DE2537070A1 - Thiazinderivate - Google Patents

Thiazinderivate

Info

Publication number
DE2537070A1
DE2537070A1 DE19752537070 DE2537070A DE2537070A1 DE 2537070 A1 DE2537070 A1 DE 2537070A1 DE 19752537070 DE19752537070 DE 19752537070 DE 2537070 A DE2537070 A DE 2537070A DE 2537070 A1 DE2537070 A1 DE 2537070A1
Authority
DE
Germany
Prior art keywords
methyl
hydroxy
thiazine
thieno
dioxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19752537070
Other languages
German (de)
English (en)
Other versions
DE2537070C2 (no
Inventor
Dieter Dr Binder
Otto Prof Dr Hromatka
Rudolf Dr Pfister
Paul Dr Zeller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1158274A external-priority patent/CH608500A5/de
Priority claimed from CH1215774A external-priority patent/CH608501A5/de
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE2537070A1 publication Critical patent/DE2537070A1/de
Application granted granted Critical
Publication of DE2537070C2 publication Critical patent/DE2537070C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Manufacturing Of Printed Wiring (AREA)
  • Electroplating Methods And Accessories (AREA)
DE19752537070 1974-08-26 1975-08-20 Thiazinderivate Granted DE2537070A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1158274A CH608500A5 (en) 1974-08-26 1974-08-26 Process for the preparation of thiazine derivatives
CH1215774A CH608501A5 (en) 1974-09-09 1974-09-09 Process for the preparation of thiazine derivatives

Publications (2)

Publication Number Publication Date
DE2537070A1 true DE2537070A1 (de) 1976-03-18
DE2537070C2 DE2537070C2 (no) 1987-06-25

Family

ID=25708582

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19752537070 Granted DE2537070A1 (de) 1974-08-26 1975-08-20 Thiazinderivate

Country Status (20)

Country Link
JP (1) JPS5826758B2 (no)
AR (1) AR216288A1 (no)
AT (1) AT350064B (no)
BR (1) BR7505463A (no)
DD (1) DD124119A5 (no)
DE (1) DE2537070A1 (no)
DK (1) DK137835B (no)
FI (1) FI59253C (no)
FR (3) FR2282893A1 (no)
GB (1) GB1519811A (no)
HU (1) HU173739B (no)
IE (1) IE41457B1 (no)
IL (1) IL47877A (no)
LU (2) LU73257A1 (no)
NL (2) NL183582C (no)
NO (1) NO146096C (no)
PL (1) PL106076B1 (no)
SE (1) SE412066B (no)
SU (1) SU603338A3 (no)
YU (1) YU40266B (no)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4187303A (en) 1977-08-22 1980-02-05 Hoffmann-La Roche Inc. Thiazine derivatives
EP0009142A1 (de) * 1978-09-02 1980-04-02 Dr. Karl Thomae GmbH Neue 4-Hydroxy-2H(1)benzothieno(2,3-e)-1,2-thiazin-3-carboxamid-1,1-dioxide sowie deren Salze, deren Verwendung und Verfahren zu ihrer Herstellung
EP0021058A2 (de) * 1979-06-13 1981-01-07 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Benzothienothiazinderivate, deren Verwendung, Verfahren und Zwischenprodukte zu deren Herstellung und diese enthaltende Arzneimittel
EP0103142A1 (de) * 1982-09-09 1984-03-21 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Thieno(2,3-e)-1,2-thiazin-Derivate
AT400437B (de) * 1993-12-14 1995-12-27 Chem Pharm Forsch Gmbh Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung
AT400568B (de) * 1994-05-18 1996-01-25 Chem Pharm Forsch Gmbh Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung
LT3947B (en) 1988-02-18 1996-05-27 Chem Pharm Forsch Gmbh Process for the preparation of 5-halogen-thienoisothiazol-3(2h)-on-1,1-dioxide containing basic substituents
US5538966A (en) * 1994-01-21 1996-07-23 Alcon Laboratories, Inc. Carbonic anhydrase inhibitors
US6613784B1 (en) 1999-03-02 2003-09-02 Nicox S.A. Nitroxyderivatives having antinflammatory, analgesic and antithrombotic activity

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2704485A1 (de) * 1977-02-03 1978-08-10 Thomae Gmbh Dr K Neue 2,5-dihydro-1,2-thiazino eckige klammer auf 5,6-b eckige klammer zu indol-3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
AU518216B2 (en) 1977-09-06 1981-09-17 Hafslund Nycomed Pharma Aktiengesellschaft Thienothiazine derivatives
ZA784958B (en) * 1977-09-06 1979-08-29 Hoffmann La Roche Thiazine derivatives
JPS58109492A (ja) * 1981-12-22 1983-06-29 Mitsui Toatsu Chem Inc チエノチアジン誘導体およびそれを含有する医薬組成物
JPS60163533U (ja) * 1984-04-02 1985-10-30 ホシデン株式会社 リ−ル台の制動装置
JPH0318748Y2 (no) * 1985-12-18 1991-04-19
EP0658559A1 (de) * 1993-12-14 1995-06-21 Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren
CN1171892C (zh) * 2001-06-25 2004-10-20 李晶 具有抗炎镇痛活性的噻吩并噻嗪化合物及其制备方法和用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.Med.Chem., 16, 1973, 493 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4187303A (en) 1977-08-22 1980-02-05 Hoffmann-La Roche Inc. Thiazine derivatives
EP0009142A1 (de) * 1978-09-02 1980-04-02 Dr. Karl Thomae GmbH Neue 4-Hydroxy-2H(1)benzothieno(2,3-e)-1,2-thiazin-3-carboxamid-1,1-dioxide sowie deren Salze, deren Verwendung und Verfahren zu ihrer Herstellung
EP0021058A2 (de) * 1979-06-13 1981-01-07 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Benzothienothiazinderivate, deren Verwendung, Verfahren und Zwischenprodukte zu deren Herstellung und diese enthaltende Arzneimittel
EP0021058A3 (de) * 1979-06-13 1981-01-28 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Benzothienothiazinderivate, deren Verwendung, Verfahren und Zwischenprodukte zu deren Herstellung und diese enthaltende Arzneimittel
EP0103142A1 (de) * 1982-09-09 1984-03-21 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Thieno(2,3-e)-1,2-thiazin-Derivate
LT3947B (en) 1988-02-18 1996-05-27 Chem Pharm Forsch Gmbh Process for the preparation of 5-halogen-thienoisothiazol-3(2h)-on-1,1-dioxide containing basic substituents
AT400437B (de) * 1993-12-14 1995-12-27 Chem Pharm Forsch Gmbh Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung
US5538966A (en) * 1994-01-21 1996-07-23 Alcon Laboratories, Inc. Carbonic anhydrase inhibitors
AT400568B (de) * 1994-05-18 1996-01-25 Chem Pharm Forsch Gmbh Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung
US6613784B1 (en) 1999-03-02 2003-09-02 Nicox S.A. Nitroxyderivatives having antinflammatory, analgesic and antithrombotic activity

Also Published As

Publication number Publication date
DK381175A (no) 1976-02-27
NO752932L (no) 1976-02-27
DD124119A5 (no) 1977-02-02
AT350064B (de) 1979-05-10
AU8418675A (en) 1977-02-24
FI59253B (fi) 1981-03-31
HU173739B (hu) 1979-08-28
FI752398A (no) 1976-02-27
DK137835C (no) 1978-10-16
SU603338A3 (ru) 1978-04-15
FR2282893B1 (no) 1980-05-16
FI59253C (fi) 1981-07-10
DK137835B (da) 1978-05-16
IL47877A (en) 1978-10-31
LU73257A1 (no) 1977-04-15
FR2303803A1 (fr) 1976-10-08
JPS5826758B2 (ja) 1983-06-04
YU216675A (en) 1982-08-31
IE41457B1 (en) 1980-01-02
LU88312I2 (de) 1994-09-09
NL183582C (nl) 1988-12-01
IE41457L (en) 1976-02-26
IL47877A0 (en) 1975-11-25
FR2303803B1 (no) 1979-07-13
NL183582B (nl) 1988-07-01
ATA655975A (de) 1978-10-15
SE412066B (sv) 1980-02-18
YU40266B (en) 1985-12-31
DE2537070C2 (no) 1987-06-25
NL930080I1 (nl) 1993-09-16
GB1519811A (en) 1978-08-02
FR2309558B1 (no) 1979-05-04
NO146096B (no) 1982-04-19
SE7509446L (sv) 1976-02-27
BR7505463A (pt) 1976-08-03
AR216288A1 (es) 1979-12-14
NO146096C (no) 1982-07-28
JPS5148694A (no) 1976-04-26
FR2282893A1 (fr) 1976-03-26
NL930080I2 (nl) 1994-01-03
FR2309558A1 (fr) 1976-11-26
PL106076B1 (pl) 1979-11-30
NL7510057A (nl) 1976-03-01

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: F. HOFFMANN-LA ROCHE AG, BASEL, CH

8328 Change in the person/name/address of the agent

Free format text: LEDERER, F., DIPL.-CHEM. DR., 8000 MUENCHEN RIEDERER FRHR. VON PAAR ZU SCHOENAU, A., DIPL.-ING., PAT.-ANWAELTE, 8300 LANDSHUT