JPS55122799A - Novel macrolide antibiotic substances a11725 1a and 2a - Google Patents

Novel macrolide antibiotic substances a11725 1a and 2a

Info

Publication number
JPS55122799A
JPS55122799A JP3131679A JP3131679A JPS55122799A JP S55122799 A JPS55122799 A JP S55122799A JP 3131679 A JP3131679 A JP 3131679A JP 3131679 A JP3131679 A JP 3131679A JP S55122799 A JPS55122799 A JP S55122799A
Authority
JP
Japan
Prior art keywords
methanol
basic
antibiotics
iia
white
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3131679A
Other languages
Japanese (ja)
Other versions
JPS6331479B2 (en
Inventor
Mitsuo Hayashi
Masaru Ono
Shuzo Satoi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Jozo KK
Original Assignee
Toyo Jozo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK
Priority to JP3131679A priority Critical patent/JPS55122799A/en
Priority to CA326,416A priority patent/CA1125203A/en
Priority to GB7915807A priority patent/GB2020647B/en
Priority to NL7903601A priority patent/NL192621C/en
Priority to ES480405A priority patent/ES480405A1/en
Priority to DE19792918711 priority patent/DE2918711A1/en
Priority to DE2954218A priority patent/DE2954218C2/en
Priority to FR7911883A priority patent/FR2425444A1/en
Priority to IT22536/79A priority patent/IT1113372B/en
Priority to US06/037,846 priority patent/US4291021A/en
Priority to ES483467A priority patent/ES483467A1/en
Publication of JPS55122799A publication Critical patent/JPS55122799A/en
Publication of JPS6331479B2 publication Critical patent/JPS6331479B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

NEW MATERIAL:Antibiotics A11725 Ia and IIa. Ia: color, white; molecular formula, C37H61NO11; molecular weight, 695; melting point, 174W176°C; specific rotation [α]D=+2.7° (c=1.0, methanol); positive to KMnO4 decoloration reaction, negative to ninhydrin reaction, etc.; basic; soluble in acidic water, methanol, benzene, etc., slightly soluble in basic water, insoluble in hexane. IIa: color, white; molecular formula, C37H61NO12; molecular weight, 711; melting point, 148W150°C; specific rotation, [α]D=+18.7° (c=1.0, methanol); basic; solubility, same to Ia.
USE: Antibacterial agent effective to respiratory diseases caused by gram-positive bacteria, e.g. staphylococci, and useful as a feed additive or remedy for animal diseases.
PROCESS: Micromonospora sp. A-11725 strain (FERM-P No.4485, 4488) is cultured to obtain novel macrolide antibiotics A11725 I and II. The epoxy groups of the above antibiotics are converted to double bonds by treating with chromous chloride in an organic solvent.
COPYRIGHT: (C)1980,JPO&Japio
JP3131679A 1978-05-10 1979-03-16 Novel macrolide antibiotic substances a11725 1a and 2a Granted JPS55122799A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP3131679A JPS55122799A (en) 1979-03-16 1979-03-16 Novel macrolide antibiotic substances a11725 1a and 2a
CA326,416A CA1125203A (en) 1978-05-10 1979-04-26 Macrolide antibiotics from micromonospora
GB7915807A GB2020647B (en) 1978-05-10 1979-05-08 Macrolide antibiotics a 11725 1 2 and 3 preparation thereo
NL7903601A NL192621C (en) 1978-05-10 1979-05-08 Method for the preparation of new antibiotics, which belong to the macrolides, microorganisms of the strain Micromonospora, which are capable of producing these new antibiotics; and new antibiotics and pharmaceutical preparations.
ES480405A ES480405A1 (en) 1978-05-10 1979-05-09 Novel macrolide antibiotics and preparation thereof
DE19792918711 DE2918711A1 (en) 1978-05-10 1979-05-09 MACROLID ANTIBIOTICS, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE ANTIBIOTICS
DE2954218A DE2954218C2 (en) 1978-05-10 1979-05-09 Macrolide antibiotics and pharmaceutical preparations containing these antibiotics
FR7911883A FR2425444A1 (en) 1978-05-10 1979-05-10 NEW MACROLIDE-TYPE ANTIBIOTICS, THEIR PREPARATION AND THERAPEUTIC USE
IT22536/79A IT1113372B (en) 1978-05-10 1979-05-10 PROCEDURE TO PRODUCE ANTIBIOTIC SUBSTANCES AND THEIR ANTIBIOTICS SO OBTAINED
US06/037,846 US4291021A (en) 1978-05-10 1979-05-10 Novel macrolide antibiotics and preparation thereof
ES483467A ES483467A1 (en) 1979-03-16 1979-08-17 Novel macrolide antibiotic substances a11725 1a and 2a

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3131679A JPS55122799A (en) 1979-03-16 1979-03-16 Novel macrolide antibiotic substances a11725 1a and 2a

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP61154817A Division JPS6226294A (en) 1986-07-01 1986-07-01 Novel macrolide antibiotic substance a11725iia

Publications (2)

Publication Number Publication Date
JPS55122799A true JPS55122799A (en) 1980-09-20
JPS6331479B2 JPS6331479B2 (en) 1988-06-23

Family

ID=12327869

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3131679A Granted JPS55122799A (en) 1978-05-10 1979-03-16 Novel macrolide antibiotic substances a11725 1a and 2a

Country Status (2)

Country Link
JP (1) JPS55122799A (en)
ES (1) ES483467A1 (en)

Also Published As

Publication number Publication date
JPS6331479B2 (en) 1988-06-23
ES483467A1 (en) 1980-04-16

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