DE2950235C2 - - Google Patents
Info
- Publication number
- DE2950235C2 DE2950235C2 DE2950235A DE2950235A DE2950235C2 DE 2950235 C2 DE2950235 C2 DE 2950235C2 DE 2950235 A DE2950235 A DE 2950235A DE 2950235 A DE2950235 A DE 2950235A DE 2950235 C2 DE2950235 C2 DE 2950235C2
- Authority
- DE
- Germany
- Prior art keywords
- general formula
- compounds
- hydroxy
- benzodiazepin
- formula iii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- YSPYFFRTSUIPCB-UHFFFAOYSA-N 1h-1,4-benzodiazepine-2,3-dione Chemical compound N1C(=O)C(=O)N=CC2=CC=CC=C21 YSPYFFRTSUIPCB-UHFFFAOYSA-N 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 239000003444 phase transfer catalyst Substances 0.000 claims 2
- CQZIEDXCLQOOEH-UHFFFAOYSA-N 3-bromopropanenitrile Chemical compound BrCCC#N CQZIEDXCLQOOEH-UHFFFAOYSA-N 0.000 claims 1
- GNHMRTZZNHZDDM-UHFFFAOYSA-N 3-chloropropionitrile Chemical compound ClCCC#N GNHMRTZZNHZDDM-UHFFFAOYSA-N 0.000 claims 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 229910001516 alkali metal iodide Inorganic materials 0.000 claims 1
- XAXMYHMKTCNRRZ-UHFFFAOYSA-N cinolazepam Chemical compound C12=CC(Cl)=CC=C2N(CCC#N)C(=O)C(O)N=C1C1=CC=CC=C1F XAXMYHMKTCNRRZ-UHFFFAOYSA-N 0.000 claims 1
- 150000003983 crown ethers Chemical class 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 150000004714 phosphonium salts Chemical class 0.000 claims 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims 1
- 239000012429 reaction media Substances 0.000 claims 1
- -1 sulfonyloxy group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Anesthesiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT903178A AT361492B (de) | 1978-12-18 | 1978-12-18 | Verfahren zur herstellung von neuen 3-hydroxy- 1,4-benzodiazepin-2-onen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2950235A1 DE2950235A1 (de) | 1980-06-26 |
| DE2950235C2 true DE2950235C2 (https=) | 1987-08-27 |
Family
ID=3610590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19792950235 Granted DE2950235A1 (de) | 1978-12-18 | 1979-12-13 | 3-hydroxy-1,4-benzodiazepin-2-one und verfahren zu deren herstellung |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4388313A (https=) |
| JP (1) | JPS5583764A (https=) |
| AT (1) | AT361492B (https=) |
| AU (1) | AU532331B2 (https=) |
| BE (1) | BE880632A (https=) |
| BG (1) | BG60474B2 (https=) |
| CA (1) | CA1113464A (https=) |
| CH (1) | CH643248A5 (https=) |
| DE (1) | DE2950235A1 (https=) |
| DK (1) | DK154973C (https=) |
| ES (1) | ES8103738A1 (https=) |
| FI (1) | FI67375C (https=) |
| FR (1) | FR2444672A1 (https=) |
| GB (1) | GB2043630B (https=) |
| GR (1) | GR73901B (https=) |
| HK (1) | HK33385A (https=) |
| IT (1) | IT1193345B (https=) |
| LU (1) | LU81990A1 (https=) |
| MY (1) | MY8600020A (https=) |
| NL (1) | NL187068C (https=) |
| NO (1) | NO151859C (https=) |
| SE (1) | SE440351B (https=) |
| SG (1) | SG13585G (https=) |
| YU (1) | YU40586B (https=) |
| ZA (1) | ZA796600B (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2084577T3 (es) * | 1986-10-24 | 1996-05-16 | Abbott Lab | Ensayo, trazadores, inmunogenos y anticuerpos para benzodiazepinas. |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3311612A (en) * | 1967-03-28 | Process for preparing | ||
| US3371085A (en) * | 1959-12-10 | 1968-02-27 | Hoffmann La Roche | 5-aryl-3h-1,4-benzodiazepin-2(1h)-ones |
| BE621819A (https=) * | 1961-08-29 | |||
| GB1050401A (https=) * | 1963-02-19 | 1900-01-01 | ||
| NL298071A (https=) * | 1963-06-04 | |||
| GB1051795A (https=) * | 1964-02-11 | |||
| FR135F (https=) * | 1964-08-13 | |||
| NO120269B (https=) * | 1965-11-02 | 1970-09-28 | Hoffmann La Roche | |
| US3464978A (en) * | 1967-04-21 | 1969-09-02 | Hoffmann La Roche | 1-substituted urea alkyl 1,2-dihydro-1,4-benzodiazepines and benzodiazepin - 2-ones |
| CH574421A5 (en) * | 1969-02-14 | 1976-04-15 | Hoffmann La Roche | Benzodiazepines |
| AT309436B (de) * | 1970-06-23 | 1973-08-27 | Gerot Pharmazeutika | Verfahren zur Herstellung von 3-Hydroxy-1,4-benzodiazepin Derivaten oder deren Salzen |
| US4065451A (en) * | 1971-03-30 | 1977-12-27 | American Home Products | 1,3-Dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one, substituted diamino acetate esters and their acid salts |
| CH573416A5 (https=) * | 1971-07-30 | 1976-03-15 | Sumitomo Chemical Co | |
| US3801568A (en) * | 1972-02-07 | 1974-04-02 | American Home Prod | Optically active 1,3-dihydro-3-substituted 5-phenyl-2h-1,4-benzodiazepin-2-ones and process for their separation |
| JPS494226A (https=) * | 1972-04-27 | 1974-01-16 |
-
1978
- 1978-12-18 AT AT903178A patent/AT361492B/de not_active IP Right Cessation
-
1979
- 1979-11-26 NO NO793827A patent/NO151859C/no unknown
- 1979-11-30 DK DK510379A patent/DK154973C/da not_active IP Right Cessation
- 1979-12-05 FR FR7929879A patent/FR2444672A1/fr active Granted
- 1979-12-05 ZA ZA00796600A patent/ZA796600B/xx unknown
- 1979-12-11 NL NLAANVRAGE7908919,A patent/NL187068C/xx not_active IP Right Cessation
- 1979-12-11 AU AU53664/79A patent/AU532331B2/en not_active Expired
- 1979-12-13 DE DE19792950235 patent/DE2950235A1/de active Granted
- 1979-12-13 LU LU81990A patent/LU81990A1/fr unknown
- 1979-12-14 BE BE0/198574A patent/BE880632A/fr not_active IP Right Cessation
- 1979-12-14 ES ES486895A patent/ES8103738A1/es not_active Expired
- 1979-12-14 GB GB7943107A patent/GB2043630B/en not_active Expired
- 1979-12-14 FI FI793924A patent/FI67375C/fi not_active IP Right Cessation
- 1979-12-14 SE SE7910333A patent/SE440351B/sv not_active IP Right Cessation
- 1979-12-17 YU YU3087/79A patent/YU40586B/xx unknown
- 1979-12-17 GR GR60778A patent/GR73901B/el unknown
- 1979-12-17 CA CA342,046A patent/CA1113464A/en not_active Expired
- 1979-12-18 IT IT28149/79A patent/IT1193345B/it active
- 1979-12-18 CH CH1123179A patent/CH643248A5/de not_active IP Right Cessation
- 1979-12-18 JP JP16367879A patent/JPS5583764A/ja active Granted
-
1981
- 1981-05-11 US US06/262,676 patent/US4388313A/en not_active Expired - Lifetime
-
1985
- 1985-02-19 SG SG135/85A patent/SG13585G/en unknown
- 1985-05-02 HK HK333/85A patent/HK33385A/xx not_active IP Right Cessation
-
1986
- 1986-12-30 MY MY20/86A patent/MY8600020A/xx unknown
-
1993
- 1993-07-21 BG BG097977A patent/BG60474B2/bg unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Free format text: VOSSIUS, V., DIPL.-CHEM. DR.RER.NAT. TAUCHNER, P., DIPL.-CHEM. DR.RER.NAT. HEUNEMANN, D., DIPL.-PHYS. DR.RER.NAT. RAUH, P., DIPL.-CHEM. DR.RER.NAT., PAT.-ANWAELTE, 8000 MUENCHEN |
|
| 8328 | Change in the person/name/address of the agent |
Free format text: TAUCHNER, P., DIPL.-CHEM. DR.RER.NAT. HEUNEMANN, D., DIPL.-PHYS. DR.RER.NAT. RAUH, P., DIPL.-CHEM. DR.RER.NAT., PAT.-ANWAELTE, 8000 MUENCHEN |