JPS5616470A - Novel manufacture of carbostyril derivative - Google Patents

Novel manufacture of carbostyril derivative

Info

Publication number
JPS5616470A
JPS5616470A JP6999180A JP6999180A JPS5616470A JP S5616470 A JPS5616470 A JP S5616470A JP 6999180 A JP6999180 A JP 6999180A JP 6999180 A JP6999180 A JP 6999180A JP S5616470 A JPS5616470 A JP S5616470A
Authority
JP
Japan
Prior art keywords
carbostyril derivative
novel manufacture
novel
manufacture
carbostyril
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6999180A
Other languages
Japanese (ja)
Other versions
JPS6326751B2 (en
Inventor
Muyuuraa Eeritsuhi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of JPS5616470A publication Critical patent/JPS5616470A/en
Publication of JPS6326751B2 publication Critical patent/JPS6326751B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
JP6999180A 1979-07-14 1980-05-26 Novel manufacture of carbostyril derivative Granted JPS5616470A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792928583 DE2928583A1 (en) 1979-07-14 1979-07-14 Substd. alkoxy-carbostyril derivs prodn. - e.g. by cyclising 2-carboxyethyl-1-aminobenzene derivs., useful as antithrombotic and positive inotropic agents

Publications (2)

Publication Number Publication Date
JPS5616470A true JPS5616470A (en) 1981-02-17
JPS6326751B2 JPS6326751B2 (en) 1988-05-31

Family

ID=6075786

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6999180A Granted JPS5616470A (en) 1979-07-14 1980-05-26 Novel manufacture of carbostyril derivative

Country Status (5)

Country Link
JP (1) JPS5616470A (en)
DE (1) DE2928583A1 (en)
DK (1) DK150156C (en)
FI (1) FI70408C (en)
NO (1) NO154131C (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3204892A1 (en) * 1981-02-17 1982-09-23 Otsuka Pharmaceutical Co. Ltd., Tokyo CARBOSTYRILE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND CARDIOTONIC COMPOSITIONS THAT CONTAIN THEM
US4514401A (en) * 1981-09-01 1985-04-30 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
KR940000785B1 (en) * 1986-04-02 1994-01-31 오오쓰까세이야꾸 가부시끼가이샤 Process for the preparation of carbostyril derivatives and salts thereof
DK167187A (en) * 1986-04-02 1987-10-03 Otsuka Pharma Co Ltd CARBOSTYRIC DERIVATIVES AND SALTS THEREOF, PROCEDURE FOR THE PREPARATION OF SUCH COMPOUNDS AND MEDICINAL CONTAINING THESE

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5321176A (en) * 1976-08-09 1978-02-27 Otsuka Pharmaceut Co Ltd Carbostyryl derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5321176A (en) * 1976-08-09 1978-02-27 Otsuka Pharmaceut Co Ltd Carbostyryl derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3204892A1 (en) * 1981-02-17 1982-09-23 Otsuka Pharmaceutical Co. Ltd., Tokyo CARBOSTYRILE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND CARDIOTONIC COMPOSITIONS THAT CONTAIN THEM
US4514401A (en) * 1981-09-01 1985-04-30 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Also Published As

Publication number Publication date
FI70408B (en) 1986-03-27
FI792426A (en) 1981-01-15
JPS6326751B2 (en) 1988-05-31
DK150156C (en) 1987-10-12
NO792659L (en) 1981-01-15
NO154131C (en) 1986-07-23
FI70408C (en) 1986-09-19
DK342079A (en) 1981-01-15
DE2928583A1 (en) 1981-01-29
NO154131B (en) 1986-04-14
DK150156B (en) 1986-12-22

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