ES8201535A1 - Un procedimiento para la preparacion de nuevos acil-deriva- dos de carnitina - Google Patents

Un procedimiento para la preparacion de nuevos acil-deriva- dos de carnitina

Info

Publication number
ES8201535A1
ES8201535A1 ES500131A ES500131A ES8201535A1 ES 8201535 A1 ES8201535 A1 ES 8201535A1 ES 500131 A ES500131 A ES 500131A ES 500131 A ES500131 A ES 500131A ES 8201535 A1 ES8201535 A1 ES 8201535A1
Authority
ES
Spain
Prior art keywords
acyl
carnitine
derivatives
novel class
therapeutic use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500131A
Other languages
English (en)
Other versions
ES500131A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of ES500131A0 publication Critical patent/ES500131A0/es
Publication of ES8201535A1 publication Critical patent/ES8201535A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACILDERIVADOS DE CARNITINA DE FORMULA (I), EN LA QUE X ES UN ANION HALOGENURO O SULFATO; Y R ES UN RADICAL DE ACIDO ORGANICO, EN SUS FORMAS OPTICAMENTE ACTIVAS Y/O RACEMICAS Y DE SUS SALES DE ACIDOS FISIOLOGICAMENTE COMPATIBLES. CONSISTE EN LA REACCION DE TRANSFORMACION DEL ACIDO ORGANICO ELEGIDO EN EL CLORURO DE ACIDO CORRESPONDIENTE, POR UN PROCEDIMIENTO CONVENCIONAL, SEGUIDO DE LA REACCION DEL CLORURO DE ACIDO CON CLORURO DE CARNITINA, EN UN DISOLVENTE ORGANICO Y A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y 80 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMOCOLOGICAS POR SUS ACTIVIDADES CARIOTROPICA, HIPERLIPOTEINEMICA E HIPERLIPIDEMICA.
ES500131A 1980-03-06 1981-03-05 Un procedimiento para la preparacion de nuevos acil-deriva- dos de carnitina Expired ES8201535A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT48099/80A IT1145362B (it) 1980-03-06 1980-03-06 Classe di acil-derivati della carnitina procedimento per la loro preparazione e loro uso terapeutico

Publications (2)

Publication Number Publication Date
ES500131A0 ES500131A0 (es) 1982-01-01
ES8201535A1 true ES8201535A1 (es) 1982-01-01

Family

ID=11264505

Family Applications (1)

Application Number Title Priority Date Filing Date
ES500131A Expired ES8201535A1 (es) 1980-03-06 1981-03-05 Un procedimiento para la preparacion de nuevos acil-deriva- dos de carnitina

Country Status (22)

Country Link
US (2) US4766222A (es)
JP (1) JPS56139442A (es)
AR (1) AR228591A1 (es)
AT (1) AT376200B (es)
AU (1) AU543799B2 (es)
BE (1) BE887695A (es)
CA (1) CA1178971A (es)
CH (1) CH653008A5 (es)
DE (1) DE3107743A1 (es)
DK (1) DK154424C (es)
ES (1) ES8201535A1 (es)
FI (1) FI78680C (es)
FR (1) FR2477536B1 (es)
GB (1) GB2071091B (es)
GR (1) GR74440B (es)
IE (1) IE50959B1 (es)
IL (1) IL62189A (es)
IT (1) IT1145362B (es)
LU (1) LU83183A1 (es)
MX (1) MX155928A (es)
NL (1) NL8101067A (es)
SE (1) SE452004B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1145371B (it) * 1980-05-30 1986-11-05 Sigma Tau Ind Farmaceuti Alcossi-acil carnitine procedimento per la loro preparazione e composizioni farmaceutiche che le contengono
IT1147079B (it) * 1980-05-30 1986-11-19 Sigma Tau Ind Farmacuetiche Ri Esteri di alcossi-acil derivati della carnitina procedimento per la loro preparatione e composizioni farmaceutiche che li contengono
IT1238344B (it) * 1989-10-20 1993-07-13 Sigma Tau Ind Farmaceuti Estere della l-carnitina con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che lo contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma
IT1240775B (it) * 1990-02-23 1993-12-17 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma.
US6323237B1 (en) * 1997-03-17 2001-11-27 Btg International Limited Therapeutic compositions
US6562869B1 (en) 1999-09-23 2003-05-13 Juvenon, Inc. Nutritional supplement for increased energy and stamina
AU7828200A (en) 1999-09-23 2001-04-24 Juvenon Corporation Nutritional supplement for increased energy and stamina
JP2003513039A (ja) 1999-11-03 2003-04-08 ジュヴェノン インコーポレイテッド 良性の健忘症を治療する方法
WO2005094897A2 (en) * 2004-04-01 2005-10-13 Cardiome Pharma Corp. Pegylated ion channel modulating compounds
JP6296433B2 (ja) * 2012-11-22 2018-03-20 国立大学法人山形大学 生体適合性ポリマー及びその製造方法並びにそれを製造するための新規化合物
WO2018226841A1 (en) * 2017-06-06 2018-12-13 Wayne State University Methods and compositions relating to carnitine- derived materials

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1108125A (fr) * 1953-05-08 1956-01-09 Laboratoires Labaz Soc D Procédé de préparation d'un dérivé stable de la carnitine
US3624887A (en) * 1970-03-02 1971-12-07 Bunker Ramo Pin and socket removal tool
AU518617B2 (en) * 1977-04-29 1981-10-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Therapeutic application of acetyl-d, 1-carnitine
JPS5481963A (en) * 1977-12-13 1979-06-29 Ihachi Nosaka Roll paper holder for lavatory
DE2903579A1 (de) * 1978-02-03 1979-08-09 Sigma Tau Ind Farmaceuti Verwendung von acetylcarnitin und anderen acylderivaten des carnitins zur behandlung der hyperlipoproteinaemie und hyperlimpidaemie sowie arzneimittel
IT1156741B (it) * 1978-05-15 1987-02-04 Sigma Tau Ind Farmaceuti Applicazione terapeutica della carnitina e di alcuni derivati acilati della carnitina nell'emodialisi
IT1156769B (it) * 1978-05-25 1987-02-04 Sigma Tau Ind Farmaceuti Applicazione terapeutica della carnitina e di altri acil derivati della carnitina
IT1156840B (it) * 1978-06-27 1987-02-04 Sigma Tau Ind Farmaceuti Acil derivati della carnitina
JPS5554821A (en) * 1978-10-18 1980-04-22 Iseki Agricult Mach Discharging dust adjuster of thresher
US4518776A (en) * 1982-07-19 1985-05-21 Ciba Geigy Corporation Process for producing sulfonylureas
DE3427847A1 (de) * 1983-12-09 1985-06-13 Bayer Ag, 5090 Leverkusen Thiolan-2,4-dion-3-carboxamide
US4707491A (en) * 1985-12-20 1987-11-17 Washington University Anticonvulsant γ-thiobutyrolactone derivatives

Also Published As

Publication number Publication date
IL62189A0 (en) 1981-03-31
CH653008A5 (it) 1985-12-13
AR228591A1 (es) 1983-03-30
US4766222A (en) 1988-08-23
ES500131A0 (es) 1982-01-01
NL8101067A (nl) 1981-10-01
ATA103981A (de) 1984-03-15
IT1145362B (it) 1986-11-05
IE50959B1 (en) 1986-08-20
SE8101267L (sv) 1981-09-07
DK100181A (da) 1981-09-07
MX155928A (es) 1988-05-24
DE3107743A1 (de) 1981-12-03
LU83183A1 (fr) 1981-06-24
IE810359L (en) 1981-09-06
AT376200B (de) 1984-10-25
CA1178971A (en) 1984-12-04
GB2071091B (en) 1984-09-12
JPS56139442A (en) 1981-10-30
DK154424C (da) 1989-05-22
FR2477536B1 (fr) 1986-04-04
FI78680C (fi) 1989-09-11
GB2071091A (en) 1981-09-16
FR2477536A1 (fr) 1981-09-11
FI78680B (fi) 1989-05-31
AU543799B2 (en) 1985-05-02
AU6802881A (en) 1981-09-24
IT8048099A0 (it) 1980-03-06
US4859698A (en) 1989-08-22
IL62189A (en) 1985-10-31
BE887695A (fr) 1981-06-15
FI810695L (fi) 1981-09-07
GR74440B (es) 1984-06-28
SE452004B (sv) 1987-11-09
DK154424B (da) 1988-11-14

Similar Documents

Publication Publication Date Title
AU2080988A (en) Esters of 13-trans-retinoic acid
ES482097A1 (es) Procedimiento para preparar derivados acilicos de carnitina.
ES8201535A1 (es) Un procedimiento para la preparacion de nuevos acil-deriva- dos de carnitina
FR2304597A1 (fr) Procede de preparation d'acides carboxyliques insatures
IL52243A0 (en) Method for reducing the dose of a biologically active substance while maintaining the biological effect
PH24568A (en) Use of bezafibrate for treating diabetes
PH14883A (en) A method of treating tumor at administering a derivative of para-aminobenzoic acid
ES8205190A1 (es) Un procedimiento para la preparacion del acido 3,7,11,15-tetrametil-2,4,6,10-14-hexadecapentaenoico.
LU79186A1 (fr) Procede de preparation d'acides 2-aryl-propioniques optiquement actifs
IT1179129B (it) Procedimento per il trattamento del legno mediante funghi
GB2044311B (en) Process for the treatment of wood
BE883698A (fr) Procede de preparation d'acides aliphatiques insatures et de leurs esters et catalyseurs utilises
ZA857721B (en) Process for treatment of rheumatic diseases
IT1096566B (it) Macchina e procedimento perfezionati per il trattamento di pelli
IE811612L (en) Thiazoles
FR2326916A1 (fr) Nouveaux acides o,o'-alkylene (sature ou insature) diphenylalkyl (ou alcenyl) carboxyliques et leurs derives
ZA7626B (en) Pharmaceutical preparations for the treatment of coronary heart diseases
IT1192960B (it) Preparato per il trattamento del l acne
BE888057A (fr) Derives d'acides 2-cyanoethyl-2-(n-benzoylamino) alcanoiques, leur procede de preparation et leur application en therapeutique
DE3280277D1 (de) Verfahren zur herstellung eines spezifisch auf das ernaehrungszentrum wirkenden appetitregelnden wirkstoffes sowie der nach diesem verfahren erhaeltliche wirkstoff.
IL63456A0 (en) Alpha-substituted ureidobenzylpenicillanic acid and process for producing the same
IT8249608A0 (it) Procedimento per la produzione di 4-metossi-2'-/2-(1-metil-2-piperidil)etil/benzanilide avente attiva'di regolazione del ritmo cardiaco
BE841204A (fr) Procede de preparation en continu de solutions organiques d'acides percarboxyliques
ES2005926A6 (es) Aparato de estimulacion de la piel mediante una senal electromagnetica.
AU500020B2 (en) Treating the bodily parts of animals with spray apparatus