DE2646186A1 - Antihypertonika - Google Patents
AntihypertonikaInfo
- Publication number
- DE2646186A1 DE2646186A1 DE19762646186 DE2646186A DE2646186A1 DE 2646186 A1 DE2646186 A1 DE 2646186A1 DE 19762646186 DE19762646186 DE 19762646186 DE 2646186 A DE2646186 A DE 2646186A DE 2646186 A1 DE2646186 A1 DE 2646186A1
- Authority
- DE
- Germany
- Prior art keywords
- amino
- compound
- dimethoxyquinazoline
- tetrahydropyran
- hydrochloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/621,980 US4026894A (en) | 1975-10-14 | 1975-10-14 | Antihypertensive agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE2646186A1 true DE2646186A1 (de) | 1977-04-28 |
DE2646186C2 DE2646186C2 (US20100268047A1-20101021-C00003.png) | 1987-10-29 |
Family
ID=24492453
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19762646186 Granted DE2646186A1 (de) | 1975-10-14 | 1976-10-13 | Antihypertonika |
Country Status (10)
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2831112A1 (de) * | 1977-08-04 | 1979-02-15 | Abbott Lab | 1-(4-amino-6,7-dimethoxy-2-chinazolinyl)-4-(2-tetrahydrofuroyl)-piperazin-hydrochloriddihydrat |
US4188390A (en) * | 1977-11-05 | 1980-02-12 | Pfizer Inc. | Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines |
US4279910A (en) * | 1979-04-25 | 1981-07-21 | Pfizer Inc. | Quinazoline therapeutic agents |
DE3346675A1 (de) * | 1983-12-23 | 1985-07-04 | Beiersdorf Ag, 2000 Hamburg | Substituierte 1-(4-amino-6,7-dialkoxy-chinazolinyl)-4- cyclohexenyl-derivate des piperazins und homopiperazins, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen und zwischenprodukte |
EP0188094A2 (en) * | 1984-12-14 | 1986-07-23 | Mitsui Petrochemical Industries, Ltd. | Quinazoline derivatives and antihypertensive preparations containing same as effective components |
AT398075B (de) * | 1989-04-21 | 1994-09-26 | Egyt Gyogyszervegyeszeti Gyar | Verfahren zur herstellung von chinazolinderivaten |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2421888A1 (fr) * | 1978-02-06 | 1979-11-02 | Synthelabo | Amides d'alkylene-diamines et leur application en therapeutique |
US4197301A (en) * | 1978-10-16 | 1980-04-08 | Allergan Pharmaceuticals, Inc. | Topical ophthalmic use of Prazosin |
US4287341A (en) * | 1979-11-01 | 1981-09-01 | Pfizer Inc. | Alkoxy-substituted-6-chloro-quinazoline-2,4-diones |
EP0022481A1 (en) * | 1979-06-21 | 1981-01-21 | Mitsubishi Yuka Pharmaceutical Co., Ltd. | 5,6-Alkylenepyrimidine derivatives, processes for preparing the same and pharmaceutical compositions |
HU180708B (en) * | 1979-10-11 | 1983-04-29 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing new 1,2,4-oxadiazine derivatives |
US4351940A (en) * | 1980-03-03 | 1982-09-28 | Pfizer Inc. | Chloro- and alkoxy-substituted-2-chloro-4-aminodquinazolines |
US4367335A (en) * | 1981-08-03 | 1983-01-04 | Mead Johnson & Company | Thiazolidinylalkylene piperazine derivatives |
FI79107C (fi) * | 1984-06-25 | 1989-11-10 | Orion Yhtymae Oy | Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid. |
DE3683760D1 (de) * | 1986-03-21 | 1992-03-12 | Heumann Pharma Gmbh & Co | Kristalline, wasserfreie sigma -form von 2-(4-(2-furoyl-(2-piperazin)-1-yl)-4-amino-6,7-dimethoxychinazolinhydrochlorid und verfahren zu ihrer herstellung. |
JPH03286800A (ja) * | 1990-04-03 | 1991-12-17 | Gunze Ltd | 衣類の折畳み装置 |
US5212176A (en) * | 1990-06-29 | 1993-05-18 | Abbott Laboratories | R(+)-terazosin |
IL101243A (en) * | 1991-03-20 | 1999-12-22 | Merck & Co Inc | Pharmaceutical preparations for the treatment of benign prostatic hyperplasia containing steroid history |
CA2077252C (en) * | 1992-08-31 | 2001-04-10 | Khashayar Karimian | Methods of making ureas and guanidines, and intermediates therefor |
US5294615A (en) * | 1993-04-29 | 1994-03-15 | Abbott Laboratories | Terazosin polymorph and pharmaceutical composition |
US5412095A (en) * | 1993-04-29 | 1995-05-02 | Abbott Laboratories | Terazosin monohydrochloride and processes and intermediate for its production |
IT1270993B (it) * | 1994-03-18 | 1997-05-26 | Recordati Chem Pharm | Derivati chinzolilamminici attivi come alfa-antagonisti |
US5504207A (en) * | 1994-10-18 | 1996-04-02 | Abbott Laboratories | Process and intermediate for the preparation of terazosin hydrochloride dihydrate |
CA2232138A1 (en) * | 1995-09-29 | 1997-04-03 | William C. Lumma | Alpha 1b adrenergic receptor antagonists |
US5587377A (en) * | 1995-10-24 | 1996-12-24 | Invamed, Inc. | Terazosin crystalline polymorph and pharmaceutical compositions thereof |
DE19546573A1 (de) * | 1995-12-13 | 1997-06-19 | Uetikon Chemie Gmbh | Kristallines Polymorph von Terazosin-Hydrochlorid, sowie Verfahren zu seiner Herstellung |
US6177430B1 (en) | 1997-03-27 | 2001-01-23 | Pfizer Inc | Use of α1-adrenoreceptor antagonists in the prevention and treatment of benign prostatic hyperplasia |
CA2173408C (en) * | 1996-04-03 | 2001-09-04 | K.S. Keshava Murthy | Process for the manufacture of intermediates suitable to make doxazosin,terazosin, prazosin, tiodazosin and related antihypertensive medicines |
US5952003A (en) * | 1996-08-01 | 1999-09-14 | Novartis Corporation | Terazosin capsules |
IT1286789B1 (it) * | 1996-11-29 | 1998-07-17 | Alfa Chem Ital | Processo per la produzione della forma i del terazosin monocloridato anidro |
IT1286790B1 (it) * | 1996-11-29 | 1998-07-17 | Alfa Chem Ital | Processo per la produzione della forma i del terazosin monocloridrato anidro |
GB9700504D0 (en) * | 1997-01-11 | 1997-02-26 | Pfizer Ltd | Pharmaceutical compounds |
US6248888B1 (en) | 1997-11-14 | 2001-06-19 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of terazosin hydrochloride dihydrate |
EP1118322A4 (en) | 1998-09-30 | 2004-10-20 | Takeda Chemical Industries Ltd | MEDICINES FOR IMPROVING BUBBLE EMPTYING STRENGTH |
US20020065286A1 (en) * | 2000-08-21 | 2002-05-30 | Davies Michael John | Treatment of wounds |
US20020091129A1 (en) * | 2000-11-20 | 2002-07-11 | Mitradev Boolell | Treatment of premature ejaculation |
US20030060513A1 (en) * | 2001-09-27 | 2003-03-27 | Arneric Stephen P. | Pharmaceutical composition |
GB0130219D0 (en) * | 2001-12-18 | 2002-02-06 | Pfizer Ltd | Compounds for the treatment of sexual dysfunction |
US20030229001A1 (en) * | 2002-01-31 | 2003-12-11 | Pfizer Inc. | Treatment of male sexual dysfunction |
EP1490090A4 (en) | 2002-02-22 | 2006-09-20 | New River Pharmaceuticals Inc | SYSTEMS FOR DELIVERING ACTIVE AGENTS AND METHODS FOR PROTECTING AND DELIVERING ACTIVE AGENTS |
GB0219961D0 (en) | 2002-08-28 | 2002-10-02 | Pfizer Ltd | Oxytocin inhibitors |
US7323462B2 (en) * | 2002-12-10 | 2008-01-29 | Pfizer Inc. | Morpholine dopamine agonists |
CA2679030A1 (en) | 2002-12-13 | 2004-07-01 | Warner-Lambert Company Llc | Alpha-2-delta ligand to treat lower urinary track symptoms |
CA2451267A1 (en) * | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
PA8597401A1 (es) * | 2003-03-14 | 2005-05-24 | Pfizer | Derivados del acido 3-(1-[3-(1,3-benzotiazol-6-il) propilcarbamoil] cicloalquil) propanoico como inhibidores de nep |
US20040220186A1 (en) * | 2003-04-30 | 2004-11-04 | Pfizer Inc. | PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease |
US20050065158A1 (en) * | 2003-07-16 | 2005-03-24 | Pfizer Inc. | Treatment of sexual dysfunction |
KR20060126448A (ko) | 2003-09-12 | 2006-12-07 | 알러간, 인코포레이티드 | 통증 및 다른 알파 2 아드레날린 매개 증상을 치료하기위한 방법 및 조성물 |
US20050059744A1 (en) * | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions |
US20050058696A1 (en) * | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions |
US7291640B2 (en) * | 2003-09-22 | 2007-11-06 | Pfizer Inc. | Substituted triazole derivatives as oxytocin antagonists |
US20050267096A1 (en) * | 2004-05-26 | 2005-12-01 | Pfizer Inc | New indazole and indolone derivatives and their use pharmaceuticals |
US20050288270A1 (en) * | 2004-05-27 | 2005-12-29 | Pfizer Inc | New aminopyridine derivatives and their use as pharmaceuticals |
CA2500676A1 (en) * | 2005-03-11 | 2006-09-11 | Apotex Pharmachem Inc. | Preparation of acid addition salts of amine bases by solid phase-gas phase reactions |
DE602006003416D1 (de) * | 2005-03-21 | 2008-12-11 | Pfizer Ltd | Substituierte triazolderivate als oxytocinantagonisten |
EP1863484A1 (en) * | 2005-03-21 | 2007-12-12 | Pfizer Limited | Substituted triazole derivatives as oxytocin antagonists |
US20060264442A1 (en) * | 2005-05-18 | 2006-11-23 | Allergan, Inc. | Methods for the treatment of ocular and neurodegenerative conditions in a mammal |
CA2618103A1 (en) * | 2005-08-10 | 2007-02-15 | Pfizer Limited | Substituted triazole derivatives as oxytocin antagonists |
US20070086958A1 (en) * | 2005-10-14 | 2007-04-19 | Medafor, Incorporated | Formation of medically useful gels comprising microporous particles and methods of use |
US20070161791A1 (en) * | 2006-01-09 | 2007-07-12 | Narsimha Reddy Penthala | Process for the preparation of terazosin hydrocloride dihydrate |
CN101190890B (zh) * | 2006-11-30 | 2011-04-27 | 江苏豪森药业股份有限公司 | 5-[(2r)-[2-[2-[2-(2,2,2-三氟乙氧基)苯氧基]乙基]氨基]丙基]-2-甲氧基苯磺酰胺 |
US8389531B2 (en) * | 2007-07-11 | 2013-03-05 | Hetero Drugs Limited | Process for erlotinib hydrochloride |
CN103739596A (zh) * | 2013-12-10 | 2014-04-23 | 刘磊 | 用于心脑血管疾病的喹唑啉衍生物 |
US11224572B1 (en) | 2020-08-17 | 2022-01-18 | Novitium Pharma LLC | Stable oral liquid composition of terazosin |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2120495A1 (de) * | 1970-05-21 | 1971-12-02 | Pfizer Inc., New York, N.Y. (V.St.A.) | Neue Trialkoxychinazolin-Verbindungen und Verfahren zu ihrer Herstellung |
DE2354389A1 (de) * | 1972-10-30 | 1974-05-09 | Eisai Co Ltd | Chinazolinverbindungen und verfahren zu ihrer herstellung |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3511836A (en) * | 1967-12-13 | 1970-05-12 | Pfizer & Co C | 2,4,6,7-tetra substituted quinazolines |
-
1975
- 1975-10-14 US US05/621,980 patent/US4026894A/en not_active Expired - Lifetime
-
1976
- 1976-08-02 CA CA258,274A patent/CA1057754A/en not_active Expired
- 1976-08-04 AU AU16557/76A patent/AU498925B2/en not_active Expired
- 1976-08-11 MX MX762894U patent/MX3620E/es unknown
- 1976-10-05 JP JP51119041A patent/JPS5248678A/ja active Granted
- 1976-10-12 CH CH1288876A patent/CH602712A5/xx not_active IP Right Cessation
- 1976-10-13 DE DE19762646186 patent/DE2646186A1/de active Granted
- 1976-10-13 FR FR7630803A patent/FR2327787A1/fr active Granted
- 1976-10-13 SE SE7611379A patent/SE422685B/xx not_active IP Right Cessation
- 1976-10-14 GB GB42802/76A patent/GB1517403A/en not_active Expired
-
1977
- 1977-01-21 US US05/760,895 patent/US4112097A/en not_active Expired - Lifetime
-
1980
- 1980-12-04 SE SE8008533A patent/SE431208B/sv not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2120495A1 (de) * | 1970-05-21 | 1971-12-02 | Pfizer Inc., New York, N.Y. (V.St.A.) | Neue Trialkoxychinazolin-Verbindungen und Verfahren zu ihrer Herstellung |
DE2354389A1 (de) * | 1972-10-30 | 1974-05-09 | Eisai Co Ltd | Chinazolinverbindungen und verfahren zu ihrer herstellung |
Non-Patent Citations (2)
Title |
---|
Brit. Med. Journal 1975, S. 727-728 * |
The Lancet 1975, S. 1095 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2831112A1 (de) * | 1977-08-04 | 1979-02-15 | Abbott Lab | 1-(4-amino-6,7-dimethoxy-2-chinazolinyl)-4-(2-tetrahydrofuroyl)-piperazin-hydrochloriddihydrat |
US4188390A (en) * | 1977-11-05 | 1980-02-12 | Pfizer Inc. | Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines |
US4279910A (en) * | 1979-04-25 | 1981-07-21 | Pfizer Inc. | Quinazoline therapeutic agents |
DE3346675A1 (de) * | 1983-12-23 | 1985-07-04 | Beiersdorf Ag, 2000 Hamburg | Substituierte 1-(4-amino-6,7-dialkoxy-chinazolinyl)-4- cyclohexenyl-derivate des piperazins und homopiperazins, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen und zwischenprodukte |
EP0188094A2 (en) * | 1984-12-14 | 1986-07-23 | Mitsui Petrochemical Industries, Ltd. | Quinazoline derivatives and antihypertensive preparations containing same as effective components |
EP0188094A3 (en) * | 1984-12-14 | 1987-12-23 | Mitsui Petrochemical Industries, Ltd. | Quinazoline derivatives and antihypertensive preparations containing same as effective components |
AT398075B (de) * | 1989-04-21 | 1994-09-26 | Egyt Gyogyszervegyeszeti Gyar | Verfahren zur herstellung von chinazolinderivaten |
Also Published As
Publication number | Publication date |
---|---|
FR2327787A1 (fr) | 1977-05-13 |
DE2646186C2 (US20100268047A1-20101021-C00003.png) | 1987-10-29 |
FR2327787B1 (US20100268047A1-20101021-C00003.png) | 1980-10-10 |
GB1517403A (en) | 1978-07-12 |
CH602712A5 (US20100268047A1-20101021-C00003.png) | 1978-07-31 |
SE7611379L (sv) | 1977-04-15 |
CA1057754A (en) | 1979-07-03 |
JPS5248678A (en) | 1977-04-18 |
JPS5543474B2 (US20100268047A1-20101021-C00003.png) | 1980-11-06 |
SE431208B (sv) | 1984-01-23 |
US4112097A (en) | 1978-09-05 |
SE422685B (sv) | 1982-03-22 |
AU498925B2 (en) | 1979-03-29 |
US4026894A (en) | 1977-05-31 |
SE8008533L (sv) | 1980-12-04 |
AU1655776A (en) | 1978-02-09 |
MX3620E (es) | 1981-04-02 |
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8110 | Request for examination paragraph 44 | ||
8128 | New person/name/address of the agent |
Representative=s name: ABITZ, W., DIPL.-ING.DR.-ING. MORF, D., DR., PAT.- |
|
D2 | Grant after examination | ||
8364 | No opposition during term of opposition |