DE2928583A1 - Verfahren zur herstellung von carbostyrilderivaten - Google Patents

Verfahren zur herstellung von carbostyrilderivaten

Info

Publication number
DE2928583A1
DE2928583A1 DE19792928583 DE2928583A DE2928583A1 DE 2928583 A1 DE2928583 A1 DE 2928583A1 DE 19792928583 DE19792928583 DE 19792928583 DE 2928583 A DE2928583 A DE 2928583A DE 2928583 A1 DE2928583 A1 DE 2928583A1
Authority
DE
Germany
Prior art keywords
group
carbon atoms
general formula
nitro
carried out
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19792928583
Other languages
German (de)
English (en)
Inventor
Erich Dipl Chem Dr Mueller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Priority to DE19792928583 priority Critical patent/DE2928583A1/de
Priority to FI792426A priority patent/FI70408C/fi
Priority to NO792659A priority patent/NO154131C/no
Priority to DK342079A priority patent/DK150156C/da
Priority to GR61730A priority patent/GR67622B/el
Priority to JP6999180A priority patent/JPS5616470A/ja
Priority to ES491859A priority patent/ES491859A0/es
Priority to AT306480A priority patent/AT375648B/de
Priority to PT7153080A priority patent/PT71530B/pt
Priority to CA000355992A priority patent/CA1156657A/en
Priority to ES498466A priority patent/ES8201139A1/es
Priority to ES498465A priority patent/ES8201138A1/es
Publication of DE2928583A1 publication Critical patent/DE2928583A1/de
Priority to AT246583A priority patent/AT376209B/de
Priority to AT246483A priority patent/AT375925B/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
DE19792928583 1979-07-14 1979-07-14 Verfahren zur herstellung von carbostyrilderivaten Withdrawn DE2928583A1 (de)

Priority Applications (14)

Application Number Priority Date Filing Date Title
DE19792928583 DE2928583A1 (de) 1979-07-14 1979-07-14 Verfahren zur herstellung von carbostyrilderivaten
FI792426A FI70408C (fi) 1979-07-14 1979-08-03 Foerfarande foer framstaellning av terapeutiskt aktiva karbostyrilderivat
NO792659A NO154131C (no) 1979-07-14 1979-08-15 Analogifremgangsmaate for fremstilling av terapeutisk aktive karbostyrilderivater.
DK342079A DK150156C (da) 1979-07-14 1979-08-15 Analogifremgangsmaade til fremstilling af carbostyrilderivater
GR61730A GR67622B (no) 1979-07-14 1980-04-21
JP6999180A JPS5616470A (en) 1979-07-14 1980-05-26 Novel manufacture of carbostyril derivative
ES491859A ES491859A0 (es) 1979-07-14 1980-05-27 Procedimiento mejorado para la preparacion de derivados de carbostirilo
AT306480A AT375648B (de) 1979-07-14 1980-06-11 Verfahren zur herstellung von neuen carbostyrilderivaten
PT7153080A PT71530B (de) 1979-07-14 1980-07-10 Verfahren zur herstellung von carbostyrilderivaten
CA000355992A CA1156657A (en) 1979-07-14 1980-07-11 Process for the preparation of pharmacologically active carbostyril derivatives
ES498466A ES8201139A1 (es) 1979-07-14 1981-01-13 Procedimiento mejorado para la preparacion de derivados de carbostirilo
ES498465A ES8201138A1 (es) 1979-07-14 1981-01-13 Procedimiento mejorado para la preparacion de derivados de carbostirilo
AT246583A AT376209B (de) 1979-07-14 1983-07-05 Verfahren zur herstellung von neuen carbostyrilderivaten
AT246483A AT375925B (de) 1979-07-14 1983-07-05 Verfahren zur herstellung von neuen carbostyrilderivaten

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792928583 DE2928583A1 (de) 1979-07-14 1979-07-14 Verfahren zur herstellung von carbostyrilderivaten

Publications (1)

Publication Number Publication Date
DE2928583A1 true DE2928583A1 (de) 1981-01-29

Family

ID=6075786

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19792928583 Withdrawn DE2928583A1 (de) 1979-07-14 1979-07-14 Verfahren zur herstellung von carbostyrilderivaten

Country Status (5)

Country Link
JP (1) JPS5616470A (no)
DE (1) DE2928583A1 (no)
DK (1) DK150156C (no)
FI (1) FI70408C (no)
NO (1) NO154131C (no)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
US4487772A (en) * 1981-02-17 1984-12-11 Otsuka Pharmaceutical Co. Ltd. Carbostyril derivatives and their salts
US5008274A (en) * 1986-04-02 1991-04-16 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and pharmaceutical composition for inhibiting adhesion of thrombocytes
US5434164A (en) * 1986-04-02 1995-07-18 Otsuka Pharmaceutical Co. Ltd. Carbostyril derivatives and salts thereof and pharmaceutical compositions for inhibiting adhesion of thrombocytes

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU532361B2 (en) * 1981-09-01 1983-09-29 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5321176A (en) * 1976-08-09 1978-02-27 Otsuka Pharmaceut Co Ltd Carbostyryl derivatives

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487772A (en) * 1981-02-17 1984-12-11 Otsuka Pharmaceutical Co. Ltd. Carbostyril derivatives and their salts
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
US5008274A (en) * 1986-04-02 1991-04-16 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and pharmaceutical composition for inhibiting adhesion of thrombocytes
US5434164A (en) * 1986-04-02 1995-07-18 Otsuka Pharmaceutical Co. Ltd. Carbostyril derivatives and salts thereof and pharmaceutical compositions for inhibiting adhesion of thrombocytes

Also Published As

Publication number Publication date
NO154131C (no) 1986-07-23
JPS6326751B2 (no) 1988-05-31
NO154131B (no) 1986-04-14
FI792426A (fi) 1981-01-15
NO792659L (no) 1981-01-15
DK342079A (da) 1981-01-15
JPS5616470A (en) 1981-02-17
DK150156B (da) 1986-12-22
FI70408C (fi) 1986-09-19
DK150156C (da) 1987-10-12
FI70408B (fi) 1986-03-27

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Legal Events

Date Code Title Description
8140 Disposal/non-payment of the annual fee for main application