PT72039B - Process for preparing of macrolide antibiotics - Google Patents

Process for preparing of macrolide antibiotics

Info

Publication number
PT72039B
PT72039B PT72039A PT7203980A PT72039B PT 72039 B PT72039 B PT 72039B PT 72039 A PT72039 A PT 72039A PT 7203980 A PT7203980 A PT 7203980A PT 72039 B PT72039 B PT 72039B
Authority
PT
Portugal
Prior art keywords
preparing
macrolide antibiotics
macrolide
antibiotics
Prior art date
Application number
PT72039A
Other languages
English (en)
Other versions
PT72039A (en
Inventor
Jay Allan Waitz
Walter Joseph Reiblein
Imbi Truumees
Ashit Kumar Ganguly
Yi-Tsung Liu
Olga Sarre
Robert Jaret
Doris Schumacher
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/093,080 external-priority patent/US4307085A/en
Application filed by Schering Corp filed Critical Schering Corp
Publication of PT72039A publication Critical patent/PT72039A/pt
Publication of PT72039B publication Critical patent/PT72039B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/48—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/29—Micromonospora

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT72039A 1979-11-09 1980-11-07 Process for preparing of macrolide antibiotics PT72039B (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/093,080 US4307085A (en) 1979-11-09 1979-11-09 Antibiotic AR-5 complex, antibiotics coproduced therewith and derivatives thereof
US10618479A 1979-12-21 1979-12-21
US13033080A 1980-03-14 1980-03-14

Publications (2)

Publication Number Publication Date
PT72039A PT72039A (en) 1980-12-01
PT72039B true PT72039B (pt) 1982-06-20

Family

ID=27377401

Family Applications (1)

Application Number Title Priority Date Filing Date
PT72039A PT72039B (pt) 1979-11-09 1980-11-07 Process for preparing of macrolide antibiotics

Country Status (10)

Country Link
EP (1) EP0033433A1 (pt)
KR (1) KR830004333A (pt)
AR (1) AR230648A1 (pt)
DK (1) DK477280A (pt)
FI (1) FI803483L (pt)
GR (1) GR72125B (pt)
IL (1) IL61437A0 (pt)
NO (1) NO803356L (pt)
NZ (1) NZ195507A (pt)
PT (1) PT72039B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487923A (en) * 1981-12-14 1984-12-11 Eli Lilly And Company Method of preparing 23-monoesters of OMT and DMT
US4528369A (en) * 1982-07-02 1985-07-09 Eli Lilly And Company 20-Dihydro-20-deoxy-23-de(mycinosyloxy)tylosin
US4629786A (en) * 1983-02-28 1986-12-16 Eli Lilly And Company C-20- and C-23 modified macrolide derivatives
US4468511A (en) * 1983-02-28 1984-08-28 Eli Lilly And Company C-20- And C-23-Modified macrolide derivatives
GB8405087D0 (en) * 1984-02-27 1984-04-04 Omura S Antibiotic
US4920103A (en) * 1986-09-29 1990-04-24 Eli Lilly And Company Modifications of mycinose and 3-O-demethylmycinose in tylosin-type macrolides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1125203A (en) * 1978-05-10 1982-06-08 Toyo Jozo Company, Ltd. Macrolide antibiotics from micromonospora

Also Published As

Publication number Publication date
AR230648A1 (es) 1984-05-31
NZ195507A (en) 1985-05-31
FI803483L (fi) 1981-05-10
NO803356L (no) 1981-05-11
GR72125B (pt) 1983-09-16
IL61437A0 (en) 1980-12-31
KR830004333A (ko) 1983-07-09
PT72039A (en) 1980-12-01
EP0033433A1 (en) 1981-08-12
DK477280A (da) 1981-05-10

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