DE2954218C2 - Macrolid-Antibiotika und diese Antibiotika enthaltende pharmazeutische Präparate - Google Patents
Macrolid-Antibiotika und diese Antibiotika enthaltende pharmazeutische PräparateInfo
- Publication number
- DE2954218C2 DE2954218C2 DE2954218A DE2954218A DE2954218C2 DE 2954218 C2 DE2954218 C2 DE 2954218C2 DE 2954218 A DE2954218 A DE 2954218A DE 2954218 A DE2954218 A DE 2954218A DE 2954218 C2 DE2954218 C2 DE 2954218C2
- Authority
- DE
- Germany
- Prior art keywords
- antibiotics
- macrolide
- pharmaceutical preparations
- preparations containing
- methanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/29—Micromonospora
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/867—Micromonospora
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Polymers & Plastics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
Ha
C37H6INO12
8,64
1,97
8,82
1,94
A11725 Ia |
|
Aussehen: | weiße Kristalle |
Summenformel: | -C37Hh NOn |
Analyse: berechnet: C H N |
63,86 8,84 2,01 |
gefunden: C H N |
64,05 9,10 2,04 |
Molekulargewicht aufgrund des Massenspektrums: |
695 |
Zersetzungspunkt:
(CDCI31IOOMHz1TMS)
an Silicagel:
Ammoniak
(40:12:20)
(3:1:1)
bei Wellenlängen von etwa: 3550, 2970, 2930,2880, 2830, 2780, 1720,1710,1670,1640,1590,1450, 1375, 1345, 1320,1270,1250,1230, 1160,1120,1100, 1070,1040, 980, 955, 925, 880, 850, 830, 740, 710 cm-')
ι > |
5 | I i |
20 | 29 54 218 | Tabelle I (Fortsetzung) | A 11725 | Farbreaktion: | . . .. ,.Λ..,. I , I,.. K | i | i | bei Erwachsenen werder | vläusen einen 1 | I | $ | |
Ia | Entfärbung wäßriger + | I | mit Weinsäu- | | ι etwa 400 bis I | Demzufolge lassen sich die erfindungs- \ | A 11725 I | |||||||||
I I |
KMnO4-Lösung |
5
S |
2000 mg Antibiotikum als wirksam gegen Infektionen der Atemwege angesehen, die durch grampositive Mikro- f | gemäßen Macrolid-Antibiotika als Futterzusatzmittel und zur Therapie von Tieren verwenden. | f Mindesthemmkonzentration, j; |
Ha I | |||||||||
ί | Ninhydrin-Reaktion, — | A 11725 | Ij | Die Macrolid-Antibiotika vorliegender Erfindung können oral in Form von Tabletten oder Pulvern oder auch f | Organismen, wie Staphylokokken, verursacht worden sind. Bei Toxizitätsmessungen hat man bei | Tabelle II | mcg/ml | 0,4 I | |||||||
10 | Sakagushi's Reaktion, | Ha | b | mittels einer intravenösen Injektion verabreicht werden. Als Tagesdosis | LDso-Wert von 2000 mg oder höher bei oraler Verabreichung gefunden. | Untersuchte Mikroorganismen | A11725 | 0,4 i | |||||||
25 | Eisen(I II)-chlorid-Reaktion: | 108 | Ia | 0,2 I | |||||||||||
Saure oder basische Natur: basisch | + | i? | χ] | 0,1 | >ioo I | ||||||||||
Löslichkeiten: löslich in angesäuertem Wasser, | I | 0,1 | >100 I | ||||||||||||
Methanol, Aceton, Äthylacetat | 1. Staphylococcus aureus (ATCC 6538 P) | 50,05 | >100 ί | ||||||||||||
und Benzol; | r | 2. Staphylococcus aureus (MS 353) | >50 | 0,8 p | |||||||||||
f: | 30 | schwerlöslich in alkalisch | 3. Staphylococcus aureus (MS 353 C36) | >50 | >ioo ι | ||||||||||
eingestelltem Wasser; | basisch | 4. Staphylococcus aureus (MS 353 AO) | >50 | °·2 I | |||||||||||
unlöslich in Hexan | wie A 11275 Ia | i | 5. Staphylococcus aureus (0116) | 0,8 | 50,05 I | ||||||||||
35 | 6. Staphylococcus aureus (0119) | >50 | >100 1 | ||||||||||||
I | 7. Staphylococcus aureus (0126) | 50,05 | >ioo I | ||||||||||||
8. Staphylococcus aureus (0127) | S0,025 | 25 ί | |||||||||||||
Die Macrolid-Antibiotika vorliegender Erfindung zeigen antibakterielle und antimycoplasmale Spektren, wie | | 9. Staphylococcus epidermis (s.p.-al-l) | >50 | <0,05 1 | ||||||||||||
40 | aus der nachstehenden Tabelle 11 ersichtlich, wobei die Agarverdünnungsmethode angewandt worden ist. 1 | 10. Streptococcus pyogenes (N.Y.5) | >50 | ο,ι Ι | |||||||||||
Demzufolge bilden einen weiteren Gegenstand vorliegender Erfindung pharmazeutische Präparate, die min- | | 11. Streptococcus pyogenes (1022) | 25 | 3,1 i | ||||||||||||
destens eines der Macrolid-Antibiotika All 725 Ia oder Ha nach dem Anspruch 1 enthalten. | 12. Streptococcus faecalis (1501) | 50,025 | 1,6 $ | ||||||||||||
Die Salze lassen sich üblicherweise mit Mineralsäuren oder organischen Säuren, beispielsweise | 13. Streptococcus agalactiae(1020) | 0,1 | >ioo i | ||||||||||||
re, Citronensäure, Bernsteinsäure herstellen. | 14. Sarcinalutea (ATCC 9341) | 1,6 | >100 f | ||||||||||||
45 | 15. Micrococcus flavus (ATCC 10240) | 0,4 | 50 p | ||||||||||||
16. Corynebacterium diphtheriae (P.W.8) | >50 | >ioo ρ | |||||||||||||
17. Bacillus subtilis (ATCC 6633) | >50 | >ioo M | |||||||||||||
18. Escherichiacoli(NIHJ-JC2) | >50 | >100 f | |||||||||||||
19. Escherichia coli (B) | >50 | >ioo k | |||||||||||||
50 | 20. Klebsieila pneumoniae (ATCC 10031) | >50 | >ioo I | ||||||||||||
21. Salmonella typnosa (E 901) | >50 | >100 § | |||||||||||||
22 Salmonella enteritidis gertner | >50 | >ioo p | |||||||||||||
23. Shigella flexneri type 3a | >50 | 0,03 p: | |||||||||||||
'■ | 24. Shigella sonney (E 33) | >50 | 0,8 I | ||||||||||||
55 | 25. Proteus vulgaris (OX19) | >50 | |||||||||||||
26. Serratia marcescence | 0,03 | ||||||||||||||
27. Pseudomonas aeruginosa (IAM 1095) | 0,8 | ||||||||||||||
28. Mycoplasma gallisepticum | |||||||||||||||
29. Mycoplasma synoviae 4 |
|||||||||||||||
60 | |||||||||||||||
65 | |||||||||||||||
1 | |||||||||||||||
Herstellung des Macrolid-Antibiotikums A 11725 Ia
Claims (1)
- Patentansprüche:
!.Macrolid-Antibiotika A 11725 Ia und Ha der allgemeinen FormelHOO — CHCH3 CH3OCH3 OCH3CH2-CH3
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5437378A JPS54148701A (en) | 1978-05-10 | 1978-05-10 | Novel macrolide antibiotic, its preparaion and its producing bacteria |
JP2478879A JPS55115900A (en) | 1979-03-02 | 1979-03-02 | Novel macrolide antibiotic substance a11725 3 and its preparation |
JP3131679A JPS55122799A (en) | 1979-03-16 | 1979-03-16 | Novel macrolide antibiotic substances a11725 1a and 2a |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2954218C2 true DE2954218C2 (de) | 1986-08-28 |
Family
ID=27284787
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19792918711 Granted DE2918711A1 (de) | 1978-05-10 | 1979-05-09 | Macrolid-antibiotika, verfahren zu ihrer gewinnung und diese antibiotika enthaltende pharmazeutische praeparate |
DE2954218A Expired DE2954218C2 (de) | 1978-05-10 | 1979-05-09 | Macrolid-Antibiotika und diese Antibiotika enthaltende pharmazeutische Präparate |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19792918711 Granted DE2918711A1 (de) | 1978-05-10 | 1979-05-09 | Macrolid-antibiotika, verfahren zu ihrer gewinnung und diese antibiotika enthaltende pharmazeutische praeparate |
Country Status (8)
Country | Link |
---|---|
US (1) | US4291021A (de) |
CA (1) | CA1125203A (de) |
DE (2) | DE2918711A1 (de) |
ES (1) | ES480405A1 (de) |
FR (1) | FR2425444A1 (de) |
GB (1) | GB2020647B (de) |
IT (1) | IT1113372B (de) |
NL (1) | NL192621C (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4307085A (en) * | 1979-11-09 | 1981-12-22 | Schering Corporation | Antibiotic AR-5 complex, antibiotics coproduced therewith and derivatives thereof |
PT72039B (pt) * | 1979-11-09 | 1982-06-20 | Schering Corp | Process for preparing of macrolide antibiotics |
US4367287A (en) * | 1979-11-09 | 1983-01-04 | Schering Corporation | Process of producing antibiotic AR-5 complex |
JPH06701B2 (ja) * | 1983-12-01 | 1994-01-05 | 旭化成工業株式会社 | 動物用組成物 |
JPS6163289A (ja) * | 1984-09-03 | 1986-04-01 | Kyowa Hakko Kogyo Co Ltd | 新規物質k―259―2 |
US4843008A (en) * | 1984-12-24 | 1989-06-27 | Yamanouchi Pharmaceutical Co., Ltd. | Novel microorganisms and a novel process for producing antibiotics |
JPH0639480B2 (ja) * | 1985-07-16 | 1994-05-25 | 麒麟麦酒株式会社 | 新規マクロライド系抗生物質m119 |
JP2787458B2 (ja) * | 1989-01-20 | 1998-08-20 | 旭化成工業株式会社 | 抗生物質l53―18aおよびその製造法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4723548U (de) * | 1971-04-09 | 1972-11-16 | ||
JPS50145588A (de) * | 1974-05-16 | 1975-11-21 | ||
US4032631A (en) * | 1975-12-19 | 1977-06-28 | Pfizer Inc. | Mixture of antibiotics produced by new species of micromonospora |
JPS5849235B2 (ja) * | 1977-03-31 | 1983-11-02 | 協和醗酵工業株式会社 | 新抗生物質xk−99およびその製造法 |
-
1979
- 1979-04-26 CA CA326,416A patent/CA1125203A/en not_active Expired
- 1979-05-08 GB GB7915807A patent/GB2020647B/en not_active Expired
- 1979-05-08 NL NL7903601A patent/NL192621C/nl not_active IP Right Cessation
- 1979-05-09 DE DE19792918711 patent/DE2918711A1/de active Granted
- 1979-05-09 ES ES480405A patent/ES480405A1/es not_active Expired
- 1979-05-09 DE DE2954218A patent/DE2954218C2/de not_active Expired
- 1979-05-10 FR FR7911883A patent/FR2425444A1/fr active Granted
- 1979-05-10 US US06/037,846 patent/US4291021A/en not_active Expired - Lifetime
- 1979-05-10 IT IT22536/79A patent/IT1113372B/it active
Non-Patent Citations (1)
Title |
---|
NICHTS-ERMITTELT * |
Also Published As
Publication number | Publication date |
---|---|
ES480405A1 (es) | 1980-01-01 |
GB2020647B (en) | 1982-07-28 |
NL7903601A (nl) | 1979-11-13 |
NL192621C (nl) | 1997-11-04 |
GB2020647A (en) | 1979-11-21 |
DE2918711C2 (de) | 1987-08-06 |
CA1125203A (en) | 1982-06-08 |
IT1113372B (it) | 1986-01-20 |
NL192621B (nl) | 1997-07-01 |
FR2425444B1 (de) | 1983-09-23 |
DE2918711A1 (de) | 1979-11-22 |
FR2425444A1 (fr) | 1979-12-07 |
US4291021A (en) | 1981-09-22 |
IT7922536A0 (it) | 1979-05-10 |
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Legal Events
Date | Code | Title | Description |
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Ref country code: DE Ref document number: 2918711 |
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8125 | Change of the main classification |
Ipc: C07C 17/08 |
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8126 | Change of the secondary classification |
Free format text: A61K 31/71 A23K 1/17 C12P 19/62 |
|
8181 | Inventor (new situation) |
Free format text: OTANI, MASARU SATOI, SHUZO MUTO, NAOKI SAITO, TETSU, SHIZUOKA, JP FUJII, TADASHIRO, MISHIMA, SHIZUOKA, JP KATSUMATA, SEIJI, SUSONO, SHIZUOKA, JP HAYASHI, MITSUO ONO, MASARU, SHIZUOKA, JP |
|
8125 | Change of the main classification |
Ipc: C07H 17/08 |
|
8126 | Change of the secondary classification |
Free format text: A61K 31/71 A23K 1/17 C12P 19/62 |
|
8128 | New person/name/address of the agent |
Representative=s name: JUNG, E., DIPL.-CHEM. DR.PHIL. SCHIRDEWAHN, J., DI |
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