JPS6310699B2 - - Google Patents

Info

Publication number
JPS6310699B2
JPS6310699B2 JP54163678A JP16367879A JPS6310699B2 JP S6310699 B2 JPS6310699 B2 JP S6310699B2 JP 54163678 A JP54163678 A JP 54163678A JP 16367879 A JP16367879 A JP 16367879A JP S6310699 B2 JPS6310699 B2 JP S6310699B2
Authority
JP
Japan
Prior art keywords
hydroxy
formula
halogen
hydrogen
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP54163678A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5583764A (en
Inventor
Haa Shuragaa Rudoitsuhi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GEROTSUTO PHARM GmbH
Original Assignee
GEROTSUTO PHARM GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GEROTSUTO PHARM GmbH filed Critical GEROTSUTO PHARM GmbH
Publication of JPS5583764A publication Critical patent/JPS5583764A/ja
Publication of JPS6310699B2 publication Critical patent/JPS6310699B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP16367879A 1978-12-18 1979-12-18 33hydroxyy1*44benzodiazepinee22ones and their manufacture Granted JPS5583764A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT903178A AT361492B (de) 1978-12-18 1978-12-18 Verfahren zur herstellung von neuen 3-hydroxy- 1,4-benzodiazepin-2-onen

Publications (2)

Publication Number Publication Date
JPS5583764A JPS5583764A (en) 1980-06-24
JPS6310699B2 true JPS6310699B2 (https=) 1988-03-08

Family

ID=3610590

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16367879A Granted JPS5583764A (en) 1978-12-18 1979-12-18 33hydroxyy1*44benzodiazepinee22ones and their manufacture

Country Status (25)

Country Link
US (1) US4388313A (https=)
JP (1) JPS5583764A (https=)
AT (1) AT361492B (https=)
AU (1) AU532331B2 (https=)
BE (1) BE880632A (https=)
BG (1) BG60474B2 (https=)
CA (1) CA1113464A (https=)
CH (1) CH643248A5 (https=)
DE (1) DE2950235A1 (https=)
DK (1) DK154973C (https=)
ES (1) ES8103738A1 (https=)
FI (1) FI67375C (https=)
FR (1) FR2444672A1 (https=)
GB (1) GB2043630B (https=)
GR (1) GR73901B (https=)
HK (1) HK33385A (https=)
IT (1) IT1193345B (https=)
LU (1) LU81990A1 (https=)
MY (1) MY8600020A (https=)
NL (1) NL187068C (https=)
NO (1) NO151859C (https=)
SE (1) SE440351B (https=)
SG (1) SG13585G (https=)
YU (1) YU40586B (https=)
ZA (1) ZA796600B (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2084577T3 (es) * 1986-10-24 1996-05-16 Abbott Lab Ensayo, trazadores, inmunogenos y anticuerpos para benzodiazepinas.

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3311612A (en) * 1967-03-28 Process for preparing
US3371085A (en) * 1959-12-10 1968-02-27 Hoffmann La Roche 5-aryl-3h-1,4-benzodiazepin-2(1h)-ones
BE621819A (https=) * 1961-08-29
GB1050401A (https=) * 1963-02-19 1900-01-01
NL298071A (https=) * 1963-06-04
GB1051795A (https=) * 1964-02-11
FR135F (https=) * 1964-08-13
NO120269B (https=) * 1965-11-02 1970-09-28 Hoffmann La Roche
US3464978A (en) * 1967-04-21 1969-09-02 Hoffmann La Roche 1-substituted urea alkyl 1,2-dihydro-1,4-benzodiazepines and benzodiazepin - 2-ones
CH574421A5 (en) * 1969-02-14 1976-04-15 Hoffmann La Roche Benzodiazepines
AT309436B (de) * 1970-06-23 1973-08-27 Gerot Pharmazeutika Verfahren zur Herstellung von 3-Hydroxy-1,4-benzodiazepin Derivaten oder deren Salzen
US4065451A (en) * 1971-03-30 1977-12-27 American Home Products 1,3-Dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one, substituted diamino acetate esters and their acid salts
CH573416A5 (https=) * 1971-07-30 1976-03-15 Sumitomo Chemical Co
US3801568A (en) * 1972-02-07 1974-04-02 American Home Prod Optically active 1,3-dihydro-3-substituted 5-phenyl-2h-1,4-benzodiazepin-2-ones and process for their separation
JPS494226A (https=) * 1972-04-27 1974-01-16

Also Published As

Publication number Publication date
NO151859C (no) 1985-06-19
YU308779A (en) 1983-02-28
GR73901B (https=) 1984-05-18
NO793827L (no) 1980-06-19
NL7908919A (nl) 1980-06-20
FR2444672A1 (fr) 1980-07-18
JPS5583764A (en) 1980-06-24
FI793924A7 (fi) 1980-06-19
CH643248A5 (de) 1984-05-30
GB2043630B (en) 1983-06-15
HK33385A (en) 1985-05-10
SG13585G (en) 1985-08-16
GB2043630A (en) 1980-10-08
FR2444672B1 (https=) 1983-05-13
NL187068B (nl) 1990-12-17
ES486895A0 (es) 1980-10-01
AU532331B2 (en) 1983-09-29
SE440351B (sv) 1985-07-29
MY8600020A (en) 1986-12-31
NO151859B (no) 1985-03-11
ZA796600B (en) 1981-07-29
AU5366479A (en) 1980-06-26
DE2950235C2 (https=) 1987-08-27
YU40586B (en) 1986-02-28
IT7928149A0 (it) 1979-12-18
SE7910333L (sv) 1980-06-19
DK154973C (da) 1989-06-05
IT1193345B (it) 1988-06-15
NL187068C (nl) 1991-05-16
BG60474B2 (bg) 1995-04-28
BE880632A (fr) 1980-06-16
ATA903178A (de) 1980-08-15
FI67375C (fi) 1985-03-11
LU81990A1 (fr) 1981-07-23
DK154973B (da) 1989-01-16
AT361492B (de) 1981-03-10
DK510379A (da) 1980-06-19
FI67375B (fi) 1984-11-30
US4388313A (en) 1983-06-14
CA1113464A (en) 1981-12-01
DE2950235A1 (de) 1980-06-26
ES8103738A1 (es) 1980-10-01

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