FI70408C - Foerfarande foer framstaellning av terapeutiskt aktiva karbostyrilderivat - Google Patents

Foerfarande foer framstaellning av terapeutiskt aktiva karbostyrilderivat Download PDF

Info

Publication number
FI70408C
FI70408C FI792426A FI792426A FI70408C FI 70408 C FI70408 C FI 70408C FI 792426 A FI792426 A FI 792426A FI 792426 A FI792426 A FI 792426A FI 70408 C FI70408 C FI 70408C
Authority
FI
Finland
Prior art keywords
group
carbon atoms
reaction
process according
carried out
Prior art date
Application number
FI792426A
Other languages
English (en)
Finnish (fi)
Other versions
FI792426A (fi
FI70408B (fi
Inventor
Erich Mueller
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Priority to GR61730A priority Critical patent/GR67622B/el
Priority to ES491859A priority patent/ES491859A0/es
Priority to AT306480A priority patent/AT375648B/de
Priority to PT7153080A priority patent/PT71530B/pt
Priority to CA000355992A priority patent/CA1156657A/en
Priority to ES498465A priority patent/ES8201138A1/es
Priority to ES498466A priority patent/ES498466A0/es
Publication of FI792426A publication Critical patent/FI792426A/fi
Application granted granted Critical
Publication of FI70408B publication Critical patent/FI70408B/fi
Publication of FI70408C publication Critical patent/FI70408C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
FI792426A 1979-07-14 1979-08-03 Foerfarande foer framstaellning av terapeutiskt aktiva karbostyrilderivat FI70408C (fi)

Priority Applications (7)

Application Number Priority Date Filing Date Title
GR61730A GR67622B (no) 1979-07-14 1980-04-21
ES491859A ES491859A0 (es) 1979-07-14 1980-05-27 Procedimiento mejorado para la preparacion de derivados de carbostirilo
AT306480A AT375648B (de) 1979-07-14 1980-06-11 Verfahren zur herstellung von neuen carbostyrilderivaten
PT7153080A PT71530B (de) 1979-07-14 1980-07-10 Verfahren zur herstellung von carbostyrilderivaten
CA000355992A CA1156657A (en) 1979-07-14 1980-07-11 Process for the preparation of pharmacologically active carbostyril derivatives
ES498465A ES8201138A1 (es) 1979-07-14 1981-01-13 Procedimiento mejorado para la preparacion de derivados de carbostirilo
ES498466A ES498466A0 (es) 1979-07-14 1981-01-13 Procedimiento mejorado para la preparacion de derivados de carbostirilo

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19792928583 DE2928583A1 (de) 1979-07-14 1979-07-14 Verfahren zur herstellung von carbostyrilderivaten
DE2928583 1979-07-14

Publications (3)

Publication Number Publication Date
FI792426A FI792426A (fi) 1981-01-15
FI70408B FI70408B (fi) 1986-03-27
FI70408C true FI70408C (fi) 1986-09-19

Family

ID=6075786

Family Applications (1)

Application Number Title Priority Date Filing Date
FI792426A FI70408C (fi) 1979-07-14 1979-08-03 Foerfarande foer framstaellning av terapeutiskt aktiva karbostyrilderivat

Country Status (5)

Country Link
JP (1) JPS5616470A (no)
DE (1) DE2928583A1 (no)
DK (1) DK150156C (no)
FI (1) FI70408C (no)
NO (1) NO154131C (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
AU532361B2 (en) * 1981-09-01 1983-09-29 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
KR940000785B1 (ko) * 1986-04-02 1994-01-31 오오쓰까세이야꾸 가부시끼가이샤 카르보스티릴 유도체 및 그의 염의 제조 방법
DK167187A (da) * 1986-04-02 1987-10-03 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5321176A (en) * 1976-08-09 1978-02-27 Otsuka Pharmaceut Co Ltd Carbostyryl derivatives

Also Published As

Publication number Publication date
DK342079A (da) 1981-01-15
JPS5616470A (en) 1981-02-17
NO792659L (no) 1981-01-15
DE2928583A1 (de) 1981-01-29
FI792426A (fi) 1981-01-15
FI70408B (fi) 1986-03-27
JPS6326751B2 (no) 1988-05-31
DK150156B (da) 1986-12-22
DK150156C (da) 1987-10-12
NO154131C (no) 1986-07-23
NO154131B (no) 1986-04-14

Similar Documents

Publication Publication Date Title
CA1333068C (en) Quinoline derivatives, their production and use thereof as inhibitors for acyl-coa: cholesterol acyltransferase
NOVELLO et al. Diuretics: 1, 2, 4-Benzothiadiazine-1, 1-dioxides
FI77026C (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 3-(alkyltio, alkylsulfinyl eller alkylsulfonyl)-4-kinoloner.
US5223513A (en) Quinoline derivatives, their production and use
Hubert et al. A Novel Reductive Cyclization of Imides
FI70408C (fi) Foerfarande foer framstaellning av terapeutiskt aktiva karbostyrilderivat
EP0145010B1 (en) Carbostyril derivatives
US3798226A (en) 3-acylamino-4-phenylquinolines carrying a substituent on the benzene ring
US3506654A (en) Benzylidene derivatives of chromene,thiochromene,quinoline,and n-alkyl quinoline and corresponding benzyl tertiary carbinol intermediates
US3206471A (en) Novel substituted 3-(alpha-alkoxycarbonyloxy-lower alkyl)-and 3-(alpha-phenoxycarbonyloxy-lower alkyl)-4, 7-indoloquinones and novel methods of preparing the same
US2652398A (en) N-substituted-2-amino (methyl) quinolines
US2935514A (en) Benzimidazoles
US3303189A (en) 2, 1-benzothiazine-2, 2-dioxides
Bajwa et al. Antimalarials. 1. Heterocyclic analogs of N-substituted naphthalenebisoxazines
IE51542B1 (en) Therapeutic agents
US3004978A (en) Certain i-tert-amino lower alkyl
US2558211A (en) Preparation of 4-hydroxyquinoline compounds
JPS6023112B2 (ja) 新規なベンゾ〔ｃ〕キノリン類製造用中間体
FI69064B (fi) Foerfarande foer framstaellning av farmakologiskt vaerdefulla karbostyril- och oxindolderivat
CA1192198A (en) Quinolylacetic acid compounds, process for producing thereof and pharmaceutical compositions containing them
Birch et al. Syntheses of flosequinan: a novel 4-quinolone shown to be useful in congestive heart failure
US4990515A (en) Benzo[1,8]naphthyridine derivatives as antimicrobials
Clinton et al. A Structure Proof for 4-(4-Diethylamino-1-methylbutylamino)-7-phenoxyquinoline
GB2085441A (en) Therapeutic agents
CA1156657A (en) Process for the preparation of pharmacologically active carbostyril derivatives

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: DR. KARL THOMAE GESELLSCHAFT MIT