DE2618009C3 - 1-N-<a-Hydroxy-to-aminoacyl)- derivate des 3'-Deoxykanamycin A und diese enthaltende Arzneimittel - Google Patents

1-N-<a-Hydroxy-to-aminoacyl)- derivate des 3'-Deoxykanamycin A und diese enthaltende Arzneimittel

Info

Publication number
DE2618009C3
DE2618009C3 DE2618009A DE2618009A DE2618009C3 DE 2618009 C3 DE2618009 C3 DE 2618009C3 DE 2618009 A DE2618009 A DE 2618009A DE 2618009 A DE2618009 A DE 2618009A DE 2618009 C3 DE2618009 C3 DE 2618009C3
Authority
DE
Germany
Prior art keywords
deoxykanamycin
hydroxy
amino
kanamycin
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2618009A
Other languages
German (de)
English (en)
Other versions
DE2618009B2 (de
DE2618009A1 (de
Inventor
Tsutomo Yokohama Kanagawa Tsuchiya (Japan)
Hamao Umezawa
Sumio Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of DE2618009A1 publication Critical patent/DE2618009A1/de
Publication of DE2618009B2 publication Critical patent/DE2618009B2/de
Application granted granted Critical
Publication of DE2618009C3 publication Critical patent/DE2618009C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE2618009A 1975-04-24 1976-04-24 1-N-<a-Hydroxy-to-aminoacyl)- derivate des 3'-Deoxykanamycin A und diese enthaltende Arzneimittel Expired DE2618009C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50049105A JPS51127045A (en) 1975-04-24 1975-04-24 A process for preparing 3'- deoxykanamycin a derivatives.

Publications (3)

Publication Number Publication Date
DE2618009A1 DE2618009A1 (de) 1976-11-04
DE2618009B2 DE2618009B2 (de) 1978-04-27
DE2618009C3 true DE2618009C3 (de) 1979-01-18

Family

ID=12821793

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2618009A Expired DE2618009C3 (de) 1975-04-24 1976-04-24 1-N-<a-Hydroxy-to-aminoacyl)- derivate des 3'-Deoxykanamycin A und diese enthaltende Arzneimittel

Country Status (6)

Country Link
US (1) US4104372A (OSRAM)
JP (1) JPS51127045A (OSRAM)
CA (1) CA1058170A (OSRAM)
DE (1) DE2618009C3 (OSRAM)
FR (1) FR2308374A1 (OSRAM)
GB (1) GB1538278A (OSRAM)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4283528A (en) * 1976-06-17 1981-08-11 Schering Corporation 1-N-aminohydroxyacyl derivatives of gentamicin B
CA1105455A (en) * 1977-09-19 1981-07-21 Junji Irisawa Aminoglycoside derivatives
JPS55105699A (en) * 1979-02-05 1980-08-13 Microbial Chem Res Found 3',4'-dideoxykanamycin a and its 1-n-aminoalkanoyl derivative
DE2921973A1 (de) * 1979-05-30 1980-12-11 Bayer Ag Sisomicin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4410516A (en) * 1981-07-21 1983-10-18 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 1-N(αHydroxy-ω-aminoalkanoyl) derivatives of 5,3',4'-trideoxy- or 5,3', 4'-trideoxy-6'-N- methyl- or 5, 3', 4',6"-tetradeoxykannamyci B and production thereof
JPS6041692A (ja) * 1983-08-15 1985-03-05 Microbial Chem Res Found ２′，３′−ジデオキシカナマイシンａ誘導体
US4661474A (en) * 1984-12-15 1987-04-28 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 2',3'-dideoxy-2'-fluorokanamycin A and 1-N-(α-hydroxy-ω-aminoalkanoyl) derivatives thereof
JPS6253997A (ja) * 1985-09-03 1987-03-09 Kowa Co 新規なアミノ配糖体及びこれを含有する製剤
IT1225484B (it) * 1987-11-27 1990-11-14 Pierrel Spa Procedimento di sintesi dell'amikacina
RU2147234C1 (ru) * 1999-03-09 2000-04-10 Жемчугов Владислав Евгеньевич Препарат для профилактики и лечения особо опасных инфекционных заболеваний

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929761A (en) * 1971-11-30 1975-12-30 Microbial Chem Res Found 3-Deoxykanamycin
US3904597A (en) * 1973-02-23 1975-09-09 Bristol Myers Co Antibiotic derivatives
GB1441202A (en) * 1973-05-15 1976-06-30 Microbial Chem Res Found 1-n-isoserylkanamycins and the production thereof

Also Published As

Publication number Publication date
US4104372A (en) 1978-08-01
DE2618009B2 (de) 1978-04-27
DE2618009A1 (de) 1976-11-04
FR2308374B1 (OSRAM) 1978-11-17
FR2308374A1 (fr) 1976-11-19
CA1058170A (en) 1979-07-10
GB1538278A (en) 1979-01-17
JPS5752358B2 (OSRAM) 1982-11-06
JPS51127045A (en) 1976-11-05

Similar Documents

Publication Publication Date Title
DE2440956C3 (de) Kanamycin B-Derivate, Verfahren zu ihrer Herstellung und solche Derivate enthaltende Arzneimittel
DE2350169C3 (de) 19.10.72 Japan 103988-72 11.12.72 Japan 123482-72 23.01.73 Japan 9146-73 1-N- [(S)-2-Hydroxy-4-amino-butyryl] -neamin-Derivate, Verfahren zu ihrer Herstellung und solche Derivate enthaltende Arzneimittel
DE2332485C2 (de) Gentamicin C1-derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2618009C3 (de) 1-N-&lt;a-Hydroxy-to-aminoacyl)- derivate des 3&#39;-Deoxykanamycin A und diese enthaltende Arzneimittel
DE2411504C3 (de) 6&#39;-Substituierte 6&#39;-Desoxylividomycine B, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2942194C2 (de) Aminoglycoside, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende antibiotische Mittel
DE2724597C3 (de) 3&#39;-Desoxykanamycin C und 3\4&#39;-Didesoxykanamycin C, deren Salze, Verfahren zu deren Herstellung und diese Verbindungen enthaltende antibakterielle Mittel
DE1811518C3 (de) Daunonibicinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE2423591C3 (de) 1-N-Isoserylkanamycine, Verfahren zu ihrer Herstellung und solche Verbindungen enthaltende Arzneimittel
DE3112124C2 (de) Formimidoylistamycin A und B, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
DE2360946A1 (de) Antibiotische derivate
DE2543535C3 (de) 1 -N-(a-Hydroxy-co-aminoalkanoyl) -6&#39;-N-methyl-3&#39;,4&#39;-didesoxy-kanamycine B, deren pharmazeutisch verträgliche Säureadditionssalze, Verfahren zur Herstellung derselben und Arzneimittel
DE2352361A1 (de) Antibiotische derivate
DE2512587C3 (de) 1 -N-(L-4-Amino-2-hydroxybutyryl)-6&#39; -N-alkylkanamycine A, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Mittel
DE2825289B2 (de) Kanamycinen und Ribostamycinen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende antibakterielle Mittel
DE2741431C3 (de) l-N-(L-4-Amino-2-hydroxybutyryl)-3&#39;-desoxykanamycin-C, l-N-(L-4-Amino-2hydroxybutyryl)-3&#39;,4&#39;-didesoxykanamycin-C und deren Säureadditionssalze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende antibakterielle Zusammensetzungen
DE2458921B2 (de) N-(2-hydroxy-4-aminobutyryl)-derivate des antibiotikums xk-62-2, ihre salze, verfahren zu ihrer herstellung und arzneimittel
DE2759475C2 (de) Verfahren zur Herstellung von Kanamycin C
DE2547738C3 (de) Derivate von Kanamycin A oder B, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE3035057C2 (de) 6&#34;-Desoxy- und 4&#34;,6&#34;-Didesoxy-dibekacin sowie deren 1-N(L-4-Amino-2-hydroxybutyryl)-Derivate. Verfahren zu Ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2855077A1 (de) 6&#39;-n-alkyl- und 6&#39;,6&#39;-die-n-alkylderivate von fortimicin a und b
DE2631462A1 (de) Derivate von xk-62-2, deren salze mit saeuren, verfahren zu ihrer herstellung und arzneipraeparate
DE4337629A1 (de) Antimikrobiell wirkende Oasomycin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung
DE2311524B2 (de) 1- eckige Klammer auf L-(-)-gamma-Amno-alpha-hydroxybutyryl eckige Klammer zu -tobramycin, dessen nicht-toxische Säureadditionssalze und Verfahren zu deren Herstellung
CH648564A5 (de) Gegebenenfalls 1-n-acyliertes 5,3,4-trideoxy- oder 5,3,4-trideoxy-6-n-methyl- oder 5,3,4,6-tetradeoxykanamycin-b und verfahren zu dessen herstellung.

Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee