DE2511576C2 - Metformin-clofibrat, Verfahren zu seiner Herstellung und dieses enthaltendes Arzneimittel - Google Patents

Metformin-clofibrat, Verfahren zu seiner Herstellung und dieses enthaltendes Arzneimittel

Info

Publication number
DE2511576C2
DE2511576C2 DE2511576A DE2511576A DE2511576C2 DE 2511576 C2 DE2511576 C2 DE 2511576C2 DE 2511576 A DE2511576 A DE 2511576A DE 2511576 A DE2511576 A DE 2511576A DE 2511576 C2 DE2511576 C2 DE 2511576C2
Authority
DE
Germany
Prior art keywords
metformin
clofibrate
salt
preparation
product containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2511576A
Other languages
German (de)
English (en)
Other versions
DE2511576A1 (de
Inventor
Claude Paris Bohuon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Merck Clevenot SA
Original Assignee
D'etudes Et D'exploitation De Marques Et Brevets Sems 92600 Asnieres Fr Ste
D'etudes Et D'exploitation De Marques Et Brevets SEMS 92600 Asnieres Ste
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by D'etudes Et D'exploitation De Marques Et Brevets Sems 92600 Asnieres Fr Ste, D'etudes Et D'exploitation De Marques Et Brevets SEMS 92600 Asnieres Ste filed Critical D'etudes Et D'exploitation De Marques Et Brevets Sems 92600 Asnieres Fr Ste
Publication of DE2511576A1 publication Critical patent/DE2511576A1/de
Application granted granted Critical
Publication of DE2511576C2 publication Critical patent/DE2511576C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE2511576A 1974-03-22 1975-03-17 Metformin-clofibrat, Verfahren zu seiner Herstellung und dieses enthaltendes Arzneimittel Expired DE2511576C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7409963A FR2264525B1 (xx) 1974-03-22 1974-03-22

Publications (2)

Publication Number Publication Date
DE2511576A1 DE2511576A1 (de) 1975-09-25
DE2511576C2 true DE2511576C2 (de) 1983-07-07

Family

ID=9136732

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2511576A Expired DE2511576C2 (de) 1974-03-22 1975-03-17 Metformin-clofibrat, Verfahren zu seiner Herstellung und dieses enthaltendes Arzneimittel

Country Status (11)

Country Link
JP (1) JPS5526134B2 (xx)
AT (1) AT346856B (xx)
BE (1) BE826999A (xx)
CA (1) CA1062280A (xx)
CH (1) CH609669A5 (xx)
DE (1) DE2511576C2 (xx)
ES (1) ES435898A1 (xx)
FR (1) FR2264525B1 (xx)
GB (1) GB1462316A (xx)
LU (1) LU72102A1 (xx)
NL (1) NL169461C (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60196425A (ja) * 1984-03-16 1985-10-04 Daido Metal Kogyo Kk 軸受すきまを一定に維持されたパツド型ジヤ−ナル軸受装置
FR2774591B1 (fr) 1998-02-12 2000-05-05 Lipha Composition pharmaceutique comprenant l'association metformine et fibrate et son utilisation pour la preparation de medicaments destines a reduire l'hyperglycemie
FR2796551B1 (fr) * 1999-07-23 2003-07-25 Lipha Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant
FR2796940B1 (fr) * 1999-07-26 2005-04-08 Lipha Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7116M (xx) * 1968-01-08 1969-07-15
AT317235B (de) * 1972-08-22 1974-08-26 Hurka Wilhelm Verfahren zur Herstellung des neuen 2-(p-Chlorphenoxy)-2-methylpropionsäuresalzes des 1-Phenäthylbiguanids

Also Published As

Publication number Publication date
ES435898A1 (es) 1976-12-16
DE2511576A1 (de) 1975-09-25
NL169461C (nl) 1982-07-16
CA1062280A (fr) 1979-09-11
ATA217875A (de) 1978-04-15
FR2264525B1 (xx) 1977-11-04
FR2264525A1 (xx) 1975-10-17
LU72102A1 (xx) 1975-08-20
CH609669A5 (en) 1979-03-15
JPS50135043A (xx) 1975-10-25
AT346856B (de) 1978-11-27
BE826999A (fr) 1975-07-16
NL7503515A (nl) 1975-09-24
GB1462316A (en) 1977-01-26
NL169461B (nl) 1982-02-16
JPS5526134B2 (xx) 1980-07-11

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Legal Events

Date Code Title Description
OB Request for examination as to novelty
OC Search report available
OD Request for examination
8126 Change of the secondary classification

Free format text: C07C 59/68 A61K 31/205 A61K 31/155

D2 Grant after examination
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LABORATOIRES MERCK CLEVENOT S.A., NOGENT-SUR-MARNE

8328 Change in the person/name/address of the agent

Free format text: GRUENECKER, A., DIPL.-ING. KINKELDEY, H., DIPL.-ING. DR.-ING. STOCKMAIR, W., DIPL.-ING. DR.-ING. AE.E. CAL TECH SCHUMANN, K., DIPL.-PHYS. DR.RER.NAT. JAKOB, P., DIPL.-ING. BEZOLD, G., DIPL.-CHEM. DR.RER.NAT. MEISTER, W., DIPL.-ING. HILGERS, H., DIPL.-ING. MEYER-PLATH, H., DIPL.-ING. DR.-ING. KINKELDEY, U., DIPL.-BIOL. DR.RER.NAT. BOTT-BODENHAUSEN, M., DIPL.-PHYS. DR.RER.NAT., PAT.-ANW., 8000 MUENCHEN