DE3008056A1 - Guanidinothiazolverbindungen, verfahren zu ihrer herstellung und arzneimittel - Google Patents

Guanidinothiazolverbindungen, verfahren zu ihrer herstellung und arzneimittel

Info

Publication number
DE3008056A1
DE3008056A1 DE19803008056 DE3008056A DE3008056A1 DE 3008056 A1 DE3008056 A1 DE 3008056A1 DE 19803008056 DE19803008056 DE 19803008056 DE 3008056 A DE3008056 A DE 3008056A DE 3008056 A1 DE3008056 A1 DE 3008056A1
Authority
DE
Germany
Prior art keywords
group
hydrogen
lower alkyl
guanidinothiazol
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19803008056
Other languages
German (de)
English (en)
Other versions
DE3008056C2 (enExample
Inventor
Yasufumi Hirata
Yoshio Ishii
Masaaki Takeda
Isao Yanagisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2574579A external-priority patent/JPS55118476A/ja
Priority claimed from JP7950879A external-priority patent/JPS565469A/ja
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of DE3008056A1 publication Critical patent/DE3008056A1/de
Application granted granted Critical
Publication of DE3008056C2 publication Critical patent/DE3008056C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DE19803008056 1979-03-06 1980-03-03 Guanidinothiazolverbindungen, verfahren zu ihrer herstellung und arzneimittel Granted DE3008056A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2574579A JPS55118476A (en) 1979-03-06 1979-03-06 Novel amidine derivative and its preparation
JP7950879A JPS565469A (en) 1979-06-23 1979-06-23 Novel amidine derivative and its preparation
KR1019800000932A KR830002478B1 (ko) 1979-03-06 1980-03-06 구아니디노 티아졸 화합물의 제조방법

Publications (2)

Publication Number Publication Date
DE3008056A1 true DE3008056A1 (de) 1980-09-18
DE3008056C2 DE3008056C2 (enExample) 1988-07-21

Family

ID=27285138

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19803008056 Granted DE3008056A1 (de) 1979-03-06 1980-03-03 Guanidinothiazolverbindungen, verfahren zu ihrer herstellung und arzneimittel

Country Status (11)

Country Link
US (1) US4362736A (enExample)
CA (1) CA1145345A (enExample)
CH (1) CH644114A5 (enExample)
DE (1) DE3008056A1 (enExample)
ES (1) ES489222A0 (enExample)
FR (1) FR2450827A1 (enExample)
GB (1) GB2052478B (enExample)
IT (1) IT1165509B (enExample)
NL (1) NL8001361A (enExample)
PH (1) PH16099A (enExample)
SE (1) SE447253B (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3116890A1 (de) * 1980-04-29 1982-03-04 Shionogi & Co., Ltd., Osaka "2-guanidinothiazolderivate"
EP0060697A1 (en) * 1981-03-18 1982-09-22 Imperial Chemical Industries Plc Heterocyclic derivatives
EP0106080A1 (de) * 1982-10-20 1984-04-25 LUDWIG HEUMANN & CO GMBH Heterocyclische Verbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3332138A1 (de) * 1982-12-03 1984-06-07 Kotobuki Seiyaku Co. Ltd., Nagano 2,4-substituierte thiazolderivate, verfahren zu deren herstellung und diese enthaltende arzneimittel

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1233818A (en) * 1981-03-09 1988-03-08 David J. Gilman Guanidine derivatives as histamine h-2 receptor antagonists
CA1209998A (en) * 1981-03-09 1986-08-19 David J. Gilman Amide derivatives as histamine h-2 receptor antagonists
US4451463A (en) * 1981-03-24 1984-05-29 Imperial Chemical Industries Plc Alcohol derivatives
EP0067508B1 (en) * 1981-05-18 1985-10-30 Imperial Chemical Industries Plc Amidine derivatives
JPS5872571A (ja) * 1981-10-27 1983-04-30 Shionogi & Co Ltd ２−グアニジノ−４−〔２−（ホルムアミド）エチルチオメチル〕チアゾ−ルの製法
US4808589A (en) * 1982-02-20 1989-02-28 Smith Kline & French Laboratories Limited Pyrimidone derivatives
EP0103390A3 (en) * 1982-08-13 1986-02-26 Imperial Chemical Industries Plc Guanidine-containing esters as histamine h2 receptor blockers
JPS59227870A (ja) * 1983-06-07 1984-12-21 Yamanouchi Pharmaceut Co Ltd 新規２−グアニジノチアゾリン誘導体ならびにその製造法
US4663347A (en) 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
GB8401751D0 (en) * 1984-01-24 1984-02-29 Ici Plc Guanidine derivatives
JPS6160673A (ja) * 1984-08-30 1986-03-28 Yamanouchi Pharmaceut Co Ltd グアニジノチアゾ−ル誘導体の製造法
CA1309557C (en) 1985-06-18 1992-10-27 Robert N. Young Leukotriene antagonists
ATE90076T1 (de) 1986-03-27 1993-06-15 Merck Frosst Canada Inc Tetrahydrocarbazole ester.
EP0284536A1 (en) * 1987-02-20 1988-09-28 Centro Marga Para La Investigacion S.A. A process for the preparation of 3-(2-guanidinothiazol-4-yl-methylthio)propionitrile
US5428033A (en) 1990-10-12 1995-06-27 Merck Frosst Canada, Inc. Saturated hydroxyalkylquinoline acids as leukotriene antagonists
US5410054A (en) * 1993-07-20 1995-04-25 Merck Frosst Canada, Inc. Heteroaryl quinolines as inhibitors of leukotriene biosynthesis
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
US8067433B2 (en) 2005-11-09 2011-11-29 Zalicus Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
WO2015002150A1 (ja) 2013-07-03 2015-01-08 株式会社新日本科学 新規化合物，有機カチオントランスポーター３の検出剤及び活性阻害剤
EP2929884A1 (en) 2014-04-11 2015-10-14 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical combinations of dabigatran and h2-receptor antagonists
EP2942058A1 (en) 2014-05-09 2015-11-11 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical combinations of rivaroxaban and H2-receptor antagonists
WO2021183259A1 (en) * 2020-03-12 2021-09-16 Nanopharmaceutics, Inc. Famotidine and famotidine analogs for corona virus treatment
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2817078A1 (de) * 1977-04-20 1978-11-02 Ici America Inc Guanidinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ186965A (en) * 1977-04-20 1980-02-21 Ici Ltd Guanidino derivatives and pharmaceutical compositions
US4165378A (en) * 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
JPS6056143B2 (ja) * 1979-08-02 1985-12-09 山之内製薬株式会社 アミジン誘導体ならびにその製造法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2817078A1 (de) * 1977-04-20 1978-11-02 Ici America Inc Guanidinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3116890A1 (de) * 1980-04-29 1982-03-04 Shionogi & Co., Ltd., Osaka "2-guanidinothiazolderivate"
EP0060697A1 (en) * 1981-03-18 1982-09-22 Imperial Chemical Industries Plc Heterocyclic derivatives
EP0106080A1 (de) * 1982-10-20 1984-04-25 LUDWIG HEUMANN & CO GMBH Heterocyclische Verbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US4596811A (en) * 1982-10-20 1986-06-24 Ludwig Heumann & Co., Gmbh Heterocyclic compounds, a process for their production and medicaments containing these compounds
DE3332138A1 (de) * 1982-12-03 1984-06-07 Kotobuki Seiyaku Co. Ltd., Nagano 2,4-substituierte thiazolderivate, verfahren zu deren herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
US4362736A (en) 1982-12-07
ES8103070A1 (es) 1981-02-16
CA1145345A (en) 1983-04-26
IT1165509B (it) 1987-04-22
SE447253B (sv) 1986-11-03
DE3008056C2 (enExample) 1988-07-21
GB2052478B (en) 1983-04-07
GB2052478A (en) 1981-01-28
SE8001691L (sv) 1980-09-07
IT8067346A0 (it) 1980-03-05
PH16099A (en) 1983-06-24
FR2450827B1 (enExample) 1983-03-25
ES489222A0 (es) 1981-02-16
CH644114A5 (de) 1984-07-13
NL8001361A (nl) 1980-09-09
FR2450827A1 (fr) 1980-10-03

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee