JPS56139442A - Acyl derivative of carnitine, manufacture and medicine as effective ingredient thereof - Google Patents
Acyl derivative of carnitine, manufacture and medicine as effective ingredient thereofInfo
- Publication number
- JPS56139442A JPS56139442A JP3305481A JP3305481A JPS56139442A JP S56139442 A JPS56139442 A JP S56139442A JP 3305481 A JP3305481 A JP 3305481A JP 3305481 A JP3305481 A JP 3305481A JP S56139442 A JPS56139442 A JP S56139442A
- Authority
- JP
- Japan
- Prior art keywords
- carnitine
- medicine
- manufacture
- effective ingredient
- acyl derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000002252 acyl group Chemical group 0.000 title 1
- 229960004203 carnitine Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000004615 ingredient Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT48099/80A IT1145362B (it) | 1980-03-06 | 1980-03-06 | Classe di acil-derivati della carnitina procedimento per la loro preparazione e loro uso terapeutico |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56139442A true JPS56139442A (en) | 1981-10-30 |
Family
ID=11264505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3305481A Pending JPS56139442A (en) | 1980-03-06 | 1981-03-06 | Acyl derivative of carnitine, manufacture and medicine as effective ingredient thereof |
Country Status (22)
Country | Link |
---|---|
US (2) | US4766222A (ja) |
JP (1) | JPS56139442A (ja) |
AR (1) | AR228591A1 (ja) |
AT (1) | AT376200B (ja) |
AU (1) | AU543799B2 (ja) |
BE (1) | BE887695A (ja) |
CA (1) | CA1178971A (ja) |
CH (1) | CH653008A5 (ja) |
DE (1) | DE3107743A1 (ja) |
DK (1) | DK154424C (ja) |
ES (1) | ES500131A0 (ja) |
FI (1) | FI78680C (ja) |
FR (1) | FR2477536B1 (ja) |
GB (1) | GB2071091B (ja) |
GR (1) | GR74440B (ja) |
IE (1) | IE50959B1 (ja) |
IL (1) | IL62189A (ja) |
IT (1) | IT1145362B (ja) |
LU (1) | LU83183A1 (ja) |
MX (1) | MX155928A (ja) |
NL (1) | NL8101067A (ja) |
SE (1) | SE452004B (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014105221A (ja) * | 2012-11-22 | 2014-06-09 | Yamagata Univ | 生体適合性ポリマー及びその製造方法並びにそれを製造するための新規化合物 |
JP2020522534A (ja) * | 2017-06-06 | 2020-07-30 | ウェイン ステート ユニバーシティWayne State University | カルニチン由来材料に関する方法および組成物 |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1147079B (it) * | 1980-05-30 | 1986-11-19 | Sigma Tau Ind Farmacuetiche Ri | Esteri di alcossi-acil derivati della carnitina procedimento per la loro preparatione e composizioni farmaceutiche che li contengono |
IT1145371B (it) * | 1980-05-30 | 1986-11-05 | Sigma Tau Ind Farmaceuti | Alcossi-acil carnitine procedimento per la loro preparazione e composizioni farmaceutiche che le contengono |
IT1238344B (it) * | 1989-10-20 | 1993-07-13 | Sigma Tau Ind Farmaceuti | Estere della l-carnitina con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che lo contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma |
IT1240775B (it) * | 1990-02-23 | 1993-12-17 | Sigma Tau Ind Farmaceuti | Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma. |
US6323237B1 (en) * | 1997-03-17 | 2001-11-27 | Btg International Limited | Therapeutic compositions |
US6562869B1 (en) | 1999-09-23 | 2003-05-13 | Juvenon, Inc. | Nutritional supplement for increased energy and stamina |
WO2001021208A1 (en) | 1999-09-23 | 2001-03-29 | Juvenon Corporation | Nutritional supplement for increased energy and stamina |
WO2001032168A1 (en) | 1999-11-03 | 2001-05-10 | Juvenon, Inc. | Method of treating benign forgetfulness |
CA2561733A1 (en) * | 2004-04-01 | 2005-10-13 | Cardiome Pharma Corp. | Pegylated ion channel modulating compounds |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS462247A (ja) * | 1970-03-02 | 1971-10-12 | ||
JPS5481963A (en) * | 1977-12-13 | 1979-06-29 | Ihachi Nosaka | Roll paper holder for lavatory |
JPS5554821A (en) * | 1978-10-18 | 1980-04-22 | Iseki Agricult Mach | Discharging dust adjuster of thresher |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1108125A (fr) * | 1953-05-08 | 1956-01-09 | Laboratoires Labaz Soc D | Procédé de préparation d'un dérivé stable de la carnitine |
AU518617B2 (en) * | 1977-04-29 | 1981-10-08 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Therapeutic application of acetyl-d, 1-carnitine |
DE2903579A1 (de) * | 1978-02-03 | 1979-08-09 | Sigma Tau Ind Farmaceuti | Verwendung von acetylcarnitin und anderen acylderivaten des carnitins zur behandlung der hyperlipoproteinaemie und hyperlimpidaemie sowie arzneimittel |
IT1156741B (it) * | 1978-05-15 | 1987-02-04 | Sigma Tau Ind Farmaceuti | Applicazione terapeutica della carnitina e di alcuni derivati acilati della carnitina nell'emodialisi |
IT1156769B (it) * | 1978-05-25 | 1987-02-04 | Sigma Tau Ind Farmaceuti | Applicazione terapeutica della carnitina e di altri acil derivati della carnitina |
IT1156840B (it) * | 1978-06-27 | 1987-02-04 | Sigma Tau Ind Farmaceuti | Acil derivati della carnitina |
US4518776A (en) * | 1982-07-19 | 1985-05-21 | Ciba Geigy Corporation | Process for producing sulfonylureas |
DE3427847A1 (de) * | 1983-12-09 | 1985-06-13 | Bayer Ag, 5090 Leverkusen | Thiolan-2,4-dion-3-carboxamide |
US4707491A (en) * | 1985-12-20 | 1987-11-17 | Washington University | Anticonvulsant γ-thiobutyrolactone derivatives |
-
1980
- 1980-03-06 IT IT48099/80A patent/IT1145362B/it active
-
1981
- 1981-02-23 IE IE359/81A patent/IE50959B1/en not_active IP Right Cessation
- 1981-02-23 IL IL62189A patent/IL62189A/xx not_active IP Right Cessation
- 1981-02-26 SE SE8101267A patent/SE452004B/sv not_active IP Right Cessation
- 1981-02-26 BE BE0/203935A patent/BE887695A/fr not_active IP Right Cessation
- 1981-02-28 DE DE19813107743 patent/DE3107743A1/de not_active Ceased
- 1981-03-03 LU LU83183A patent/LU83183A1/fr unknown
- 1981-03-03 AU AU68028/81A patent/AU543799B2/en not_active Expired
- 1981-03-04 FR FR8104331A patent/FR2477536B1/fr not_active Expired
- 1981-03-04 GB GB8106836A patent/GB2071091B/en not_active Expired
- 1981-03-04 GR GR64312A patent/GR74440B/el unknown
- 1981-03-05 CA CA000372368A patent/CA1178971A/en not_active Expired
- 1981-03-05 FI FI810695A patent/FI78680C/fi not_active IP Right Cessation
- 1981-03-05 MX MX186251A patent/MX155928A/es unknown
- 1981-03-05 NL NL8101067A patent/NL8101067A/nl not_active Application Discontinuation
- 1981-03-05 CH CH1485/81A patent/CH653008A5/it not_active IP Right Cessation
- 1981-03-05 ES ES500131A patent/ES500131A0/es active Granted
- 1981-03-05 DK DK100181A patent/DK154424C/da not_active IP Right Cessation
- 1981-03-06 AT AT0103981A patent/AT376200B/de not_active IP Right Cessation
- 1981-03-06 AR AR284535A patent/AR228591A1/es active
- 1981-03-06 JP JP3305481A patent/JPS56139442A/ja active Pending
-
1987
- 1987-06-30 US US07/068,748 patent/US4766222A/en not_active Expired - Lifetime
-
1988
- 1988-05-31 US US07/200,641 patent/US4859698A/en not_active Expired - Lifetime
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS462247A (ja) * | 1970-03-02 | 1971-10-12 | ||
JPS5481963A (en) * | 1977-12-13 | 1979-06-29 | Ihachi Nosaka | Roll paper holder for lavatory |
JPS5554821A (en) * | 1978-10-18 | 1980-04-22 | Iseki Agricult Mach | Discharging dust adjuster of thresher |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014105221A (ja) * | 2012-11-22 | 2014-06-09 | Yamagata Univ | 生体適合性ポリマー及びその製造方法並びにそれを製造するための新規化合物 |
JP2020522534A (ja) * | 2017-06-06 | 2020-07-30 | ウェイン ステート ユニバーシティWayne State University | カルニチン由来材料に関する方法および組成物 |
Also Published As
Publication number | Publication date |
---|---|
IL62189A0 (en) | 1981-03-31 |
IT1145362B (it) | 1986-11-05 |
ES8201535A1 (es) | 1982-01-01 |
DK154424C (da) | 1989-05-22 |
AT376200B (de) | 1984-10-25 |
LU83183A1 (fr) | 1981-06-24 |
AU6802881A (en) | 1981-09-24 |
IE50959B1 (en) | 1986-08-20 |
FI810695L (fi) | 1981-09-07 |
GB2071091A (en) | 1981-09-16 |
GB2071091B (en) | 1984-09-12 |
ES500131A0 (es) | 1982-01-01 |
FI78680B (fi) | 1989-05-31 |
AU543799B2 (en) | 1985-05-02 |
US4766222A (en) | 1988-08-23 |
SE452004B (sv) | 1987-11-09 |
SE8101267L (sv) | 1981-09-07 |
IT8048099A0 (it) | 1980-03-06 |
GR74440B (ja) | 1984-06-28 |
CH653008A5 (it) | 1985-12-13 |
FR2477536A1 (fr) | 1981-09-11 |
IL62189A (en) | 1985-10-31 |
IE810359L (en) | 1981-09-06 |
US4859698A (en) | 1989-08-22 |
ATA103981A (de) | 1984-03-15 |
BE887695A (fr) | 1981-06-15 |
CA1178971A (en) | 1984-12-04 |
DK154424B (da) | 1988-11-14 |
FR2477536B1 (fr) | 1986-04-04 |
DE3107743A1 (de) | 1981-12-03 |
FI78680C (fi) | 1989-09-11 |
DK100181A (da) | 1981-09-07 |
AR228591A1 (es) | 1983-03-30 |
NL8101067A (nl) | 1981-10-01 |
MX155928A (es) | 1988-05-24 |
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