallensäure |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69319356T Expired - Fee Related DE69319356T2 (de) | 1992-01-17 | 1993-01-11 | Thiolderivate von Gallensäure |
Country Status (11)
Country | Link |
---|---|
US (1) | US5321019A (de) |
EP (1) | EP0551844B1 (de) |
JP (1) | JP3490470B2 (de) |
AT (1) | ATE167869T1 (de) |
CA (1) | CA2087298C (de) |
DE (2) | DE551844T1 (de) |
DK (1) | DK0551844T3 (de) |
ES (1) | ES2049703T3 (de) |
GR (1) | GR930300124T1 (de) |
HK (1) | HK1012007A1 (de) |
IT (1) | IT1258788B (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY117939A (en) * | 1996-07-25 | 2004-08-30 | Lg Chemical Ltd | Composition for enhancing oral hygiene |
US20060260005A1 (en) * | 1998-02-26 | 2006-11-16 | Zhizhen Chen | Transformation of Brassica |
US20040045056A1 (en) * | 1998-02-26 | 2004-03-04 | Zhizheng Chen | Transformation of Brassica |
US7960439B1 (en) | 2006-06-12 | 2011-06-14 | Iowa State University Research Foundation, Inc. | Environmentally sensitive foldable oligomers |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU206367B (en) * | 1988-04-30 | 1992-10-28 | Sandoz Ag | Process for producing acid addition salts of steroid carboxylic acid-amidated taurine and glycine, as well as pharmaceutical compositions comprising such salts |
GB8910364D0 (en) * | 1989-05-05 | 1989-06-21 | Nat Res Dev | Anti-fungal compounds |
FI106800B (fi) * | 1990-12-06 | 2001-04-12 | Hoechst Ag | Menetelmä uusien terapeuttisesti käyttökelpoisten dimeeristen sappihappojohdannaisten valmistamiseksi |
-
1992
- 1992-01-17 IT ITMI920082A patent/IT1258788B/it active IP Right Grant
-
1993
- 1993-01-11 AT AT93100266T patent/ATE167869T1/de not_active IP Right Cessation
- 1993-01-11 DK DK93100266T patent/DK0551844T3/da active
- 1993-01-11 DE DE93100266T patent/DE551844T1/de active Pending
- 1993-01-11 DE DE69319356T patent/DE69319356T2/de not_active Expired - Fee Related
- 1993-01-11 ES ES93100266T patent/ES2049703T3/es not_active Expired - Lifetime
- 1993-01-11 EP EP93100266A patent/EP0551844B1/de not_active Expired - Lifetime
- 1993-01-11 US US08/002,971 patent/US5321019A/en not_active Expired - Fee Related
- 1993-01-14 JP JP02198793A patent/JP3490470B2/ja not_active Expired - Fee Related
- 1993-01-14 CA CA002087298A patent/CA2087298C/en not_active Expired - Fee Related
- 1993-12-30 GR GR930300124T patent/GR930300124T1/el unknown
-
1998
- 1998-12-14 HK HK98113257A patent/HK1012007A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPH0656880A (ja) | 1994-03-01 |
ATE167869T1 (de) | 1998-07-15 |
IT1258788B (it) | 1996-02-29 |
DK0551844T3 (da) | 1999-04-12 |
DE69319356T2 (de) | 1998-11-12 |
EP0551844A2 (de) | 1993-07-21 |
HK1012007A1 (en) | 1999-07-23 |
ES2049703T3 (es) | 1998-09-16 |
CA2087298C (en) | 2003-09-09 |
ITMI920082A0 (it) | 1992-01-17 |
EP0551844A3 (de) | 1996-05-22 |
JP3490470B2 (ja) | 2004-01-26 |
CA2087298A1 (en) | 1993-07-18 |
ES2049703T1 (es) | 1994-05-01 |
DE69319356D1 (de) | 1998-08-06 |
ITMI920082A1 (it) | 1993-07-17 |
EP0551844B1 (de) | 1998-07-01 |
US5321019A (en) | 1994-06-14 |
GR930300124T1 (en) | 1993-12-30 |
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