DE3107743A1 - Neue klasse von acylderivaten des carnitins, verfahren zu deren herstellung sowie ihre therapeutische verwendung - Google Patents

Neue klasse von acylderivaten des carnitins, verfahren zu deren herstellung sowie ihre therapeutische verwendung

Info

Publication number
DE3107743A1
DE3107743A1 DE19813107743 DE3107743A DE3107743A1 DE 3107743 A1 DE3107743 A1 DE 3107743A1 DE 19813107743 DE19813107743 DE 19813107743 DE 3107743 A DE3107743 A DE 3107743A DE 3107743 A1 DE3107743 A1 DE 3107743A1
Authority
DE
Germany
Prior art keywords
acid
carnitine
group
acyl derivatives
organic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19813107743
Other languages
German (de)
English (en)
Inventor
Claudio 00144 Roma Cavazza
Maria Ornella 00135 Roma Tinti
Paolo de 00143 Roma Witt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of DE3107743A1 publication Critical patent/DE3107743A1/de
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19813107743 1980-03-06 1981-02-28 Neue klasse von acylderivaten des carnitins, verfahren zu deren herstellung sowie ihre therapeutische verwendung Ceased DE3107743A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT48099/80A IT1145362B (it) 1980-03-06 1980-03-06 Classe di acil-derivati della carnitina procedimento per la loro preparazione e loro uso terapeutico

Publications (1)

Publication Number Publication Date
DE3107743A1 true DE3107743A1 (de) 1981-12-03

Family

ID=11264505

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19813107743 Ceased DE3107743A1 (de) 1980-03-06 1981-02-28 Neue klasse von acylderivaten des carnitins, verfahren zu deren herstellung sowie ihre therapeutische verwendung

Country Status (22)

Country Link
US (2) US4766222A (enExample)
JP (1) JPS56139442A (enExample)
AR (1) AR228591A1 (enExample)
AT (1) AT376200B (enExample)
AU (1) AU543799B2 (enExample)
BE (1) BE887695A (enExample)
CA (1) CA1178971A (enExample)
CH (1) CH653008A5 (enExample)
DE (1) DE3107743A1 (enExample)
DK (1) DK154424C (enExample)
ES (1) ES500131A0 (enExample)
FI (1) FI78680C (enExample)
FR (1) FR2477536B1 (enExample)
GB (1) GB2071091B (enExample)
GR (1) GR74440B (enExample)
IE (1) IE50959B1 (enExample)
IL (1) IL62189A (enExample)
IT (1) IT1145362B (enExample)
LU (1) LU83183A1 (enExample)
MX (1) MX155928A (enExample)
NL (1) NL8101067A (enExample)
SE (1) SE452004B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3120913A1 (de) * 1980-05-30 1982-04-01 Sigma Tau S.p.A. Industrie Farmaceutiche Riunite, 00144 Roma Alkoxy-acylcarnitine, verfahren zu deren herstellung und arzneimittel

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1147079B (it) * 1980-05-30 1986-11-19 Sigma Tau Ind Farmacuetiche Ri Esteri di alcossi-acil derivati della carnitina procedimento per la loro preparatione e composizioni farmaceutiche che li contengono
IT1238344B (it) * 1989-10-20 1993-07-13 Sigma Tau Ind Farmaceuti Estere della l-carnitina con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che lo contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma
IT1240775B (it) * 1990-02-23 1993-12-17 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma.
US6323237B1 (en) * 1997-03-17 2001-11-27 Btg International Limited Therapeutic compositions
WO2001021208A1 (en) 1999-09-23 2001-03-29 Juvenon Corporation Nutritional supplement for increased energy and stamina
US6562869B1 (en) 1999-09-23 2003-05-13 Juvenon, Inc. Nutritional supplement for increased energy and stamina
CA2389623A1 (en) 1999-11-03 2001-05-10 Juvenon, Inc. Method of treating benign forgetfulness
EP1729814A2 (en) * 2004-04-01 2006-12-13 Cardiome Pharma Corp. Pegylated ion channel modulating compounds
JP6296433B2 (ja) * 2012-11-22 2018-03-20 国立大学法人山形大学 生体適合性ポリマー及びその製造方法並びにそれを製造するための新規化合物
US11103588B2 (en) 2017-06-06 2021-08-31 Wayne State University Methods and compositions relating to carnitine-derived materials

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2817358A1 (de) * 1977-04-29 1978-11-02 Sigma Tau Ind Farmaceuti Neue therapeutische anwendung von acylderivaten des d,l-carnitin
DE2925945A1 (de) * 1978-06-27 1980-01-10 Sigma Tau Ind Farmaceuti Acylderivate von carnitin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1108125A (fr) * 1953-05-08 1956-01-09 Laboratoires Labaz Soc D Procédé de préparation d'un dérivé stable de la carnitine
US3624887A (en) * 1970-03-02 1971-12-07 Bunker Ramo Pin and socket removal tool
JPS5481963A (en) * 1977-12-13 1979-06-29 Ihachi Nosaka Roll paper holder for lavatory
DE2903579A1 (de) * 1978-02-03 1979-08-09 Sigma Tau Ind Farmaceuti Verwendung von acetylcarnitin und anderen acylderivaten des carnitins zur behandlung der hyperlipoproteinaemie und hyperlimpidaemie sowie arzneimittel
IT1156741B (it) * 1978-05-15 1987-02-04 Sigma Tau Ind Farmaceuti Applicazione terapeutica della carnitina e di alcuni derivati acilati della carnitina nell'emodialisi
IT1156769B (it) * 1978-05-25 1987-02-04 Sigma Tau Ind Farmaceuti Applicazione terapeutica della carnitina e di altri acil derivati della carnitina
JPS5554821A (en) * 1978-10-18 1980-04-22 Iseki Agricult Mach Discharging dust adjuster of thresher
US4518776A (en) * 1982-07-19 1985-05-21 Ciba Geigy Corporation Process for producing sulfonylureas
DE3427847A1 (de) * 1983-12-09 1985-06-13 Bayer Ag, 5090 Leverkusen Thiolan-2,4-dion-3-carboxamide
US4707491A (en) * 1985-12-20 1987-11-17 Washington University Anticonvulsant γ-thiobutyrolactone derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2817358A1 (de) * 1977-04-29 1978-11-02 Sigma Tau Ind Farmaceuti Neue therapeutische anwendung von acylderivaten des d,l-carnitin
DE2925945A1 (de) * 1978-06-27 1980-01-10 Sigma Tau Ind Farmaceuti Acylderivate von carnitin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Biochem. J. 136, 157-171, 1973 *
Biochimica et Biophysica Acta 222, 372-380, 1970 *
Biochimica et Biophysica Acta 248, 515-519, 1971 *
Biochimica et Biophysica Acta 260, 515-526, 1972 *
Pesticide Biochemistry and Physiology 11, 159-165,1979 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3120913A1 (de) * 1980-05-30 1982-04-01 Sigma Tau S.p.A. Industrie Farmaceutiche Riunite, 00144 Roma Alkoxy-acylcarnitine, verfahren zu deren herstellung und arzneimittel

Also Published As

Publication number Publication date
SE452004B (sv) 1987-11-09
IE50959B1 (en) 1986-08-20
LU83183A1 (fr) 1981-06-24
GR74440B (enExample) 1984-06-28
IT8048099A0 (it) 1980-03-06
NL8101067A (nl) 1981-10-01
DK154424B (da) 1988-11-14
AU543799B2 (en) 1985-05-02
ES8201535A1 (es) 1982-01-01
AR228591A1 (es) 1983-03-30
ATA103981A (de) 1984-03-15
CA1178971A (en) 1984-12-04
FI78680B (fi) 1989-05-31
FR2477536A1 (fr) 1981-09-11
FI810695L (fi) 1981-09-07
IT1145362B (it) 1986-11-05
IL62189A (en) 1985-10-31
ES500131A0 (es) 1982-01-01
US4859698A (en) 1989-08-22
BE887695A (fr) 1981-06-15
AT376200B (de) 1984-10-25
GB2071091A (en) 1981-09-16
FI78680C (fi) 1989-09-11
US4766222A (en) 1988-08-23
FR2477536B1 (fr) 1986-04-04
SE8101267L (sv) 1981-09-07
MX155928A (es) 1988-05-24
AU6802881A (en) 1981-09-24
DK100181A (da) 1981-09-07
CH653008A5 (it) 1985-12-13
IE810359L (en) 1981-09-06
GB2071091B (en) 1984-09-12
DK154424C (da) 1989-05-22
IL62189A0 (en) 1981-03-31
JPS56139442A (en) 1981-10-30

Similar Documents

Publication Publication Date Title
DE2923815C2 (enExample)
DE2634288C3 (enExample)
EP0600949A1 (de) Neue 3,5-di-tert.butyl-4-hydroxyphenyl-derivate, verfahren zu ihrer herstellung und arzneimittel.
DE2925945A1 (de) Acylderivate von carnitin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel
DE2011806B2 (enExample)
DE2305092C2 (enExample)
DE3107743A1 (de) Neue klasse von acylderivaten des carnitins, verfahren zu deren herstellung sowie ihre therapeutische verwendung
DE1804691C3 (de) Taurocholensäurederivate
DE3925496C2 (enExample)
DE2851416C2 (enExample)
DE3787844T2 (de) Thioester und dessen Verwendung zur Herstellung von pharmazeutischen Zusammensetzungen zur Behandlung von Ischämie und von Reperfusion-Syndromen.
DE1960910A1 (de) Neue Benzylidenamino-oxyalkylcarbonsaeuren und Carbonsaeurederivate
CH643843A5 (de) Phenthiazin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
DE2618936C3 (de) N-Acyl-glutamine, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen
DE2038835B2 (de) l,10-Bis-(carboxyalkylen-thio)-decane, deren Herstellung und Verwendung
DE3323077A1 (de) Racemische und optisch aktive eburnan-oxim-ether, verfahren zu deren herstellung und pharmazeutische praeparate, welche diese enthalten
DE2903917C2 (enExample)
EP0051247B1 (de) 4-Thia- und 4-Sulfinyl-PGI1-Derivate, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende pharmazeutische Präparate
DE2410201B2 (de) 6-substituierte 3-carbaethoxyhydrazinopyridazine beziehungsweise ihre salze sowie solche enthaltende arzneimittel und verfahren zur herstellung derselben
DE3641907A1 (de) 4h-benzo(4,5)cyclohepta(1,2-b)thiophen derivate
DE1927786A1 (de) Neue organische Verbindungen und Verfahren zu ihrer Herstellung
DE2157694C3 (de) Phenylessigsäurederivate, Verfahren zu ihrer Herstellung und Phenylessigsäurederivate enthaltende pharmazeutische Zubereitungen
DE3120913A1 (de) Alkoxy-acylcarnitine, verfahren zu deren herstellung und arzneimittel
DE2612114A1 (de) Prostaglandin-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische oder veterinaermedizinische zusammensetzungen
DE1643460C (de) (3-Trifluormethylphenoxy)-(4-chlorphenyl)-essigsäureester, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8131 Rejection