ES483289A1 - Un procedimiento para la preparacion de 1,2,3,5, tetrahidro-himidazotienopirimidin-2-onas. - Google Patents

Un procedimiento para la preparacion de 1,2,3,5, tetrahidro-himidazotienopirimidin-2-onas.

Info

Publication number
ES483289A1
ES483289A1 ES483289A ES483289A ES483289A1 ES 483289 A1 ES483289 A1 ES 483289A1 ES 483289 A ES483289 A ES 483289A ES 483289 A ES483289 A ES 483289A ES 483289 A1 ES483289 A1 ES 483289A1
Authority
ES
Spain
Prior art keywords
tetrahydroimidazothienopyrimidin
carbon atoms
ones
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES483289A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Publication of ES483289A1 publication Critical patent/ES483289A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Abstract

1. Un procedimiento para la preparación 1, 2, 3, 5- tetrahidrobimidazotienopirimidin -2- onas de fórmula (I) **(Fórmula-01)** donde uno de los radicales Z1, Z2 o Z3 es un átomo de azufre y los otros dos radicales Z1, Z2 o Z3 representan Ch; R1 y R2 representan cada uno de ellos un átomo de hidrógeno, un grupo alquilo de 1 a 5 átomos de carbono, un grupo fenilo, un átomo de cloro o bien, unidos, R1 y R2 representan una cadena alquilénica de 3 a 5 átomos de carbono y R3 representa un átomo de hidrógeno o un grupo alquilo de 1 a 5 átomos de carbono, y sus sales de adición de ácidos farmacéuticamente aceptables, cuyo procedimiento comprende hacer reaccionar un compuesto de fórmula IV **(Fórmula-02)** donde R4 representa un grupo alquilo inferior, X1 es un átomo de cloro o de bromo y los restantes símbolos tienen los significados dados anteriormente, con amoniaco, para obtener el compuesto de fórmula (I) deseado.
ES483289A 1978-08-11 1979-08-09 Un procedimiento para la preparacion de 1,2,3,5, tetrahidro-himidazotienopirimidin-2-onas. Expired ES483289A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9783278A JPS5527105A (en) 1978-08-11 1978-08-11 Imidazothienopyrimidinones compound

Publications (1)

Publication Number Publication Date
ES483289A1 true ES483289A1 (es) 1980-09-01

Family

ID=14202683

Family Applications (1)

Application Number Title Priority Date Filing Date
ES483289A Expired ES483289A1 (es) 1978-08-11 1979-08-09 Un procedimiento para la preparacion de 1,2,3,5, tetrahidro-himidazotienopirimidin-2-onas.

Country Status (16)

Country Link
US (1) US4284773A (es)
EP (1) EP0008408B1 (es)
JP (1) JPS5527105A (es)
AU (1) AU529068B2 (es)
CA (1) CA1116597A (es)
CS (1) CS219256B2 (es)
DE (1) DE2961552D1 (es)
DK (1) DK153844C (es)
ES (1) ES483289A1 (es)
GR (1) GR73839B (es)
IL (1) IL57923A (es)
MX (1) MX6242E (es)
PH (1) PH15530A (es)
SU (1) SU880252A3 (es)
YU (1) YU41170B (es)
ZA (1) ZA793909B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287340A (en) * 1979-08-27 1981-09-01 Warner-Lambert Company Dihydro-oxo-pyrido[1,2-a]thienopyrimidine compounds
CA1142924A (en) * 1980-06-27 1983-03-15 Hoffmann-La Roche Limited Pyrimidine derivatives
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
CA3089569C (en) 2007-06-04 2023-12-05 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
GB0808950D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2828346C (en) 2011-03-01 2021-01-26 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
KR20160042039A (ko) 2013-08-09 2016-04-18 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
EP3972599A1 (en) 2019-05-21 2022-03-30 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3890321A (en) * 1971-09-20 1975-06-17 Pfizer 6-aryl-5-ethyl-pyrimidin-4-ol compounds useful as intermediates and bronchodilators
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
DE2411273A1 (de) * 1974-03-06 1975-09-18 Schering Ag Neue thieno eckige klammer auf 2,3-d eckige klammer zu pyrimidinone und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
PH15530A (en) 1983-02-09
DK153844B (da) 1988-09-12
US4284773A (en) 1981-08-18
CA1116597A (en) 1982-01-19
JPS5527105A (en) 1980-02-27
DE2961552D1 (en) 1982-02-04
EP0008408A1 (en) 1980-03-05
YU41170B (en) 1986-12-31
DK336779A (da) 1980-02-12
IL57923A (en) 1982-09-30
GR73839B (es) 1984-05-04
ZA793909B (en) 1980-10-29
MX6242E (es) 1985-01-28
YU194779A (en) 1983-10-31
CS219256B2 (en) 1983-03-25
AU529068B2 (en) 1983-05-26
EP0008408B1 (en) 1981-12-09
AU4973579A (en) 1980-02-14
SU880252A3 (ru) 1981-11-07
DK153844C (da) 1989-01-30
JPS627914B2 (es) 1987-02-19
IL57923A0 (en) 1979-11-30

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506