FR2450827A1 - Composes du guanidinothiazole utiles comme inhibiteurs des secretions d'acide gastrique, leurs procedes de preparation et les compositions medicales contenant de tels composes - Google Patents

Composes du guanidinothiazole utiles comme inhibiteurs des secretions d'acide gastrique, leurs procedes de preparation et les compositions medicales contenant de tels composes

Info

Publication number
FR2450827A1
FR2450827A1 FR8004690A FR8004690A FR2450827A1 FR 2450827 A1 FR2450827 A1 FR 2450827A1 FR 8004690 A FR8004690 A FR 8004690A FR 8004690 A FR8004690 A FR 8004690A FR 2450827 A1 FR2450827 A1 FR 2450827A1
Authority
FR
France
Prior art keywords
alprene
compounds
inhibitors
guanidinothiazole
gastric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8004690A
Other languages
English (en)
Other versions
FR2450827B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2574579A external-priority patent/JPS55118476A/ja
Priority claimed from JP7950879A external-priority patent/JPS565469A/ja
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of FR2450827A1 publication Critical patent/FR2450827A1/fr
Application granted granted Critical
Publication of FR2450827B1 publication Critical patent/FR2450827B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

LA PRESENTE INVENTION CONCERNE UN COMPOSE DU GUANIDINOTHIAZOLE DE FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R REPRESENTE UN HYDROGENE OU UN ALCOYLE INFERIEUR, Y REPRESENTE UN SOUFRE OU UN METHYLENE, M ET N REPRESENTENT CHACUN UN NOMBRE ENTIER DE 1 A 3, A EST REPRESENTE PAR: (CF DESSIN DANS BOPI) AVEC R REPRESENTANT UN HYDROGENE, UN GROUPE CYANO, CARBAMOYLE, UREIDO, HYDROXYLE, ALCOXY INFERIEUR, ACYLE INFERIEUR, ACYLAMINO ARYLSULFAMOYLE, ARALCOYLE OU CARBOXYMETHYL, R REPRESENTANT UN HYDROGENE, UN GROUPE ALCOYLE INFERIEUR, ALCOYLENE INFERIEUR, ALCYNYLE INFERIEUR, CYANO OU ACYLE INFERIEUR, ET R REPRESENTANT UN HYDROGENE, UN GROUPE ALCOYLE INFERIEUR, HYDROXYLE OU SULFAMOYLE) ET LEURS SELS D'ADDITION AVEC UN ACIDE ACCEPTABLE PHARMACOLOGIQUEMENT. CES COMPOSES SONT UTILES COMME INHIBITEURS DES SECRETIONS D'ACIDE GASTRIQUE.
FR8004690A 1979-03-06 1980-03-03 Composes du guanidinothiazole utiles comme inhibiteurs des secretions d'acide gastrique, leurs procedes de preparation et les compositions medicales contenant de tels composes Granted FR2450827A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2574579A JPS55118476A (en) 1979-03-06 1979-03-06 Novel amidine derivative and its preparation
JP7950879A JPS565469A (en) 1979-06-23 1979-06-23 Novel amidine derivative and its preparation
KR1019800000932A KR830002478B1 (ko) 1979-03-06 1980-03-06 구아니디노 티아졸 화합물의 제조방법

Publications (2)

Publication Number Publication Date
FR2450827A1 true FR2450827A1 (fr) 1980-10-03
FR2450827B1 FR2450827B1 (fr) 1983-03-25

Family

ID=27285138

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8004690A Granted FR2450827A1 (fr) 1979-03-06 1980-03-03 Composes du guanidinothiazole utiles comme inhibiteurs des secretions d'acide gastrique, leurs procedes de preparation et les compositions medicales contenant de tels composes

Country Status (11)

Country Link
US (1) US4362736A (fr)
CA (1) CA1145345A (fr)
CH (1) CH644114A5 (fr)
DE (1) DE3008056A1 (fr)
ES (1) ES8103070A1 (fr)
FR (1) FR2450827A1 (fr)
GB (1) GB2052478B (fr)
IT (1) IT1165509B (fr)
NL (1) NL8001361A (fr)
PH (1) PH16099A (fr)
SE (1) SE447253B (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0060094A2 (fr) * 1981-03-09 1982-09-15 Imperial Chemical Industries Plc Dérivés de guanidine
EP0060093A2 (fr) * 1981-03-09 1982-09-15 Imperial Chemical Industries Plc Dérivés d'amides
EP0061318A2 (fr) * 1981-03-24 1982-09-29 Imperial Chemical Industries Plc Dérivés de guanidinoheterocycles, comme antagonists d'histamine H-2
EP0067508A1 (fr) * 1981-05-18 1982-12-22 Imperial Chemical Industries Plc Dérivés d'amidine
FR2537134A1 (fr) * 1982-12-03 1984-06-08 Kotobuki Seiyaku Co Ltd Derives de thiazole et leur procede de synthese
EP0150099A1 (fr) * 1984-01-24 1985-07-31 Imperial Chemical Industries Plc Dérivés de guanidine
FR2569692A1 (fr) * 1984-08-30 1986-03-07 Yamanouchi Pharma Co Ltd Procede de preparation de derives de guanidinothiazole
EP0284536A1 (fr) * 1987-02-20 1988-09-28 Centro Marga Para La Investigacion S.A. Procédé de préparation de 3-(2-guanidinothiazol-4-yl)-méthylthio)propionitrile

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ196923A (en) * 1980-04-29 1983-12-16 Shionogi & Co 2-guanidino-4-(-acylaminoalkyl(thio)methyl)thiazoles and analogs
IN158869B (fr) * 1981-03-18 1987-02-07 Ici Plc
JPS5872571A (ja) * 1981-10-27 1983-04-30 Shionogi & Co Ltd ２−グアニジノ−４−〔２−（ホルムアミド）エチルチオメチル〕チアゾ−ルの製法
US4808589A (en) * 1982-02-20 1989-02-28 Smith Kline & French Laboratories Limited Pyrimidone derivatives
EP0103390A3 (fr) * 1982-08-13 1986-02-26 Imperial Chemical Industries Plc Esters contenant des guanidines bloqueurs de récepteur d'histamine H2
DE3238867A1 (de) * 1982-10-20 1984-04-26 Ludwig Heumann & Co GmbH, 8500 Nürnberg Heterocyclische verbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS59227870A (ja) * 1983-06-07 1984-12-21 Yamanouchi Pharmaceut Co Ltd 新規２−グアニジノチアゾリン誘導体ならびにその製造法
US4663347A (en) 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
CA1309557C (fr) 1985-06-18 1992-10-27 Robert N. Young Antagonistes de leucotrienes
EP0239306B1 (fr) 1986-03-27 1993-06-02 Merck Frosst Canada Inc. Esters de tétrahydrocarbazoles
HUT61980A (en) 1990-10-12 1993-03-29 Merck Frosst Canada Inc Process for producing saturated hydroxyalkylquinoline acids and pharmaceutical compositions comprising such compounds as active ingredient
US5410054A (en) * 1993-07-20 1995-04-25 Merck Frosst Canada, Inc. Heteroaryl quinolines as inhibitors of leukotriene biosynthesis
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
JP2009514969A (ja) 2005-11-09 2009-04-09 コンビナトアールエックス インコーポレーティッド 医学的状態を治療するための方法、組成物、およびキット
WO2015002150A1 (fr) 2013-07-03 2015-01-08 株式会社新日本科学 Nouveau composé, agent de détection du transporteur de cations organiques 3 et inhibiteur de l'activité du transporteur de cations organiques 3
WO2015155297A1 (fr) 2014-04-11 2015-10-15 Sanovel Ilac Sanayi Ve Ticaret A.S. Combinaisons pharmaceutiques de dabigatran et d'antagonistes du récepteur h2
WO2015169957A1 (fr) 2014-05-09 2015-11-12 Sanovel Ilac Sanayi Ve Ticaret A.S. Combinaisons pharmaceutiques de rivaroxaban et d'antagonistes du récepteur h2
WO2021183259A1 (fr) * 2020-03-12 2021-09-16 Nanopharmaceutics, Inc. Famotidine et analogues de la famotidine pour le traitement du coronavirus
WO2022034121A1 (fr) 2020-08-11 2022-02-17 Université De Strasbourg Bloqueurs de h2 ciblant des macrophages du foie pour la prévention et le traitement d'une maladie du foie et du cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2387970A1 (fr) * 1977-04-20 1978-11-17 Ici Ltd Derives de la guanidine et medicament en contenant
US4165378A (en) * 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2817078C2 (de) * 1977-04-20 1995-06-14 Zeneca Ltd Guanidinderivate
JPS6056143B2 (ja) * 1979-08-02 1985-12-09 山之内製薬株式会社 アミジン誘導体ならびにその製造法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2387970A1 (fr) * 1977-04-20 1978-11-17 Ici Ltd Derives de la guanidine et medicament en contenant
US4165378A (en) * 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0060094A2 (fr) * 1981-03-09 1982-09-15 Imperial Chemical Industries Plc Dérivés de guanidine
EP0060093A2 (fr) * 1981-03-09 1982-09-15 Imperial Chemical Industries Plc Dérivés d'amides
EP0060094A3 (en) * 1981-03-09 1982-11-17 Imperial Chemical Industries Plc Guanidine derivatives
EP0060093A3 (en) * 1981-03-09 1982-11-17 Imperial Chemical Industries Plc Amide derivatives
EP0061318A2 (fr) * 1981-03-24 1982-09-29 Imperial Chemical Industries Plc Dérivés de guanidinoheterocycles, comme antagonists d'histamine H-2
EP0061318B1 (fr) * 1981-03-24 1985-10-09 Imperial Chemical Industries Plc Dérivés de guanidinoheterocycles, comme antagonists d'histamine H-2
EP0067508A1 (fr) * 1981-05-18 1982-12-22 Imperial Chemical Industries Plc Dérivés d'amidine
FR2537134A1 (fr) * 1982-12-03 1984-06-08 Kotobuki Seiyaku Co Ltd Derives de thiazole et leur procede de synthese
EP0150099A1 (fr) * 1984-01-24 1985-07-31 Imperial Chemical Industries Plc Dérivés de guanidine
FR2569692A1 (fr) * 1984-08-30 1986-03-07 Yamanouchi Pharma Co Ltd Procede de preparation de derives de guanidinothiazole
EP0284536A1 (fr) * 1987-02-20 1988-09-28 Centro Marga Para La Investigacion S.A. Procédé de préparation de 3-(2-guanidinothiazol-4-yl)-méthylthio)propionitrile

Also Published As

Publication number Publication date
IT8067346A0 (it) 1980-03-05
IT1165509B (it) 1987-04-22
PH16099A (en) 1983-06-24
DE3008056A1 (de) 1980-09-18
SE8001691L (sv) 1980-09-07
DE3008056C2 (fr) 1988-07-21
GB2052478A (en) 1981-01-28
FR2450827B1 (fr) 1983-03-25
NL8001361A (nl) 1980-09-09
ES489222A0 (es) 1981-02-16
US4362736A (en) 1982-12-07
ES8103070A1 (es) 1981-02-16
CH644114A5 (de) 1984-07-13
GB2052478B (en) 1983-04-07
SE447253B (sv) 1986-11-03
CA1145345A (fr) 1983-04-26

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Legal Events

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ST Notification of lapse