DE2706360A1 - Cephalosporinantibiotika, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen - Google Patents
Cephalosporinantibiotika, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungenInfo
- Publication number
- DE2706360A1 DE2706360A1 DE19772706360 DE2706360A DE2706360A1 DE 2706360 A1 DE2706360 A1 DE 2706360A1 DE 19772706360 DE19772706360 DE 19772706360 DE 2706360 A DE2706360 A DE 2706360A DE 2706360 A1 DE2706360 A1 DE 2706360A1
- Authority
- DE
- Germany
- Prior art keywords
- ceph
- fur
- formula
- carbamoyloxymethyl
- cefuroxime
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 3
- 239000003242 anti bacterial agent Substances 0.000 title description 9
- 229940088710 antibiotic agent Drugs 0.000 title description 9
- 229930186147 Cephalosporin Natural products 0.000 title description 7
- 229940124587 cephalosporin Drugs 0.000 title description 7
- 150000001780 cephalosporins Chemical class 0.000 title description 7
- 238000004519 manufacturing process Methods 0.000 title description 4
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- 238000007911 parenteral administration Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- WSHJJCPTKWSMRR-RXMQYKEDSA-N penam group Chemical group S1CCN2[C@H]1CC2=O WSHJJCPTKWSMRR-RXMQYKEDSA-N 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 1
- 150000004965 peroxy acids Chemical class 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical class OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229940059096 powder for oral suspension Drugs 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 239000004173 sunset yellow FCF Substances 0.000 description 1
- 235000012751 sunset yellow FCF Nutrition 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- IXZDIALLLMRYOU-UHFFFAOYSA-N tert-butyl hypochlorite Chemical compound CC(C)(C)OCl IXZDIALLLMRYOU-UHFFFAOYSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 150000003952 β-lactams Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB6010/76A GB1572993A (en) | 1976-02-16 | 1976-02-16 | Ester derivatives of cefuroxime |
| GB2730076 | 1976-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2706360A1 true DE2706360A1 (de) | 1977-08-18 |
Family
ID=26240323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19772706360 Ceased DE2706360A1 (de) | 1976-02-16 | 1977-02-15 | Cephalosporinantibiotika, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4446317A (enExample) |
| JP (1) | JPS52100493A (enExample) |
| AT (1) | AT358726B (enExample) |
| CA (1) | CA1093549A (enExample) |
| CH (1) | CH629814A5 (enExample) |
| DE (1) | DE2706360A1 (enExample) |
| DK (1) | DK63777A (enExample) |
| ES (1) | ES455918A1 (enExample) |
| FR (1) | FR2340951A1 (enExample) |
| IE (1) | IE44698B1 (enExample) |
| IL (1) | IL51451A (enExample) |
| NL (1) | NL7701567A (enExample) |
| SE (1) | SE432255B (enExample) |
| YU (1) | YU41077A (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1598568A (en) * | 1977-04-19 | 1981-09-23 | Glaxo Lab Ltd | Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid |
| GB8400024D0 (en) * | 1984-01-03 | 1984-02-08 | Glaxo Group Ltd | Cephalosporin antibiotics |
| GB8524001D0 (en) * | 1985-09-30 | 1985-11-06 | Glaxo Group Ltd | Pharmaceutical composition |
| SE9804002D0 (sv) | 1998-11-23 | 1998-11-23 | Astra Ab | New manufacturing process |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2350230A1 (de) * | 1972-10-05 | 1974-04-18 | Leo Pharm Prod Ltd | Verfahren zur herstellung von cephalosporinestern |
| DE2439880A1 (de) * | 1973-08-21 | 1975-04-03 | Glaxo Lab Ltd | Antibiotika und verfahren zu ihrer herstellung |
| DE2460537A1 (de) * | 1973-12-21 | 1975-07-03 | Glaxo Lab Ltd | Cephalosporin-antibiotika |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3974153A (en) * | 1971-05-14 | 1976-08-10 | Glaxo Laboratories Limited | 7-Hydrocarbonoxy imino-acetamido-3-carbamoyloxy methylceph-3-em-4 carboxylic acids |
| PL98296B1 (pl) * | 1973-02-07 | 1978-04-29 | Politechnika Gdanskapo | Sposob otrzymywania estrow acetoksymetylowych cefalosporyn |
| US3962227A (en) * | 1973-02-23 | 1976-06-08 | Eli Lilly And Company | 3-halo cephalosporins |
| CA1094545A (en) * | 1976-02-16 | 1981-01-27 | Michael Gregson | Cephalosporin antibiotics |
-
1977
- 1977-02-11 CA CA271,579A patent/CA1093549A/en not_active Expired
- 1977-02-15 NL NL7701567A patent/NL7701567A/xx not_active Application Discontinuation
- 1977-02-15 DE DE19772706360 patent/DE2706360A1/de not_active Ceased
- 1977-02-15 DK DK63777A patent/DK63777A/da not_active Application Discontinuation
- 1977-02-15 AT AT100577A patent/AT358726B/de not_active IP Right Cessation
- 1977-02-15 IL IL51451A patent/IL51451A/xx unknown
- 1977-02-15 IE IE324/77A patent/IE44698B1/en unknown
- 1977-02-15 CH CH187377A patent/CH629814A5/de not_active IP Right Cessation
- 1977-02-15 JP JP1601977A patent/JPS52100493A/ja active Pending
- 1977-02-15 ES ES455918A patent/ES455918A1/es not_active Expired
- 1977-02-15 SE SE7701667A patent/SE432255B/xx unknown
- 1977-02-15 YU YU00410/77A patent/YU41077A/xx unknown
- 1977-02-16 FR FR7704340A patent/FR2340951A1/fr active Granted
-
1982
- 1982-01-27 US US06/343,326 patent/US4446317A/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2350230A1 (de) * | 1972-10-05 | 1974-04-18 | Leo Pharm Prod Ltd | Verfahren zur herstellung von cephalosporinestern |
| DE2439880A1 (de) * | 1973-08-21 | 1975-04-03 | Glaxo Lab Ltd | Antibiotika und verfahren zu ihrer herstellung |
| DE2460537A1 (de) * | 1973-12-21 | 1975-07-03 | Glaxo Lab Ltd | Cephalosporin-antibiotika |
Non-Patent Citations (2)
| Title |
|---|
| Morin - Gorman: Chemistry and Biology of ?-Lactam-Antibiotics, 1982, Bd. 1, 404-407 |
| Morin - Gorman: Chemistry and Biology of beta-Lactam-Antibiotics, 1982, Bd. 1, 404-407 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CH629814A5 (de) | 1982-05-14 |
| IL51451A (en) | 1980-12-31 |
| SE7701667L (sv) | 1977-08-17 |
| YU41077A (en) | 1982-06-30 |
| US4446317A (en) | 1984-05-01 |
| FR2340951B1 (enExample) | 1981-11-06 |
| CA1093549A (en) | 1981-01-13 |
| AT358726B (de) | 1980-09-25 |
| IE44698B1 (en) | 1982-02-24 |
| FR2340951A1 (fr) | 1977-09-09 |
| IE44698L (en) | 1977-08-16 |
| ATA100577A (de) | 1980-02-15 |
| IL51451A0 (en) | 1977-04-29 |
| JPS52100493A (en) | 1977-08-23 |
| DK63777A (da) | 1977-08-17 |
| NL7701567A (nl) | 1977-08-18 |
| ES455918A1 (es) | 1978-01-01 |
| SE432255B (sv) | 1984-03-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8128 | New person/name/address of the agent |
Representative=s name: ZUMSTEIN SEN., F., DR. ASSMANN, E., DIPL.-CHEM. DR |
|
| 8131 | Rejection |