ES8103070A1 - Un procedimiento para preparar un compuesto de guanidinotia-zol - Google Patents

Un procedimiento para preparar un compuesto de guanidinotia-zol

Info

Publication number
ES8103070A1
ES8103070A1 ES80489222A ES489222A ES8103070A1 ES 8103070 A1 ES8103070 A1 ES 8103070A1 ES 80489222 A ES80489222 A ES 80489222A ES 489222 A ES489222 A ES 489222A ES 8103070 A1 ES8103070 A1 ES 8103070A1
Authority
ES
Spain
Prior art keywords
group
hydrogen atom
compounds
lower alkyl
arylsulfamoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES80489222A
Other languages
English (en)
Other versions
ES489222A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2574579A external-priority patent/JPS55118476A/ja
Priority claimed from JP7950879A external-priority patent/JPS565469A/ja
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of ES489222A0 publication Critical patent/ES489222A0/es
Publication of ES8103070A1 publication Critical patent/ES8103070A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN COMPUESTO DE GUANIDINOTIAZOL. AL COMPUESTO DE FORMULA (I), DONDE R ES UN ATOMO DE HIDROGENO O UN ALQUILO INFERIROR, Y UN ATOMO DE AZUFRE O UN GRUPO METILENO <M> Y <N> NUMEROS ENTEROS DEL 1 AL 13 Y R'' Y R1 SON ATOMOS DE HIDROGENO, SE LE HACE REACCIONAR CON AMONIACO EN UN DISOLVENTE ORGANICO SIN AGUA A TEMPERATURA AMBIENTE EN MEDIO NEUTRO O BASICO. DE SUSO INHIBIDOR, NO ANTICOLINERGICO, DE LA SECCION DE ACIDOS GASTRICOS Y POR TANTO, PARA EL TRATAMIENTO DEL ULCERA GASTRICA O DUODENAL. *FORMULA*. S
ES80489222A 1979-03-06 1980-03-05 Un procedimiento para preparar un compuesto de guanidinotia-zol Expired ES8103070A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2574579A JPS55118476A (en) 1979-03-06 1979-03-06 Novel amidine derivative and its preparation
JP7950879A JPS565469A (en) 1979-06-23 1979-06-23 Novel amidine derivative and its preparation
KR1019800000932A KR830002478B1 (ko) 1979-03-06 1980-03-06 구아니디노 티아졸 화합물의 제조방법

Publications (2)

Publication Number Publication Date
ES489222A0 ES489222A0 (es) 1981-02-16
ES8103070A1 true ES8103070A1 (es) 1981-02-16

Family

ID=27285138

Family Applications (1)

Application Number Title Priority Date Filing Date
ES80489222A Expired ES8103070A1 (es) 1979-03-06 1980-03-05 Un procedimiento para preparar un compuesto de guanidinotia-zol

Country Status (11)

Country Link
US (1) US4362736A (es)
CA (1) CA1145345A (es)
CH (1) CH644114A5 (es)
DE (1) DE3008056A1 (es)
ES (1) ES8103070A1 (es)
FR (1) FR2450827A1 (es)
GB (1) GB2052478B (es)
IT (1) IT1165509B (es)
NL (1) NL8001361A (es)
PH (1) PH16099A (es)
SE (1) SE447253B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ196923A (en) * 1980-04-29 1983-12-16 Shionogi & Co 2-guanidino-4-(-acylaminoalkyl(thio)methyl)thiazoles and analogs
CA1233818A (en) * 1981-03-09 1988-03-08 David J. Gilman Guanidine derivatives as histamine h-2 receptor antagonists
CA1209998A (en) * 1981-03-09 1986-08-19 David J. Gilman Amide derivatives as histamine h-2 receptor antagonists
IN158869B (es) * 1981-03-18 1987-02-07 Ici Plc
US4451463A (en) * 1981-03-24 1984-05-29 Imperial Chemical Industries Plc Alcohol derivatives
EP0067508B1 (en) * 1981-05-18 1985-10-30 Imperial Chemical Industries Plc Amidine derivatives
JPS5872571A (ja) * 1981-10-27 1983-04-30 Shionogi & Co Ltd ２−グアニジノ−４−〔２−（ホルムアミド）エチルチオメチル〕チアゾ−ルの製法
US4808589A (en) * 1982-02-20 1989-02-28 Smith Kline & French Laboratories Limited Pyrimidone derivatives
EP0103390A3 (en) * 1982-08-13 1986-02-26 Imperial Chemical Industries Plc Guanidine-containing esters as histamine h2 receptor blockers
DE3238867A1 (de) * 1982-10-20 1984-04-26 Ludwig Heumann & Co GmbH, 8500 Nürnberg Heterocyclische verbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS59104370A (ja) * 1982-12-03 1984-06-16 Kotobuki Seiyaku Kk チアゾ−ル誘導体及びその製造方法
JPS59227870A (ja) * 1983-06-07 1984-12-21 Yamanouchi Pharmaceut Co Ltd 新規２−グアニジノチアゾリン誘導体ならびにその製造法
US4663347A (en) 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
GB8401751D0 (en) * 1984-01-24 1984-02-29 Ici Plc Guanidine derivatives
JPS6160673A (ja) * 1984-08-30 1986-03-28 Yamanouchi Pharmaceut Co Ltd グアニジノチアゾ−ル誘導体の製造法
CA1309557C (en) 1985-06-18 1992-10-27 Robert N. Young Leukotriene antagonists
EP0239306B1 (en) 1986-03-27 1993-06-02 Merck Frosst Canada Inc. Tetrahydrocarbazole esters
EP0284536A1 (en) * 1987-02-20 1988-09-28 Centro Marga Para La Investigacion S.A. A process for the preparation of 3-(2-guanidinothiazol-4-yl-methylthio)propionitrile
US5428033A (en) 1990-10-12 1995-06-27 Merck Frosst Canada, Inc. Saturated hydroxyalkylquinoline acids as leukotriene antagonists
US5410054A (en) * 1993-07-20 1995-04-25 Merck Frosst Canada, Inc. Heteroaryl quinolines as inhibitors of leukotriene biosynthesis
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
MX2008006076A (es) 2005-11-09 2008-12-16 Combinatorx Inc Metodos, composiciones y kits para el tratamiento de condiciones medicas.
WO2015002150A1 (ja) 2013-07-03 2015-01-08 株式会社新日本科学 新規化合物，有機カチオントランスポーター３の検出剤及び活性阻害剤
EP2929884A1 (en) 2014-04-11 2015-10-14 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical combinations of dabigatran and h2-receptor antagonists
EP2942058A1 (en) 2014-05-09 2015-11-11 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical combinations of rivaroxaban and H2-receptor antagonists
WO2021183259A1 (en) * 2020-03-12 2021-09-16 Nanopharmaceutics, Inc. Famotidine and famotidine analogs for corona virus treatment
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4165378A (en) * 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
GR62452B (en) * 1977-04-20 1979-04-12 Ici Ltd Preparation process of guanidine derivatives
DE2817078C2 (de) * 1977-04-20 1995-06-14 Zeneca Ltd Guanidinderivate
JPS6056143B2 (ja) * 1979-08-02 1985-12-09 山之内製薬株式会社 アミジン誘導体ならびにその製造法

Also Published As

Publication number Publication date
CH644114A5 (de) 1984-07-13
CA1145345A (en) 1983-04-26
DE3008056C2 (es) 1988-07-21
SE447253B (sv) 1986-11-03
US4362736A (en) 1982-12-07
DE3008056A1 (de) 1980-09-18
NL8001361A (nl) 1980-09-09
IT8067346A0 (it) 1980-03-05
SE8001691L (sv) 1980-09-07
ES489222A0 (es) 1981-02-16
FR2450827A1 (fr) 1980-10-03
IT1165509B (it) 1987-04-22
GB2052478A (en) 1981-01-28
PH16099A (en) 1983-06-24
FR2450827B1 (es) 1983-03-25
GB2052478B (en) 1983-04-07

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